Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T46365 | Target Info | |||
| Target Name | M-phase inducer phosphatase 2 (MPIP2) | ||||
| Synonyms |
Dual specificity phosphatase Cdc25B; Cdc25B phosphatase; CDC25HU2
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|
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| Target Type | Clinical trial Target | ||||
| Gene Name | CDC25B | ||||
| Biochemical Class | Phosphoric monoester hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 76 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
BENZOQUINONE
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|
Investigative | Compound Info | ||
| Synonyms |
p-benzoquinone; Benzoquinone; 1,4-BENZOQUINONE; Quinone; 106-51-4; p-Quinone; Chinone; 2,5-Cyclohexadiene-1,4-dione; para-Benzoquinone; cyclohexa-2,5-diene-1,4-dione; Cyclohexadienedione; para-Quinone; 1,4-Benzoquine; Steara pbq; 1,4-Dioxybenzene; p-Chinon; 1,4-Cyclohexadienedione; Benzo-chinon; Benzo-1,4-quinone; 1,4-Diossibenzene; Chinon; 1,4-Dioxy-benzol; 1,4-Cyclohexadiene dioxide; Semiquinone anion; semiquinone radicals; RCRA waste number U197; p-Chinon [German]; NCI-C55845; Caswell No. 719C; Benzo-chinon [German]; USAF P-220
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1,4-Naphthalenedione, 2-[(2-hydroxyethyl)amino]-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL462058; CHEMBL351927; SCHEMBL14764737; CTK0J8005; DTXSID70345410; ZINC101211357; 2-[(2-Hydroxyethyl)amino]naphthoquinone #; 2-(2-Hydroxyethyl)amino-1,4-naphthoquinone; 2-(2-Hydroxyethylamino)-1,4-naphthoquinone; 2-((2-hydroxyethyl)amino)naphthalene-1,4-dione
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(S)-6,8-Diiodo-2-(3-phenyl-propionyl)-7-(3-trifluoromethyl-benzyloxy)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL158272; BDBM50087193
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|
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| Activity |
IC50 = 50000 nM
|
[2] | |||
| Compound Name |
(S)-2-(4-(Benzamidomethyl)-1H-1,2,3-triazol-1-yl)-3-(4-hydroxyphenyl)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1667962; BDBM50336334
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
4-Benzoyl-3-(p-tolylamino)isoquinolin-1(2H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1876186; Oprea1_040104; Oprea1_663470; CC-PMLSC-PW-wdp2249; MLS000541737; HMS2203F19; HMS3358O06; ZINC4095300; BDBM50084508; AKOS024603539; MCULE-6524894377; CCPMLSC06AWDP002249:002; SMR000472421; EU-0045467; F1172-0006
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(2R,3R)-2,3-Dibromo-3-methyl-1,1-dioxo-2H-thiochromen-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1765352; BDBM50341996; (2R,3R)-2,3-Dibromo-3-methyl-1,1-dioxo-1lambda*6*-thiochroman-4-one
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| Activity |
IC50 = 50000 nM
|
[5] | |||
| Compound Name |
(S)-7-(2,4-Dichloro-benzyloxy)-6,8-diiodo-2-(3-phenyl-propionyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL158651; BDBM50087230
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| Activity |
IC50 = 50000 nM
|
[2] | |||
| Compound Name |
5-[2-(4-Ethoxyphenyl)-1,3-thiazol-4-yl]-1-methyl-2,3-dihydro-1H-indol-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3219193; ZINC8297210; AKOS001178081; MCULE-4130039536; AB00774042-01; Z118590134
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| Activity |
IC50 = 50000 nM
|
[6] | |||
| Compound Name |
(S)-6,8-Diiodo-2-[(E)-3-(4-nitro-phenyl)-acryloyl]-7-(3-trifluoromethyl-benzyloxy)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL350669; BDBM50087176
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|
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| Activity |
