Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T50461 | Target Info | |||
| Target Name | Ribonuclease (RNase) | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | NO-GeName | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 9 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
5-Nitro-furan-2-carboxylic acid [[4-(4-bromo-phenyl)-thiazol-2-yl]-(tetrahydro-furan-2-ylmethyl)-carbamoyl]-methyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL522795; BDBM50292881; AKOS007957276; MCULE-4980821041
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|
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| Activity | Ribonuclease H1 |
IC50 = 50000 nM
|
[1] | ||
| Compound Name |
2-Benzyl-5,6-dihydroxy-pyrimidine-4-carboxylic acid methyl ester
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Investigative | Compound Info | ||
| Synonyms |
methyl 2-benzyl-5,6-dihydroxypyrimidine-4-carboxylate; CHEMBL539211; SCHEMBL5128630; pyrimidinol carboxylic acid, 12; BDBM33420; CTK6J1190; DTXSID40716198; 1571AJ; ZINC21994345; AKOS015965697; SB37474; DB-071447; FT-0748923; Z-7191; methyl 2-benzyl-5-hydroxy-4-oxo-1H-pyrimidine-6-carboxylate; Methyl 2-benzyl-5-hydroxy-6-oxo-3,6-dihydropyrimidine-4-carboxylate
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|
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| Activity | Ribonuclease H1 |
IC50 = 70000 nM
|
[2] | ||
| Compound Name |
Thymidine 3'-benzoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL259808; EINECS 241-352-7; 3'-O-Benzoyl thymidine; SCHEMBL2056750; CTK0H7473; ZINC5765077; BDBM50375419
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|
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| Activity | Ribonuclease pancreatic |
Ki = 95000 nM
|
[3] | ||
| Compound Name |
Cytidine 3'-monophosphate
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Investigative | Compound Info | ||
| Synonyms |
3'-Cytidylic acid; Cytidine-3'-Monophosphate; 3'-CMP; 3-Cytidylic acid; Cytidine 3'-phosphate; UNII-6DZL5I6D4D; 6DZL5I6D4D; CHEMBL258728; ST057096; cytidine-3'-phosphate; CYTIDINE3'-MONOPHOSPHATE; EINECS 201-537-5; CytidylsA currencyure b; cytidine-3''-monophosphate; SCHEMBL79966; Cytidine 3'-monophosphoric acid; CTK8C5691; UOOOPKANIPLQPU-XVFCMESISA-; DTXSID301004260; ZINC4096919; 4-Imino-1-(3-O-phosphonopentofuranosyl)-1,4-dihydropyrimidin-2-ol; BDBM50233301; MFCD00006543; SBB002949; AKOS015856718; AKOS015895646; DB01961; NCGC00142494-01; C05822; 006C543; Q27104806
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|
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| Activity | Ribonuclease pancreatic |
Ki = 103000 nM
|
[3] | ||
| Compound Name |
1-[3-(4-Carboxypiperidin-1-YL)-3-deoxy-beta-D-arabinofuranosyl]pyrimidine-2,4(1H,3H)-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL469949; 3-N-PIPERIDINE-4-CARBOXYL-3-DEOXY-ARA-URIDINE; BDBM50276039; Q27463668; 3''-[1-(4-carboxylpiperdinyl)]-3''-deoxy-ara-uridine
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|
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| Activity | Ribonuclease pancreatic |
Ki = 103000 nM
|
[4] | ||
| Compound Name |
3''-[1-(4-Ethoxycarbonylpiperdinyl)]-3''-deoxy-ara-uridine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL471836; BDBM50276040
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|
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| Activity | Ribonuclease pancreatic |
Ki = 120000 nM
|
[4] | ||
| Compound Name |
2-((2S,3S,5R)-2-(Hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-ylamino)-2-oxoacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL593706; BDBM50304292
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|
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| Activity | Ribonuclease pancreatic |
Ki = 132000 nM
|
[5] | ||
| Compound Name |
3'-Thymidylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
thymidine 3'-monophosphate; UNII-Q84LAH3NDH; Q84LAH3NDH; THYMIDINE-3'-PHOSPHATE; CHEMBL408119; Octothymidylate; Thymidine 3'-monophosphate ammonium salt; 3'-Tmp; Thymidine 3'-phosphate; thymidin-3'-monophosphat; ALPHA-ANOMERIC THYMIDINE-3'-PHOSPHATE; 3'-dTMP; SCHEMBL887983; 2'-Deoxythymidine 3'-monophosphate; ZINC6521315; BDBM50375418; J-016420; Q27104819
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|
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| Activity | Ribonuclease pancreatic |
IC50 = 167000 nM
|
[3] | ||
| Compound Name |
3'-O-Acetylthymidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL266234; C12H16N2O6; SCHEMBL265600; 3'-O-Ac-T; ZINC6521309; 5277AH; BDBM50375420; MFCD00056059; AC-32259; 3 inverted exclamation mark -O-Methylthymidine
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|
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| Activity | Ribonuclease pancreatic |
IC50 = 197000 nM
|
[3] | ||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-((2S,3S,5R)-2-(Hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-ylamino)-3-oxopropanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL593464; BDBM50304294
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|
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| Activity | Ribonuclease pancreatic |
Ki = 380000 nM
|
[5] | ||
| Compound Name |
4-((2S,3S,5R)-2-(Hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-ylamino)-4-oxobutanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL593956; BDBM50304293
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|
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| Activity | Ribonuclease pancreatic |
Ki = 918000 nM
|
[5] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Derivatives of 5-nitro-furan-2-carboxylic acid carbamoylmethyl ester inhibit RNase H activity associated with HIV-1 reverse transcriptase. J Med Chem. 2009 Mar 12;52(5):1380-7. | ||||
| REF 2 | RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information. J Med Chem. 2009 Oct 8;52(19):5781-4. | ||||
| REF 3 | Exploring the potential of 3'-O-carboxy esters of thymidine as inhibitors of ribonuclease A and angiogenin. Bioorg Med Chem. 2008 Mar 15;16(6):2819-28. | ||||
| REF 4 | Using proton nuclear magnetic resonance to study the mode of ribonuclease A inhibition by competitive and noncompetitive inhibitors. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5503-6. | ||||
| REF 5 | Inhibition of ribonuclease A by nucleoside-dibasic acid conjugates. Bioorg Med Chem. 2009 Sep 15;17(18):6491-5. | ||||
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