Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T42337 | Target Info | |||
| Target Name | Methionyl aminopeptidase 1 (METAP1) | ||||
| Synonyms |
Peptidase M 1; Methionine aminopeptidase 1; MetAP 1; MAP 1; KIAA0094
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| Target Type | Literature-reported Target | ||||
| Gene Name | METAP1 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 76 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Thiabendazole
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Approved | Compound Info | ||
| Synonyms |
Biogard; Bioguard; Bovizole; Cropasal; Drawipas; Eprofil; Equizole; Hymush; Lombristop; Mertec; Mertect; Mintesol; Mintezol; Mintezole; Minzolum; Mycozol; Nemacin; Nemapan; Omnizole; Ormogal; Pitrizet; Polival; RPH; Sistesan; Storite; Tbdz; Tebuzate; Tecto; Testo; Thiaben; Thiabendazol; Thiabendazolum; Thiabendole; Thiabenzazole; Thiabenzole; Thibendole; Thibenzol; Thibenzole; Thiprazole; Tiabenda; Tiabendazol; Tiabendazole; Tiabendazolum; Tobaz; Tresaderm; Triasox; Tubazole; Captan T; Equivet TZ; Equizole A; Helmindrax octelmin; Hokustar HP; Mertect lsp; RTU Flowable Fungicide; Tecto B; Tecto rph; Thibenzole att; Top Form Wormer; Chemviron TK 100; G 491; MK 360; Mertect 160; Mertect 340f; Metasol TK 100; Metasol tk 10; PS1057_SUPELCO; Sanaizol 100; Syntol M100; TBZ 6; TBZ 60W; Tecto 10P; Tecto 40F; Tecto 60; Thibenzole 200; Tibimix 20; APL-luster; Arbotect (TN); MK-360; Metasol TK-100; Mintezol (TN); TBZ-6; Thiabendazole (USP); Thiabendazole [BSI:ISO]; Thiabendazole [USAN:BAN]; Tiabendazolum [INN-Latin]; Tresaderm (TN); E-Z-Ex; Mintezol, Equizole, Thiabendazole; Tiabendazol [INN-Spanish, French]; Tiabendazole (JAN/INN); 2-(1,3-Thiazol-4-yl)-1H-benzimidazole; 2-(1,3-Thiazol-4-yl)benzimidazole; 2-(1,3-thiazol-4-yl)-1H-1,3-benzodiazole; 2-(4'-Thiazolyl)benzimidazole; 2-(4-Thiazolyl)-1H-benzimidazole; 2-(4-Thiazolyl)benzimidazole; 2-(Thiazol-4-yl)benzimidazole; 2-Thiazol-4-yl-1H-benzoimidazole; 2-Thiazole-4-ylbenzimidazole; 2-[4-Thiazoly]benzimidazole; 4-(1H-benzimidazol-2-yl)-1,3-thiazole; 4-(2-Benzimidazolyl)thiazole
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
5-Chloro-7-(morpholin-4-ylmethyl)quinolin-8-ol
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Investigative | Compound Info | ||
| Synonyms |
5-chloro-7-(morpholinomethyl)quinolin-8-ol; CHEMBL2407599; Oprea1_518144; Oprea1_533159; SCHEMBL1240342; HMS1736I03; BDBM50437326; SBB038797; STK974307; ZINC19790451; AKOS000267176; CCG-195347; MCULE-3591579606; DA-37461; ST007925; EU-0072638; FT-0748114; 5-chloro-7-morpholin-4-ylmethyl-quinolin-8-ol; SR-01000443103; SR-01000443103-1; F0388-0085; 5-chloro-7-(morpholin-4-ylmethyl)quinolin-8-ol, AldrichCPR
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
5-Chloro-7-(piperidin-1-ylmethyl)quinolin-8-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2023325; Cambridge id 6153772; Oprea1_088729; IFLab1_001866; SCHEMBL9996355; HMS1417E18; BDBM50437327; STL487358; ZINC19345335; AKOS000641017; MCULE-1731175397; 5-chloro-7-(piperidinomethyl)-8-quinolinol; 5-chloro-7-(piperidylmethyl)quinolin-8-ol; ST50037437; VU0488373-1; F0472-0112
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
5-Chloro-7-[(4-methylpiperazinyl)methyl]quinolin-8-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1368981; 5-chloro-7-((4-methylpiperazin-1-yl)methyl)quinolin-8-ol; Oprea1_099027; Oprea1_834382; IFLab1_004215; SCHEMBL2312166; HMS1423P13; KUC109636N; BDBM50437325; CCG-19016; SBB042376; ZINC19680931; AKOS000270805; MCULE-8232294774; NCGC00161898-01; ST007951; KSC-228-001-1; EU-0042758; SR-01000474167; 5-Chloro-7-(4-methylpiperazinomethyl)-8-quinolinol; SR-01000474167-1; F0870-0072; 5-chloro-7-[(4-methylpiperazin-1-ium-1-yl)methyl]quinolin-8-olate
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(S)-3-Amino-N-[2-(2,4-dichloro-phenyl)-ethyl]-2-hydroxy-4-isobutylsulfanyl-butyramide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL168268; BDBM50141702
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| Activity |
IC50 = 53000 nM
|
[3] | |||
| Compound Name |
2-[(Dimethylamino)methyl]-5-methoxy-2,3-dihydroinden-1-one;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3337743; BDBM50497529
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| Activity |
IC50 = 53700 nM
|
[4] | |||
| Compound Name |
1-Phosphono-2-methylpentylamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1673077; BDBM50078540
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| Activity |
Ki = 54800 nM
|
[5] | |||
| Compound Name |
N'-((2S,3R)-3-Amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-N-3-chlorobenzoyl hydrazide
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Investigative | Compound Info | ||
| Synonyms |
A-357300; CHEMBL352764; bestatin-type inhibitor, 9; SCHEMBL6484698; BDBM17594; ZINC1909912; DB07377; Q27096597
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| Activity |
IC50 = 56000 nM
|
[3] | |||
| Compound Name |
(S)-2-((S)-3-Amino-2-hydroxy-4-propylsulfanyl-butyrylamino)-propionic acid ethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL172388; BDBM50141686