IC50 = 50000 nM
|
[2] | |||
| Compound Name |
(S)-6,8-Diiodo-7-(3-trifluoromethyl-benzyloxy)-2-[(E)-3-(3-trifluoromethyl-phenyl)-acryloyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL160965; BDBM50087209
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|
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| Activity |
IC50 = 50000 nM
|
[2] | |||
| Compound Name |
Methyl (2S)-2-[4-(benzamidomethyl)triazol-1-yl]-3-(4-hydroxyphenyl)propanoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1667961; BDBM50336333; (S)-2-(4-(benzamidomethyl)-1H-1,2,3-triazol-1-yl)-3-(4-hydroxyphenyl)propanoate methyl ester
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(S)-7-(3-Chloro-propoxy)-2-[(E)-3-(2,4-dichloro-phenyl)-acryloyl]-6,8-diiodo-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL159202; BDBM50087233
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| Activity |
IC50 = 52000 nM
|
[2] | |||
| Compound Name |
N-(4,5-Diphenyl-2-thiazolyl)-2-(4-nitrophenyl)ethenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL320586; BDBM50096689; (E)-2-(4-Nitro-phenyl)-ethenesulfonic acid (4,5-diphenyl-thiazol-2-yl)-amide
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| Activity |
IC50 = 54000 nM
|
[7] | |||
| Compound Name |
(S)-2-[(E)-3-(2-Fluoro-phenyl)-acryloyl]-6,8-diiodo-7-(4-trifluoromethyl-benzyloxy)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL160131; BDBM50087174
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| Activity |
IC50 = 55000 nM
|
[2] | |||
| Compound Name |
(S)-7-(2,6-Dichloro-benzyloxy)-2-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-6,8-diiodo-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL158157; BDBM50087222
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|
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| Activity |
IC50 = 55000 nM
|
[2] | |||
| Compound Name |
(S)-6,8-Diiodo-2-[(E)-3-(4-nitro-phenyl)-acryloyl]-7-(4-trifluoromethyl-benzyloxy)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL160261; BDBM50087215
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|
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| Activity |
IC50 = 55000 nM
|
[2] | |||
| Compound Name |
4-(2-Carboxyethyl)-3-decylfuran-2,5-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL228358; SCHEMBL3170708; BDBM50197851; 2-(2-carboxyethyl)-3-decyl maleic anhydride; 3-(4-decyl-2,5-dioxofuran-3-yl)propanoic acid; (Z)-3-Tetradecene-1,3,4-tricarboxylic 3,4-anhydride; 3-(4-decyl-2,5-dioxo-2,5-dihydrofuran-3-yl)propanoicacid
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| Activity |
IC50 = 55200 nM
|
[8] | |||
| Compound Name |
(S)-6,8-Diiodo-7-(4-trifluoromethyl-benzyloxy)-2-[(E)-3-(3,4,5-trimethoxy-phenyl)-acryloyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL161091; BDBM50087184
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|
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| Activity |
IC50 = 57000 nM
|
[2] | |||
| Compound Name |
(5Z)-2-[2-[4-[2-[[(5Z)-5-[(4-Hydroxyphenyl)methylidene]-4-oxo-1,3-thiazolidin-2-ylidene]amino]ethyl]piperazin-1-yl]ethylimino]-5-[(E)-3-phenylprop-2-enylidene]-1,3-thiazolidin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206743; BDBM50402662
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|
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| Activity |
IC50 = 57300 nM
|
[9] | |||
| Compound Name |
(S)-2-((E)-3-2,4-Dioxa-bicyclo[3.3.1]nona-1(8),5(9),6-trien-6-yl-acryloyl)-6,8-diiodo-7-(3-methoxy-benzyloxy)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL160681; BDBM50087185
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|
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| Activity |
