Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T47215 | Target Info | |||
| Target Name | Cholecystokinin receptor (CCKR) | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | NO-GeName | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 57 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chlordiazepoxide
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|
Approved | Compound Info | ||
| Synonyms |
Abboxide; Balance; Chloradiazepoxide; Chlordiazachel; Chlordiazepoxid; Chlordiazepoxidum; Chlordiazepoxydum; Chloridazepoxide; Chloridiazepide; Chloridiazepoxide; Chlorodiazepoxide; Chlozepid; Clopoxide; Clordiazepossido; Clordiazepoxido; Control; Decacil; Disarim; Eden; Elenium; Helogaphen; Ifibrium; Kalmocaps; Librelease; Librinin; Libritabs; Librium; Lygen; Menrium; Mesural; Methaminodiazepoxide; Mildmen; Multum; Napoton; Napton; Psicosan; Radepur; Risolid; Silibrin; Sonimen; Tropium; Viopsicol; Zeisin; Zetran; Chlordiazepoxide Base; Clordiazepossido [Italian]; A-Poxide; Apo-Chlordiazepoxide; Balance (pharmaceutical); Chlordiazepoxidum [INN-Latin]; Clordiazepoxido [INN-Spanish]; Eden-psich; Libritabs (TN); Librium (TN); MENRIUM 10-4; MENRIUM 5-4; Novapam (TN); Novo-Poxide; Tropium (TN); Chlordiazepoxide (JP15/USP/INN); Chlordiazepoxide [USAN:INN:BAN:JAN]; 3H-1,4-Benzodiazepin-2-amine, 7-chloro-N-methyl-5-phenyl, 4-oxide; 3H-1,4-Benzodiazepin-2-amine, 7-chloro-N-methyl-5-phenyl-, 4-oxide; 3H-1,4-Benzodiazepine, 7-chloro-2-(methylamino)-5-phenyl-, 4-oxide; 3H-1,4-benzodiazepin-2-amine,7-chloro-N-methyl-5-phenyl-,4-oxide; 7-Chlor-2-methylamino-5-phenyl-3H-1,4-benzodiazepin-4-oxid; 7-Chlor-2-methylamino-5-phenyl-3H-1,4-benzodiazepin-4-oxid [German]; 7-Chloro-2-(methylamino)-5-phenyl-3H-1,4-benzodiazepine 4-oxide; 7-Chloro-N-methyl-5-phenyl-3H-1,4-benzodiazepin-2-amine 4-oxide; 7-Cloro-2-metilamino-5-fenil-3H-1,4-benzodiazepina 4-ossido; 7-Cloro-2-metilamino-5-fenil-3H-1,4-benzodiazepina 4-ossido [Italian]; 7-chloro-4-hydroxy-N-methyl-5-phenyl-3H-1,4-benzodiazepin-2-imine
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
Clonazepam
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|
Approved | Compound Info | ||
| Synonyms |
Antelepsin; Antilepsin; Chlonazepam; Cloazepam; Clonazepamum; Clonex; Clonopin; Iktorivil; Kenoket; Klonopin; Landsen; Lktorivil; Lonazep; Melzap; Paxam; Ravotril; Rivatril; Rivoril; Rivotril; Solfidin; Klonopin Rapidly Disintegrating; DF2374250; RO4023; Ro 4023; Ro 54023; Alti-Clonazepam; Clonazepamum [INN-Latin]; Klonopin (TN); Ravotril (TN); Rivatril (TN); Rivotril (TN); Ro 4-8180; Ro 5-4023; Ro-5-4023; Clonazepam (JP15/USP/INN); Clonazepam [USAN:INN:BAN:JAN]; Ro 5-4023/B-7; 1,3-Dihydro-5-(o-chlorophenyl)-7-nitro-3H-1,4-benzodiazepin-2-one; 1,3-Dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one; 5-(2-Chloro-phenyl)-7-nitro-1,3-dihydro-benzo[e][1,4]diazepin-2-one; 5-(2-Chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one; 5-(2-Chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 5-(2-Chlorophenyl)-7-nitro-3H-1,4-benzodiazepin-2(1H)-one; 5-(2-chlorophenyl)-7-nitro-1,3-dihydro-1,4-benzodiazepin-2-one; 5-(o-Chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one; 5-(o-Chlorophenyl)-7-nitro-1H-1,4-benzodiazepin-2(3H)-one; 5-(o-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 7-Nitro-5-(2-chlorophenyl)-3H-1,4-benzodiazepin-2(1H)-one
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Flunitrazepam
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Approved | Compound Info | ||
| Synonyms |
Flunibeta; Flunimerck; Fluninoc; Flunitrazepamum; Fluridrazepam; Narcozep; Primun; Rohipnol; Rohypnol; Roipnol; Betapharm Brand of Flunitrazepam; Ct Arzneimittel Brand of Flunitrazepam; Flunitrazepam Teva; Flunitrazepam neuraxpharm; Flunitrazepam ratiopharm; Flunizep von ct; Hexal Brand of Flunitrazepam; Merck dura Brand ofFlunitrazepam; Neuraxpharm Brand of Flunitrazepam; Ratiopharm Brand of Flunitrazepam; Roche Brand of Flunitrazepam; Teva Brand of Flunitrazepam; Fluni 1A Pharma; RO54200; [3H]flunitrazepam; Ct-Arzneimittel Brand of Flunitrazepam; Darkene (TN); Flunipam (TN); Flunitrazepam-Teva; Flunitrazepam-neuraxpharm; Flunitrazepam-ratiopharm; Flunitrazepamum [INN-Latin]; Hipnosedon (TN); Hypnodorm (TN); Ilman(TN); Insom (TN); Nilium (TN); Ro 5-4200; Rohypnol (TN); Rufinol (TN); Silece (TN); Vulbegal (TN); RO-5-4200; Flunitrazepam (JP15/USAN/INN); Flunitrazepam [USAN:INN:BAN:JAN]; 1,3-Dihydro-5-(o-fluorophenyl)-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-one; 1-Methyl-7-nitro-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2(1H)-one; 1A Brand of Flunitrazepam; 5-(2-Fluorophenyl)-1-methyl-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 5-(2-Fluorophenyl)-1-methyl-7-nitro-3H-1,4-benzodiazepin-2(1H)-one; 5-(2-fluorophenyl)-1-methyl-7-nitro-3H-1,4-benzodiazepin-2-one; 5-(o-Fluorophenyl)-1,3-dihydro-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-one
