Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
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| Target ID | T46526 | Target Info | |||
| Target Name | Bacterial Fimbrin D-mannose adhesin (Bact FimH) | ||||
| Synonyms |
fimH; b4320; Type 1 fimbrin D-mannose specific adhesin; Protein FimH; JW4283
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| Target Type | Clinical trial Target | ||||
| Gene Name | Bact FimH | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 1 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Heptyl D-glucoside
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Investigative | Compound Info | ||
| Synonyms |
n-Heptyl-beta-D-glucopyranoside; CHEMBL1170455; EINECS 309-364-8; Heptyl hexopyranoside; 2-heptoxy-6-(hydroxymethyl)oxane-3,4,5-triol; SCHEMBL14210465; SCHEMBL22111992; CTK8G1827; DTXSID90905277; BDBM50347460; FT-0626931
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| Activity |
IC50 = 77140 nM
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[1] | |||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
D-mannose
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Investigative | Compound Info | ||
| Synonyms |
D-Mannose; Mannose; D-Mannopyranose; Seminose; Carubinose; Mannopyranose; Mannopyranoside; D-(+)-Mannose; 530-26-7; CHEBI:4208; DL-Mannose; D(+)-Mannose; (+-)-Mannose; (3S,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol; D-Mannopyranoside; D-Man; WQZGKKKJIJFFOK-QTVWNMPRSA-N; Man; Mannopyranose, D-; SMR000857125; EINECS 208-474-2; D-Mannose,(S); alpha,beta-D-mannopyranose; bmse000018; bmse000882; Epitope ID:152206; bmse000874; AC1L2D5C; SCHEMBL38300; MLS001332528; MLS001332527; GTPL4650; CHEMBL469448; DTXSID5040463
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| Activity |
IC50 = 560000 nM
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[2] | |||
| Compound Name |
Methyl alpha-D-mannopyranoside
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Investigative | Compound Info | ||
| Synonyms |
Methyl a-D-mannopyranoside; Methyl alpha-D-mannoside; alpha-Methyl-D-mannoside; alpha-Methyl mannopyranoside; 1-O-Methyl-alpha-D-mannopyranoside; alpha-Methyl-D-mannopyranoside; alpha-D-Methyl mannoside; Methyl-alpha-D-mannoside; Methyl-alpha-D-mannopyranoside; MFCD00063262; alpha-Methyl-D-(-)-mannoside; NSC 1225; CHEMBL195368; O1-Methyl-Mannose; (2R,3S,4S,5S,6S)-2-(hydroxymethyl)-6-methoxyoxane-3,4,5-triol; (2R,3S,4S,5S,6S)-2-(hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol; .alpha.-D-Mannopyranoside, methyl; alpha-Methyl-D-mannopyranoside, 99+%; methyl; A-d-mannopyranoside; methyl -D-mannoside; Methyl .alpha.-D-mannoside; Methyl-alpha-D-glucopyranoside; Methyl .alpha.-D-mannopyranoside; Methyl alpha-D-mannoside (VAN); EINECS 210-502-3; Mannopyranoside, methyl, .alpha.-D-; a-methyl-D-mannoside; a-Methyl D-mannoside; NSC 224429; alpha-Methyl D-mannoside; Methyl-a-D-mannopyranoside; Epitope ID:145662; .alpha.-D-Methyl mannoside; .alpha.-Methyl-D-mannoside; Methyl-alphaD-mannopyranoside; SCHEMBL136446; alpha-D-Mannopyranoside, methyl; .alpha.-Methyl-D-mannopyranoside; DTXSID10897266; Methyl-.alpha.-D-mannopyranoside; ZINC4261920; 9257AB; BDBM50166886; CCG-53954; CM0190; s5047; 1-O-Methyl-.alpha.-D-mannopyranoside; DB01979; MCULE-4215248759; AS-58701; SC-96071; Mannopyranoside, methyl, alpha-D- (8CI); CS-0098154; M0368; Methyl alpha-D-mannopyranoside, >=99% (GC); A-8322; SR-01000643077-1; Q27093072; Methyl alpha-D-mannopyranoside, for microbiology, >=99.0%; 35B8275C-EB56-4981-81A0-8E358215B1A9
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| Activity |
IC50 = 450000 nM
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[2] | |||
| References | Top | ||||
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| REF 1 | FimH antagonists for the oral treatment of urinary tract infections: from design and synthesis to in vitro and in vivo evaluation. J Med Chem. 2010 Dec 23;53(24):8627-41. | ||||
| REF 2 | Branched alpha-d-mannopyranosides: a new class of potent FimH antagonists. Medchemcomm. 2014;5:1247-53. | ||||
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