Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T40812 | Target Info | |||
| Target Name | Poly [ADP-ribose] polymerase 2 (PARP2) | ||||
| Synonyms |
pADPRT-2; hPARP-2; Protein poly-ADP-ribosyltransferase PARP2; Poly[ADP-ribose] synthase 2; PARP-2; NAD(+) ADP-ribosyltransferase 2; DNA ADP-ribosyltransferase PARP2; ARTD2; ADPRTL2; ADPRT2; ADPRT-2; ADP-ribosyltransferase diphtheria toxin-like 2
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| Target Type | Clinical trial Target | ||||
| Gene Name | PARP2 | ||||
| Biochemical Class | Glycosyltransferases | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 20 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-[(4-Oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-3-phenyl-N-(thiophen-2-ylmethyl)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2419712; SCHEMBL14647642; BDBM50439811
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| Activity |
IC50 = 56400 nM
|
[1] | |||
| Compound Name |
4-Methoxybenzamide
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Investigative | Compound Info | ||
| Synonyms |
p-Anisamide; p-Methoxybenzamide; 4-Methoxy benzamide; Benzamide, 4-methoxy-; 4-methoxy-benzamide; UNII-Z85FX3977E; CHEMBL449635; Z85FX3977E; MFCD00007995; 4-Methoxybenzamide, 97%; P-methyoxybenzamide; EINECS 222-319-6; BRN 1862847; ACMC-1CJJO; 4-Methoxybenzamide, 98%; Oprea1_456315; 4-10-00-00433 (Beilstein Handbook Reference); KSC225C6N; SCHEMBL201761; SCHEMBL12015238; CTK1C5166; KS-00000FKR; DTXSID40879434; ZINC161203; ACT03272; NSC11139; ANW-27812; BDBM50340090; NSC-11139; STL482885; AKOS000266484; AB00908; CS-W022205; GS-6794; MCULE-3713623573; VZ29332; AC-17055; AK114264; SC-65292; AB0016899; DB-006861; FT-0600843; M1679; ST50824264; 24M939; W-2595; W-106742; Q20059730; Z33546492
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| Activity |
IC50 = 77000 nM
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[2] | |||
| Compound Name |
4-(4-Carbamoylphenoxy)benzamide
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Investigative | Compound Info | ||
| Synonyms |
4,4'-oxydibenzamide; OUL35; 4,4'-Oxybis[benzamide]; MLS000736992; 4-(4-aminocarbonylphenoxy)benzamide; NSC39047; Oprea1_001354; IFLab1_001185; OUL 35; SCHEMBL3137816; CHEMBL1438938; CTK5B8808; DTXSID10284793; BDBM199181; HMS1415F19; HMS2754A23; ZINC235625; NSC-39047; AKOS001482413; MCULE-8450176580; IDI1_009052; OUL35, >=98% (HPLC); SMR000393949; EU-0000374; SR-01000391101; SR-01000391101-1; 4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carboxamide (OUL35)
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
Benzyl N-[[4-(8-methyl-4-oxo-1H-quinazolin-2-yl)phenyl]methyl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098935; SCHEMBL15775230; BDBM50444541
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
4-(4-Formyl-phenoxy)-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4287655; 4-(4-Formylphenoxy)-benzamide; 4-(4-formylphenoxy)benzamide; SCHEMBL754740; BDBM50468581; ZINC20297191; A1-11748
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
1,2-Dihydro-2-(4-isopropylphenyl)-4(3H)-quinazolinone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3594136; Oprea1_576221; 2-[4-(propan-2-yl)phenyl]-1,2,3,4-tetrahydroquinazolin-4-one; BDBM50104287; AKOS001314013; MCULE-7496308930; Z48978364; 2-(4-Isopropylphenyl)-2,3-dihydroquinazolin-4(1H)-one; 2-(4-Isopropylphenyl)-1,2,3,4-tetrahydroquinazoline-4-one
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Compound Name |
N-[3-Chloranyl-4-[[4-(4-Methoxyphenyl)oxan-4-Yl]methylcarbamoyl]phenyl]furan-2-Carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3752386; SCHEMBL15057674; BDBM50136755; Q27464764; N-[3-chloro-4-[[4-(4-methoxyphenyl)oxan-4-yl]methylcarbamoyl]phenyl]furan-2-carboxamide
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| Activity |
IC50 ~ 100000 nM
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[5] | |||
| Compound Name |
4-[(2-Fluorophenyl)methoxy]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4208737; OUL35 derivative 32; SCHEMBL20883219; 4-[(2-fluorobenzyl)oxy]benzamide; ZINC7509736; BDBM50452662; STL506080; AKOS017030557; MCULE-5507437194; Z26312097
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
2-(4-Tert-Butylphenyl)-2,3-dihydroquinazoline-4(1H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3594137; Oprea1_675665; HMS1742P09; BDBM50104288; AKOS008017587; MCULE-4232890698; SR-01000074054; SR-01000074054-1
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Compound Name |
2-(4-Bromophenyl)-3,4-Dihydroquinazolin-4-One
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Investigative | Compound Info | ||
| Synonyms |
2-(4-bromophenyl)quinazolin-4(3h)-one; CHEMBL2058057; 2-(4-bromophenyl)quinazolin-4(1h)-one; 2-(4-bromophenyl)-1H-quinazolin-4-one; Cambridge id 5234833; Oprea1_095695; SCHEMBL5795292; SCHEMBL15775265; DTXSID50966728; HMS1579J06; ZINC289772; BDBM50188337; STL506688; AKOS034469035; MCULE-8062991764; 2-(4-Bromophenyl)quinazoline-4(3H)-one; Q27452728; Z56974849
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
4-(4-Carbamoylphenoxy)benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4287262; BDBM50468579; ZINC20297208; AKOS009229962; MCULE-8977258216; NE43435; EN300-70101; Z1222331858
