Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T50224 | Target Info | |||
| Target Name | Ribosomal protein S6 kinase alpha-5 (RSK5) | ||||
| Synonyms |
S6K-alpha-5; RSKL; RSK-like protein kinase; Nuclear mitogen- and stress-activated protein kinase 1; MSK1; 90 kDa ribosomal protein S6 kinase 5
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| Target Type | Patented-recorded Target | ||||
| Gene Name | RPS6KA5 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 7 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
AM7
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Investigative | Compound Info | ||
| Synonyms |
pyrimidone, 22; AM 7; AM-7
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
4(3H)-Pyrimidinone,2-[(4-fluorophenyl)amino]-5-[5-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]-2-pyridinyl]-3-methyl-
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Investigative | Compound Info | ||
| Synonyms |
pyrimidone, 62; CHEMBL447602; SCHEMBL13511902; BDBM24772; ZINC43202030
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| Activity |
IC50 = 52000 nM
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[1] | |||
| Compound Name |
1-(2-Hydroxy-2-methylpropyl)-N-(5-((7-methoxyquinolin-4-yl)oxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
AMG-458; AMG 458; AMG458; UNII-4535RW5Y3A; 4535RW5Y3A; C30H29N5O5; Substituted Pyrazolone, 17; cc-602; MLS006010963; SCHEMBL197714; CHEMBL460472; BDBM24466; AMG-458,AMG458; DTXSID80238521; SYN1144; AMG458/AMG-458/; HMS3656H21; BCP01917; EX-A2447; 2209AH; ABP000135; s2747; ZINC43194549; AKOS027422876; CCG-269954; SB19374; NCGC00346670-01; NCGC00346670-05; AS-16283; HY-14723; SMR004702767; AMG-458(AMG458;AMG 458); CS-0003527; FT-0752842; SW220166-1; Z-3256; Q27258802
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| Activity |
IC50 = 100000 nM
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[2] | |||
| Compound Name |
5-[3-Fluoro-4-[[6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yl]oxy]phenyl]-2-(4-fluorophenylamino)-3-methylpyrimidin-4(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
AMG-51; pyrimidone, 51; AMG51; CHEMBL453737; SCHEMBL2868963; AMG-51;AMG 51; BDBM24769; SYN1111; C34H33F2N5O5; BCP21618; ZINC43178754; NCGC00263201-01; NCGC00263201-02; AS-16255
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Aminopyrimidine amide, 13b
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL272888; SCHEMBL2943385; BDBM26369
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Lck Inhibitor
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Investigative | Compound Info | ||
| Synonyms |
TC-S 7003; CHEMBL410295; SCHEMBL5235694; C31H30N8O; 4090AH; BDBM50374608; ZINC53214756; AKOS024457690; CS-1448; NCGC00378811-02; HY-12072; W-5787; Q27457537
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Compound Name |
Pyrrolopyridine, 9
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL388566; BDBM30178
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| Activity |
IC50 = 146000 nM
|
[5] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 4 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
PMID17480064C16
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Investigative | Compound Info | ||
| Synonyms |
724711-21-1; 3fhr; 2jbp; 2jbo; P4O; Pyrrolopyridine, 16; Kinome_3179; 3r2y; GTPL8177; BDBM30185; ZINC16052855; AKOS027322581; DB08358; KB-19275; DB-013997; FT-0745988
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| Activity |
IC50 > 200000 nM
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[5] | |||
| Compound Name |
7-Methoxy-3,4,5,10-tetrahydro-1H-2,5-methanoazepino[3,4-b]indole-1-carboxylic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL392876; SCHEMBL1655459; BDBM50215481
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| Activity |
IC50 > 200000 nM
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[6] | |||
| Compound Name |
2-[2-(2-Fluorophenyl)pyridin-4-yl]-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one
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Investigative | Compound Info | ||
| Synonyms |
Pyrrolopyridine, 23; Kinome_2487; CHEMBL226471; SCHEMBL15508853; BDBM30192; DB07728; Q27096944
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| Activity |
IC50 > 200000 nM
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[5] | |||
| Compound Name |
6-Methoxy-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-1-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL395157; 6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid; 6-METHOXY-1H,2H,3H,4H,9H-PYRIDO[3,4-B]INDOLE-1-CARBOXYLIC ACID; SCHEMBL608164; SCHEMBL12660570; CTK0H2172; DTXSID00397280; BDBM50215483; MFCD00010826; STL525685; AKOS015894383; MCULE-5714246217; ST065834; 952M635; J-011460; Z2216905627; 6-methoxy-1,2,3,4-tetrahydrobeta-carbolinecarboxylic acid; 6-Methoxy-1,2,3,4-tetrahydro-beta-carboline-1-carboxylic acid; 6-methoxy-2,3,4,9-tetrahydro-1h-beta-carboline-1-carboxylic acid; 1H-Pyrido[3,4-b]indole-1-carboxylic acid, 2,3,4,9-tetrahydro-6-methoxy-; 1H-Pyrido[3,4-b]indole-1-carboxylicacid, 2,3,4,9-tetrahydro-6-methoxy-; 6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-2-ium-1-carboxylate; 6-Methoxy-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-1-carboxylic acid, 97%
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| Activity |
IC50 > 200000 nM
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[6] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design, synthesis, and biological evaluation of potent c-Met inhibitors. J Med Chem. 2008 Sep 25;51(18):5766-79. | ||||
| REF 2 | Structure-based design of novel class II c-Met inhibitors: 2. SAR and kinase selectivity profiles of the pyrazolone series. J Med Chem. 2012 Mar 8;55(5):1868-97. | ||||
| REF 3 | Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation. J Med Chem. 2008 Mar 27;51(6):1681-94. | ||||
| REF 4 | Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory activity. J Med Chem. 2008 Mar 27;51(6):1637-48. | ||||
| REF 5 | Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). J Med Chem. 2007 May 31;50(11):2647-54. | ||||
| REF 6 | Novel tetrahydro-beta-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Bioorg Med Chem Lett. 2007 Aug 15;17(16):4657-63. | ||||
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