IC50 = 58000 nM
|
[2] | |||
| Compound Name |
(E)-2-(4-Butyl-phenyl)-ethenesulfonic acid (4,5-diphenyl-thiazol-2-yl)-amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL108584; BDBM50096702
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|
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| Activity |
IC50 = 58000 nM
|
[7] | |||
| Compound Name |
(S)-6,8-Diiodo-7-(3-methoxy-benzyloxy)-2-[(E)-3-(4-nitro-phenyl)-acryloyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL160574; BDBM50087210
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|
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| Activity |
IC50 = 59000 nM
|
[2] | |||
| Compound Name |
(S)-2-[(E)-3-(3-Chloro-phenyl)-acryloyl]-7-(2-fluoro-benzyloxy)-6,8-diiodo-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL160205; BDBM50087211
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|
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| Activity |
IC50 = 60000 nM
|
[2] | |||
| Compound Name |
(S)-7-(2,4-Dichloro-benzyloxy)-2-((E)-3-2,4-dioxa-bicyclo[3.3.1]nona-1(8),5(9),6-trien-6-yl-acryloyl)-6,8-diiodo-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL435043; BDBM50087194
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|
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| Activity |
IC50 = 60000 nM
|
[2] | |||
| Compound Name |
(S)-6,8-Diiodo-7-(3-methoxy-benzyloxy)-2-((E)-3-p-tolyl-acryloyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL160316; BDBM50087216
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|
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| Activity |
IC50 = 62000 nM
|
[2] | |||
| Compound Name |
(S)-2-((E)-3-2,4-Dioxa-bicyclo[3.3.1]nona-1(8),5(9),6-trien-6-yl-acryloyl)-6,8-diiodo-7-(3-trifluoromethyl-benzyloxy)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL160769; BDBM50087221
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| Activity |
IC50 = 66000 nM
|
[2] | |||
| Compound Name |
(2S)-3-[[1-[[(2R,3R,4S,5R,6S)-6-Methoxy-3,4,5-tris(phenylmethoxy)oxan-2-yl]methyl]triazol-4-yl]methoxy]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1795944; BDBM50347239
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| Activity |
IC50 = 67500 nM
|
[10] | |||
| Compound Name |
N-[4-(2-Naphthyl)-5-propyl-2-thiazolyl]-2-(2-naphthyl)ethenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL321599; BDBM50096696; (E)-2-Naphthalen-2-yl-ethenesulfonic acid (4-naphthalen-2-yl-5-propyl-thiazol-2-yl)-amide
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| Activity |
IC50 = 69000 nM
|
[7] | |||
| Compound Name |
(S)-7-Benzyloxycarbonylmethoxy-2-[(E)-3-(2-chloro-phenyl)-acryloyl]-6,8-diiodo-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL346125; BDBM50087214
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|
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| Activity |
IC50 = 70000 nM
|
[2] | |||
| Compound Name |
(S)-2-[(E)-3-(4-Bromo-phenyl)-acryloyl]-7-(3-chloro-propoxy)-6,8-diiodo-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL155756; BDBM50087236
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|
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| Activity |
IC50 = 70000 nM
|
[2] | |||
| Compound Name |
(S)-2-[(E)-3-(3-Bromo-phenyl)-acryloyl]-7-(3-chloro-propoxy)-6,8-diiodo-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL422713; BDBM50087178
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| Activity |
IC50 = 70000 nM
|
[2] | |||
| Compound Name |
(E)-2-Biphenyl-4-yl-ethenesulfonic acid (4,5-diphenyl-thiazol-2-yl)-amide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL108690; BDBM50096694
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| Activity |
