Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T43115 | Target Info | |||
| Target Name | Leukocyte common antigen (PTPRC) | ||||
| Synonyms |
T200; Receptor-type tyrosine-protein phosphatase C; L-CA; CD45 antigen; CD45
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| Target Type | Clinical trial Target | ||||
| Gene Name | PTPRC | ||||
| Biochemical Class | Phosphoric monoester hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 97 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
6-(Oxalyl-Amino)-1h-Indole-5-Carboxylic Acid
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|
Investigative | Compound Info | ||
| Synonyms |
6-(OXALYL-AMINO)-1H-INDOLE-5-CARBOXYLIC ACID; CHEMBL342478; 243967-44-4; 1H-Indole-5-carboxylic acid, 6-[(carboxycarbonyl)amino]-; 6-(carboxyformamido)-1H-indole-5-carboxylic acid; OAI; AC1L9GUL; SCHEMBL4318827; CTK0J4951; DTXSID50332166; 1c83; BDBM50118796; DB04001; N-(5-Carboxy-1H-indole-6-yl)oxamidic acid; 6-(oxaloamino)-1H-indole-5-carboxylic acid; 6-[(carboxycarbonyl)amino]-1H-indole-5-carboxylic acid
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| Activity |
Ki = 56000 nM
|
[1] | |||
| Compound Name |
2-(Oxalyl-Amino)-Benzoic Acid
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Investigative | Compound Info | ||
| Synonyms |
2-(oxaloamino)benzoic acid; 2-(OXALYL-AMINO)-BENZOIC ACID; CHEMBL139050; CHEBI:44493; 2-[(carboxycarbonyl)amino]benzoic acid; OBA; 2-oxaloaminobenzoic acid; AC1L9GUO; SCHEMBL4315667; 2-(Carboxyformamido)Benzoic Acid; 1c85; ZINC2007905; BDBM50118789; AKOS022649621; DB02622; SC-57508; 5651-01-4; BENZOIC ACID,2[(CARBOXYCARBONYL)AMINO]-
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| Activity |
Ki = 160000 nM
|
[1] | |||
| Compound Name |
[(4-{2,2-Bis-benzyloxy-3-[4-(difluoro-phosphono-methyl)-phenyl]-propyl}-phenyl)-difluoro-methyl]-phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL276376; BDBM50142319
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
({4-[2-Benzotriazol-1-yl-2-phenyl-3-(2''-sulfamoyl-biphenyl-4-yl)-propyl]-phenyl}-difluoro-methyl)-phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL9252; SCHEMBL7533384; BDBM50142322
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| Activity |
IC50 = 50000 nM
|
[3] | |||
| Compound Name |
[(3-Bromo-7-cyano-2-naphthalenyl)-difluoromethyl]phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
PTP1B-IN-3; CHEMBL259628; [(3-bromo-7-cyanonaphthalen-2-yl)-difluoromethyl]phosphonic acid; SCHEMBL340568; BDBM50239833; HY-15133; CS-0003783; BRD-K16554956-001-01-5; Q27166757; (3-bromo-7-cyanonaphthalen-2-yl)difluoromethylphosphonic acid; [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid; [(3-bromo-7-cyano-2-naphthyl)-(difluoro)methyl]phosphonic acid; P-[(3-Bromo-7-cyano-2-naphthalenyl)difluoromethyl]phosphonic Acid
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
[[3-Bromo-7-(methylsulfonylmethyl)naphthalen-2-yl]-difluoromethyl]phosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL259267; BDBM50373444
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
{[2-Chloro-4-(3-oxo-2,3-diphenyl-propyl)-phenyl]-difluoro-methyl}-phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL428651; BDBM50142318
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
[(6-Bromo-2-methylquinolin-7-yl)-difluoromethyl]phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL405419; SCHEMBL4413820; BDBM50373452
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
2-Benzotriazol-1-yl-3-[4-(difluoro-phosphono-methyl)-phenyl]-2-phenyl-propionic acid benzyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL267245; BDBM50142327
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|
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| Activity |
IC50 = 50000 nM
|
[3] | |||
| Compound Name |
[[6-Bromo-2-[(3-fluorophenyl)carbamoyl]quinolin-7-yl]-difluoromethyl]phosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL261362; BDBM50373449
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
{[4-(2-Benzotriazol-1-yl-2-phenyl-ethyl)-phenyl]-difluoro-methyl}-phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL9363; SCHEMBL7175356; BDBM50142332; [[4-[2-(benzotriazol-1-yl)-2-phenylethyl]phenyl]-difluoromethyl]phosphonic acid
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-[4-(Difluoro-phosphono-methyl)-benzyl]-2-(4-methanesulfonyl-benzyl)-malonic acid dibenzyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL267981; SCHEMBL6952150; BDBM50142321
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2,2-Bis-[4-(difluoro-phosphono-methyl)-benzyl]-malonic acid benzyl ester methyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8725; SCHEMBL6951017; BDBM50142312
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
[alpha,alpha-Difluoro-4-[3-[4-[2-(1-methoxyisopentyl)-8-phosphonoquinoline-6-yl]phenyl]-2-phenyl-2-(1H-benzotriazole-1-yl)propyl]benzyl]phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL266753; SCHEMBL7527019; BDBM13604; Aryldifluoromethyl-Phosphonic Acid Inhibitor 11
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|
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| Activity |
IC50 = 50000 nM
|
[3] | |||
| Compound Name |
[4-[2,5-Diphenyl-2-(1H-benzotriazole-1-yl)-4-pentenyl]-alpha,alpha-difluorobenzyl]phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL416145; BDBM13815; benzotriazole phenyldifluoromethylphosphonic acid compound 2
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|
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| Activity |
IC50 = 50000 nM
|
[3] | |||
| Compound Name |
[(3-Bromo-7-methylnaphthalen-2-yl)-difluoromethyl]phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL408382; SCHEMBL2691376; BDBM50373446
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