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| Activity |
IC50 = 57000 nM
|
[3] | |||
| Compound Name |
(2S,3R)-3-Amino-4-cyclohexyl-2-hydroxy-N'-naphthalen-1-ylbutanehydrazide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL169681; BDBM50141675; 3-Amino-4-cyclohexyl-2-(S)-hydroxy-butyric acid (R)-N''-naphthalen-1-yl-hydrazide
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| Activity |
IC50 = 58000 nM
|
[3] | |||
| Compound Name |
N'-[(2S,3R)-3-Amino-4-cyclohexyl-2-hydroxybutanoyl]naphthalene-2-carbohydrazide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL353170; BDBM50141728; Naphthalene-2-carboxylic acid N''-((S)-hydroxy-1-(R)-3-amino-4-cyclohexyl-2-oxo-butyl)-hydrazide
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| Activity |
IC50 = 63000 nM
|
[3] | |||
| Compound Name |
(S)-2-((R)-3-Amino-2-hydroxy-5-methylsulfanyl-pentanoylamino)-propionic acid ethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL169341; SCHEMBL7356220; BDBM50141729
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| Activity |
IC50 = 63000 nM
|
[3] | |||
| Compound Name |
(2S,3R)-3-Amino-4-cyclohexyl-N-[2-(2,4-dichloro-phenyl)-ethyl]-2-hydroxy-butyramide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL171029; BDBM50141706
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| Activity |
IC50 = 63000 nM
|
[3] | |||
| Compound Name |
(S)-2-((S)-3-Amino-2-hydroxy-4-isobutylsulfanyl-butyrylamino)-propionic acid ethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL170222; BDBM50141687
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| Activity |
IC50 = 66000 nM
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[3] | |||
| Compound Name |
(2S,3R)-3-Amino-4-cyclohexyl-2-hydroxy-N-[(1R)-2-hydroxy-1-phenylethyl]butanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL169423; BDBM50141726; 3-Amino-4-cyclohexyl-2-(S)-hydroxy-N-((R)-2-hydroxy-1-phenyl-ethyl)-butyramide
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| Activity |
IC50 = 68000 nM
|
[3] | |||
| Compound Name |
(S)-2-((R)-3-Amino-5-ethylsulfanyl-2-hydroxy-pentanoylamino)-propionic acid ethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL171591; SCHEMBL7361480; BDBM50141705
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| Activity |
IC50 = 69000 nM
|
[3] | |||
| Compound Name |
(2S,3R)-3-Amino-N-[2-(2,4-dichlorophenyl)ethyl]-2-hydroxy-5-propan-2-ylsulfanylpentanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL172291; BDBM50141724; (R)-3-Amino-2-hydroxy-5-isopropylsulfanyl-pentanoic acid [2-(2,4-dichloro-phenyl)-ethyl]-amide
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| Activity |
IC50 = 69000 nM
|
[3] | |||
| Compound Name |
(2S,3R)-3-Amino-2-hydroxy-N-[(1R)-2-hydroxy-1-phenylethyl]-5-phenylpentanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL168390; BDBM50141696; 3-Amino-2-(S)-hydroxy-5-phenyl-pentanoic acid ((R)-2-hydroxy-1-phenyl-ethyl)-amide
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| Activity |
IC50 = 75000 nM
|
[3] | |||
| Compound Name |
(R)-3-Amino-3-cyclohexyl-2-hydroxy-N-((S)-1-naphthalen-1-yl-ethyl)-propionamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL353506; BDBM50141717
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| Activity |
IC50 = 76000 nM
|
[3] | |||
| Compound Name |
(2S,3R)-3-Amino-4-cyclohexyl-2-hydroxy-N-methyl-N-naphthalen-1-ylmethyl-butyramide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL171084; BDBM50141716
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| Activity |
IC50 = 78000 nM
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[3] | |||
| Compound Name |
(2S,3R)-3-Amino-3-cyclohexyl-2-hydroxy-N-[(1R)-2-hydroxy-1-phenylethyl]propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL352369; BDBM50141755; 3-Amino-3-cyclohexyl-2-(S)-hydroxy-N-((R)-2-hydroxy-1-phenyl-ethyl)-propionamide
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| Activity |
IC50 = 79000 nM
|
[3] | |||
| Compound Name |
(2S,3R)-3-Amino-2-hydroxy-N-methyl-N-(naphthalen-1-ylmethyl)-5-propan-2-ylsulfanylpentanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL353100; BDBM50141744; (2S,3R)-3-Amino-2-hydroxy-5-isopropylsulfanyl-pentanoic acid methyl-naphthalen-1-ylmethyl-amide
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| Activity |
IC50 = 81000 nM
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[3] | |||
| Compound Name |
(S)-2-((2S,3R)-3-Amino-4-cyclohexyl-2-hydroxy-butyrylamino)-propionic acid ethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL354728; BDBM50141734
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| Activity |
IC50 = 84000 nM
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[3] | |||
| Compound Name |
(S)-2-((R)-3-Amino-4-cyclohexyl-2-hydroxy-butyrylamino)-propionic acid ethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL355657; BDBM50141752
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| Activity |
IC50 = 84000 nM
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[3] | |||
