Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T44861 | Target Info | |||
| Target Name | Protein kinase C delta (PRKCD) | ||||
| Synonyms |
nPKC-delta; Tyrosine-protein kinase PRKCD; SDK1; Protein kinase C delta type catalytic subunit; Protein kinase C delta type; PKC-delta
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| Target Type | Clinical trial Target | ||||
| Gene Name | PRKCD | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 31 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Dasatinib
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Approved | Compound Info | ||
| Synonyms |
Sprycel (TN); BMS 354825; BMS-354825; BMS-354825, Sprycel, BMS354825, Dasatinib; BMS354825; Dasatinib (USAN); Dasatinib [USAN]; Dasatinib anhydrous; Dasatinib, BMS 354825; Dasatinibum; Sprycel; Spyrcel
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Imatinib
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Approved | Compound Info | ||
| Synonyms |
Cgp 57148; Glamox; Glamox (TN); Gleevec (TN); Glivec (TN); Imatinib (INN); Imatinib (STI571); Imatinib Methansulfonate; Imatinib [INN:BAN]; 112GI019; 152459-95-5; BKJ8M8G5HI; CCRIS 9076; CGP-57148; CHEMBL941; Imatinib free base; STI; UNII-BKJ8M8G5HI
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
L-751250
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Preclinical | Compound Info | ||
| Synonyms |
Purvalanol B; 212844-54-7; PURVALANOL; Purvalanol B(NG-95); (R)-2-chloro-4-((2-((1-hydroxy-3-methylbutan-2-yl)amino)-9-isopropyl-9H-purin-6-yl)amino)benzoic acid; (2R)-2-[[6-[(3-CHLORO-4-CARBOXYPHENYL)AMINO]-9-(1-METHYLETHYL)-9H-PURIN-2-YL]AMINO]-3-METHYL-1-BUTANOL; CHEMBL23254; CHEBI:49840; NG 95; NG-95; C20H25ClN6O3; 2-chloro-4-[[2-[[(2R)-1-hydroxy-3-methylbutan-2-yl]amino]-9-propan-2-ylpurin-6-yl]amino]benzoic acid; J-502183; PVB
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
A-432411
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Investigative | Compound Info | ||
| Synonyms |
43A; (3Z)-6-(4-HYDROXY-3-METHOXYPHENYL)-3-(1H-PYRROL-2-YLMETHYLENE)-1,3-DIHYDRO-2H-INDOL-2-ONE; 2ayp; indolinone analog 13; A-432411; CHEMBL202930; SCHEMBL6674605; BDBM14649; DB07078; 29690-EP2311842A2; 29690-EP2289868A1; 29690-EP2289894A2; (3Z)-6-(4-hydroxy-3-methoxyphenyl)-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-2-one; (3Z)-6-(4-hydroxy-3-methoxyphenyl)-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
aloisine A
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Investigative | Compound Info | ||
| Synonyms |
ALOISINE A; 4-(7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenol; 496864-16-5; RP107; 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE; CHEMBL75680; 7-n-Butyl-6-(4-hydroxyphenyl)[5H]pyrrolo[2,3-b]pyrazine; RP-107; ALH; 4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol; 1ung; SCHEMBL80147; BDBM7377; GTPL5924; AC1NS169; 4-(7-Butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)-phenol; CHEBI:93641; CTK8D4068; DTXSID30416115; HMS3229A14; RM-39; BCP26893; ZINC2540737; ACT06534; IN1539; HSCI1_000219; MFCD04973541; AKOS005145972; CCG-206814; DB07364; RTC-063070; AJ-39131
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
Ro-4396686
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL5809947; CHEMBL606964
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| Activity |
IC50 ~ 125000 nM
|
[6] | |||
| Compound Name |
3-(5-Chloro-2-{[1-(dimethylamino)propan-2-yl]oxy}phenyl)-1-(5-cyanopyrazin-2-yl)urea
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Investigative | Compound Info | ||
| Synonyms |