IC50 = 70000 nM
|
[7] | |||
| Compound Name |
(E)-2-(3,4-Difluorophenyl)-N-(4,5-diphenyl-1,3-thiazol-2-yl)ethenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL106479; BDBM50096691; (E)-2-(3,4-Difluoro-phenyl)-ethenesulfonic acid (4,5-diphenyl-thiazol-2-yl)-amide
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| Activity |
IC50 = 72000 nM
|
[7] | |||
| Compound Name |
(S)-2-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-7-(2-fluoro-benzyloxy)-6,8-diiodo-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL347261; BDBM50087180
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|
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| Activity |
IC50 = 75000 nM
|
[2] | |||
| Compound Name |
(S)-2-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-6,8-diiodo-7-(3-trifluoromethyl-benzyloxy)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL415743; BDBM50087220
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| Activity |
IC50 = 75000 nM
|
[2] | |||
| Compound Name |
(S)-2-[(E)-3-(4-Chloro-phenyl)-acryloyl]-6,8-diiodo-7-(3-methoxy-benzyloxy)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL350019; BDBM50087175
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| Activity |
IC50 = 75000 nM
|
[2] | |||
| Compound Name |
(S)-7-(2-Fluoro-benzyloxy)-2-[(E)-3-(3-fluoro-phenyl)-acryloyl]-6,8-diiodo-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL158498; BDBM50087219
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| Activity |
IC50 = 75000 nM
|
[2] | |||
| Compound Name |
(E)-2-(4-Cyano-phenyl)-ethenesulfonic acid (4,5-diphenyl-thiazol-2-yl)-amide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL106194; BDBM50096706
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| Activity |
IC50 = 76000 nM
|
[7] | |||
| Compound Name |
(E)-2-(4-Butylphenyl)-N-[4-(4-phenylphenyl)-5-propyl-1,3-thiazol-2-yl]ethenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL320558; BDBM50096679; (E)-2-(4-Butyl-phenyl)-ethenesulfonic acid (4-biphenyl-4-yl-5-propyl-thiazol-2-yl)-amide
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| Activity |
IC50 = 80000 nM
|
[7] | |||
| Compound Name |
(S)-7-(2-Fluoro-benzyloxy)-6,8-diiodo-2-(3-phenyl-propionyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL158869; BDBM50087212
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| Activity |
IC50 = 80000 nM
|
[2] | |||
| Compound Name |
2-Methoxy-5-((4-methyl-2-oxo-1,2-dihydro-quinolin-6-yl)methyl)benzenesulfonic acid
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Investigative | Compound Info | ||
| Synonyms |
NSC109483; NSC-109483; CHEMBL507159; NCIStruc1_001390; NCIStruc2_001194; CTK7A7541; ZINC8582190; BDBM50388538; CCG-37455; NCGC00014106; NCI109483; NCGC00014106-02; NCGC00097215-01; NCI60_000228; 5-((2-hydroxy-4-methyl-6-quinolinyl)methyl)-2-methoxybenzenesulfonic acid
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| Activity |
Ki = 84000 nM
|
[11] | |||
| Compound Name |
Dysidiolide
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Investigative | Compound Info | ||
| Synonyms |
UNII-JV53JWY86D; JV53JWY86D; CHEMBL1765353; (-)-Dysidiolide; Dysidiolide [MI]; BDBM50341997; Q27281710
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| Activity |
IC50 = 87000 nM
|
[12] | |||
| Compound Name |
N-(4-Phenyl-5-ethyl-2-thiazolyl)-2-(4-nitrophenyl)ethenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL108689; BDBM50096695; (E)-2-(4-Nitro-phenyl)-ethenesulfonic acid (5-ethyl-4-phenyl-thiazol-2-yl)-amide
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| Activity |
IC50 = 88000 nM
|
[7] | |||
| Compound Name |