| Compound Name |
(2S,3R)-3-Amino-3-cyclohexyl-2-hydroxy-N'-naphthalen-1-ylpropanehydrazide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL352844; BDBM50141676; 3-Amino-3-cyclohexyl-2-(S)-hydroxy-propionic acid (R)-N''-naphthalen-1-yl-hydrazide
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| Activity |
IC50 = 89000 nM
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[3] | |||
| Compound Name |
(2S,3R)-3-Amino-4-cyclohexyl-2-hydroxy-N-(3-methoxy-phenyl)-butyramide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL440746; BDBM50141748
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| Activity |
IC50 = 90000 nM
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[3] | |||
| Compound Name |
(2S,3R)-3-Amino-2-hydroxy-N'-naphthalen-1-yl-5-phenylpentanehydrazide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL354202; BDBM50141679; 3-Amino-2-(S)-hydroxy-5-phenyl-pentanoic acid (R)-N''-naphthalen-1-yl-hydrazide
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| Activity |
IC50 = 93000 nM
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[3] | |||
| Compound Name |
(R)-3-Amino-3-cyclohexyl-2-hydroxy-N-phenoxy-propionamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL172217; SCHEMBL6477499; BDBM50141677; (3R)-3-amino-3-cyclohexyl-2-hydroxy-N-phenoxypropanamide
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| Activity |
IC50 = 95000 nM
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[3] | |||
| Compound Name |
2,3-Dihydro-5-(3-phenyl-2-propenylidene)-2-thioxo-4,6(1H,5H)-pyrimidinedione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL402646; NSC96634; SCHEMBL13848519; HMS548D21; ZINC136832; BDBM50375163; CCG-47734; NSC-96634; AKOS002960735; AB00079608-01; SR-01000637329-1
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| Activity |
Ki = 98000 nM
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[6] | |||
| Compound Name |
5-(3-Nitrobenzylidene)-2-thioxodihydropyrimidine-4,6(1h,5h)-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL408043; NSC89382; NCIOpen2_005684; CTK8D4549; DTXSID90975470; ZINC5671368; BDBM50375184; NSC-89382; STL481918; AKOS001047743; MCULE-1317729995; ST50183386; SR-01000212833; SR-01000212833-1; 4,6-Dihydroxy-5-[(3-nitrophenyl)methylidene]pyrimidine-2(5H)-thione; 5-(3-Nitrobenzylidene)-2-thioxo-2,3-dihydropyrimidine-4,6(1H,5H)-dione; 5-[(3-nitrophenyl)methylene]-2-thioxo-1,3-dihydropyrimidine-4,6-dione
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| Activity |
Ki ~ 100000 nM
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[6] | |||
| Compound Name |
2,2'-Bipyridine
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Investigative | Compound Info | ||
| Synonyms |
2,2'-Dipyridyl; 2,2'-Bipyridyl; Bipyridine; 2,2'-Dipyridine; 2-(2-Pyridyl)pyridine; 2,2'-Bipyridin; alpha,alpha'-Dipyridyl; alpha,alpha'-Bipyridyl; Bipyridyl; alpha,alpha'-Dipyridine; AA-DP; 2,2-bipyridyl; dipyridyl; 2-pyridin-2-ylpyridine; 2-(pyridin-2-yl)pyridine; NSC 1550; MFCD00006212; .alpha.,.alpha.'-Bipyridine; [2,2]bipyridinyl; NSC 615009; UNII-551W113ZEP; alpha,alpha'-Bipyridine; Umdipyridyl; .alpha.,.alpha.'-Bipyridyl; .alpha.,.alpha.'-Dipyridyl; [2,2']BIPYRIDINYL; .alpha.,.alpha.'-Dipyridine; CHEMBL39879; MLS000069417; 551W113ZEP; CI 588; NSC615009; SMR000059069; 2,2'-Bipyridine, 99%; 2,2'-Dipyridyl, 99+%; 2,2-Bipyridine; 2,2 Bipyridyl; 2,2-Dipyridyl; 2,2' Bipyridine; CCRIS 3426; HSDB 5423; alpha,alpha'-Dwupirydylu [Polish]; alpha,alpha'-Dwupirydylu; EINECS 206-674-4; BRN 0113089; bi-pyridine; AI3-00491; 2-pyridylpyridine; 2,2bipyridyl; 2'2-bipyridine; 2,2'Bipyridine; 2, 2-Bipyridine; 2,2' bipyridyl; 2,2`-Bipyridine; [2,2']bipyridyl; 2,2''-bipyridyl; 2,2''-dipyridyl; 2,2''-bipyridine; 2,2''-dipyridine; 2,2'- bipyridine; 2,2\\'-bipyridine; 2,2''-Bipyridin; PubChem2134; alpha, alpha-Dipyridyl; 2-pyridin-2-ylpyridin; ACMC-209ino; alpha,alpha''-bipyridyl; alpha,alpha''-dipyridyl; alpha,alpha''-bipyridine; alpha,alpha''-dipyridine; Maybridge3_006205; Opera_ID_1615; Lopac-D-7505; 2,2'-Bipyridine, ACS; (aR)-2,2'-Bipyridine; (aS)-2,2'-Bipyridine; EC 206-674-4; SCHEMBL5922; UPCMLD00WV-71; DSSTox_CID_20635; DSSTox_RID_79518; DSSTox_GSID_40635; Lopac0_000471; 5-23-08-00016 (Beilstein Handbook Reference); KSC226A4T; 2,2'-Dipyridyl, ACS grade; WLN: T6NJ B- BT6NJ; DTXSID9040635; CTK1C6049; NSC1550; HMS1448K01; HMS2234F20; HMS3261O04; HMS3371D05; ZINC105227; ACT09618; BCP27263; NSC-1550; STR02551; Tox21_301430; Tox21_500471; ANW-28450; BDBM50042874; CCG-54708; RW2020; SBB079580; STL282738; AKOS004901459; 2,2'-Bipyridyl, p.a., 99.5%; AC-7556; AM81312; CS-W009134; FS-1056; LP00471; LS21121; MCULE-8524562351; NSC-615009; SC11754; SDCCGSBI-0050456.P002; IDI1_017592; NCGC00015364-01; NCGC00015364-02; NCGC00015364-03; NCGC00015364-04; NCGC00015364-05; NCGC00015364-07; NCGC00093368-02; NCGC00093368-03; NCGC00255575-01; NCGC00261156-01; 2,2'-Bipyridyl, >=98.0% (NT); AK-41113; BP-10293; BR-41113; SC-03874; 2,2'-Bipyridine;2-(pyridin-2-yl)pyridine; DB-013205; 2,2'-Bipyridyl, ReagentPlus(R), >=99%; B0468; EU-0100471; FT-0632048; FT-0636412; FT-0637152; ST50308286; 66D187; D 7505; D-7200; D-7250; D-7255; M-6336; 2,2'-Dipyridyl, JIS special grade, >=99.0%; 2,2'-Bipyridyl, Vetec(TM) reagent grade, 98%; Q209143; SR-01000075829; 2,2'-Bipyridyl, PESTANAL(R), analytical standard; SR-01000075829-1; SR-01000075829-3; Z57160161; F0001-1045