urea-based inhibitor 2d; A-690002; CHEMBL425904; SCHEMBL5865729; BDBM14829; 1-[5-chloro-2-[1-(dimethylamino)propan-2-yloxy]phenyl]-3-(5-cyanopyrazin-2-yl)urea; (+/-)1-[5-Chloro-2-(2-dimethylamino-1-methyl-ethyloxy)-phenyl]-3-(5-cyano-pyrazin-2-yl)-urea
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| Activity |
IC50 = 50000 nM
|
[7] | |||
| Compound Name |
3-{5-Chloro-2-[(3-methyloxetan-3-yl)methoxy]phenyl}-1-(5-cyanopyrazin-2-yl)urea
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Investigative | Compound Info | ||
| Synonyms |
urea-based inhibitor 2e; A-641397; CHEMBL192161; BDBM14830; (+/-)1-[5-Chloro-2-(3-methyl-oxetan-3-ylmethoxy)-phenyl]-3-(5-cyano-pyrazin-2-yl)-urea
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
3-[4-(4-Hydroxyphenyl)phenyl]-N-(pyridin-4-ylmethyl)-1,4-dihydroindeno[1,2-c]pyrazole-6-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL242753; SCHEMBL6794625; BDBM50204693
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
3-(4'-Hydroxybiphenyl-4-Yl)-N-(4-Hydroxycyclohexyl)-1,4-Dihydroindeno[1,2-C]pyrazole-6-Carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL438485; SCHEMBL4809259; SCHEMBL4809267; BDBM91830; BDBM50204694; ZINC100469705; ZINC253994709; Q27456666
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
2-[9-(4-Amino-3-methoxyphenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepin-3-yl]-N-(4-morpholin-4-ylphenyl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL395080; BDBM50218700
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
(3Z)-6-(4-Hydroxy-3-methoxyphenyl)-3-(1H-imidazol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one
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Investigative | Compound Info | ||
| Synonyms |
indolinone analog 29; CHEMBL199299; BDBM14665
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
4-(2-(5-Cyano-4-(4-methyl-1H-indol-5-ylamino)pyridin-3-yl)vinyl)-N,N-dipropylbenzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1079904; BDBM50311948
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| Activity |
IC50 = 51000 nM
|
[10] | |||
| Compound Name |
4-(1-Methyl-1H-indol-5-ylamino)-5-styrylnicotinonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL568186; SCHEMBL2928650; BDBM50302513; 4-[(1-methylindol-5-yl)amino]-5-[(E)-2-phenylethenyl]pyridine-3-carbonitrile
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| Activity |
IC50 = 64000 nM
|
[11] | |||
| Compound Name |
8-Decyl-5-hydroxymethyl-2-isopropyl-1-methyl-1,2,5,6-tetrahydro-benzo[e][1,4]oxazocin-3-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL318971; BDBM50097751; (2S,5S)-8-Decyl-5-hydroxymethyl-2-isopropyl-1-methyl-1,2,5,6-tetrahydro-benzo[e][1,4]oxazocin-3-one
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| Activity |
Ki = 70600 nM
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[12] | |||
| Compound Name |
1-(Tert-Butyl)-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
1-NAPHTHYL PP1; 1-NA-PP1; pp1 analog; 4-Amino-1-tert-butyl-3-(1'-naphthyl)pyrazolo[3,4-d]pyrimidine; 1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 1-tert-butyl-3-naphthalen-1-ylpyrazolo[3,4-d]pyrimidin-4-amine; CHEMBL264406; 1-tert-butyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; C19H19N5; 1-tert-butyl-3-naphthalen-1-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 1-tert-butyl-3-naphthalen-1-yl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine; 1-Na PP1; 1-NaphthylPP1; NA-PP1; K00047; SCHEMBL173288; 1-NA-PP 1; CTK4E8691; 1-Naphthyl PP1(1-NA-PP1); DTXSID00274446; EX-A867; HMS3266C18; HMS3413H14; HMS3677H14; PP1-AG1872; BCP09108; ZINC2576349; 3272AH; 4-Amino-1-tert-butyl-3-(1'naphthyl)pyrazolo[3,4-d]pyrimidine; BDBM50229961; MFCD03425471; QC-203; s2642; AKOS024457409; ACN-046104; CS-1804; MB02817; KS-00001D85; NCGC00262627-06; AS-56537; HY-13941; AB0094864; PP1 Analog - CAS 221243-82-9; FT-0661645; A13232; InSolution PP1 Analog - CAS 221243-82-9; 425B471; W-201916; BRD-K29542628-001-01-3; Q27123369; 1-t-butyl-3-naphthalen-1-yl-1h-pyrazolo[3,4-d]pyrimidin-4-ylamine; 4-Amino-1-tert-butyl-3-(1''-naphthyl)pyrazolo[3,4-d]pyrimidine; 4-Amino-1-tert-butyl-3-(1?