Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T48780 | Target Info | |||
| Target Name | Early activation antigen CD69 (CD69) | ||||
| Synonyms |
MLR3; Leukocyte surface antigen Leu23; GP32/28; Early Tcell activation antigen p60; EA1; Ctype lectin domain family 2 member C; CD69; BLAC/P26; Activation inducer molecule
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| Target Type | Literature-reported Target | ||||
| Gene Name | CD69 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 2 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose
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Investigative | Compound Info | ||
| Synonyms |
Beta-N-Acetylglucosamine; betaGlcNAc; GlcNAc-beta; CHEBI:28009; UNII-8P59336F68; 2-Acetamido-2-deoxy-beta-D-glucose; AI3-51898; 8P59336F68; N-[(2R,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide; Cheon shim bo yun
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| Activity |
IC50 = 125892.54 nM
|
[1] | |||
| Compound Name |
2-[[5,11,17,23-Tetratert-butyl-27-(carboxymethoxy)-26,28-dihydroxy-2,8,14,20-tetraoxo-2lambda4,8lambda4,14lambda4,20lambda4-tetrathiapentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(24),3,5,7(28),9,11,13(27),15(26),16,18,21(25),22-dodecaen-25-yl]oxy]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL591695; BDBM50481444
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| Activity |
IC50 = 79432.82 nM
|
[2] | |||
| Non Binders of This Target (in total, 6 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-[[11,23,26,28-Tetratert-butyl-17,25,27-tris(carboxymethoxy)-5-pentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(24),3,5,7(28),9,11,13(27),15(26),16,18,21(25),22-dodecaenyl]oxy]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL601306; BDBM50481446
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| Activity |
IC50 = 251188.64 nM
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[2] | |||
| Compound Name |
2-[[5,11,17,23-Tetratert-butyl-26,27,28-tris(carboxymethoxy)-2,8,14,20-tetrathiapentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(24),3,5,7(28),9,11,13(27),15(26),16,18,21(25),22-dodecaen-25-yl]oxy]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL601101; BDBM50481439
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| Activity |
IC50 = 398107.17 nM
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[2] | |||
| Compound Name |
N-[(2R,3S,4R,5R,6R)-2-[(2R,3R,4R,5S)-4,5-Dihydroxy-2-(hydroxymethyl)piperidin-3-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1210903; BDBM50482394
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| Activity |
IC50 = 501187.23 nM
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[3] | |||
| Compound Name |
Duvoglustat hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
Duvoglustat HCl; 1-Deoxynojirimycin hydrochloride; (2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol hydrochloride; UNII-0RN23C42QR; Deoxynojirimycin hydrochloride; AT2220; 0RN23C42QR; Duvoglustat hydrochloride [USAN]; AT-2220; 73285-50-4 (HCL); 1-Deoxy-L-altronojirimycin Hydrochloride; Duvoglustat hydrochloride (USAN); Moranoline HCl; BAY-h-5595; 1-Deoxynojirimycin (hydrochloride); Moranoline hydrochloride; AT 2220; Moranolin hydrochloride; 1,5-Dideoxy-1,5-imino-D-sorbitol hydrochloride; CHEMBL460785; SCHEMBL1320203; CTK8F0904; DTXSID401017351; HGT-3510; HY-14860A; MFCD00133247; AKOS030253224; SB17422; AS-60890; CS-0101849; D09606; 732D504; Q27237146; (2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol;hydrochloride; 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, hydrochloride (1:1), (2R,3R,4R,5S)-
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| Activity |
IC50 = 630957.34 nM
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[3] | |||
| Compound Name |
2-(Acetylamino)-2-deoxy-beta-d-talopyranose
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1210905; BDBM50482396; ZINC16124914
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| Activity |
IC50 = 1000000000 nM
|
[3] | |||
| Compound Name |
2-(Acetylamino)-2-deoxy-alpha-D-mannopyranose
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Investigative | Compound Info | ||
| Synonyms |
alpha-ManAc; alpha-D-ManpAc; alpha-D-ManAc; N-acetyl-alpha-D-mannosamine; 2-acetamido-2-deoxy-alpha-D-mannopyranose; UNII-A1O5EUP7KS; 2-acetamido-2-deoxy-alpha-D-mannose; A1O5EUP7KS; 2-acetylamino-alpha-D-2-deoxy-mannopyranose; N-acetylmannosamine; Epitope ID:149549; alpha-D-N-Acetylmannosamine; N-acetyl- -D-mannosamine; SCHEMBL379737; CHEMBL1231391; ZINC4096030; BDBM50482397; N-[(2S,3S,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide; N-Acetyl-D-mannosamine, >=98% (TLC); Mannopyranose, 2-acetamido-2-deoxy-, alpha-D-
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| Activity |
IC50 = 1000000000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and biological activity of glycosyl-1H-1,2,3-triazoles. Bioorg Med Chem Lett. 2010 Jul 15;20(14):4263-5. | ||||
| REF 2 | Carboxylated calixarenes bind strongly to CD69 and protect CD69(+) killer cells from suicidal cell death induced by tumor cell surface ligands. Bioorg Med Chem. 2010 Feb 15;18(4):1434-40. | ||||
| REF 3 | Deoxynojirimycin and its hexosaminyl derivatives bind to natural killer cell receptors rNKR-P1A and hCD69. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4645-8. | ||||
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