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| Activity |
EC50 ~ 100000 nM
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[1] | |||
| Compound Name |
2-(5-Chloropyridin-2-yl)-4-[4-(4-methoxyphenyl)piperazin-1-yl]quinoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2375625; BDBM50433396
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[(4,6-Dioxo-2-sulfanylidene-1,3-diazinan-5-ylidene)methyl]benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL439416; NSC90729; NCIOpen2_005675; ZINC374564; BDBM50375183; NSC-90729
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| Activity |
Ki ~ 100000 nM
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[6] | |||
| Compound Name |
6-Methyl-N-(2-phenylethyl)-2-pyridin-2-ylpyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL454036; SCHEMBL12674351; BDBM50435235
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
4,6(1H,5H)-Pyrimidinedione, dihydro-5-((4-methoxyphenyl)methylene)-2-thioxo-
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Investigative | Compound Info | ||
| Synonyms |
MLS002703315; CHEMBL271859; 5-(4-methoxybenzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione; NSC95890; AI3-52532; TimTec1_005034; NCIOpen2_006381; SCHEMBL14027497; DTXSID70208773; 5-(anisylidene)-2-thiobarbituric; HMS1548E18; HMS1671K10; BDBM50375181; NSC-95890; STK721916; STL264935; ZINC16956709; 5-[(4-methoxyphenyl)methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione; AKOS000612314; AKOS002230729; MCULE-8741496260; UPCMLD0ENAT5575546:001; SMR001570038; ST094989; 2-Thioxo-5-(4-methoxybenzylidene)hexahydropyrimidine-4,6-dione; (5E)-6-hydroxy-5-(4-methoxybenzylidene)-2-sulfanylpyrimidin-4(5H)-one; 5-(4-Methoxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione; 5-[(4-methoxyphenyl)methylene]-2-thioxo-1,3-dihydropyrimidine-4,6-dione
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| Activity |
Ki ~ 100000 nM
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[6] | |||
| Compound Name |
Tert-Butyl {2-[(1,3-Thiazol-2-Ylamino)carbonyl]pyridin-3-Yl}carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL327579; BDBM17847; DB07902; pyridine-2-carboxylic acid inhibitor, 1; Q27097137; tert-butyl [2-(1,3-thiazol-2-ylcarbamoyl)pyridin-3-yl]carbamate; tert-butyl N-[2-(1,3-thiazol-2-ylcarbamoyl)pyridin-3-yl]carbamate; N-(2-Thiazolyl)-3-[(tert-butoxycarbonyl)amino]-2-pyridinecarboxamide
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| Activity |
EC50 ~ 100000 nM
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[1] | |||
| Compound Name |
N'-[(2S,3R)-3-Amino-4-cyclohexyl-2-hydroxybutanoyl]-2,5-dichlorobenzohydrazide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL169319; BDBM50141692; 2,5-Dichloro-benzoic acid N''-((2S,3R)-3-amino-4-cyclohexyl-2-hydroxy-butyryl)-hydrazide
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
(S)-2-((S)-3-Amino-4-cyclohexylmethylsulfanyl-2-hydroxy-butyrylamino)-propionic acid ethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL169405; BDBM50141684
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
(2S,3R)-3-Amino-2-hydroxy-N-methyl-N-(naphthalen-1-ylmethyl)-5-phenylpentanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL166829; BDBM50141680; (2S,3R)-3-Amino-2-hydroxy-5-phenyl-pentanoic acid methyl-naphthalen-1-ylmethyl-amide
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
(1S)-N'-[5-Chloro-2-(5-chloropyridin-2-yl)-6-methylpyrimidin-4-yl]-1-phenyl-N-(4-phenylbutyl)ethane-1,2-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2375627; BDBM50433376
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-(1,3-Dimethyl-2,4,6-trioxo-tetrahydro-pyrimidin-5-ylidenemethyl)-benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL404693; CBMicro_038820; 4-[(1,3-dimethyl-2,4,6-trioxo-1,3-diazinan-5-ylidene)methyl]benzoic acid; CTK7H4713; ZINC2889629; BDBM50375178; SBB027606; STK170878; AKOS000301049; MCULE-9396046770; BIM-0038826.P001; ST50265813; AN-655/12947027
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| Activity |
Ki ~ 100000 nM
|
[6] | |||
| Compound Name |
5-(4-Hydroxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL271674; CDS1_003868; CBMicro_017372; DivK1c_004908; SCHEMBL15421462; CCG-6094; ZINC4551021; BDBM50237564; STK386440; STL151207; STL276910; STL453859; 5-[(4-hydroxyphenyl)methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione; AKOS000521249; AKOS002230401; AKOS022140097; MCULE-8845401019; BIM-0017414.P001; SR-01000420981; SR-01000420981-1; 5-(4-hydroxybenzylidene)-2-thioxohexahydropyrimidine-4,6-dione; (5E)-5-(4-hydroxybenzylidene)-2-sulfanylpyrimidine-4,6(1H,5H)-dione; (5E)-6-hydroxy-5-(4-hydroxybenzylidene)-2-sulfanylpyrimidin-4(5H)-one; 2-Thioxo-5-(4-hydroxybenzylidene)-1,2-dihydropyrimidine-4,6(3H,5H)-dione; 5-(4-hydroxybenzylidene)-2-thioxo-dihydropyrimidine-4,6(1H,5H)-dione; 5-(4-hydroxybenzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione; 5-(4-Hydroxybenzylidene)-2-thioxodihydropyrimidine-4,6-(1H,5H)-dione; (5E)-6-hydroxy-5-(4-hydroxybenzylidene)-2-thioxo-2,5-dihydropyrimidin-4(3H)-one; 6-hydroxy-5-[(E)-1-(4-hydroxyphenyl)methylidene]-2-sulfanyl-4(5H)-pyrimidinone