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
PMID27607364-Compound-4
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Patented | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
RO-054520
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL13095; 844-11-1; 5-(2-Fluorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one; RO-054520; AC1L4W0W; SCHEMBL11858895; CTK5F2279; DTXSID00233371; ZINC3650317; BDBM50019250; AKOS030555310; Ro-05-4520; 5-(2-fluorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one; 1-Methyl-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2(3H)-one
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-[5-(2-Fluoro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-4-nitro-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL303724; SCHEMBL9526500; BDBM50019254; N-[5-(2-fluorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-4-nitrobenzamide; N-[5-(2-Fluoro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-4-nitro-benzamide: 0.1CHCl3
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
5-Bromo-N-[5-(2-fluorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL72667; SCHEMBL9525370; BDBM50019184
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| Activity |
IC50 = 50000 nM
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[2] | |||
| Compound Name |
N-[5-(2-Fluorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]thiophene-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL70550; SCHEMBL9525369; BDBM50019173; 1,3-Dihydro-5-(2-fluorophenyl)-3-(RS)-(3-thiophene carbonylamino)-2H-1,4-benzodiazepin-2-one
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| Activity |
IC50 ~ 50000 nM
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[2] | |||
| Compound Name |
4-[(2S,3As,4S)-4-[[(7S)-5,13-dioxo-6,7,7a,8-tetrahydroquinazolino[3,2-a][1,4]benzodiazepin-7-yl]methyl]-4-hydroxy-2-(2-methylpropyl)-1-oxo-2,3a-dihydroimidazo[1,2-a]indol-3-yl]-4-oxobutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL432511; BDBM50225862
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| Activity |
IC50 = 54000 nM
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[3] | |||
| Compound Name |
N-(2-Oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-4-trifluoromethyl-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL302359; BDBM50019211; N-(2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl)-4-(trifluoromethyl)benzamide
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| Activity |
IC50 = 65000 nM
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[2] | |||
| Compound Name |
CID 14208299
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907844; BDBM50367633; 2-bromo-N-[(3S)-5-(2-fluorophenyl)-1-methyl-2-oxo-3H-1,4-benzodiazepin-3-yl]benzamide; N-[[(3S)-1-Methyl-2-oxo-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin]-3-yl]-2-bromobenzamide
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| Activity |
IC50 = 70000 nM
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[2] | |||
| Compound Name |
2-Iodo-N-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907839; SCHEMBL9865574; BDBM50367632; (S)-N-(2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-2-iodobenzamide; N-[[(3S)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin]-3-yl]-2-iodobenzamide
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| Activity |
IC50 = 71000 nM
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[2] | |||
| Compound Name |
3-Chloro-N-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL74125; SCHEMBL9526673; BDBM50019225; 3-chloro-N-(2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl)benzamide; 3-Chloro-N-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-benzamide:0.5CHCl3
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| Activity |
IC50 = 75000 nM
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[2] | |||
| Compound Name |
N-[5-(2-Fluorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-hydroxy-2-phenylacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL419997; BDBM50019243
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| Activity |