-naphthyl)pyrazolo[3,4-d]pyrimidine; 1-(tert-butyl)-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (4); 1H-pyrazolo[3,4-d]pyrimidin-4-amine, 1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-; 1H-Pyrazolo[3,4-d]pyrimidin-4-amine,1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-
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| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
N-Benzoyl-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL277430; BDBM50287092
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| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
4-Pyridin-4-yl-N-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]pyrimidin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL55662; SCHEMBL1269; BDBM50290420; 4-(4-Pyridinyl)-N-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]pyrimidin-2-amine; N-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-4(4-pyridyl)-2-pyrimidineamine; N-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-4-(4-pyridyl)-2-pyrimidine-amine; (4-Pyridin-4-yl-pyrimidin-2-yl)-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-amine
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-[4-Chloro-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL278630; BDBM50287094
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| Activity |
IC50 ~ 100000 nM
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[14] | |||
| Compound Name |
[4-(4-Chloro-phenyl)-pyrimidin-2-yl]-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL57581; SCHEMBL8837820; BDBM50290425; 4-(4-chlorophenyl)-N-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]pyrimidin-2-amine; N-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-4-(4-chloro-phenyl)-2-pyrimidineamine
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
4,N*1*-Dimethyl-N*3*-(4-pyridin-3-yl-pyrimidin-2-yl)-benzene-1,3-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL21215; SCHEMBL15159937; BDBM50287095; N1,4-dimethyl-N3-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
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| Activity |
IC50 ~ 100000 nM
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[14] | |||
| Compound Name |
N-[4-Methoxy-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL21086; BDBM50287088
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| Activity |
IC50 ~ 100000 nM
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[14] | |||
| Compound Name |
4-Chloro-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL21162; SCHEMBL9677; BDBM50287090; VCC374125; 4-Chloro-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-{4-Methyl-3-[4-(1-oxy-pyridin-3-yl)-pyrimidin-2-ylamino]-phenyl}-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL21079; SCHEMBL3048286; BDBM50287098; N-[4-methyl-3-[[4-(1-oxidopyridin-1-ium-3-yl)pyrimidin-2-yl]amino]phenyl]benzamide
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| Activity |
IC50 ~ 100000 nM
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[14] | |||
| Compound Name |
N-[4-Methyl-3-(4-thiophen-2-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL21078; BDBM50287087
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| Activity |
IC50 ~ 100000 nM
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[14] | |||
| Compound Name |
Purvalanol A