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| Activity |
Ki ~ 100000 nM
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[6] | |||
| Compound Name |
N-Benzyl-5-chloro-6-methyl-2-pyridin-3-ylpyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2392767; Bio6B3; Maybridge3_004870; Oprea1_450328; ZINC74769; HMS1444N08; CCG-1386; BDBM50435233; MCULE-7139116123; IDI1_016257; SR-01000643246-1
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
1,3-Dimethyl-5-[3-[4-(dimethylamino)phenyl]-2-propene-1-ylidene]pyrimidine-2,4,6(1H,3H,5H)-trione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL258079; SCHEMBL16543010; BDBM50375174; AKOS034104756
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| Activity |
Ki ~ 100000 nM
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[6] | |||
| Compound Name |
5-(4-Hydroxybenzylidene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL273177; NSC265537; SCHEMBL13751815; DTXSID00418424; HMS1653J02; ZINC2990214; BDBM50375186; STK219595; AKOS000432454; MCULE-5335513949; NSC-265537; ST50170953; SR-01000200407; SR-01000200407-1; 5-(4-hydroxybenzylidene)-1,3-dimethylbarbituric acid; F1593-0036; 1,3-Dimethyl-5-(4-hydroxybenzylidene)hexahydropyrimidine-2,4,6-trione; 2,6(1H,3H,5H)-Pyrimidinetrione, 5-[(4-hydroxyphenyl)methylene]-1,3-dimethyl-; 5-[(4-hydroxyphenyl)methylene]-1,3-dimethyl-1,3-dihydropyrimidine-2,4,6-trione
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| Activity |
Ki ~ 100000 nM
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[6] | |||
| Compound Name |
1,3-Dimethyl-5-(phenylmethylidene)-1,3-diazinane-2,4,6-trione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL403400; 1,3-dimethyl-5-(phenylmethylene)-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-BENZYLIDENE-1,3-DIMETHYL-PYRIMIDINE-2,4,6-TRIONE; 5-benzylidene-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione; 2,4,6(1H,3H,5H)-Pyrimidinetrione, 1,3-dimethyl-5-(phenylmethylene)-; TimTec1_005062; SCHEMBL13848423; CTK1H4801; 5-benzylidene-1,3-dimethyl-1,3-diazinane-2,4,6-trione; DTXSID00382838; HMS1548G02; ZINC3128867; BDBM50375187; MFCD00218553; STK708156; AKOS001355539; CCG-233212; MCULE-1714704213; MS-2278; KS-0000283J; UPCMLD0ENAT5856804:001; 1,3-dimethyl-5-benzylidenebarbituric acid; 5-benzylidene-1,3-dimethylpyrimidine-2,4,6-trione; Z44299021; 1,3-Dimethyl-5-benzylidenehexahydropyrimidine-2,4,6-trione; 5-benzylidene-1,3-dimethylhexahydropyrimidine-2,4,6-trione
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| Activity |
Ki ~ 100000 nM
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[6] | |||
| Compound Name |
4,5-Dimethylaminobenzylidene-2-thiobarbituric acid
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Investigative | Compound Info | ||
| Synonyms |
UNII-RTU8Z2WNX3; RTU8Z2WNX3; MLS002695027; CHEMBL269821; DABTB; 5-[4-(Dimethylamino)benzylidene]-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione; DABTB-Ag(I) complex; NSC 90755; 5-[4-(dimethylamino)benzylidene]-2-thioxohexahydropyrimidine-4,6-dione; NCIOpen2_006091; 5-p-Dimethylaminobenzylidene-2-thiobarbituric acid; SCHEMBL4037782; SCHEMBL14050043; CTK4F9669; DTXSID40181847; HMS1607L07; HMS3092I13; Silver(I) 5-p-dimethylaminobenzylidene-2-thiobarbituric acid; NSC90755; BDBM50375164; NSC-90755; STL281750; ZINC18180762; AKOS000734174; AKOS002984087; AKOS003628128; AKOS037445463; MCULE-4779962018; NCGC00184563-01; NCGC00184563-02; NCGC00184563-03; SMR001560940; ST50220543; 5-(p-dimeth-ylaminobenzylidene)-2-thiobarbituric; AE-848/01000049; AE-848/30739043; 5-[4-(Dimethylamino)benzylidene]-2-thiobarbituric acid; 2-Thioxo-5-[4-(dimethylamino)benzylidene]hexahydropyrimidine-4,6-dione; 5-[4-(dimethylamino)benzylidene]-4,6-dihydroxy-2(5H)-pyrimidinethione; (5E)-5-[4-(dimethylamino)benzylidene]-2-sulfanyl-4,6(1H,5H)-pyrimidinedione; (5E)-5-[4-(dimethylamino)benzylidene]-2-sulfanylpyrimidine-4,6(1H,5H)-dione; 5-[4-(Dimethylamino)benzylidene]-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione #
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| Activity |
Ki ~ 100000 nM
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[6] | |||
| Compound Name |
2-((2S,3R)-3-Amino-4-cyclohexyl-2-hydroxy-butyrylamino)-2-methyl-propionic acid ethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL169963; BDBM50141694
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
(S)-3-Amino-4-cyclohexylmethylsulfanyl-N-[2-(2,4-dichloro-phenyl)-ethyl]-2-hydroxy-butyramide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL355223; BDBM50141695
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
(S)-2-((2S,3R)-3-Amino-4-cyclohexyl-2-hydroxy-butyrylamino)-propionic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL172210; BDBM50141749
