Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T53350 | Target Info | |||
| Target Name | Bone morphogenetic protein 1 (BMP1) | ||||
| Synonyms |
Procollagen C-proteinase; PCP protein; PCOLC; Mammalian tolloid protein; MTld; BMP-1
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| Target Type | Literature-reported Target | ||||
| Gene Name | BMP1 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 16 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
UK-356618
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|
Investigative | Compound Info | ||
| Synonyms |
UK 356618; 230961-08-7; CHEMBL117225; UK-356,618; SCHEMBL6437730; GTPL6528; CHEBI:94305; DTXSID50438778; MolPort-023-277-089; ZINC3924338; BDBM50097263; AKOS024458021; FT-0675728; PF 03890101; PF-03890101; UK-356618, > J-014983; BRD-K57011718-001-01-5; (R)-N*1*-[(S)-2,2-Dimethyl-1-((R)-1-phenyl-ethylcarbamoyl)-propyl]-N*4*-hydroxy-2-[3-(2-methyl-biphenyl-4-yl)-propyl]-succinamide
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| Activity |
IC50 = 52000 nM
|
[1] | |||
| Compound Name |
2-[Butylsulfonyl-[2-(4-methoxyphenyl)ethyl]amino]-N-hydroxyacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2204092; BDBM50402535
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| Activity |
IC50 = 55000 nM
|
[2] | |||
| Compound Name |
(2R)-2-[(2-Chloro-4-fluorophenyl)sulfonylamino]-N-hydroxy-5-[[(1R)-1-phenylethyl]carbamoylamino]pentanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL292267; BDBM50102986
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| Activity |
IC50 = 61000 nM
|
[3] | |||
| Compound Name |
2-Acetylamino-N-[(S)-1-(hydroxycarbamoylmethyl-carbamoyl)-2-(4-hydroxy-phenyl)-ethyl]-3-(4-hydroxy-phenyl)-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2369943; BDBM50093825
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| Activity |
IC50 = 65000 nM
|
[4] | |||
| Compound Name |
N-Hydroxy-2-[(4-methoxyphenyl)sulfonyl-[[4-(trifluoromethyl)phenyl]methyl]amino]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2204829; SCHEMBL8003589; BDBM50402549
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|
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| Activity |
IC50 = 67000 nM
|
[2] | |||
| Compound Name |
[1-Hydroxycarbamoyl-2-(1H-indol-3-yl)-ethyl]-carbamic acid benzyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL278678; BDBM50093868
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| Activity |
IC50 = 67000 nM
|
[4] | |||
| Compound Name |
(S)-3-((S)-3-Carbamoyl-1-methylcarbamoyl-propylcarbamoyl)-4-hydroxycarbamoyl-butyric acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL309468; BDBM50093858
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|
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| Activity |
IC50 = 68000 nM
|
[4] | |||
| Compound Name |
N-Hydroxy-2-(N-(4-methoxyphenyl)sulfonylanilino)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2204847; SCHEMBL7109099; BDBM50402560
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|
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| Activity |
IC50 = 69000 nM
|
[2] | |||
| Compound Name |
N-Hydroxy-2-(4-methoxy-N-(4-methoxyphenyl)sulfonylanilino)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2204827; SCHEMBL7003318; BDBM50402551
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|
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| Activity |
IC50 = 73000 nM
|
[2] | |||
| Compound Name |
N-Hydroxy-3-[(4-methoxyphenyl)sulfonyl-(2-morpholin-4-ylethyl)amino]propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2204831; SCHEMBL7004503; BDBM50402547
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|
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| Activity |
IC50 = 81000 nM
|
[2] | |||
| Compound Name |
(4S)-4-[[2-(Carboxymethyl)-3-sulfanylpropanoyl]amino]-5-(methylamino)-5-oxopentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2204843; BDBM50402507
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|
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| Activity |
IC50 = 85000 nM
|
[2] | |||
| Compound Name |
1-Hydroxy-1-[2-[2-(4-methoxyphenyl)ethyl-(4-methylsulfonylphenyl)sulfonylamino]ethyl]urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2204812; BDBM50402524
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-[Benzhydryl-(4-methoxyphenyl)sulfonylamino]-N-hydroxyacetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2204830; BDBM50402548
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|
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| Activity |
IC50 = 102000 nM
|
[2] | |||
| Compound Name |
Calbiochem 444235
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL84594; SCHEMBL6420436; CGS 27023A Analog 30; BDBM13102; 2-[butan-2-yl(4-methoxybenzene)sulfonamido]-N-hydroxyacetamide; 2-[butan-2-yl-(4-methoxyphenyl)sulfonylamino]-N-hydroxyacetamide
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|
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| Activity |
IC50 = 112000 nM
|
[2] | |||
| Compound Name |
N-Hydroxy-3-[(4-methoxyphenyl)sulfonylamino]propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2204090; SCHEMBL7417568; BDBM50402537
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|
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| Activity |
IC50 = 166000 nM
|
[2] | |||
| Compound Name |
Butyl 2-[[2-(hydroxyamino)-2-oxoethyl]-(4-methoxyphenyl)sulfonylamino]acetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2204826; BDBM50402552
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|
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| Activity |
IC50 = 167000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 4 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(S)-2-Acetylamino-N-hydroxycarbamoylmethyl-3-(4-hydroxy-phenyl)-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL311264; BDBM50093848
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|
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| Activity |
IC50 = 280000 nM
|
[4] | |||
| Compound Name |
2-(N-(2-(Hydroxyamino)-2-oxoethyl)-4-methoxyphenylsulfonamido)acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL515083; SCHEMBL8001734; BDBM50246600
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|
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| Activity |
IC50 = 345000 nM
|
[2] | |||
| Compound Name |
(S)-2-Acetylamino-5-guanidino-pentanoic acid ((S)-1-hydroxycarbamoyl-ethyl)-amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL81890; BDBM50093822
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|
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| Activity |
IC50 > 800000 nM
|
[4] | |||
| Compound Name |
(4S)-4-[[(2S)-3-Carboxy-2-(carboxymethylamino)propanoyl]amino]-5-(methylamino)-5-oxopentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2204842; BDBM50402508
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|
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| Activity |
IC50 = 1500000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers. J Med Chem. 2003 Jul 31;46(16):3514-25. | ||||
| REF 2 | Design and synthesis of procollagen C-proteinase inhibitors. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7397-401. | ||||
| REF 3 | Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-proteinase: solid-phase synthesis of ornithine analogues. Bioorg Med Chem Lett. 2001 Aug 20;11(16):2085-8. | ||||
| REF 4 | Solid-phase synthesis of di- and tripeptidic hydroxamic acids as inhibitors of procollagen C-proteinase. Bioorg Med Chem Lett. 2000 Nov 20;10(22):2513-6. | ||||
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