P-[(3-Bromo-6-cyano-2-naphthalenyl)difluoromethyl]-phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL260442; SCHEMBL2690335; BDBM50373442; [(3-bromo-6-cyanonaphthalen-2-yl)-difluoromethyl]phosphonic acid
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
[[6-Bromo-2-[(E)-2-phenylethenyl]quinolin-7-yl]-difluoromethyl]phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL261419; SCHEMBL15525074; BDBM50373457
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
[(4-{2-[4-(Difluoro-phosphono-methyl)-benzyl]-3-oxo-2,3-diphenyl-propyl}-phenyl)-difluoro-methyl]-phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL266056; SCHEMBL6951733; BDBM50142311
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
4-{2-[4-(Difluoro-phosphono-methyl)-benzyl]-3-oxo-2,3-diphenyl-propyl}-benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8660; SCHEMBL6943560; BDBM50142309; 4-(2-{4-[Difluoro(phosphono)methyl]benzyl}-3-oxo-2,3diphenylpropyl)benzoic acid; 4-[2-[[4-[difluoro(phosphono)methyl]phenyl]methyl]-3-oxo-2,3-diphenylpropyl]benzoic acid
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
{Difluoro-[5-(3-oxo-2,3-diphenyl-propyl)-biphenyl-2-yl]-methyl}-phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL9047; BDBM50142320
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
[alpha,alpha-Difluoro-4-[3-(3'-phosphonobiphenyl-4-yl)-2-phenyl-2-(1H-benzotriazole-1-yl)propyl]benzyl]phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL269166; SCHEMBL7526510; BDBM13599; Aryldifluoromethyl-Phosphonic Acid Inhibitor 6
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|
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| Activity |
IC50 = 50000 nM
|
[3] | |||
| Compound Name |
{[2-(1H-1,2,3-Benzotriazol-1-YL)-2-(3,4-difluorophenyl)propane-1,3-diyl]bis[4,1-phenylene(difluoromethylene)]}bis(phosphonic acid)
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL267048; SCHEMBL4322786; BDBM13596; DB02651; Aryldifluoromethyl-Phosphonic Acid Inhibitor 3; 23051-EP2305250A1; 23051-EP2314591A1; Q27093608
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|
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| Activity |
IC50 = 50000 nM
|
[3] | |||
| Compound Name |
[[3-Bromo-7-(methoxymethyl)naphthalen-2-yl]-difluoromethyl]phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL259050; BDBM50373454
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(2-Bromo-4-(3-oxo-2,3-diphenylpropyl)phenyl)difluoromethylphosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8758; SCHEMBL7161699; BDBM50142317; [[2-bromo-4-(3-oxo-2,3-diphenylpropyl)phenyl]-difluoromethyl]phosphonic acid; {[2-Bromo-4-(3-oxo-2,3-diphenyl-propyl)-phenyl]-difluoro-methyl}-phosphonic acid; Phosphonic acid, P-[[2-bromo-4-(3-oxo-2,3-diphenylpropyl)phenyl]difluoromethyl]-
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
[Difluoro-(2-methylquinolin-7-yl)methyl]phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL260210; BDBM50373453
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
[[4-[2-(Benzotriazol-1-yl)-2-phenyl-1-[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]ethyl]phenyl]-difluoromethyl]phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL276648; BDBM50142326
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|
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| Activity |
IC50 = 50000 nM
|
[3] | |||
| Compound Name |
Difluoro(4-(3-oxo-2,3-diphenylpropyl)phenyl)methylphosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL267022; SCHEMBL7166517; BDBM50142314; [difluoro-[4-(3-oxo-2,3-diphenylpropyl)phenyl]methyl]phosphonic acid; {Difluoro-[4-(3-oxo-2,3-diphenyl-propyl)-phenyl]-methyl}-phosphonic acid
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
[4-(2-(1H-1,2,3-Benzotriazol-1-YL)-3-{4-[difluoro(phosphono)methyl]phenyl}-2-phenylpropyl)phenyl](difluoro)methylphosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL276647; SCHEMBL6944262; BDBM13595; Aryldifluoromethyl-Phosphonic Acid Inhibitor 2; Q27453503
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| Activity |
IC50 = 50000 nM
|
[3] | |||
| Compound Name |
2-[4-(Carboxy-difluoro-methyl)-benzyl]-2-[4-(difluoro-phosphono-methyl)-benzyl]-malonic acid dibenzyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL9046; SCHEMBL6949886; BDBM50142315
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2,2-Bis-[4-(difluoro-phosphono-methyl)-benzyl]-malonic acid diisopropyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8767; SCHEMBL6951738; BDBM50142313
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
[[2-(Benzylcarbamoyl)-6-bromoquinolin-7-yl]-difluoromethyl]phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL261108; SCHEMBL10309196; BDBM50373456
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
({4-[2-Benzotriazol-1-yl-3-[4-(difluoro-phosphono-methyl)-phenyl]-2-(4-phenyl-thiazol-2-yl)-propyl]-phenyl}-difluoro-methyl)-phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL9473; BDBM50142329
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|
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| Activity |
IC50 = 50000 nM
|
[3] | |||
| Compound Name |
[(6-Bromo-2-carbamoylquinolin-7-yl)-difluoromethyl]phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL260914; SCHEMBL10309199; BDBM50373447
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
4-{1-Benzotriazol-1-yl-1-[4-(difluoro-phosphono-methyl)-benzyl]-2-[4-(difluoro-phosphono-methyl)-phenyl]-ethyl}-benzoic acid methyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL268903; SCHEMBL7161106; BDBM50142328
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|
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| Activity |
IC50 = 50000 nM
|
[3] | |||
| Compound Name |
