Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T50973 | Target Info | |||
| Target Name | Kynurenine 3-hydroxylase (KMO) | ||||
| Synonyms |
Kynurenine 3monooxygenase; Kynurenine 3-monooxygenase
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| Target Type | Clinical trial Target | ||||
| Gene Name | KMO | ||||
| Biochemical Class | Paired donor oxygen oxidoreductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-Amino-2-(hydroxymethyl)propane-1,3-diol;3-[5-chloro-6-(2-methoxyethoxy)-2-oxo-1,3-benzoxazol-3-yl]propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4068504; SCHEMBL16836520; BDBM50266014
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| Activity |
IC50 = 50118.72 nM
|
[1] | |||
| Compound Name |
2-Amino-2-(hydroxymethyl)propane-1,3-diol;3-[5-chloro-2-oxo-6-[(1S)-1-pyridin-2-ylethoxy]-1,3-benzoxazol-3-yl]propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4075981; SCHEMBL18185362; BDBM50266115
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| Activity |
IC50 = 63095.73 nM
|
[1] | |||
| Compound Name |
ClC=1C(=CC2=C(N(C(O2)=O)CCC(=O)O)C1)C#N
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4069680; SCHEMBL16836417; BDBM50237997
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| Activity |
IC50 = 79432.82 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis. J Med Chem. 2017 Apr 27;60(8):3383-3404. | ||||
| REF 2 | The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis. Bioorg Med Chem Lett. 2017 May 1;27(9):2023-2028. | ||||
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