IC50 = 80000 nM
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[2] | |||
| Compound Name |
N-[5-(2-Fluorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]quinazoline-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL70896; BDBM50019193
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| Activity |
IC50 = 80000 nM
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[2] | |||
| Compound Name |
4-[(2S,3As,4S)-4-[[(7S)-5,13-dioxo-6,7-dihydroquinazolino[3,2-a][1,4]benzodiazepin-7-yl]methyl]-4-hydroxy-2-(2-methylpropyl)-1-oxo-2,3a-dihydroimidazo[1,2-a]indol-3-yl]-4-oxobutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL301427; BDBM50225851
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| Activity |
IC50 = 81000 nM
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[3] | |||
| Compound Name |
(7S)-7-[[(2S,3As,4S)-3-ethyl-4-hydroxy-2-(2-methylpropyl)-1-oxo-2,3a-dihydroimidazo[1,2-a]indol-4-yl]methyl]-6,7,7a,8-tetrahydroquinazolino[3,2-a][1,4]benzodiazepine-5,13-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL293744; BDBM50225856
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| Activity |
IC50 = 81000 nM
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[3] | |||
| Compound Name |
2-Chloro-N-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907854; SCHEMBL9526717; BDBM50367637; N-[[(3S)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin]-3-yl]-2-chlorobenzamide
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| Activity |
IC50 = 83000 nM
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[2] | |||
| Compound Name |
N-[(3S)-5-(2-Fluorophenyl)-1-methyl-2-oxo-3H-1,4-benzodiazepin-3-yl]-4-pentylbenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907840; SCHEMBL9866187; BDBM50367640
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| Activity |
IC50 = 100000 nM
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[2] | |||
| Compound Name |
4-Dimethylamino-N-[5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL73745; SCHEMBL9526416; BDBM50019253; 4-(dimethylamino)-N-[5-(2-fluorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]benzamide
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
4-(1H-Indol-3-yl)-N-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-butyramide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL73110; BDBM50019271
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
N-[(3R)-1-Methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-4-pentylbenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907843; SCHEMBL9865231; BDBM50367644
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
(3R)-5-(2-Fluorophenyl)-3-(1H-indol-3-ylmethyl)-N-phenyl-3H-1,4-benzodiazepin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL314081; BDBM50227022
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| Activity |
IC50 = 100000 nM
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[1] | |||
| Compound Name |
3-[2-(1H-Indol-3-yl)ethylamino]-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL70405; SCHEMBL9526053; BDBM50019244; 3-[2-(1H-Indol-3-yl)-ethylamino]-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one: 0.13CH2Cl2
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| Activity |
IC50 = 100000 nM
|
[2] | |||
| Compound Name |
(R)-2-Amino-N-((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-3-phenylpropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL307034; 2-Amino-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-3-phenyl-propionamide; BDBM50019192
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
3,5-Dichloro-N-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL72616; SCHEMBL9527083; BDBM50019223; 3,5-dichloro-N-(2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl)benzamide
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
3-[5-(2-Fluorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-1-methyl-1-phenylurea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL306958; BDBM50019234
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| Activity |
IC50 = 100000 nM
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[2] | |||
| Compound Name |
3-Amino-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL306271; SCHEMBL8533212; BDBM50019177; 1,3-dihydro-3(RS)-amino-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one; 1,3-Dihydro-3-(RS)-amino-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one; 1,3-dihydro-5-(2-fluorophenyl)-3-amino-2H-1,4-benzodiazepin-2-one; 3-(RS)-Amino-1,3-dihydro-5-(2'-fluorophenyl)-2H-1,4-benzodiazepin-2-one; 3-(RS)-Amino-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one; 3-Amino-5-(2-fluoro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one: 0.095CH2Cl2
