Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T48268 | Target Info | |||
| Target Name | Melatonin receptor type 1B (MTNR1B) | ||||
| Synonyms |
Mel1b receptor; Mel1b melatonin receptor; Mel-1B-R
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| Target Type | Successful Target | ||||
| Gene Name | MTNR1B | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 4 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
SEROTONIN
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Investigative | Compound Info | ||
| Synonyms |
serotonin; 5-HYDROXYTRYPTAMINE; 3-(2-Aminoethyl)-1H-indol-5-ol; 50-67-9; Enteramine; 5-HT; Serotonine; Thrombotonin; Thrombocytin; Antemovis; Ds substance; Hippophain; Antemoqua; Substance DS; Substanz DS; 1H-Indol-5-ol, 3-(2-aminoethyl)-; 5-Hta; Tryptamine, 5-hydroxy-; 3-(2-Aminoethyl)indol-5-ol; Enteramin; UNII-333DO1RDJY; Indol-5-ol, 3-(2-aminoethyl)-; 5-Hydroxy-3-(beta-aminoethyl)indole; 3-(beta-Aminoethyl)-5-hydroxyindole; EINECS 200-058-9; 3-(2-Amino-ethyl)-1H-indol-5-ol; BRN 0143524; 333DO1RDJY; CHEBI:28790
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
Acetamide, N-[(1R)-1-methyl-2-phenoxyethyl]-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1223274; BDBM50416701
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| Activity |
Ki = 53703.18 nM
|
[2] | |||
| Compound Name |
N-[(2R)-1-Phenylsulfanylpropan-2-yl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1223346; BDBM50416695
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| Activity |
Ki = 64565.42 nM
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[2] | |||
| Compound Name |
N-[(1H-Indol-2-yl)alkyl]acylamino Derivatives 13
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL99000; BDBM85366; N-[3-(5-Methoxy-1H-indole-2-yl)propyl]acetamide
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| Activity |
Ki = 102329.3 nM
|
[3] | |||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chembl4285498
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Investigative | Compound Info | ||
| Synonyms |
BDBM50468601; 2-(beta-D-Glucopyranosyloxy)-5,5'-diallylbiphenyl-2'-ol
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| Activity |
EC50 = 383000 nM
|
[4] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The development of a charged melatonin receptor ligand. Bioorg Med Chem Lett. 1997 Sep 23;7(18):2409-14. | ||||
| REF 2 | Design, synthesis, and pharmacological effects of structurally simple ligands for MT(1) and MT(2) melatonin receptors. Bioorg Med Chem. 2010 Sep 1;18(17):6496-511. | ||||
| REF 3 | 2-N-acylaminoalkylindoles: design and quantitative structure-activity relationship studies leading to MT2-selective melatonin antagonists. J Med Chem. 2001 Aug 30;44(18):2900-12. | ||||
| REF 4 | Synthesis and biological evaluation of magnolol derivatives as melatonergic receptor agonists with potential use in depression. Eur J Med Chem. 2018 Aug 5;156:381-393. | ||||
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