[[6-Bromo-2-(phenylcarbamoyl)quinolin-7-yl]-difluoromethyl]phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL261418; SCHEMBL2691742; BDBM50373450
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
[[7-(Acetamidomethyl)-3-bromonaphthalen-2-yl]-difluoromethyl]phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL259266; BDBM50373445
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
[[6-Bromo-2-(methylcarbamoyl)quinolin-7-yl]-difluoromethyl]phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL407893; SCHEMBL10309197; BDBM50373448
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
2,2-Bis-[4-(difluoro-phosphono-methyl)-benzyl]-malonic acid monomethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL9070; SCHEMBL6947267; BDBM50142308; 2,2-Di{4-[difluoro(phosphono)methyl]benzyl}-3-methoxy-3-oxopropanoic acid; 2,2-bis[[4-[difluoro(phosphono)methyl]phenyl]methyl]-3-methoxy-3-oxopropanoic acid
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
[(4-{2-Benzotriazol-1-yl-3-[4-(difluoro-phosphono-methyl)-phenyl]-2-quinolin-2-yl-propyl}-phenyl)-difluoro-methyl]-phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL273474; BDBM50142325
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|
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| Activity |
IC50 = 50000 nM
|
[3] | |||
| Compound Name |
[[4-[2-(Benzotriazol-1-yl)-2-phenylpropyl]phenyl]-difluoromethyl]phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL410646; BDBM50373441
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|
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| Activity |
IC50 = 50000 nM
|
[4] | |||
| Compound Name |
[(4-{4-Benzotriazol-1-yl-5-[4-(difluoro-phosphono-methyl)-phenyl]-4-phenyl-pent-1-enyl}-phenyl)-difluoro-methyl]-phosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL274435; BDBM50142335
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| Activity |
IC50 = 50000 nM
|
[3] | |||
| Compound Name |
6-{4-[2-(1H-1,2,3-Benzotriazol-1-yl)-3-{4-[difluoro(phosphono)methyl]phenyl}-2-phenylpropyl]phenyl}-2-methylquinoline-8-phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL268526; SCHEMBL7526713; BDBM13602; Aryldifluoromethyl-Phosphonic Acid Inhibitor 9
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| Activity |
IC50 = 50000 nM
|
[3] | |||
| Compound Name |
3-(Benzylthio)thiophene-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910876; BDBM50355647
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| Activity |
IC50 = 50000 nM
|
[5] | |||
| Compound Name |
2-(Oxalyl-amino)-4,7-dihydro-5H-thieno[2,3-C]pyran-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL138806; SCHEMBL4312414; BDBM50118744; DB03102; Q27094059; 2-(carboxyformamido)-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxylic acid; N-(3-Carboxy-4,5-dihydro-7H-thieno[2,3-c]pyran-2-yl)oxamidic acid; 2-[(carboxycarbonyl)amino]-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid
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| Activity |
Ki = 53000 nM
|
[1] | |||
| Compound Name |
4-Bromo-3-(carboxymethoxy)-5-[4-[[oxo(3-pyridinyl)methyl]amino]phenyl]-2-thiophenecarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL214378; 4-bromo-3-(carboxymethoxy)-5-[4-(pyridine-3-carbonylamino)phenyl]thiophene-2-carboxylic acid; Monocyclic thiophene analog 27; SCHEMBL3908592; BDBM14258; HMS3295G19; BRD-K12811596-001-01-9; Q27216111; 4-bromo-3-(carboxymethoxy)-5-[4-(pyridine-3-amido)phenyl]thiophene-2-carboxylic acid
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| Activity |
Ki = 55000 nM
|
[1] | |||
| Compound Name |
[1-Hydroxy-1-(3-nitro-phenyl)-ethyl]-phosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL309125; BDBM50289999
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| Activity |
IC50 = 58000 nM
|
[6] | |||
| Compound Name |
2-(Oxalyl-amino)-4,5,6,7-tetrahydro-thieno[2,3-C]pyridine-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
TCS-401; CHEMBL139393; 2-(oxaloamino)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid; SCHEMBL4293286; TCS 401 pound>>TCS401; BCP29628; ZINC1551920; BDBM50118792; DB03670; Q27094586; N-(3-Carboxy-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-yl)oxamidic acid; 2-(carboxyformamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid
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| Activity |
Ki = 59000 nM
|
[1] | |||
| Compound Name |
[[26,28-Dihydroxy-17-[hydroxy(diphosphono)methyl]-25,27-dipropoxy-5-pentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(25),3,5,7(28),9(27),10,12,15(26),16,18,21,23-dodecaenyl]-hydroxy-phosphonomethyl]phosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2430578; BDBM50441104; AKOS026705841; ZINC150558140; F1170-0253
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| Activity |
IC50 = 59000 nM
|
[7] | |||
| Compound Name |
3-(3,4-Dibromobenzylthio)thiophene-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910882; BDBM50355635
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| Activity |
IC50 = 60000 nM
|
[5] | |||
| Compound Name |
({4-[2-Benzotriazol-1-yl-3-(4-benzyloxy-phenyl)-2-phenyl-propyl]-phenyl}-difluoro-methyl)-phosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL9374; BDBM50142334
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|
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| Activity |
IC50 = 64000 nM
|
[3] | |||
| Compound Name |
4-Bromo-3-(carboxymethoxy)-5-[4-(dimethylamino)phenyl]thiophene-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Monocyclic thiophene analog 24; CHEMBL379196; SCHEMBL3909188; BDBM14255
Click to Show/Hide
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| Activity |
Ki = 64000 nM
|
[1] | |||
| Compound Name |
3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-(thiazol-2-yl)benzofuran-6-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL598832; BDBM50308000