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
1,3-Dimethyl-5-(4-nitrobenzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL256269; ZINC3189284; BDBM50375180; STK219594; AKOS001708787; MCULE-1941967737; AG-205/09851011; 5-{4-nitrobenzylidene}-1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione; 1,3-dimethyl-5-[(4-nitrophenyl)methylene]-2,4,6(1H,3H,5H)-pyrimidinetrione
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| Activity |
Ki ~ 100000 nM
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[6] | |||
| Compound Name |
N'-[(2S,3R)-3-Amino-4-cyclohexyl-2-hydroxybutanoyl]-3-chlorobenzohydrazide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL355472; BDBM50141740; 3-Chloro-benzoic acid N''-((S)-hydroxy-1-(R)-3-amino-4-cyclohexyl-2-oxo-butyl)-hydrazide
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
(R)-2-((2S,3R)-3-Amino-4-cyclohexyl-2-hydroxy-butyrylamino)-propionic acid ethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL166337; BDBM50141689
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
N-Phenyl-N'-(2-pyridin-2-ylquinazolin-4-yl)ethane-1,2-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2375611; SCHEMBL12674275; BDBM50433379
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[5-Chloro-6-Methyl-2-(Pyridin-2-Yl)pyrimidin-4-Yl]-N'-[5-(Trifluoromethyl)pyridin-2-Yl]ethane-1,2-Diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2375628; Maybridge3_004606; SCHEMBL11900317; HMS1444B08; CCG-1359; BDBM50433377; IDI1_015993; Q27466217
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
5-((4-(Dimethylamino)phenyl)methylene)-1,3-dimethylbarbituric acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL404233; 5-[[4-(DIMETHYLAMINO)PHENYL]METHYLENE]-1,3-DIMETHYLBARBITURIC ACID; 5-[4-(dimethylamino)benzylidene]-1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-[4-(dimethylamino)benzylidene]-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione; EINECS 260-658-1; NSC266135; SCHEMBL125194; CTK5A6553; DTXSID80205894; ZINC2831782; 5-(4-Dimethylamino-benzylidene)-1,3-dimethyl-pyrimidine-2,4,6-trione; BDBM50375176; STK708157; AKOS000532641; MCULE-9068906850; NSC-266135; ST055951; AG-205/09850054; 1,3-Dimethyl-5-[4-(dimethylamino)benzylidene]barbituric acid
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| Activity |
Ki ~ 100000 nM
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[6] | |||
| Compound Name |
4-(4-Methylpiperazino)-2-(2-pyridyl)quinoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL49678; DTXSID70332365; BDBM50433385; ZINC19908879; MCULE-7478533139; 4-(4-methylpiperazin-1-yl)-2-(2-pyridyl)quinoline; 4-(4-Methyl-1-piperazinyl)-2-(2-pyridinyl)quinoline; N-(4-Methyl-1-piperazinyl)-2-(2-pyridinyl)quinoline; Quinoline, 4-(4-methyl-1-piperazinyl)-2-(2-pyridinyl)-, dihydrobromide
Click to Show/Hide
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[4-(2-Pyridin-2-ylquinolin-4-yl)piperazin-1-yl]benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2375617; BDBM50433388
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(R)-3-Amino-3-cyclooctyl-2-hydroxy-N-phenoxy-propionamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL171041; BDBM50141714
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
(S)-2-((R)-3-Amino-2-hydroxy-heptanoylamino)-propionic acid ethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL169039; SCHEMBL7356309; BDBM50141674
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| Activity |
IC50 = 100000 nM
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[3] | |||
| Compound Name |
5-[(4-Nitrophenyl)methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL408042; NSC89381; NCIOpen2_005724; DTXSID70350347; BDBM50375188; NSC-89381; STL281768; ZINC15922267; AKOS000519646; AKOS002984217; MCULE-7324698864; ST50220828; SR-01000360868; SR-01000360868-1; 5-(4-nitrobenzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione; 5-(4-Nitrobenzylidene)-2-thioxo-2,3-dihydropyrimidine-4,6(1H,5H)-dione; 5-[(4-nitrophenyl)methylene]-2-thioxo-1,3-dihydropyrimidine-4,6-dione
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| Activity |
Ki ~ 100000 nM
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[6] | |||
| Compound Name |
4-Chloro-2-(pyridin-2-yl)quinazoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2375629; Quinazoline, 4-chloro-2-(2-pyridinyl)-; 4-chloro-2-pyridin-2-ylquinazoline; ACMC-20luwb; C13H8ClN3; SCHEMBL4473954; CTK3I0435; DTXSID20359002; ZINC522072; 2-(2-Pyridyl)-4-chloroquinazoline; BDBM50433378; STK549316; 4-chloro-2(yridin-2-yl) quinazoline; AKOS005232589; MCULE-2945868860; NE51246; Z1982491203
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1,3-Dimethyl-5-(4-fluorobenzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL403366; ZINC2819840; BDBM50375177; STK830418; AKOS004902299; MCULE-1975895058; SR-01000197645; SR-01000197645-1; 5-(4-fluorobenzylidene)-1,3-dimethylhexahydro-pyrimidine-2,4,6-trione; 5-(4-fluorobenzylidene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione