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Investigative | Compound Info | ||
| Synonyms |
2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine; 6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine; CHEMBL23327; UNII-YP483E75C4; NG-60; NG 60; YP483E75C4; MFCD02179211; (2R)-2-[[6-(3-chloroanilino)-9-propan-2-ylpurin-2-yl]amino]-3-methylbutan-1-ol; C19H25ClN6O; Tocris-1580; Purvalanol A(NG 60); Lopac-P-4484; MLS006010846; SCHEMBL1217069; BCBcMAP01_000180; BDBM27216; AOB6163; DTXSID30175553; EX-A648; 2,6,9-Trisubstitute purine, 1; 2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropyl-purine; HMS3268E19; HMS3412L07; HMS3676L07; ZINC582575; BCP06309; 3983AH; HY-18299A; s7793; AKOS022185058; CCG-101285; CS-4001; DB04751; SMP1_000251; NCGC00015814-01; NCGC00025219-01; NCGC00025219-02; NCGC00025219-04; NCGC00025219-10; Purvalanol A, >=98% (HPLC), powder; Purvalanol A - CAS 212844-53-6; SMR004701771; J-013971; BRD-K50836978-001-01-7; Q27464217; (2R)-2-[[6-(3-chloroanilino)-9-isopropyl-purin-2-yl]amino]-3-methyl-butan-1-ol; 6-(3-CHLOROANILINO)-2(1R)-ISOPROPYL-2-HYDROXYETHYLAMINO-9-ISOPROPYLPURINE
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
N-Methyl-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL278287; SCHEMBL5972157; BDBM50287089
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| Activity |
IC50 ~ 100000 nM
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[14] | |||
| Compound Name |
3-[[4-(3-Pyridinyl)-2-pyrimidinyl]amino]benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL57556; 3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzoic Acid; SCHEMBL1655099; BDBM50290410; ZINC29557832; 3-(4-Pyridin-3-yl-pyrimidin-2-ylamino)-benzoic acid; 3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-benzoic acid; Benzoic acid,3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
2-Methoxy-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL418010; SCHEMBL9666; BDBM50287096; VCC863136; 2-Methoxy-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
(3E)-5-(2,2-Dimethylpropoxymethyl)-5-(hydroxymethyl)-3-[5-methyl-3-(2-methylpropyl)hexylidene]oxolan-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL363418; BDBM50172486
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| Activity |
Ki = 101000 nM
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[15] | |||
| Compound Name |
(+)-(1R,3R)-1-(3-Hydroxy-cyclopentyl)-3-(4-methoxy-phenyl)-7-phenylamino-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1952210; Ro-4383596; SCHEMBL5772118; BDBM50363957; 7-anilino-1-[(1R,3R)-3-hydroxycyclopentyl]-3-(4-methoxyphenyl)-4H-pyrimido[4,5-d]pyrimidin-2-one
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| Activity |
IC50 ~ 125000 nM
|
[16] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 12 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(3-Nitro-phenyl)-(4-pyridin-3-yl-pyrimidin-2-yl)-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL56081; SCHEMBL1977; 2-Pyrimidinamine,N-(3-nitrophenyl)-4-(3-pyridinyl)-; BDBM50290423; VCC117886; N-(3-nitrophenyl)-4-pyridin-3-ylpyrimidin-2-amine; 4-(3-Pyridinyl)-N-(3-nitrophenyl)pyrimidin-2-amine; N-(3-nitrophenyl)-4-(3-pyridyl)-2-pyrimidine-amine
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| Activity |
IC50 > 500000 nM
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[2] | |||
| Compound Name |
(3-Nitro-phenyl)-(4-pyridin-2-yl-pyrimidin-2-yl)-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL60816; SCHEMBL1886; BDBM50290424; N-(3-nitrophenyl)-4-pyridin-2-ylpyrimidin-2-amine; 4-(2-Pyridinyl)-N-(3-nitrophenyl)pyrimidin-2-amine; N-(3-nitrophenyl)-4-(2-pyridyl)-2-pyrimidine-amine
