Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T42658 | Target Info | |||
| Target Name | Herpesvirus ubiquitin-specific protease (HAUSP) | ||||
| Synonyms |
Ubiquitin-specific-processing protease 7; Ubiquitin thioesterase 7; Ubiquitin carboxyl-terminal hydrolase 7; Herpesvirus-associated ubiquitin-specific protease; Deubiquitinating enzyme 7
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|
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| Target Type | Preclinical Target | ||||
| Gene Name | USP7 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 23 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1-(5-((3,4-Dichlorophenyl)thio)thiazol-2-yl)ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4076683; SCHEMBL17059820; BDBM50234359; 1-[5-(3,4-dichlorophenyl)sulfanyl-1,3-thiazol-2-yl]ethanone
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-(5-((3,4-Dimethoxyphenyl)thio)-4-nitrothiazol-2-yl)ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4085087; SCHEMBL17059877; BDBM50234354
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-[5-[(3,4-Dichlorophenyl)methylamino]-4-nitro-1,3-thiazol-2-yl]ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4084117; SCHEMBL17059842; BDBM50234355
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-(5-Phenylsulfanyl-4-nitro-2-thienyl)ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159496; P22074; 1-(4-nitro-5-(phenylthio)thiophen-2-yl)ethan-1-one; BDBM50393438; 1-(4-Nitro-5-(phenylthio)thiophen-2-yl)ethanone
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
1-(5-((2,3-Dichlorophenyl)thio)thiazol-2-yl)ethanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4059609; SCHEMBL17059821; BDBM50234349; 1-[5-(2,3-dichlorophenyl)sulfanyl-1,3-thiazol-2-yl]ethanone
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3,5-Bis(4-hydroxyphenyl)pyridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL68661; SCH-21418; SCHEMBL4944183; BDBM50250961
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
1-(5-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiazol-2-yl)ethyl benzoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4099610; SCHEMBL17059867; BDBM50234358
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
4-[2-Amino-4-ethyl-5-(2-methylindazol-6-yl)-3-pyridyl]phenol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4099910; SCHEMBL18066824; BDBM50250948
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|
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| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
1-(5-((3-Methoxyphenyl)thio)-4-nitrothiazol-2-yl)ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4103033; SCHEMBL17059882; BDBM50234346
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-[5-(3,5-Dichloropyridin-4-yl)sulfanyl-4-nitro-1,3-thiazol-2-yl]ethyl acetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4073763; SCHEMBL17059843; BDBM50234347
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Chembl4287544
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Investigative | Compound Info | ||
| Synonyms |
BDBM50465220
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|
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| Activity |
IC50 = 60000 nM
|
[4] | |||
| Compound Name |
Chembl4128728
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL22479984; BDBM50271122
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|
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| Activity |
IC50 ~ 63300 nM
|
[2] | |||
| Compound Name |
Chembl4288834
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50465219
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| Activity |
IC50 = 78000 nM
|
[4] | |||
| Compound Name |
4-[3-(1-Methylpiperidin-4-yl)-1,2,4-oxadiazol-5-yl]phenol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4069137; BDBM50250965; AJJ
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|
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| Activity |
IC50 = 79200 nM
|
[3] | |||
| Compound Name |
4-(4-Piperidin-4-yl-1,3-oxazol-2-yl)phenol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4064074; BDBM50250966
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|
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| Activity |
IC50 = 85200 nM
|
[3] | |||
| Compound Name |
Chembl4280933
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL20087279; BDBM50465243
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|
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| Activity |
IC50 = 87000 nM
|
[4] | |||
| Compound Name |
Chembl4290072
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL20087360; BDBM50465208
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|
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| Activity |
IC50 = 90000 nM
|
[4] | |||
| Compound Name |
4-(3-Piperidin-4-yl-1,2,4-oxadiazol-5-yl)phenol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4097744; BDBM50250953
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|
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| Activity |
IC50 = 97700 nM
|
[3] | |||
| Compound Name |
Chebi:149900
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233809; N-[(3-acetamidophenyl)methyl]-1-[(1R)-1-naphthalen-1-ylethyl]piperidine-4-carboxamide; BDBM50007788; N-[3-(Acetylamino)benzyl]-1-[(R)-1-(1-naphthyl)ethyl]piperidine-4-carboxamide
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|
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
Chembl4292244
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL20087206; BDBM50465240
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|
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| Activity |
IC50 = 115000 nM
|
[4] | |||
| Compound Name |
Chembl4292642
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL20087203; BDBM50465226
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|
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| Activity |
IC50 = 130000 nM
|
[4] | |||
| Compound Name |
4-[3-(1-Methylpyrrolidin-3-yl)-1,2,4-oxadiazol-5-yl]phenol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4079712; BDBM50250955
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|
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| Activity |
IC50 = 131000 nM
|
[3] | |||
| Compound Name |
4-(3-Pyrrolidin-3-yl-1,2,4-oxadiazol-5-yl)phenol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4085645; BDBM50250956
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|
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| Activity |
IC50 = 132000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 3 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-Amino-3,5-bis(4-hydroxyphenyl)pyridine-4-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4084198; BDBM50250964
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|
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| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
Chembl4277330
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50465197
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
4-[(3-Fluorophenoxy)methyl]piperidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4090018; SCHEMBL1476345; CTK7C2090; BDBM50250954; STL068228; ZINC12137840; AKOS000184939; MCULE-3546113389
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|
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| Activity |
IC50 > 2000000 nM
|
[3] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and biological evaluation of thiazole derivatives as novel USP7 inhibitors. Bioorg Med Chem Lett. 2017 Feb 15;27(4):845-849. | ||||
| REF 2 | Chemical Approaches to Intervening in Ubiquitin Specific Protease 7 (USP7) Function for Oncology and Immune Oncology Therapies. J Med Chem. 2018 Jan 25;61(2):422-443. | ||||
| REF 3 | Discovery of Small-Molecule Inhibitors of Ubiquitin Specific Protease 7 (USP7) Using Integrated NMR and in Silico Techniques. J Med Chem. 2017 Dec 28;60(24):10056-10070. | ||||
| REF 4 | Identification and Structure-Guided Development of Pyrimidinone Based USP7 Inhibitors. ACS Med Chem Lett. 2018 Feb 21;9(3):238-243. | ||||
| REF 5 | X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases. J Med Chem. 2014 Mar 27;57(6):2393-412. | ||||
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