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| Activity |
Ki ~ 100000 nM
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[6] | |||
| Compound Name |
5-Benzylidene-2-thioxodihydropyrimidine-4,6(1h,5h)-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL256700; 5-Benzylidene-2-thiobarbituric acid; 5-benzylidene-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione; NSC89373; ChemDiv3_001980; NCIOpen2_005660; SCHEMBL1520357; 5-benzylidene-2-sulfanylidene-1,3-diazinane-4,6-dione; DTXSID10950163; HMS1478J22; BDBM50375173; NSC-89373; STK213742; ZINC15777334; AKOS001486865; AKOS002948394; AKOS002984086; AKOS003363508; AKOS024290276; MCULE-6240596439; IDI1_020946; 5-Benzylidene-4,6-dihydroxypyrimidine-2(5H)-thione; 5-Benzylidene-2-thioxo-dihydro-pyrimidine-4,6-dione; (5Z)-5-benzylidene-2-sulfanylpyrimidine-4,6(1H,5H)-dione; 5-(PHENYLMETHYLIDENE)-2-SULFANYLIDENE-1,3-DIAZINANE-4,6-DIONE
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| Activity |
Ki ~ 100000 nM
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[6] | |||
| Compound Name |
5,6-Dimethyl-N-(2-phenylethyl)-2-pyridin-2-ylpyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2392765; SCHEMBL12674472; BDBM50435236; AKOS007906098
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| Activity |
IC50 ~ 100000 nM
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[7] | |||
| Compound Name |
1,3-Dimethyl-5-(3-phenyl-allylidene)-pyrimidine-2,4,6-trione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL256879; (E)-1,3-dimethyl-5-(3-phenylallylidene)pyrimidine-2,4,6(1H,3H,5H)-trione; SCHEMBL14713047; ZINC41869; HMS1671F01; BDBM50375175; STK824352; AKOS000523344; SR-01000356118; SR-01000356118-1; F0777-1023
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| Activity |
Ki ~ 100000 nM
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[6] | |||
| Compound Name |
5-(4-Methoxybenzylidene)-1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL256878; 5-(4-methoxybenzylidene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione; NSC265534; SCHEMBL3128647; DTXSID10313012; HMS1676A22; ZINC2990201; BDBM50375185; STK824350; 5-[(4-methoxyphenyl)methylidene]-1,3-dimethyl-1,3-diazinane-2,4,6-trione; AKOS000445035; MCULE-2182306339; NSC-265534; ST50170934; AB00076359-01; AG-690/11629158; 1,3-Dimethyl-5-(4-methoxybenzylidene)barbituric acid; 2,6(1H,3H,5H)-Pyrimidinetrione, 5-[(4-methoxyphenyl)methylene]-1,3-dimethyl-; 5-[(4-methoxyphenyl)methylene]-1,3-dimethyl-1,3-dihydropyrimidine-2,4,6-trione
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| Activity |
Ki ~ 100000 nM
|
[6] | |||
| Compound Name |
4-Piperidin-1-yl-2-pyridin-2-ylquinoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2375614; MMV560185; Maybridge3_003438; Oprea1_797237; SCHEMBL2547815; HMS1440M06; BDBM50433383; CCG-48252; ZINC20432400; AKOS024326127; MCULE-2929383612; IDI1_014825; 4-PIPERIDIN-1-YL-2-PYRIDIN-2-YL-QUINOLINE; SR-01000637808-1
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-(5-Bromopyridin-2-yl)-4-[4-(4-methoxyphenyl)piperazin-1-yl]quinoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2375626; BDBM50433397
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Quinoline, 4-(4-morpholinyl)-2-(2-pyridinyl)-
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Investigative | Compound Info | ||
| Synonyms |
4-Morpholino-2-(2-pyridyl)quinoline; 4-(4-MORPHOLINYL)-2-(PYRIDIN-2-YL)QUINOLINE; CHEMBL45721; 4-(2-(Pyridin-2-yl)quinolin-4-yl)morpholine; 4-(2-pyridin-2-ylquinolin-4-yl)morpholine; SCHEMBL2545683; CTK4B8765; DTXSID20158335; BDBM50433384; GEO-03297; ZINC19809797; 4-Morpholino-2-(2-pyridinyl)quinoline; MCULE-6426149545; 4-[2-(2-pyridyl)-4-quinolyl]morpholine
Click to Show/Hide
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1,3-Dimethyl-5-(3-nitrobenzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL257927; NSC265538; DTXSID30313014; ZINC2826168; BDBM50375179; STL221306; AKOS002160650; MCULE-1397471101; NSC-265538; SR-01000203487; SR-01000203487-1
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| Activity |
Ki ~ 100000 nM
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[6] | |||
| Compound Name |
(S)-2-((R)-3-Amino-2-hydroxy-5-phenyl-pentanoylamino)-propionic acid ethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL169592; BDBM50141731
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| Activity |
IC50 = 101000 nM
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[3] | |||
| Compound Name |
(alpha-Aminobenzyl)phosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
[amino(phenyl)methyl]phosphonic acid; (Aminophenylmethyl)phosphonic acid; Phosphonic acid, (aminophenylmethyl)-; amino(phenyl)methylphosphonic acid; 1-amino-1-phenylmethyl phosphonic acid; BRN 2049498; Phosphonic acid, (alpha-aminobenzyl)- (6CI,8CI); CHEMBL1090366; NSC669595; (amino(phenyl)methyl)phosphonic acid; (R)-1-PHOSPHONO-BENZYLAMINE; Melengestrolacetate; NSC 133874; bmse000171; a-aminobenzylphosphonic acid; Oprea1_794855; SCHEMBL233491; alpha-Aminobenzylphosphonic acid; BDBM50316031; NSC133874; AKOS001016495; AKOS017344475; NSC-133874; NSC-669595; (1-amino-1-phenylmethyl)phosphonic acid; 4-07-00-00555 (Beilstein Handbook Reference); Q27159222