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| Activity |
IC50 > 500000 nM
|
[2] | |||
| Compound Name |
N-[4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CGP-53716; CGP53716;CGP 53716; CHEMBL20926; cgp53716; SCHEMBL9782; BCP34642; BDBM50240407; MFCD00945675; VCC347042; AK688902; BS-15548; N-(4-Methyl-3(4-(pyridine-3-yl)pyrimidin-2-ylamino)phenyl)benzamide; N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)benzamide; N-[4-Methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
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| Activity |
IC50 > 500000 nM
|
[2] | |||
| Compound Name |
N-[4-Methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL423288; SCHEMBL19556857; BDBM50240406; N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)acetamide
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| Activity |
IC50 > 500000 nM
|
[2] | |||
| Compound Name |
N-[4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]naphthalene-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL20252; SCHEMBL9837; BDBM50287091; VCC051689; Naphthalene-2-carboxylic acid [4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-amide
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| Activity |
IC50 > 500000 nM
|
[2] | |||
| Compound Name |
2-Methoxy-N-[3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL299707; SCHEMBL9338; BDBM50290429; VCC092935; 2-Methoxy-N-[3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide; 2-Methoxy-N-[3-[[4-(3-pyridinyl)pyrimidin-2-yl]amino]phenyl]benzamide
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| Activity |
IC50 > 500000 nM
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[2] | |||
| Compound Name |
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine
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Investigative | Compound Info | ||
| Synonyms |
6-methyl-N1-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine; 2-(5-Amino-2-methylanilino)-4-(3-pyridyl)pyrimidine; JR9RZF7KDS; UNII-JR9RZF7KDS; CHEMBL278103; 4-methyl-3-N-(4-pyridin-3-ylpyrimidin-2-yl)benzene-1,3-diamine; 1,3-Benzenediamine, 4-methyl-N3-[4-(3-pyridinyl)-2-pyrimidinyl]-; N-(5-Amino-o-tolyl)-4-(3-pyridyl)-2-pyrimidinamine; N-(5-Amino-2-methylphenyl)-4-(3-pyridinyl)-2-pyrimidineamine; 4-Methyl-N3-[4-(3-Pyridinyl)-2-Pyrimidinyl]-1,3-Benzenediamine; 4-methyl-3-[4-(3-pyridyl)pyrimidin-2-ylamino]aniline; 1,3-Benzenediamine, 4-methyl-N3-(4-(3-pyridinyl)-2-pyrimidinyl)-; 4-Methyl-N*3*-(4-pyridin-3-yl-pyrimidin-2-yl)-benzene-1,3-diamine; N-(5-Amino-2-methylphenyl)-4-(3-pridyl)-2-pyrimidineamine; Imatinib amine; 4-Methyl-N3-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine; 4-Methyl-N3-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine; 6-METHYL-N1-[4-(PYRIDIN-3-YL)PYRIMIDIN-2-YL]BENZENE-1,3-DIAMINE; zlchem 1354; Imatinib amine [USP]; PubChem18212; Imatinib EP Impurity F; ACMC-209d7r; SCHEMBL2392; KSC174K2P; BEN021; CTK0H4527; DTXSID30433443; ZLE0132; Imatinib related compound F [USP]; ACT04895; BCP22918; AC-619; ANW-21397; BDBM50287097; CA0157; MFCD09028125; VCC489937; ZINC21985310; AKOS015888614; AC-2147; ACN-026829; CCG-310976; CS-W014568; DS-0284; LS41060; MCULE-2150821496; QC-1118; 112GI007; AK-23922; AT-20154; BR-23922; SC-19340; AB0005260; A3351; AM20050827; FT-0647597; FT-0655675; FT-0696298; VU0549314-1; M-1404; 460A101; Q-100177; N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimid; F9995-0188; 3-[[4-(3-Pyridinyl)pyrimidine-2-yl]amino]-4-methylaniline; n-(2-methyl-5-aminophenyl)-4-(3-pyridyl)-2-pyrimidine amine; N-(5-Amino-2-methyl phenyl)-4-(3-pyridyl)-2-pyrimidineamine; N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2- pyrimidineamine; N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidine