Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T43031 | Target Info | |||
| Target Name | NIMA-related kinase 1 (NEK1) | ||||
| Synonyms |
Serine/threonine-protein kinase Nek1; Renal carcinoma antigen NY-REN-55; NimA-related protein kinase 1; Never in mitosis A-related kinase 1; KIAA1901
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| Target Type | Literature-reported Target | ||||
| Gene Name | NEK1 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Unii-O5YT36mst0
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Investigative | Compound Info | ||
| Synonyms |
EF-24; O5YT36MST0; CHEMBL379849; SCHEMBL8119310; BDBM50431030; ZINC34009101; EF-24, >=98% (HPLC); 3,5-bis(2-flurobenzylidene) piperidin-4-one; (3E,5E)-3,5-Bis((2-fluorophenyl)methylene)-4-piperidinone; 4-Piperidinone, 3,5-bis((2-fluorophenyl)methylene)-, (3E,5E)-
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| Activity |
IC50 = 77000 nM
|
[1] | |||
| Compound Name |
(3S,5E)-1-Methyl-3-(pyridin-2-ylmethyl)-5-(pyridin-2-ylmethylidene)piperidin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2338335; BDBM50431025
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| Activity |
IC50 = 83000 nM
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[1] | |||
| Compound Name |
(3R,5E)-1-Methyl-3-(pyridin-2-ylmethyl)-5-(pyridin-2-ylmethylidene)piperidin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2338334; BDBM50431026
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| Activity |
IC50 = 83000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Monocarbonyl curcumin analogues: heterocyclic pleiotropic kinase inhibitors that mediate anticancer properties. J Med Chem. 2013 May 9;56(9):3456-66. | ||||
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