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
1-[3-[4-(2-Chlorophenyl)-5-pyrimidin-4-yl-1,2,4-triazol-3-yl]cyclobutyl]-2-oxidanylidene-3~{H}-benzimidazole-5-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4095003; SCHEMBL20302234; SCHEMBL20333643; SCHEMBL20333645; BDBM50250875
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| Activity |
IC50 ~ 100000 nM
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[6] | |||
| Compound Name |
4-[(3Ar,4r,7s,7as)-1,3-Dioxooctahydro-2h-4,7-Methanoisoindol-2-Yl]-N-(Quinolin-8-Yl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956162; SCHEMBL14960033; BDBM50234919; Q27453509
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| Activity |
IC50 ~ 100000 nM
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[7] | |||
| Compound Name |
N-{4-[(2-Chlorophenyl)(Pyrimidin-4-Yl)carbamoyl]phenyl}-4-Methoxybenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3752492; BDBM50136772; Q27456886; 8IR
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| Activity |
IC50 ~ 100000 nM
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[5] | |||
| Compound Name |
IWR-1-endo
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Investigative | Compound Info | ||
| Synonyms |
IWR-1; CHEMBL562310; C25H19N3O3; IWR1-endo; exo-IWR 1; IWR-1 endo; endo-IWR-1; cc-714; SCHEMBL15315470; EX-A642; BCP05700; ZINC2483738; 1806AH; 2489AH; BDBM50007583; MFCD18086875; CCG-208104; IWR-1, >=98% (HPLC); HY-12238; B2306; BRD-K61314889-001-01-0; Q27132252
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| Activity |
IC50 ~ 170000 nM
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[8] | |||
| Compound Name |
2-Amino-5-[4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]cyclohexyl]pyridine-3-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099718; SCHEMBL15272388; SCHEMBL15289173; BDBM50444584
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| Activity |
IC50 ~ 170000 nM
|
[9] | |||
| Compound Name |
N-[4-[(4S)-5,5-Dimethyl-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]cyclohexyl]-7-fluoro-1,5-naphthyridine-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2381936; SCHEMBL15289210; SCHEMBL16444265; BDBM50434158
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| Activity |
IC50 ~ 170000 nM
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[8] | |||
| Compound Name |
(4s)-3-{trans-4-[6-Amino-5-(Pyrimidin-2-Yl)pyridin-3-Yl]cyclohexyl}-5,5-Dimethyl-4-Phenyl-1,3-Oxazolidin-2-One
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099716; CHEMBL3099717; SCHEMBL15289095; SCHEMBL15289211; SCHEMBL16444735; BDBM231052; BDBM50444583; US9340549, 72; Q27452995
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| Activity |
IC50 ~ 170000 nM
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[9] | |||
| Compound Name |
(4s)-3-{4-[6-Amino-5-(Pyrimidin-2-Yl)pyridin-3-Yl]phenyl}-5,5-Dimethyl-4-Phenyl-1,3-Oxazolidin-2-One
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099720; SCHEMBL15269793; BDBM50444585; Q27452997; (4S)-3-[4-(6-amino-5-pyrimidin-2-ylpyridin-3-yl)phenyl]-5,5-dimethyl-4-phenyl-1,3-oxazolidin-2-one; (S)-3-(4-(6-Amino-5-(pyrimidin-2-yl)pyridin-3-yl)phenyl)-5,5-dimethyl-4-phenyloxazolidin-2-one
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| Activity |
IC50 ~ 170000 nM
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[9] | |||
| Compound Name |
1-[4-[(4S)-5,5-Dimethyl-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]cyclohexyl]-4-fluoro-2-oxo-3H-benzimidazole-5-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2381946; SCHEMBL15289088; SCHEMBL16444649; SCHEMBL16456028; BDBM50434155
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| Activity |
IC50 ~ 170000 nM
|
[8] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor. J Med Chem. 2013 Aug 22;56(16):6495-511. | ||||
| REF 2 | 4-(Phenoxy) and 4-(benzyloxy)benzamides as potent and selective inhibitors of mono-ADP-ribosyltransferase PARP10/ARTD10. Eur J Med Chem. 2018 Aug 5;156:93-102. | ||||
| REF 3 | Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases. Eur J Med Chem. 2016 Aug 8;118:316-27. | ||||
| REF 4 | Discovery of potent and selective nonplanar tankyrase inhibiting nicotinamide mimics. Bioorg Med Chem. 2015 Aug 1;23(15):4139-4149. | ||||
| REF 5 | Development and structural analysis of adenosine site binding tankyrase inhibitors. Bioorg Med Chem Lett. 2016 Jan 15;26(2):328-333. | ||||
| REF 6 | Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach. J Med Chem. 2017 Dec 28;60(24):10013-10025. | ||||
| REF 7 | Highly Potent and Isoform Selective Dual Site Binding Tankyrase/Wnt Signaling Inhibitors That Increase Cellular Glucose Uptake and Have Antiproliferative Activity. J Med Chem. 2017 Jan 26;60(2):814-820. | ||||
| REF 8 | Discovery of novel, induced-pocket binding oxazolidinones as potent, selective, and orally bioavailable tankyrase inhibitors. J Med Chem. 2013 Jun 13;56(11):4320-42. | ||||
| REF 9 | Structure-based design of 2-aminopyridine oxazolidinones as potent and selective tankyrase inhibitors. ACS Med Chem Lett. 2013 Oct 21;4(12):1218-23. | ||||
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