amine; N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidine-amine; 1,3-Benzenediamine, 4-methyl-N3-[4-(3-pyridinyl)-2-pyrimidinyl; 4-Methyl-N-3-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine; 4-methyl-N~3~-(4-pyridin-3-ylpyrimidin-2-yl)benzene-1,3-diamine; 4-Methyl-N3-(4-pyridin-3-yl-pyrimidin-2-yl)-benzene-1,3-diamine; 4-methyl-N3-[4-(3-piridinyl)-2-pirimidinyl]-1,3-benzendiamine; 4-Methyl-N3-[4-(3-pyridyl)-2-pyrimidinyl]-1,3-phenylenediamine; 6-Methyl-N-(4-(pyridine-3-yl)pyrimidin-2-yl)benzene-1,3-diamine; 6-Methyl-N1-(4-(pyridine-3-yl)pyrimidin-2-yl)benzene-1,2-diamine; N-(5-amino-2-methyl phenyl)-4-(3-pyridinyl)2-pyrimidine-amine; N-(5-amino-2-methylphenyl)-4-(3-pyridinyl)-2-pyrimidine-amine; 4-Methyl-N~3~-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine
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| Activity |
IC50 > 500000 nM
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[2] | |||
| Compound Name |
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
N-(2-Methyl-5-nitrophenyl)-4-pyridin-3-ylpyrimidin-2-amine; N-(2-Methyl-5-nitrophenyl)-4-(3-pyridyl)-2-pyrimidine-amine; n-(2-methyl-5-nitrophenyl)-4-(3-pyridyl)-2-pyrimidineamine; CHEMBL20426; 2-Pyrimidinamine, N-(2-methyl-5-nitrophenyl)-4-(3-pyridinyl)-; (2-Methyl-4-nitro-phenyl)-(4-pyridin-3-yl-pyrimidin-2-yl)-amine; MFCD02179269; N-(2-methyl-5-nitrophenyl)-4-(3-pyridyl)-2-pyrimidinamine; 2-Pyrimidinamine,N-(2-methyl-5-nitrophenyl)-4-(3-pyridinyl)-; 2-Methyl-5-nitro-N-[4-(pyridin-3-yl)pyrimidin-2-yl]benzenamine; SCHEMBL1550; ACMC-1C66W; KSC527I5D; N-(2-methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimid; PYR402; SCHEMBL13597737; CTK4C7451; DTXSID50443544; ACT04899; BCP12559; N-(2-methyl-5-nitro-phenyl)-4-pyridin-3-yl-pyrimidin-2-amine; ANW-41942; BDBM50287093; VCC987289; ZINC21298122; AKOS015909809; AC-2148; ACN-026830; MCULE-9226886591; QC-1117; 112GI008; AK-47893; DS-14539; SC-47708; AB0005259; AM20050826; FT-0654432; M2584; X2637; VU0549313-1; M-8440; 460M098; A809314; J-008922; 2-(2-methyl-5-nitroanilino)-4-(3-pyridinyl)pyrimidine; F9995-0184; N-(2-methyl-5-nitrophenyl)-4-(3-pyridyl)-pyrimidine-amine; N-(2-methyl-5-nitrophenyl)-4-(3-pyridinyl)-2-pyrimidinamine; N-(2-Methyl-5-nitrophenyl)-4-(3-pyridyl)-2-pyrimidinylamine; N-(5-nitro-2-methylphenyl)-4-(3-pyridinyl)-2-pyrimidineamine; (2-Methyl-5-nitro-phenyl)-(4-pyridin-3-yl-pyrimidin-2-yl)-amine; N-(2-Methyl-5-nitrophenyl)-4- (pyridin-3-yl)pyrimidin-2-amine; N-(2-methyl-5-nitrophenyl)-4-(3-pyridinyl)-2 pyrimidine amine; N-(2-methyl-5-nitrophenyl)-4-(3-pyridinyl)-2-pyrimidine amine
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| Activity |
IC50 > 500000 nM
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[14] | |||
| Compound Name |
N-(4-Pyridin-3-yl-pyrimidin-2-yl)-benzene-1,3-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL57553; SCHEMBL1465; BDBM50045528; VCC415532; 4-(3-Pyridinyl)-N-(3-aminophenyl)pyrimidin-2-amine; N-(3-aminophenyl)-4-(3-pyridyl)-2-pyrimidine-amine; 3-N-(4-pyridin-3-ylpyrimidin-2-yl)benzene-1,3-diamine; N-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine; N1-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
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| Activity |
IC50 > 500000 nM
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[2] | |||
| Compound Name |
4-Cyano-N-[3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL58580; SCHEMBL9642; BDBM50290411; VCC015466; 4-Cyano-N-[3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide; 4-Cyano-N-[3-[[4-(3-pyridinyl)pyrimidin-2-yl]amino]phenyl]benzamide
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| Activity |