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
2-Chloro-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL432334; SCHEMBL9526709; BDBM50019239; 2-chloro-N-(1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl)benzamide; (R)-2-Chloro-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-benzamide; (S)-2-Chloro-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-benzamide; 2-Chloro-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-benzamide:0.55H2O
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
(3R)-5-(2-Fluorophenyl)-3-(1H-indol-3-ylmethyl)-3H-1,4-benzodiazepin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL423869; BDBM50227025
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| Activity |
IC50 = 100000 nM
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[1] | |||
| Compound Name |
7-Chloro-3-(1H-indol-3-ylmethyl)-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL70728; CCK antagonist synthetic 5; SCHEMBL7514683; BDBM50019202
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
(3R)-3-Amino-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL171531; (R)-3-Amino-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one; SCHEMBL1835654; (R)-3-Amino-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one; CTK4A2012; 2H-1,4-Benzodiazepin-2-one,3-amino-1,3-dihydro-1-methyl-5-phenyl-, (3S)-; ZINC4375654; BDBM50281710; 1,3-dihydro-1-methyl-3(R)-amino-5-phenyl-2H-1,4-benzodiazepin-2-one; 3(R)-amino-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one; 3-(R)-amino-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one; (3R)-1-Methyl-3alpha-amino-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepine-2-one
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(3S)-1-Methyl-3-[(cyclohexylcarbonyl)amino]-5-phenyl-1H-1,4-benzodiazepin-2(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907662; SCHEMBL9866322; BDBM50367631; N-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]cyclohexanecarboxamide; (S)-N-(2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-cyclohexanecarboxamide
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-Amino-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
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Investigative | Compound Info | ||
| Synonyms |
3-Amino-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one; 3-amino-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one; 3-AMINO-5-PHENYL-1,3-DIHYDRO-BENZO[E][1,4]DIAZEPIN-2-ONE; CHEMBL306396; (+)-(3R)-3-Amino-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one; (-)-(3S)-3-Amino-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 3-AMINO-1,3-DIHYDRO-5-PHENYL-2H-1,4-BENZODIAZEPIN-2-ONE; 3-Amino-5-phenyl-1,3-dihydro-benzo(E)(1,4)diazepin-2-one; SCHEMBL642305; CTK7H6184; DTXSID50401326; 3-AMINO-5-PHENYL-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-; CS-M3233; 0807AA; ANW-58943; BDBM50019183; MFCD01318260; (-)-ISOPROTERENOLHYDROCHLORIDE; AKOS015911309; AB08690; MCULE-6765475818; AK-56098; AS-54966; SC-30425; DB-058984; BB 0260764; FT-0705599; VU0549300-1; A-7465; J-000944; F9995-0129; 2H-1,4-Benzodiazepin-2-one, 3-amino-1,3-dihydro-5-phenyl-; 2H-1,4-Benzodiazepin-2-one,3-amino-1,3-dihydro-5-phenyl-; (+/-)-3-amino-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one; (3RS)-1,3-dihydro-3-amino-5-phenyl-2H-1,4-benzodiazepine-2-one; 1,3-dihydro-3-(RS)-amino-5-phenyl-2H-1,4-benzodiazepin-2-one; 3(R,S)-amino-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one; 3(RS)-Amino-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one; 3-(RS)-Amino-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one; 3-(RS)-Amino-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-one; racemic 3-amino-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one; 3-Amino-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one: 0.56H2O
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-[(3S)-1-Methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-4-pentylbenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907664; SCHEMBL9877101; BDBM50452487
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-[5-(2-Fluoro-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-4-pentyl-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL70361; SCHEMBL7593316; BDBM50019248; N-[5-(2-fluorophenyl)-1-methyl-2-oxo-3H-1,4-benzodiazepin-3-yl]-4-pentylbenzamide; N-(5-(2-Fluorophenyl)-2,3-dihydro-1-methyl-2-oxo-1H-1,4-benzodiazepin-3-yl)-4-pentylbenzamide
