Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T47888 | Target Info | |||
| Target Name | Sphingosine-1-phosphate receptor 2 (S1PR2) | ||||
| Synonyms |
Sphingosine 1-phosphate receptor Edg-5; S1PR2; S1P2; S1P receptor Edg-5; S1P receptor 2; Endothelial differentiation G-protein coupled receptor 5
Click to Show/Hide
|
||||
| Target Type | Clinical trial Target | ||||
| Gene Name | S1PR2 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 19 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
5-Cyclopropyl-N,N-bis(2-methylcyclohexyl)-1,2-oxazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1969371; BDBM50494319; SR-03000000621; SR-03000000621-2
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-Cyclohexyl-5-cyclopropyl-N-(2-methylcyclohexyl)-1,2-oxazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2004782; MLS003675930; BDBM50494315; SMR002356555; SR-03000000623; SR-03000000623-2
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N,N-Dicyclohexyl-5-(4-methoxyphenyl)-1,2-oxazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1984536; MLS003675928; BDBM50494307; SMR002356553; SR-03000000605; SR-03000000605-2
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-Cycloheptyl-5-cyclopropyl-N-(2-methylcyclohexyl)-1,2-oxazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1965004; MLS003675926; BDBM50494314; SMR002356551; SR-03000000624; SR-03000000624-2
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N,N-Dicyclohexyl[5-(methylethyl)isoxazol-3-yl]carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1968913; MLS003675927; BDBM50494310; ZINC20550160; AKOS003398015; MCULE-5325429407; SMR002356552; ST50676741; SR-03000000651; SR-03000000651-2
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CYM 5541; CYM5541; CYM-5541; ML249; ML-249; CHEMBL1970071; N,N-dicyclohexyl-5-cyclopropyl-1,2-oxazole-3-carboxamide; MLS003675929; GTPL9494; AOB1281; CYM 554; BDBM50494318; MFCD09782785; s6552; ZINC20428865; AKOS003403809; CS-6415; MCULE-9777169244; AK688819; AS-16635; SMR002356554; ST092984; HY-101419; SR-03000000611; SR-03000000611-2; N,N-dicyclohexyl(5-cyclopropylisoxazol-3-yl)carboxamide
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N,N-Dicyclohexyl-5-phenyl-1,2-oxazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1973788; BDBM50494308; SR-03000000612; SR-03000000612-2
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N,N-Dicyclohexyl-5-propyl-3-isoxazolecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SMR000093349; MLS000116372; N,N-dicyclohexyl-5-propyl-1,2-oxazole-3-carboxamide; SR-01000624234; ChemDiv3_008445; CHEMBL1455786; BDBM37340; cid_5309153; HMS1496P19; HMS2246C14; ML004; ZINC3908927; MCULE-1836110190; IDI1_026355; N,N-dicyclohexyl-5-propylisoxazole-3-carboxamide; N,N-dicyclohexyl-5-propyl-isoxazole-3-carboxamide; SR-01000624234-2; SR-01000624234-4; SR-01000624234-5; BRD-K14048378-001-01-0; Q27164008
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-(7-(5-(3-Cyano-5-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-3-yl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2048287; SCHEMBL2562414; BDBM50386853
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
5-[(4-Naphthalen-2-yl-1-benzothiophen-2-yl)methylamino]pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3883572; BDBM50209070
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
1-[(5-Naphthalen-2-yl-1-benzothiophen-2-yl)methyl]azetidine-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3883597; BDBM50209025
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-[(4-Naphthalen-2-yl-1-benzothiophen-2-yl)methylamino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3883447; BDBM50209035
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-[(4-Naphthalen-2-yl-1-benzothiophen-2-yl)methylamino]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3885331; BDBM50209074
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
CID 44517795
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1916399; SCHEMBL4429194; BDBM50357764
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-(7-(5-(3-Cyano-5-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2048293; SCHEMBL949280; BDBM50386859
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-[(4-Naphthalen-2-yl-1-benzothiophen-2-yl)methylamino]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3883812; BDBM50209028
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-[[(4-Naphthalen-2-yl-1-benzothiophen-2-yl)methylamino]methyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3884011; BDBM50209044
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-[5-[5-[3,5-Bis(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl]-2,3-dihydroindol-1-yl]-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1916559; SCHEMBL4421450; BDBM50357781
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
4-({[7-(Naphthalen-2-yl)-1-benzothiophen-2-yl]methyl}amino)butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3884038; GTPL9495; BDBM50209027; compound 5c [PMID: 27894870]
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery, design and synthesis of a selective S1P(3) receptor allosteric agonist. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6346-9. | ||||
| REF 2 | Fused tricyclic indoles as S1P1 agonists with robust efficacy in animal models of autoimmune disease. Bioorg Med Chem Lett. 2012 Jul 1;22(13):4404-9. | ||||
| REF 3 | A benzo[b]thiophene-based selective type 4 S1P receptor agonist. Bioorg Med Chem Lett. 2017 Jan 1;27(1):1-5. | ||||
| REF 4 | Discovery and characterization of potent and selective 4-oxo-4-(5-(5-phenyl-1,2,4-oxadiazol-3-yl)indolin-1-yl)butanoic acids as S1P1 agonists. Bioorg Med Chem Lett. 2011 Oct 1;21(19):6013-8. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.