(E)-N-(5-Ethyl-4-phenyl-1,3-thiazol-2-yl)-2-naphthalen-2-ylethenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL323995; BDBM50096698; (E)-2-Naphthalen-2-yl-ethenesulfonic acid (5-ethyl-4-phenyl-thiazol-2-yl)-amide
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| Activity |
IC50 = 89000 nM
|
[7] | |||
| Compound Name |
(E)-2-(2-Chlorophenyl)-N-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]ethenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL107245; BDBM50096686; (E)-2-(2-Chloro-phenyl)-ethenesulfonic acid [4-(4-chloro-phenyl)-thiazol-2-yl]-amide
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| Activity |
IC50 = 89000 nM
|
[7] | |||
| Compound Name |
(S)-7-Benzyloxycarbonylmethoxy-2-((Z)-2-fluoro-3-phenyl-acryloyl)-6,8-diiodo-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL158615; BDBM50087229
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| Activity |
IC50 = 90000 nM
|
[2] | |||
| Compound Name |
(S)-2-(2-Chloro-pyridine-3-carbonyl)-7-(2-fluoro-benzyloxy)-6,8-diiodo-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL158551; BDBM50087172
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| Activity |
IC50 = 90000 nM
|
[2] | |||
| Compound Name |
(S)-7-Benzyloxycarbonylmethoxy-2-[(E)-3-(4-bromo-phenyl)-acryloyl]-6,8-diiodo-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL160557; BDBM50087207
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| Activity |
IC50 = 90000 nM
|
[2] | |||
| Compound Name |
(S)-7-Benzyloxycarbonylmethoxy-2-[(E)-3-(3-bromo-phenyl)-acryloyl]-6,8-diiodo-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL158565; BDBM50087192
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| Activity |
IC50 = 90000 nM
|
[2] | |||
| Compound Name |
N-[4-(4-Biphenylyl)-5-propyl-2-thiazolyl]-2-[4-(trifluoromethyl)phenyl]ethenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL320953; BDBM50096701; (E)-2-(4-Trifluoromethyl-phenyl)-ethenesulfonic acid (4-biphenyl-4-yl-5-propyl-thiazol-2-yl)-amide
Click to Show/Hide
|
||||
| Activity |
IC50 = 92000 nM
|
[7] | |||
| Compound Name |
N-(4,5-Diphenyl-2-thiazolyl)-2-(2-furyl)ethenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL107206; BDBM50096705; (E)-2-Furan-2-yl-ethenesulfonic acid (4,5-diphenyl-thiazol-2-yl)-amide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-[3-(2-Phenyl-1,3-thiazol-4-yl)phenyl]-2-furamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3219177; ZINC387105; MCULE-9414355543; AQ-432/42868839; N-[3-(2-Phenylthiazole-4-yl)phenyl]-2-furancarboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
5-(1-Hydroxy-2-methylpropylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Isobutyryl Meldrum's Acid; CHEMBL3427134; SCHEMBL3590452; CTK8G0370; DTXSID50716083; BDBM50088052; AKOS030242875; ZINC100984330; FT-0670431; 2,2-Dimethyl-5-(1-hydroxy-2-methylpropylidene)-1,3-dioxane-4,6-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
2-(4-Ethoxyphenyl)-4-(naphthalen-2-yl)-1,3-thiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3219406; ZINC3330119; AKOS034401691; MCULE-4233281928; Z48863660
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
4-[N-[(3-Chlorophenyl)methyl]-C-pentadecylcarbonimidoyl]-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2062592; BDBM50388822
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
3-Hydroxy-2-(hydroxymethyl)-4-[N-[(3-methylphenyl)methyl]-C-pentadecylcarbonimidoyl]-2H-furan-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2062591; CHEMBL3260030; RE-12; BDBM50012280; BDBM50388821
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
3-(4-Nonyl-2,5-dioxo-2,5-dihydrofuran-3-yl)propanoicacid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL375036; BDBM50197857