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| Activity |
Ki = 111600 nM
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[5] | |||
| Compound Name |
(S)-2-((R)-3-Amino-5-cyclohexyl-2-hydroxy-pentanoylamino)-propionic acid ethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL434309; BDBM50141672
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| Activity |
IC50 = 137000 nM
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[3] | |||
| Compound Name |
5-Benzylidenebarbituric acid
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Investigative | Compound Info | ||
| Synonyms |
Benzalbarbituric acid; 5-benzylidenepyrimidine-2,4,6(1H,3H,5H)-trione; 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(phenylmethylene)-; CHEMBL272757; 5-benzylidene-1,3-diazinane-2,4,6-trione; 5-(phenylmethylidene)-1,3-diazinane-2,4,6-trione; NSC636605; 5-BENZYLIDENE-PYRIMIDINE-2,4,6-TRIONE; 5-Benzylidene-2,4,6(1H,3H,5H)-pyrimidinetrione; 2,6(1H,3H,5H)-Pyrimidinetrione, 5-(phenylmethylene)-; 5-(phenylmethylene)-1,3-dihydropyrimidine-2,4,6-trione; 5-benzylidenehexahydropyrimidine-2,4,6-trione; benzylidene barbituric; 5-benzylidenebarbituric; ACMC-209gwv; CBMicro_032410; 5-BenzylidenebarbituricAcid; 5-benzylidene-hexahydro-pyrimidine-2,4,6-trione; SCHEMBL1495340; CTK4F9617; DTXSID50286913; 3,4-bis(benzyloxy)benzoylchloride; HMS1609O06; NSC48255; ANW-26189; BDBM50375161; MFCD00059761; NSC-48255; NSC179809; SBB095238; STK100078; STL047538; ZINC18202813; AKOS001604867; AKOS005700952; MCULE-2682527924; NSC-179809; NSC-636605; SDCCGMLS-0064598.P001; KS-0000140M; AK309417; AS-66981; BIM-0032393.P001; ST4027867; B0007; 5-(phenylmethylene)-1,3-diazinane-2,4,6-trione; A819047; 5-benzylidenepyrimidine-2,4,6-(1H,3H,5H)-trione; (5Z)-5-benzylidene-2,6-dihydroxypyrimidin-4(5H)-one; F0030-0022; 2,4,6(1H,3H,5H)-Pyrimidinetrione,5-(phenylmethylene)-; 6-hydroxy-5-(phenylmethylidene)-2,3,4,5-tetrahydropyrimidine-2,4-dione
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| Activity |
Ki = 162000 nM
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[6] | |||
| Compound Name |
[((R)-2-Amino-propionyl)-hydroxy-amino]-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL164406; D-Ala-N-Hydroxy-Gly-OH; BDBM50137354
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| Activity |
Ki = 180000 nM
|
[8] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 4 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
[((S)-2-Amino-4-methylsulfanyl-butyryl)-hydroxy-amino]-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL349154; L-Met-N-Hydroxy-Gly-OH; BDBM50137353
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| Activity |
Ki = 390000 nM
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[8] | |||
| Compound Name |
2-[4-[4-(2-Pyridin-2-ylquinolin-4-yl)piperazin-1-yl]phenoxy]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2375619; BDBM50433390
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| Activity |
EC50 > 400000 nM
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[1] | |||
| Compound Name |
alpha-Phosphonocyclohexanemethanamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3414949; BDBM50078541; [amino(cyclohexyl)methyl]phosphonic acid; 1-amino-1-cyclohexylmethyl phosphonic acid
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| Activity |
Ki > 500000 nM
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[5] | |||
| Compound Name |
1-Phosphono-2-cyclohexylethanamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1673062; 1-amino-2-cyclohexylethane-phosphonic acid; BDBM50337150; (RS)-1-amino-2-cyclohexylethylphosphonic acid
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| Activity |
Ki > 500000 nM
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[5] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells. J Med Chem. 2013 May 23;56(10):3996-4016. | ||||
| REF 2 | Discovery of Inhibitors of Burkholderia pseudomallei Methionine Aminopeptidase with Antibacterial Activity. ACS Med Chem Lett. 2013 Jul 1;4(8):699-703. | ||||
| REF 3 | 3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2. Bioorg Med Chem Lett. 2004 Feb 23;14(4):865-8. | ||||
| REF 4 | Beta-aminoketones as prodrugs for selective irreversible inhibitors of type-1 methionine aminopeptidases. Bioorg Med Chem Lett. 2014 Nov 15;24(22):5310-4. | ||||
| REF 5 | Identification of the molecular basis of inhibitor selectivity between the human and streptococcal type I methionine aminopeptidases. J Med Chem. 2015 Mar 12;58(5):2350-7. | ||||
| REF 6 | Synthesis of barbiturate-based methionine aminopeptidase-1 inhibitors. Bioorg Med Chem Lett. 2008 Apr 1;18(7):2373-6. | ||||
| REF 7 | Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1. Bioorg Med Chem. 2013 May 1;21(9):2600-17. | ||||
| REF 8 | Peptidyl hydroxamic acids as methionine aminopeptidase inhibitors. Bioorg Med Chem Lett. 2004 Jan 5;14(1):77-9. | ||||
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