IC50 > 500000 nM
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[2] | |||
| Compound Name |
(3-Nitro-phenyl)-(4-pyridin-4-yl-pyrimidin-2-yl)-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL55683; SCHEMBL1144; BDBM50290426; VCC792768; N-(3-nitrophenyl)-4-pyridin-4-ylpyrimidin-2-amine; 4-(4-Pyridinyl)-N-(3-nitrophenyl)pyrimidin-2-amine; N-(3-nitrophenyl)-4-(4-pyridyl)-2-pyrimidine-amine
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| Activity |
IC50 > 500000 nM
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[2] | |||
| Compound Name |
4-Methyl-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL20867; SCHEMBL9820; BDBM50175491; VCC643561; 4-Methyl-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
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| Activity |
IC50 > 500000 nM
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[2] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
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| REF 1 | Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem. 2004 Dec 30;47(27):6658-61. | ||||
| REF 2 | Potent and selective inhibitors of the Abl-kinase: phenylamino-pyrimidine (PAP) derivatives. Bioorg Med Chem Lett. 1997 Jan 21;7(2):187-92. | ||||
| REF 3 | Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science. 1998 Jul 24;281(5376):533-8. | ||||
| REF 4 | Synthesis and biological evaluation of 3-ethylidene-1,3-dihydro-indol-2-ones as novel checkpoint 1 inhibitors. Bioorg Med Chem Lett. 2006 Jan 15;16(2):421-6. | ||||
| REF 5 | Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects. J Med Chem. 2003 Jan 16;46(2):222-36. | ||||
| REF 6 | Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1950-3. | ||||
| REF 7 | 1-(5-Chloro-2-alkoxyphenyl)-3-(5-cyanopyrazin-2-yl)ureas [correction of cyanopyrazi] as potent and selective inhibitors of Chk1 kinase: synthesis, preliminary SAR, and biological activities. J Med Chem. 2005 May 5;48(9):3118-21. | ||||
| REF 8 | Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors. Bioorg Med Chem. 2007 Apr 1;15(7):2759-67. | ||||
| REF 9 | Design, synthesis, and biological activity of 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one-based potent and selective Chk-1 inhibitors. J Med Chem. 2007 Aug 23;50(17):4162-76. | ||||
| REF 10 | Synthesis and PKCtheta inhibitory activity of a series of 5-vinyl phenyl sulfonamide-3-pyridinecarbonitriles. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6575-7. | ||||
| REF 11 | First generation 5-vinyl-3-pyridinecarbonitrile PKCtheta inhibitors. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5829-32. | ||||
| REF 12 | Synthesis and binding selectivity of 7- and 15-decylbenzolactone-V8 for the C1 domains of protein kinase C isozymes. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3015-9. | ||||
| REF 13 | Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2... J Biol Chem. 2007 Nov 9;282(45):33052-63. | ||||
| REF 14 | Phenylamino-pyrimidine (PAP) - derivatives: a new class of potent and highly selective PDGF-receptor autophosphorylation inhibitors. Bioorg Med Chem Lett. 1996 Jun 4;6(11):1221-6. | ||||
| REF 15 | Conformationally constrained analogues of diacylglycerol (DAG). 25. Exploration of the sn-1 and sn-2 carbonyl functionality reveals the essential role of the sn-1 carbonyl at the lipid interface in the binding of DAG-lactones to protein kinase C. J Med Chem. 2005 Sep 8;48(18):5738-48. | ||||
| REF 16 | RO4383596, an orally active KDR, FGFR, and PDGFR inhibitor: synthesis and biological evaluation. Bioorg Med Chem. 2005 Aug 15;13(16):4835-41. | ||||
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