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-{3-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]phenyl}cyclopropanecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3219176; ZINC8042062; AKOS033148284; MCULE-3175900996; AB00762115-01; Z118604202; N-[3-[4-(p-Anisyl)thiazole-2-yl]phenyl]cyclopropanecarboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
(E)-2-(2-Chlorophenyl)-N-[4-(4-phenylphenyl)-5-propyl-1,3-thiazol-2-yl]ethenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL419196; BDBM50096697; (E)-2-(2-Chloro-phenyl)-ethenesulfonic acid (4-biphenyl-4-yl-5-propyl-thiazol-2-yl)-amide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
[6-Oxo-2-(phenylmethoxymethyl)-2,3-dihydropyran-4-yl] hexadecanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3427128; BDBM50088045
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
(S)-2-(2-Chloro-pyridine-3-carbonyl)-7-(2,4-dichloro-benzyloxy)-6,8-diiodo-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL158492; BDBM50087218
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
5-(1-Hydroxydecylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3427133; SCHEMBL3303140; BDBM50088053
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
(E)-2-(2-Chlorophenyl)-N-[4-(4-chlorophenyl)-5-methyl-1,3-thiazol-2-yl]ethenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL107355; BDBM50096703; (E)-2-(2-Chloro-phenyl)-ethenesulfonic acid [4-(4-chloro-phenyl)-5-methyl-thiazol-2-yl]-amide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
2,5-Dioxo-4-octylfuran-3-propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL228357; BDBM50197850; 3-(4-octyl-2,5-dioxo-2,5-dihydrofuran-3-yl)propanoicacid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-(4,5-Diphenyl-2-thiazolyl)-2-(3,4-dimethoxyphenyl)ethenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL322750; BDBM50096692; (E)-2-(3,4-Dimethoxy-phenyl)-ethenesulfonic acid (4,5-diphenyl-thiazol-2-yl)-amide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
2,5-Dioxo-4-hexylfuran-3-propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL228356; BDBM50197853; 3-(4-hexyl-2,5-dioxo-2,5-dihydrofuran-3-yl)propanoicacid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-(4,5-Diphenyl-2-thiazolyl)-2-(4-methylphenyl)ethenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL321179; BDBM50096688; (E)-2-p-Tolyl-ethenesulfonic acid (4,5-diphenyl-thiazol-2-yl)-amide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
2-Cyclopentanecarbonyl-7-(2,6-dichloro-benzyloxy)-6,8-diiodo-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL160631; PNU-108937; BDBM50087182
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[2] | |||
| Compound Name |
(S)-7-(3-Chloro-propoxy)-2-((Z)-2-fluoro-3-phenyl-acryloyl)-6,8-diiodo-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL160475; BDBM50087217
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[2] | |||
| Compound Name |
N-(4-Phenyl-5-ethyl-2-thiazolyl)-2-[4-(methylsulfonyl)phenyl]ethenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL108779; BDBM50096677; (E)-2-(4-Methanesulfonyl-phenyl)-ethenesulfonic acid (5-ethyl-4-phenyl-thiazol-2-yl)-amide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-(4-Phenyl-5-ethyl-2-thiazolyl)-2-(2-chlorophenyl)ethenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL108880; BDBM50096678; (E)-2-(2-Chloro-phenyl)-ethenesulfonic acid (5-ethyl-4-phenyl-thiazol-2-yl)-amide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-[4-Phenyl-5-decyl-2-thiazolyl]-2-(2-chlorophenyl)ethenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL108328; BDBM50096699; (E)-2-(2-Chloro-phenyl)-ethenesulfonic acid (5-decyl-4-phenyl-thiazol-2-yl)-amide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