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-Amino-5-(2-fluoro-phenyl)-1-methyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL72151; 3-Amino-1,3-dihydro-1-methyl-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one; 3-Amino-1,3-dihydro-1-methyl-5-(2-fluorophenyl]-2H-1,4-benzodiazepin-2-one; SCHEMBL3292886; BDBM50019236; 3-amino-5-(2-fluorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one; 3(R,S)-amino-1,3-dihydro-1-methyl-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one; 3-Amino-1,3-dihydro-1-methyl-5-(2-fluorophenyl)-2H-1.4-benzodiazepin-2-one; 3-Amino-1.3-dihydro-1-methyl-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(3S)-1-Methyl-3-[(2-methylpropanoyl)amino]-5-phenyl-1H-1,4-benzodiazepin-2(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907665; SCHEMBL9868116; BDBM50367630; 2-methyl-N-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]propanamide; (S)-N-(2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-2-methylpropanamide
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-[5-(2-Fluorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-1H-pyrrole-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL73272; SCHEMBL9525040; BDBM50019245
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| Activity |
IC50 = 100000 nM
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[2] | |||
| Compound Name |
2-[(3R)-3-(1H-Indol-3-ylmethyl)-2-methylimino-1,3-dihydro-1,4-benzodiazepin-5-yl]-N-methylaniline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL315358; BDBM50227027
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| Activity |
IC50 = 100000 nM
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[1] | |||
| Compound Name |
[(3R)-5-(2-Fluorophenyl)-3-(1H-indol-3-ylmethyl)-3H-1,4-benzodiazepin-2-yl]cyanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL314579; BDBM50227026
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| Activity |
IC50 = 100000 nM
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[1] | |||
| Compound Name |
4-Methyl-N-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]pentanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907663; BDBM50367647
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-Tert-Butyl-N-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL302282; SCHEMBL9526593; BDBM50019214; 4-tert-butyl-N-(2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl)benzamide; 4-tert-Butyl-N-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-benzamide: 0.12CHCl3
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| Activity |
IC50 = 100000 nM
|
[2] | |||
| Compound Name |
4-Hydroxy-N-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL310250; SCHEMBL9526638; BDBM50019251; 4-hydroxy-N-(2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl)benzamide; 4-Hydroxy-N-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-benzamide: 0.3H2O
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| Activity |
IC50 = 100000 nM
|
[2] | |||
| Compound Name |
4-Cyano-N-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL72710; SCHEMBL9525525; BDBM50019269; 4-cyano-N-(2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl)benzamide; 4-Cyano-N-(2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-benzamide; 4-Cyano-N-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-benzamide: : 0.05CHCl3
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
1-Methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL73096; 1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one; 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-1-methyl-5-phenyl-; 1,3-Dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one; 7-Dechlorodiazepam; Maybridge1_006601; Oprea1_248381; SCHEMBL877728; CTK4G5012; HMS560E01; ZINC83341; 1-Methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one; BDA-250; DTXSID90346661; BDBM50019266; CCG-45615; AKOS022181278; MCULE-9525719354; Ro 5-3464; AS-70597; RH 01461; 5-Phenyl-N-methyl-1,4-benzodiazepin-2-one; CS-0130656; SR-01000635369-1; 1-methyl-5-phenyl-2,3-dihydro-1h-1,4-benzodiazepin-2-one; 1-Methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one #; 2H-1,4-Benzodiazepin-2-one,1,3-dihydro-1-methyl-5-phenyl-; 1-Methyl-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
