Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T46465 | Target Info | |||
| Target Name | Plasmodium Plasmepsin 2 (Malaria PLA2) | ||||
| Synonyms |
Plasmepsin-2; PFAPD; Aspartic hemoglobinase II
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| Target Type | Patented-recorded Target | ||||
| Gene Name | Malaria PLA2 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 4 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
6-bromo-2'-de-N-methylaplysinopsin
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Investigative | Compound Info | ||
| Activity |
IC50 = 53000 nM
|
[1] | |||
| Compound Name |
N-[(2S,3S)-5-(Butylamino)-3-hydroxy-5-oxo-1-phenylpentan-2-yl]-4-[2-(2-phenylethoxy)ethyl]-1-[3-(3,4,5-trimethoxyphenyl)propanoyl]piperazine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL431861; BDBM50072542; PS-349374
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| Activity |
IC50 ~ 65000 nM
|
[2] | |||
| Compound Name |
6-{3-((1S,2S)-1-Benzyl-3-butylcarbamoyl-2-hydroxy-propylcarbamoyl)-4-[3-(3,4,5-trimethoxy-phenyl)-propionyl]-piperazin-1-yl}-6-oxo-hexanoic acid ethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL324234; BDBM50072545; PS-990762
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(3S,4S)-4-((2S,3R)-2-(2-(4-(2-((2S)-1-((2R)-6-Amino-1-(4-(6-methoxyquinolin-8-ylamino)pentylamino)-1-oxohexan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-2-oxoethyl)phenyl)acetamido)-3-methylpentanamido)-N-butyl-3-hydroxy-6-methylheptanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL538889; BDBM50297450
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| Activity |
IC50 = 135000 nM
|
[3] | |||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N1-((2S)-1-((2R)-6-Amino-1-(4-(6-methoxyquinolin-8-ylamino)pentylamino)-1-oxohexan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-N4-((2S,3R)-1-((3S,4S)-1-(butylamino)-3-hydroxy-6-methyl-1-oxoheptan-4-ylamino)-3-methyl-1-oxopentan-2-yl)succinamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL555659; BDBM50297449
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| Activity |
IC50 = 396000 nM
|
[3] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | New antiinfective and human 5-HT2 receptor binding natural and semisynthetic compounds from the Jamaican sponge Smenospongia aurea. J Nat Prod. 2002 Apr;65(4):476-80. | ||||
| REF 2 | Evaluation of a structure-based statine cyclic diamino amide encoded combinatorial library against plasmepsin II and cathepsin D. Bioorg Med Chem Lett. 1998 Nov 17;8(22):3203-6. | ||||
| REF 3 | Recent developments in the design and synthesis of hybrid molecules based on aminoquinoline ring and their antiplasmodial evaluation. Eur J Med Chem. 2009 Aug;44(8):3091-113. | ||||
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