Click to Show/Hide
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||||
| Activity |
IC50 = 66700 nM
|
[8] | |||
| Compound Name |
({4-[2-(1H-1,2,3-Benzotriazol-1-yl)-2-phenyl-3-(4-phenylphenyl)propyl]phenyl}difluoromethyl)phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL267759; SCHEMBL7163888; BDBM13598; Aryldifluoromethyl-Phosphonic Acid Inhibitor 5; [[4-[2-(benzotriazol-1-yl)-2-phenyl-3-(4-phenylphenyl)propyl]phenyl]-difluoromethyl]phosphonic acid
Click to Show/Hide
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||||
| Activity |
IC50 = 69000 nM
|
[3] | |||
| Compound Name |
2-[(3,4-Dichlorobenzyl)sulfanyl]-4-(4-Hydroxybut-1-Yn-1-Yl)benzoic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910966; BDBM50355650; Q27463982; NXV
Click to Show/Hide
|
||||
| Activity |
IC50 = 70000 nM
|
[5] | |||
| Compound Name |
3-[(3,4-Dichlorobenzyl)sulfanyl]-N-(Methylsulfonyl)thiophene-2-Carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910886; 3qch; BDBM50355643; Q27463968; NX2
Click to Show/Hide
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||||
| Activity |
IC50 = 73000 nM
|
[5] | |||
| Compound Name |
5-(3-{[1-(Benzylsulfonyl)piperidin-4-Yl]amino}phenyl)-4-Bromo-3-(Carboxymethoxy)thiophene-2-Carboxylic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL541214; SCHEMBL3904696; BDBM50219566; ZINC14210715; Q27455409
Click to Show/Hide
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||||
| Activity |
Ki = 77000 nM
|
[9] | |||
| Compound Name |
3-[(3,4-Dichlorobenzyl)sulfanyl]-2-thiophenecarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
compound 1 [PMID: 21882820]; CHEMBL1403981; 3-[(3,4-dichlorophenyl)methylsulfanyl]thiophene-2-carboxylic acid; 3-(3,4-dichlorobenzylthio)thiophene-2-carboxylic acid; 3-[(3,4-Dichlorobenzyl)sulfanyl]thiophene-2-Carboxylic Acid; MLS000328032; GTPL8831; SCHEMBL7509205; CTK7J1491; KS-00001QMT; HMS2375J14; ZINC3883136; 3-{[(3,4-dichlorophenyl)methyl]sulfanyl}thiophene-2-carboxylic acid; BDBM50355636; MFCD00663856; AKOS005069187; MCULE-3404579720; 10G-330S; SMR000168583; SR-01000678515; SR-01000678515-2; Q27076384; 3-((3,4-Dichlorobenzyl)thio)thiophene-2-carboxylic acid
Click to Show/Hide
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||||
| Activity |
IC50 = 79000 nM
|
[5] | |||
| Compound Name |
3-(3,4-Dichlorobenzyloxy)thiophene-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910883; BDBM50355655; AKOS012642447
Click to Show/Hide
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||||
| Activity |
IC50 = 80000 nM
|
[5] | |||
| Compound Name |
3-Ethynyl-6-hydroxy-2-phenyl-benzofuran-5-carboxylic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2316901; SCHEMBL15829174; BDBM50425823; 3-ethynyl-6-hydroxy-2-phenyl-1-benzofuran-5-carboxylic acid
Click to Show/Hide
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||||
| Activity |
IC50 = 80000 nM
|
[10] | |||
| Compound Name |
2-[4-(Methylthio)-2-pyridinylmethylsulfinyl]-5-(cyclohexyloxy)-1H-benzimidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL87002; BDBM50094940; 5-Cyclohexyloxy-2-(4-methylsulfanyl-pyridin-2-ylmethanesulfinyl)-1H-benzoimidazole
Click to Show/Hide
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||||
| Activity |
IC50 = 80500 nM
|
[11] | |||
| Compound Name |
N-[(3-Aminophenyl)sulfonyl]-3-[(3,4-Dichlorobenzyl)sulfanyl]thiophene-2-Carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910888; 3qci; BDBM50355642; Q27463969; NX3
Click to Show/Hide
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||||
| Activity |
IC50 = 81000 nM
|
[5] | |||
| Compound Name |
3-[2-Azaspiro[5.5]undecan-2-yl-(1-cyclopentyltetrazol-5-yl)methyl]-6-methyl-1H-quinolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
E3P13; MLS-0412204.0001; Oprea1_521818; CHEMBL1721448; SCHEMBL13196818; BDBM46264; cid_3182456; AKOS000776291
Click to Show/Hide
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||||
| Activity |
IC50 = 87000 nM
|
[12] | |||
| Compound Name |
Acetamide,2-[(1,4-dihydro-5,6-dimethyl-4-oxothieno[2,3-D]pyrimidin-2-YL)thio]-N-(6-ethoxy-2-benzothiazolyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159725; SCHEMBL13196820; BDBM50393495; ZINC12494251
Click to Show/Hide
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||||
| Activity |
IC50 = 90000 nM
|
[12] | |||
| Compound Name |
3-(3-Chlorobenzylthio)thiophene-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910878; BDBM50355653
Click to Show/Hide
|
||||
| Activity |
IC50 = 90000 nM
|
[5] | |||
| Compound Name |
N-(1,3-Benzodioxol-5-ylmethyl)-2-[(2-cyclopropyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)sulfanyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MLS-0412205.0001; CHEMBL1710150; SCHEMBL13196828; BDBM46265; cid_1435211; AKOS000704480; 2-[(2-cyclopropyl-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]pyrimidin-4-yl)thio]-N-piperonyl-acetamide
Click to Show/Hide
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||||
| Activity |
IC50 ~ 90000 nM
|
[12] | |||
| Compound Name |
6-Hydroxy-3-[2-(3-methoxyphenyl)ethynyl]-2-phenyl-benzofuran-5-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2316909; BDBM50425817
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
2-(3-Bromoanilino)-5-hydroxybenzothiazole-6-carboxylic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3596431; BDBM50498446
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
5-[({3-[(3,4-Dichlorobenzyl)sulfanyl]thiophen-2-Yl}carbonyl)sulfamoyl]-2-Methoxybenzoic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910889; BDBM50355649; Q27463970; NX4
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
4-[2-[3-[(2-Aminoacetyl)amino]phenyl]ethynyl]-2-[(3,4-dichlorophenyl)methylsulfanyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910968; BDBM50355641
