Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T46245 | Target Info | |||
| Target Name | Glutaminyl cyclase (QPCT) | ||||
| Synonyms |
sQC; QPCT; QC; Glutamyl cyclase; GlutaminyltRNA cyclotransferase; Glutaminylpeptide cyclotransferase; EC
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| Target Type | Clinical trial Target | ||||
| Gene Name | QPCT | ||||
| Biochemical Class | Acyltransferase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Benzimidazole
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Patented | Compound Info | ||
| Synonyms |
BENZIMIDAZOLE; 51-17-2; 1H-Benzimidazole; 1H-Benzo[d]imidazole; 1,3-Benzodiazole; Benzoimidazole; o-Benzimidazole; 3-Azaindole; Benziminazole; Benzoglyoxaline; Azindole; 1,3-Diazaindene; 1H-Benzoimidazole; N,N'-Methenyl-o-phenylenediamine; NSC 759; Benzimidazol; 1H-1,3-benzodiazole; BZI; UNII-E24GX49LD8; CCRIS 5967; Benzimidazole, 98%; CHEBI:41275; HSDB 2797; EINECS 200-081-4; BRN 0109682; AI3-03737; E24GX49LD8; HYZJCKYKOHLVJF-UHFFFAOYSA-N; DSSTox_CID_4573; DSSTox_RID_77454; DSSTox_GSID_24573; F3366-5347; CAS-51-17-2; bezimidazole
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| Activity |
Ki = 150000 nM
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[1] | |||
| Compound Name |
5-(3H-Benzimidazol-5-yl)-N-(4-chlorophenyl)-1,3,4-oxadiazol-2-amine
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1706078; CHEMBL3963868; BDBM179618; US9126987, 21
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| Activity |
IC50 = 58200 nM
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[2] | |||
| Compound Name |
3-(1H-Benzo[d]imidazol-5-yl)-2,3-dihydro-2-thioxoquinazolin-4(1H)-one
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL5126851; CHEMBL3703783; 3-(3H-benzimidazol-5-yl)-2-sulfanylidene-1H-quinazolin-4-one
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| Activity |
IC50 = 120800 nM
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[3] | |||
| References | Top | ||||
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| REF 1 | Structure-activity relationships of benzimidazole-based glutaminyl cyclase inhibitors featuring a heteroaryl scaffold. J Med Chem. 2013 Sep 12;56(17):6613-25. | ||||
| REF 2 | US patent application no. 9126987B2, Inhibitors of glutaminyl cyclase | ||||
| REF 3 | US patent application no. 9034907B2, Inhibitors of glutaminyl cyclase | ||||
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