(3S)-3-Amino-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL171651; (R)-3-Amino-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one; SCHEMBL2929181; ZINC4375653; BDBM50281708; CS-0116266; (S)-3-Amino-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one; (S)-3amino-1-methyl-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one; 3(S)-amino-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one; 3-(S)-amino-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one; (3S)-1-Methyl-3beta-amino-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepine-2-one; 3(S)-(-)-Amino-1,3-dihydro-1-methyl-5-phenyl-2 H-1,4-benzodiazepin-2-one; 3(S)-(-)-amino-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
3-(1H-Indol-3-yl)-N-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-propionamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL74181; SCHEMBL9866743; BDBM50019267; 3-(1H-Indol-3-yl)-N-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-propionamide: 0.5H2O
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| Activity |
IC50 = 100000 nM
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[2] | |||
| Compound Name |
N-(2-Oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-4-trifluoromethylsulfanyl-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL70499; BDBM50019280
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
(2R)-2-Amino-N-(2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl)-3-phenylpropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL308404; BDBM50019201; 2-Amino-N-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-3-phenyl-propionamide: 0.1H2O
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
5-(2-Fluoro-phenyl)-3-[(1H-indol-2-ylmethyl)-amino]-1,3-dihydro-benzo[e][1,4]diazepin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL72550; SCHEMBL9526021; BDBM50019235; 1,3-Dihydro-5-(2-fluorophenyl)-3-(RS)-(2-indolylmethyl-amino)-2H-1,4-benzodiazepin-2-one; 1,3-Dihydro-5-(2-fluorophenyl)-3-(RS)-(2-indolylmethylamino)-2H-1,4-benzodiazepin-2-one; 5-(2-fluorophenyl)-3-(1H-indol-2-ylmethylamino)-1,3-dihydro-1,4-benzodiazepin-2-one
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| Activity |
IC50 = 100000 nM
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[2] | |||
| Compound Name |
[2-(1H-Indol-3-yl)-1-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL73535; SCHEMBL9423164; BDBM50019265
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
2-Chloro-N-methyl-N-(1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL431185; SCHEMBL9527023; BDBM50019255
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| Activity |
IC50 = 100000 nM
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[2] | |||
| Compound Name |
N-(2-Oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl)pyrazine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL308297; Pyrazine-2-carboxylic acid (2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide; Pyrazine-2-carboxylic acid [2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-amide; SCHEMBL643117; BDBM50019226
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
(3R)-5-(2-Fluorophenyl)-3-(1H-indol-3-ylmethyl)-N-methyl-1,3-dihydro-1,4-benzodiazepin-2-imine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL316190; BDBM50227028
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| Activity |
IC50 = 100000 nM
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[1] | |||
| Compound Name |
(3R)-5-(2-Fluorophenyl)-3-(1H-indol-3-ylmethyl)-N-propyl-1,3-dihydro-1,4-benzodiazepin-2-imine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL316238; BDBM50227024
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| Activity |
IC50 = 100000 nM
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[1] | |||
| Compound Name |
2,2-Dimethyl-N-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907660; (S)-N-(2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-2,2-dimethylpropanamide; (S)-N-(2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-2,2-dimethylpropanamide; SCHEMBL9864922; BDBM50367638
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Cholecystokinin antagonists. Synthesis and biological evaluation of 3-substituted 1,4-benzodiazepin-2-amines. J Med Chem. 1988 Jan;31(1):264-8. | ||||
| REF 2 | Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists. J Med Chem. 1988 Dec;31(12):2235-46. | ||||
| REF 3 | Cholecystokinin antagonists. Synthesis of asperlicin analogues with improved potency and water solubility. J Med Chem. 1986 Oct;29(10):1941-5. | ||||
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