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
N-(4-Fluoro-1,3-benzothiazol-2-yl)-5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MLS-0437605.0002; CHEMBL1882430; SCHEMBL15575767; BDBM82577; cid_7158830; ZINC4265903; AKOS024591044; MCULE-1744435959; MLS-0437605.0001; AB00670847-01; F0646-1821; N-(4-fluorobenzo[d]thiazol-2-yl)-5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-amine
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
(4-(4-Bromo-3,5-bis(trifluoromethyl)phenylcarbamoyl)phenyl)difluoromethylphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1081579; BDBM50312261; [[4-[[4-bromo-3,5-bis(trifluoromethyl)phenyl]carbamoyl]phenyl]-difluoro-methyl]phosphonic acid
Click to Show/Hide
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||||
| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
(Z)-5-[(4R,4As,6aR,7R,9aS,9bS)-4,6a-dimethyl-7-(6-methylheptan-2-yl)-2-oxo-4a,5,6,7,8,9,9a,9b-octahydro-1H-cyclopenta[f]isochromen-4-yl]pent-2-enenitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL143666; BDBM50068033
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
(S)-5-(2-((S)-1-((S)-1-((S)-1-((S)-2-(((S)-5-Amino-1-((S)-2-carbamoylpyrrolidin-1-yl)-1,5-dioxopentan-2-yl)carbamoyl)pyrrolidin-1-yl)-5-amino-1,5-dioxopentan-2-ylamino)-1-oxo-3-(4-(phosphonomethyl)phenyl)propan-2-ylamino)-5-amino-1,5-dioxopentan-2-ylamino)-2-oxoethylamino)-4-((2S,3R)-2-acetamido-3-hydroxybutanamido)-5-oxopentanoic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL248431; BDBM50233479
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[17] | |||
| Compound Name |
2-[(3,4-Dichlorophenyl)methylsulfanyl]-N-methylsulfonylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910964; BDBM50355654
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
[(3S,5S,8R,9S,10S,13R,14S,17R)-10,13-Dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxymethanedithioic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL169020; BDBM50097528
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
6-Hydroxy-3-[2-[(8R,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]ethynyl]-2-phenyl-1-benzofuran-5-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2316899; BDBM50425822
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
6-Hydroxy-3-(3-hydroxyprop-1-ynyl)-2-phenyl-benzofuran-5-carboxylic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2316900; BDBM50425821
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
2-[(3,4-Dichlorobenzyl)sulfanyl]benzoic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910963; ZINC6884503; BDBM50355652; AKOS008964961; MCULE-8961895668; 2-(3,4-Dichlorobenzylthio)Benzoic Acid; ST51027422; 2-[(3,4-dichlorophenyl)methylthio]benzoic acid; Q27463971
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
Azane;[[6-[difluoro(phosphono)methyl]naphthalen-2-yl]-difluoromethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL119693
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
[(4-{3-[4-(Difluoro-phosphono-methyl)-benzyloxy]-phenoxymethyl}-phenyl)-difluoro-methyl]-phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL140524; SCHEMBL13727362; BDBM50107740; [m-Phenylenebis[(oxymethylene-p-phenylene)(difluoromethylene)]]bis(phosphonic acid)
Click to Show/Hide
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||||
| Activity |
IC50 = 108000 nM
|
[19] | |||
| Compound Name |
3-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)naphthalen-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3910462
Click to Show/Hide
|
||||
| Activity |
IC50 = 112400 nM
|
[20] | |||
| Compound Name |
3-(3,4-Dichlorobenzylsulfonyl)thiophene-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910885; BDBM50355637
Click to Show/Hide
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||||
| Activity |
IC50 ~ 120000 nM
|
[5] | |||
| Compound Name |
2-(2-Pyridinylmethylsulfinyl)-5-isopropoxy-1H-benzimidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL90953; BDBM50094937; 5-Isopropoxy-2-(pyridin-2-ylmethanesulfinyl)-1H-benzoimidazole
Click to Show/Hide
|
||||
| Activity |
IC50 = 120000 nM
|
[11] | |||
| Compound Name |
3-[(3,4-Dimethylphenyl)methylsulfanyl]thiophene-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910880; BDBM50355645
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 120000 nM
|
[5] | |||
| Compound Name |
3-[2-(3-Fluorophenyl)ethyl]-6-hydroxy-2-phenyl-benzofuran-5-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2316898; BDBM50425812
Click to Show/Hide
|
||||
| Activity |
IC50 = 120000 nM
|
[10] | |||
| Compound Name |
3-[(4-Chlorobenzyl)sulfanyl]-2-thiophenecarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910877; 3-[(4-chlorophenyl)methylsulfanyl]thiophene-2-carboxylic Acid; 3-(4-chlorobenzylthio)thiophene-2-carboxylic acid; SCHEMBL7830138; CTK6H0242; KS-00001QNW; ZINC166221; 3-{[(4-chlorophenyl)methyl]sulfanyl}thiophene-2-carboxylic acid; BDBM50355640; MFCD00663876; AKOS005069192; MCULE-4540645649; 10G-447S; 3-((4-Chlorobenzyl)thio)thiophene-2-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 120000 nM
|
[5] | |||
| Compound Name |
3-(Naphthalen-2-ylmethylsulfanyl)thiophene-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910881; BDBM50355648
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 120000 nM
|
[5] | |||
| Compound Name |
3-(3,4-Dichlorobenzylamino)thiophene-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910884; BDBM50355651
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 120000 nM
|
[5] | |||
| Compound Name |
Azane;[4-[4-ethoxy-2,2-bis(methoxycarbonyl)-4-oxobutyl]phenyl]sulfamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL378423
Click to Show/Hide
|
||||
| Activity |
IC50 = 126000 nM