(E)-2-Naphthalen-2-yl-N-[4-(4-phenylphenyl)-5-propyl-1,3-thiazol-2-yl]ethenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL106077; BDBM50096684; (E)-2-Naphthalen-2-yl-ethenesulfonic acid (4-biphenyl-4-yl-5-propyl-thiazol-2-yl)-amide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
(S)-7-(2,6-Dichloro-benzyloxy)-6,8-diiodo-2-(3-phenyl-propionyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL350248; BDBM50087177
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-[[1-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]triazol-4-yl]methoxy]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1795952; BDBM50347245
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 120000 nM
|
[10] | |||
| Compound Name |
5-[3-Pyridin-2-yl-6-(5-sulfofuran-2-yl)-1,2,4-triazin-5-yl]furan-2-sulfonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Ferene; CHEMBL1270061; 3-(2-PYRIDYL)-5,6-bis-[2-(5-FURYL-SULFONIC ACID)]-1,2,4-TRIAZINE; 2-Furansulfonic acid, 5,5'-[3-(2-pyridinyl)-1,2,4-triazine-5,6-diyl]bis-; NSC-601364; NSC601364; ACMC-20ltah; NCIStruc1_001777; NCIStruc2_001716; SCHEMBL2946864; CTK3G6293; ZINC1607791; BDBM50328823; NCGC00182101-01; NCGC00182101-02; NCI60_004528; 551P147; 5,5'-(3-(pyridin-2-yl)-1,2,4-triazine-5,6-diyl)difuran-2-sulfonic acid; 5,5'-[3-(2-Pyridyl)-1,2,4-triazine-5,6-diyl]bis(2-furansulfonic acid); 5,5''-(3-(pyridin-2-yl)-1,2,4-triazine-5,6-diyl)difuran-2-sulfonic acid; 5-[3-(2-pyridyl)-6-(5-sulfo-2-furyl)-1,2,4-triazin-5-yl]furan-2-sulfonic acid
Click to Show/Hide
|
||||
| Activity |
Ki = 159000 nM
|
[11] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 10 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-[1-Hydroxy-2-(1-methylcyclohexyl)ethyl]-5-hydroxy-2,5-dihydrofuran-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL86451; BDBM50093973; 5-Hydroxy-4-[1-hydroxy-2-(1-methyl-cyclohexyl)-ethyl]-5H-furan-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[12] | |||
| Compound Name |
Vanadate ion
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
vanadate(3-); trioxido(oxo)vanadium; ortho-Vanadate; Vanadates; tetraoxovanadate; tetraoxovanadate(V); tetraoxovanadate(3-); tetraoxidovanadate(3-); Vanadium (V) tetraoxide; CHEMBL179166; BDBM50391109; VO4(3+); VO4(3-); [VO4](3-); AB01566832_01; Q27104568
Click to Show/Hide
|
||||
| Activity |
IC50 = 910000 nM
|
[15] | |||
| Compound Name |
Ethyl 2,4-dimethyl-5-[(Z)-(4-oxo-3-phenyl-2-phenylimino-1,3-thiazolidin-5-ylidene)methyl]-1H-pyrrole-3-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3903987; BDBM50201805
Click to Show/Hide
|
||||
| Activity |
IC50 = 1660000 nM
|
[15] | |||
| Compound Name |
(S)-5-Hydroxy-4-{(R)-1-hydroxy-2-[(1S,2S,5S,8aR)-1,2,5,8a-tetramethyl-5-(4-methyl-pent-4-enyl)-1,2,3,5,6,7,8,8a-octahydro-naphthalen-1-yl]-ethyl}-5H-furan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL87951; BDBM50080993
Click to Show/Hide
|
||||
| Activity |
IC50 > 2000000 nM
|
[16] | |||
| Compound Name |
(2Z,5Z)-2-Hydroxyimino-5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methylidene]-3-propan-2-yl-1,3-thiazolidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3934071; BDBM50201807
Click to Show/Hide
|
||||
| Activity |
IC50 = 2470000 nM
|
[15] | |||
| Compound Name |
Ethyl 5-[(Z)-[3-(4-methoxyphenyl)-2-(4-methoxyphenyl)imino-4-oxo-1,3-thiazolidin-5-ylidene]methyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3981128; BDBM50201802
Click to Show/Hide
|
||||
| Activity |
IC50 = 2740000 nM
|
[15] | |||
| Compound Name |
Ethyl 5-[(Z)-[3-(4-fluorophenyl)-2-(4-fluorophenyl)imino-4-oxo-1,3-thiazolidin-5-ylidene]methyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3942806; BDBM50201801