|
[21] | |||
| Compound Name |
4-Bromo-3-(Carboxymethoxy)-5-{3-[(3,3,5,5-Tetramethylcyclohexyl)amino]phenyl}thiophene-2-Carboxylic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL243942; SCHEMBL3909849; BDBM50219573; Q27454567; 2-[2-Carboxy-4-bromo-5-[3-(3,3,5,5-tetramethylcyclohexylamino)phenyl]-3-thienyloxy]acetic acid
Click to Show/Hide
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||||
| Activity |
Ki = 151000 nM
|
[1] | |||
| Compound Name |
2-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)-6-phenylphenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3938397
Click to Show/Hide
|
||||
| Activity |
IC50 = 157200 nM
|
[20] | |||
| Compound Name |
Azane;[[7-[difluoro(phosphono)methyl]naphthalen-2-yl]-difluoromethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL119459
Click to Show/Hide
|
||||
| Activity |
IC50 = 180000 nM
|
[18] | |||
| Compound Name |
3-[1-[3-[(1-Naphthyl)carbamoyl]propyl]-1H-1,2,3-triazole-4-yl]-6-hydroxy-2-phenylbenzofuran-5-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL260920; SCHEMBL13883163; GTPL10374; I-C11; BDBM50335895
Click to Show/Hide
|
||||
| Activity |
IC50 = 186000 nM
|
[22] | |||
| Compound Name |
[(4-{4-[4-(Difluoro-phosphono-methyl)-phenyl]-butyl}-phenyl)-difluoro-methyl]-phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL4316970; CHEMBL1161222; DB04204; Q27095031; Tetramethylenebis[(p-phenylene)(difluoromethylene)]bis(phosphonic acid); {butane-1,4-diylbis[benzene-4,1-diyl(difluoromethanediyl)]}bis(phosphonic acid)
Click to Show/Hide
|
||||
| Activity |
IC50 = 198000 nM
|
[19] | |||
| Compound Name |
4-Hydroxyphenylglyoxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Pisolithin A; 2-(4-hydroxyphenyl)-2-oxoacetic acid; (4-hydroxyphenyl)(oxo)acetic acid; 4-Hydroxyphenylglyoxylate; 4-hydroxybenzoylformate; Benzeneacetic acid, 4-hydroxy-alpha-oxo-; CHEMBL129918; Benzeneacetic acid,4-hydroxy-a-oxo-; 2-(4-hydroxyphenyl)-2-oxoacetate; 4-Hydroxyphenylglyoxylicacid; para-Hydroxybenzoylformic acid; p-hydroxybenzoylformic acid; SCHEMBL593133; CTK4C8800; DTXSID40165960; ZINC1529704; (4-Hydroxy-phenyl)-oxo-acetic acid; 4-hydroxy-alpha-oxobenzeneacetic acid; BDBM50118093; MFCD13192798; AKOS022504983; AS-47881; A18241; C03590; AE-562/43460298; Q27103861; Z2510259620
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[23] | |||
| Compound Name |
Click to Show/Hide
|
Compound Info | |||
| Activity |
IC50 = 84473 nM
|
[24] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 30 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-{4-[2-(S)-Allyloxycarbonylamino-3-{4-[(2-carboxy-phenyl)-oxalyl-amino]-phenyl}-propionylamino]-butoxy}-6-hydroxy-benzoic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL325029; OIC ACID METHYL ESTER; SCHEMBL6500588; BDBM50131545; DB04088; Q27454316
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[25] | |||
| Compound Name |
2-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)-4-methylphenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3928298; SCHEMBL17286687
Click to Show/Hide
|
||||
| Activity |
IC50 = 207100 nM
|
[20] | |||
| Compound Name |
2-(Carboxyformamido)thiophene-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL342612; SCHEMBL5836577; CTK0J4945; DTXSID30658432; BDBM50118749; N-(3-Carboxy-2-thienyl)oxamidic acid; 2-(Oxaloamino)thiophene-3-carboxylic acid; 2-(Oxalyl-amino)-thiophene-3-carboxylic acid; 3-Thiophenecarboxylic acid, 2-[(carboxycarbonyl)amino]-
Click to Show/Hide
|
||||
| Activity |
Ki = 210000 nM
|
[1] | |||
| Compound Name |
Azane;[[4-[2-[[4-[difluoro(phosphono)methyl]phenyl]methoxy]ethoxymethyl]phenyl]-difluoromethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL344437
Click to Show/Hide
|
||||
| Activity |
IC50 = 236000 nM
|
[19] | |||
| Compound Name |
3-(Carboxyformamido)thiophene-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL336879; SCHEMBL5838354; BDBM50118779; N-(2-Carboxy-3-thienyl)oxamidic acid; 3-(Oxalyl-amino)-thiophene-2-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
Ki = 260000 nM
|
[1] | |||
| Compound Name |
[Fluoro-[7-[fluoro(phosphono)methyl]naphthalen-2-yl]methyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1160962
Click to Show/Hide
|
||||
| Activity |
IC50 = 279000 nM
|
[18] | |||
| Compound Name |
4-Bromo-3-(carboxymethoxy)-5-phenylthiophene-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL213758; Monocyclic thiophene analog 11; SCHEMBL3907607; BDBM14245; DB07130; Q27096045
Click to Show/Hide
|
||||
| Activity |
Ki = 280000 nM
|
[1] | |||
| Compound Name |
Azane;[4-[2-ethoxycarbonyl-3-methoxy-3-oxo-2-(phenylmethoxycarbonylamino)propyl]phenyl]sulfamic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL213452
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| Activity |
IC50 = 280000 nM
|
[21] | |||
| Compound Name |
Oxalylarylaminobenzoic Acid Analog 12a
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL303333; BDBM13953; linked-fragment derived compound 12; 2-({4-[2-acetamido-2-(pentylcarbamoyl)ethyl]naphthalen-1-yl}amidoformic acid)benzoic acid; 2-{[4-(2-Acetylamino-2-pentylcarbamoylethyl)naphthalen-1-yl]oxalylamino}benzoic Acid; n-acetyl-4-[(carboxycarbonyl)(2-carboxyphenyl)amino]-n-pentyl-1-naphthylalaninamide
Click to Show/Hide
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| Activity |
Ki > 300000 nM
|
[26] | |||
| Compound Name |
Oxalyl-aryl-amino benzoic acid-based inhibitor 19
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL55243; SCHEMBL6495467; BDBM15819
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| Activity |
Ki > 300000 nM
|
[27] | |||
| Compound Name |
2-(4-Methyl-2-pyridinylmethylsulfinyl)-5-isopropoxy-1H-benzimidazole
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL89824; BDBM50094935; 5-Isopropoxy-2-(4-methyl-pyridin-2-ylmethanesulfinyl)-1H-benzoimidazole
Click to Show/Hide
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||||
| Activity |
IC50 = 380000 nM
|
[11] | |||
| Compound Name |
7-(1,1-Dioxo-1H-benzo[D]isothiazol-3-yloxymethyl)-2-(oxalyl-amino)-4,7-dihydro-5H-thieno[2,3-C]pyran-3-carboxylic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL577144; BDBM50299461; DB02827; Q27093781
Click to Show/Hide
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||||
| Activity |
Ki = 489000 nM
|
[1] | |||
| Compound Name |
{3(S)-Methylcarbamoyl-2-[3-(3-sulfoamino-phenyl)-propionyl]-1,2,3,4-tetrahydro-isoquinolin-7-YL}-sulfamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL204337; SCHEMBL6393262; BDBM13461; ZINC14952759; Tetrahydroisoquinoline (TIQ) deriv. 10i; Q27466911
Click to Show/Hide
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||||
| Activity |
IC50 > 500000 nM
|
[28] | |||
| Compound Name |
2-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)-5-phenylphenol
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3901405
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||||
| Activity |
IC50 > 500000 nM
|
[20] | |||
| Compound Name |
2-(2-Hydroxy-1,1,1,3,3,3-hexafluoropropyl)-1-naphthol
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)naphthalen-1-ol; SCHEMBL589730; CHEMBL3911513; CTK4E5485; DTXSID10379370; ZINC4348173; 7113AD; MFCD06247736; AKOS015856309; DB-045436; 2-(2-Hydroxyhexafluoroisopropyl)naphth-1-ol; FT-0634033; J-013725; 2-Naphthalenemethanol,1-hydroxy-a,a-bis(trifluoromethyl)-
Click to Show/Hide
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||||
| Activity |
IC50 > 500000 nM
|
[20] | |||
| Compound Name |
[[3-(3-Cyclohexyl-2-oxidanyl-phenyl)phenyl]-bis(fluoranyl)methyl]phosphonic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431708; BDBM50441298; AY8
Click to Show/Hide
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||||
| Activity |
Ki > 500000 nM
|
[29] | |||
| Compound Name |
[7-(Phosphonomethyl)naphthalen-2-yl]methylphosphonic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL9169463; CHEMBL1160960
Click to Show/Hide
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||||
| Activity |
IC50 = 500000 nM
|
[18] | |||
| Compound Name |
2-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)-4-phenylphenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3929350
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[20] | |||
| Compound Name |
1,1,1,3,3,3-Hexafluoro-2-phenylpropan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1,1,1,3,3,3-Hexafluoro-2-phenyl-2-propanol; (Hexafluoro-2-hydroxyisopropyl)benzene; Benzenemethanol, .alpha.,.alpha.-bis(trifluoromethyl)-; alpha,alpha-Bis(trifluoromethyl)benzyl alcohol; 2,2,2,2',2',2'-Hexafluorocumyl alcohol; hexafluoro-2-phenylisopropanol; Hexafluoro-2-phenyl isopropanol; Hexafluoro-2-phenyl-2-propanol; Benzenemethanol, alpha,alpha-bis(trifluoromethyl)-; MFCD00040983; Bis(trifluoromethyl)phenylcarbinol; EINECS 211-943-4; A,A-Bis(trifluoromethyl)benzyl alcohol; ACMC-209okf; SCHEMBL542694; Hexafluoro-2-phenylpropan-2-ol; CHEMBL3955910; DTXSID3061051; CTK2H8729; IZPIZCAYJQCTNG-UHFFFAOYSA-; ZINC157910; 2-hydroxy-2-phenylhexafluoropropane; KS-000016YZ; NSC96337; 1158AC; ANW-36109; NSC-96337; SBB099807; AKOS003619425; MCULE-2651808885; 2,2,2,2,2,2-Hexafluorocumyl Alcohol; 2,2,2,2,2,2,-hexafluorocumyl alcohol; AS-48861; DB-055578; alpha,alpha-Di(trifluoromethyl)benzyl alcohol; Benzyl alcohol,.alpha.-bis(trifluoromethyl)-; FT-0604631; ST51007775; Benzenemethanol,.alpha.-bis(trifluoromethyl)-; 1,1,1,3,3,3-Hexafluoro-2-phenyl-2-propanol #; 1,1,1,3,3,3-Hexafluoro-2-phenyl-2-propanol, 99%
Click to Show/Hide
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||||
| Activity |
IC50 > 500000 nM
|
[20] | |||
| Compound Name |
Methyl 2-hydroxy-5-(5-(((1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)amino)methyl)furan-2-yl)benzoate
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL227608; BDBM50292297
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[30] | |||
| Compound Name |
4-(5-((4-Hydroxy-3-(methoxycarbonyl)phenyl)amino)-5-oxopentanamido)-2,2,6,6-tetramethylpiperidin-1-olate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL265864; BDBM50292293
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[30] | |||
| Compound Name |
(E)-2,2,6,6-Tetramethyl-4-(3-(5-(3-nitrophenyl)furan-2-yl)acrylamido)piperidin-1-olate
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL389502; BDBM50292298
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[30] | |||
| Compound Name |
2-[4-(Methylthio)-2-pyridinylmethylthio]-5-isopropoxy-1H-benzimidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL314528; BDBM50094939; 5-Isopropoxy-2-(4-methylsulfanyl-pyridin-2-ylmethylsulfanyl)-1H-benzoimidazole
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
Difluoro(1-naphthyl)methylphosphonic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
difluoro(1-naphthyl)methylphosphonate; SCHEMBL341944; CHEMBL1160963; [difluoro(naphthalen-1-yl)methyl]phosphonic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[18] | |||
| Compound Name |
4-(5-((3-Carboxy-4-hydroxyphenyl)amino)-5-oxopentanamido)-2,2,6,6-tetramethylpiperidin-1-olate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL445152; BDBM50292294
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[30] | |||
| Compound Name |
2-Hydroxy-5-(5-(((1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)amino)methyl)furan-2-yl)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL390576; BDBM50292295
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[30] | |||
| Compound Name |