Click to Show/Hide
|
||||
| Activity |
IC50 = 2870000 nM
|
[15] | |||
| Compound Name |
Ethyl 5-[(Z)-[3-(3-fluorophenyl)-2-(3-fluorophenyl)imino-4-oxo-1,3-thiazolidin-5-ylidene]methyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3944187; BDBM50201798
Click to Show/Hide
|
||||
| Activity |
IC50 = 3390000 nM
|
[15] | |||
| Compound Name |
Ethyl 5-[(Z)-[3-(2-fluorophenyl)-2-(2-fluorophenyl)imino-4-oxo-1,3-thiazolidin-5-ylidene]methyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3952328; BDBM50201804
Click to Show/Hide
|
||||
| Activity |
IC50 = 3660000 nM
|
[15] | |||
| Compound Name |
Ethyl 5-[(Z)-[(2E)-2-hydroxyimino-4-oxo-3-propan-2-yl-1,3-thiazolidin-5-ylidene]methyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3908947; BDBM50201803
Click to Show/Hide
|
||||
| Activity |
IC50 = 5830000 nM
|
[15] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases. Bioorg Med Chem. 2009 Mar 15;17(6):2276-81. | ||||
| REF 2 | The solid phase synthesis of tetrahydroisoquinolines having cdc25B inhibitory activity. Bioorg Med Chem Lett. 2000 Apr 3;10(7):649-52. | ||||
| REF 3 | A unique and rapid approach toward the efficient development of novel protein tyrosine phosphatase (PTP) inhibitors based on 'clicked' pseudo-glycopeptides. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1092-6. | ||||
| REF 4 | Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B. Bioorg Med Chem. 2015 Jun 15;23(12):2810-8. | ||||
| REF 5 | Using small molecules to target protein phosphatases. Bioorg Med Chem. 2011 Apr 1;19(7):2145-55. | ||||
| REF 6 | Prospective use of molecular field points in ligand-based virtual screening: efficient identification of new reversible Cdc25 inhibitors. Medchemcomm. 2013;4:1148-55. | ||||
| REF 7 | Sulfonylated aminothiazoles as new small molecule inhibitors of protein phosphatases. Bioorg Med Chem Lett. 2001 Feb 12;11(3):313-7. | ||||
| REF 8 | Synthesis and biological evaluation of dialkylsubstituted maleic anhydrides as novel inhibitors of Cdc25 dual specificity phosphatases. Eur J Med Chem. 2007 Feb;42(2):243-7. | ||||
| REF 9 | Design and synthesis of novel bis-thiazolone derivatives as micromolar CDC25 phosphatase inhibitors: effect of dimerisation on phosphatase inhibition. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7345-50. | ||||
| REF 10 | Facile fabrication of promising protein tyrosine phosphatase (PTP) inhibitor entities based on 'clicked' serine/threonine-monosaccharide hybrids. Bioorg Med Chem. 2011 Jul 1;19(13):3892-900. | ||||
| REF 11 | Discovery of new inhibitors of Cdc25B dual specificity phosphatases by structure-based virtual screening. J Med Chem. 2012 May 10;55(9):4142-58. | ||||
| REF 12 | Synthesis of the novel analogues of dysidiolide and their structure-activity relationship. Bioorg Med Chem Lett. 2000 Nov 20;10(22):2571-4. | ||||
| REF 13 | Is RK-682 a promiscuous enzyme inhibitor? Synthesis and in vitro evaluation of protein tyrosine phosphatase inhibition of racemic RK-682 and analogues. Eur J Med Chem. 2015 Jun 5;97:42-54. | ||||
| REF 14 | Dual-Specificity Phosphatase CDC25A/B Inhibitor Identified from a Focused Library with Nonelectrophilic Core Structure. ACS Med Chem Lett. 2012 Apr 12;3(4):294-298. | ||||
| REF 15 | Design and synthesis of new potent PTP1B inhibitors with the skeleton of 2-substituted imino-3-substituted-5-heteroarylidene-1,3-thiazolidine-4-one: Part I. Eur J Med Chem. 2016 Oct 21;122:756-769. | ||||
| REF 16 | Dysidiolide and related gamma-hydroxy butenolide compounds as inhibitors of the protein tyrosine phosphatase, CDC25. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2537-8. | ||||
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