Phosphonic acid, (difluoro-2-naphthalenylmethyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL60857; difluoro(2-naphthyl)methylphosphonate; Difluoro(Naphthalen-2-yl)Methylphosphonate; napth; ACMC-20n2zo; SCHEMBL20815736; CTK0E9907; DTXSID90439688; BDBM50075312; (Difluoro-naphthalen-2-yl-methyl)-phosphonic acid
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[18] | |||
| Compound Name |
(E)-2,2,6,6-Tetramethyl-4-(3-(5-(4-nitrophenyl)furan-2-yl)acrylamido)piperidin-1-olate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL390088; BDBM50292296
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[30] | |||
| Compound Name |
Benzo[b]thieno[2,3-d]thiophene-2-carboxylic acid,3-(carboxymethoxy)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
thienobenzothiophene 20; CHEMBL583175; SCHEMBL3198156; BDBM14230; ZINC14955016; Benzo[b]thieno[2,3-d]thiophene-2-carboxylic acid, 3-(carboxymethoxy)-; 3-(carboxymethoxy)thieno[3,2-b][1]benzothiole-2-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
Ki > 1250000 nM
|
[1] | |||
| Compound Name |
2-(Oxalyl-amino)-6-phenethyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL140120; SCHEMBL6317692; BDBM50118750
Click to Show/Hide
|
||||
| Activity |
Ki = 1400000 nM
|
[31] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Knowledge-based characterization of similarity relationships in the human protein-tyrosine phosphatase family for rational inhibitor design. J Med Chem. 2009 Nov 12;52(21):6649-59. | ||||
| REF 2 | The development of potent non-peptidic PTP-1B inhibitors. Bioorg Med Chem Lett. 2004 Feb 23;14(4):1039-42. | ||||
| REF 3 | Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors. Bioorg Med Chem Lett. 2004 Feb 23;14(4):1043-8. | ||||
| REF 4 | Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3200-5. | ||||
| REF 5 | Small molecule receptor protein tyrosine phosphatase (RPTP) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop. J Med Chem. 2011 Oct 13;54(19):6548-62. | ||||
| REF 6 | Novel hydroxyphosphonate inhibitors of CD-45 tyrosine phosphatase. Bioorg Med Chem Lett. 1997 Sep 9;7(17):2169-72. | ||||
| REF 7 | Calix[4]arene methylenebisphosphonic acids as inhibitors of protein tyrosine phosphatase 1B. Bioorg Med Chem Lett. 2013 Oct 15;23(20):5619-23. | ||||
| REF 8 | Novel thiophene derivatives as PTP1B inhibitors with selectivity and cellular activity. Bioorg Med Chem. 2010 Mar 1;18(5):1773-82. | ||||
| REF 9 | Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site. J Med Chem. 2007 Sep 20;50(19):4681-98. | ||||
| REF 10 | Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold. J Med Chem. 2013 Feb 14;56(3):832-42. | ||||
| REF 11 | Synthesis and characterization of a potent and selective protein tyrosine phosphatase inhibitor, 2. Bioorg Med Chem Lett. 2000 Dec 4;10(23):2657-60. | ||||
| REF 12 | Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells. J Med Chem. 2011 Mar 24;54(6):1640-54. | ||||
| REF 13 | Diversity-Oriented Synthesis for Novel, Selective and Drug-like Inhibitors for a Phosphatase from Mycobacterium Tuberculosis. Medchemcomm. 2014 Oct;5(10):1496-1499. | ||||
| REF 14 | Perspective: Tyrosine phosphatases as novel targets for antiplatelet therapy. Bioorg Med Chem. 2015 Jun 15;23(12):2786-97. | ||||
| REF 15 | Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6851-4. | ||||
| REF 16 | Syntheses and biological activities of a novel group of steroidal derived inhibitors for human Cdc25A protein phosphatase. J Med Chem. 2001 Mar 1;44(5):834-48. | ||||
| REF 17 | A highly efficient route to enantiomerically pure l-N-Bz-Pmp(t-Bu)2-OH and incorporation into a peptide-based protein tyrosine phosphatase inhibitor. Bioorg Med Chem Lett. 2008 Jan 15;18(2):679-81. | ||||
| REF 18 | Naphthalenebis[alpha,alpha-difluoromethylenephosphonates] as potent inhibitors of protein tyrosine phosphatases. Bioorg Med Chem Lett. 1998 Feb 17;8(4):345-50. | ||||
| REF 19 | Structure of protein tyrosine phosphatase 1B in complex with inhibitors bearing two phosphotyrosine mimetics. J Med Chem. 2001 Dec 20;44(26):4584-94. | ||||
| REF 20 | Design, synthesis and evaluation of novel 19 F magnetic resonance sensitive protein tyrosine phosphatase inhibitors. Medchemcomm. 2016 Aug 1;7(8):1672-1680. | ||||
| REF 21 | Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4252-6. | ||||
| REF 22 | Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19767-72. | ||||
| REF 23 | Divalent and trivalent alpha-ketocarboxylic acids as inhibitors of protein tyrosine phosphatases. J Med Chem. 2002 Aug 29;45(18):3946-52. | ||||
| REF 24 | US patent application no. 8987474B2, Inhibition of Shp2/PTPN11 protein tyrosine phosphatase by NSC-87877, NSC-117199 and their analogs | ||||
| REF 25 | Selective protein tyrosine phosphatase 1B inhibitors: targeting the second phosphotyrosine binding site with non-carboxylic acid-containing ligands. J Med Chem. 2003 Jul 31;46(16):3437-40. | ||||
| REF 26 | Discovery and structure-activity relationship of oxalylarylaminobenzoic acids as inhibitors of protein tyrosine phosphatase 1B. J Med Chem. 2003 May 22;46(11):2093-103. | ||||
| REF 27 | Potent, selective inhibitors of protein tyrosine phosphatase 1B. Bioorg Med Chem Lett. 2003 Jun 2;13(11):1887-90. | ||||
| REF 28 | 1,2,3,4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1574-8. | ||||
| REF 29 | Substrate-based fragment identification for the development of selective, nonpeptidic inhibitors of striatal-enriched protein tyrosine phosphatase. J Med Chem. 2013 Oct 10;56(19):7636-50. | ||||
| REF 30 | Development of molecular probes for second-site screening and design of protein tyrosine phosphatase inhibitors. J Med Chem. 2007 May 3;50(9):2137-43. | ||||
| REF 31 | Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B. J Med Chem. 2002 Sep 26;45(20):4443-59. | ||||
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