Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T40103 | Target Info | |||
| Target Name | Cathepsin H (CTSH) | ||||
| Synonyms |
Pro-cathepsin H
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| Target Type | Literature-reported Target | ||||
| Gene Name | CTSH | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 26 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Iboctadekin + rituximab
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|
Phase 1 | Compound Info | ||
| Synonyms |
Pepstatin A; 26305-03-3; Pepstatine; Ahpatinin C; UNII-V6Y2T27Q1U; MLS002222329; Iva-Val-Val-Sta-Ala-Sta-OH; V6Y2T27Q1U; CHEMBL296588; 39324-30-6; FAXGPCHRFPCXOO-LXTPJMTPSA-N; C34H63N5O9; NCGC00161670-06; Pepstatin (nonspecific); DSSTox_RID_81334; DSSTox_CID_26095; DSSTox_GSID_46095; CCRIS 3603; Pepstatina; Pepstatinum; Pepstatin (VAN); Ia Quinidine
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Trifluoroethylamine inhibitor, 2
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL400387; SCHEMBL3476615; BDBM19492
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(2R)-2-Amino-N-[(1S,2S)-1-cyano-2-phenylcyclopropyl]-3-thiophen-2-ylpropanamide;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL478737
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(2S)-2-Amino-N-[(1R,2R)-1-cyano-2-phenylcyclopropyl]-3-thiophen-2-ylpropanamide;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL516292
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
cis-(S)-2-Amino-N-((1R,2R)-1-cyano-2-phenylcyclopropyl)-3-(thiophen-2-yl)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1078411; BDBM50310690; (2S)-N-[[(1R)-1alpha-Cyano-2beta-phenylcyclopropane]-1-yl]-2-amino-3-(2-thienyl)propanamide
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-Amino-N-[(1R,2R)-1-cyano-2-phenylcyclopropyl]-3-(3-fluorothiophen-2-yl)propanamide;2,2,2-trifluoroacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL515494
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
3-Acetyl-8-chloro-2-(2,4-dibromophenylamino)-5-methylquinolin-4(1H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL523822; SCHEMBL20094464; BDBM50249659
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| Activity |
IC50 = 66520 nM
|
[1] | |||
| Compound Name |
2-Methyl-5-nitroquinoline-8-ol
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Investigative | Compound Info | ||
| Synonyms |
2-methyl-5-nitroquinolin-8-ol; CHEMBL4229176; SCHEMBL8381316; DTXSID10876218; 8-Quinolinol, 2-methyl-5-nitro-; BDBM50460480
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| Activity |
Ki = 89000 nM
|
[4] | |||
| Compound Name |
3-Acetyl-5,8-dibromo-2-(4-bromophenylamino)quinolin-4(1H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL470707; SCHEMBL20094427; BDBM50249605
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| Activity |
IC50 = 91760 nM
|
[1] | |||
| Compound Name |
Chembl346155
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2371131; BDBM50074051
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| Activity |
Ki = 93000 nM
|
[5] | |||
| Compound Name |
5-((2,3-Dimethylphenoxy)methyl)-3-methyloxazolidin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL397973; SCHEMBL3958229; BDBM50201707; 5-[(2,3-dimethylphenoxy)methyl]-3-methyl-1,3-oxazolidin-2-one
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
(3R,4R)-4-(2,3-Dimethylphenoxy)piperidin-3-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL230479; SCHEMBL3961271; BDBM50201706; trans-4-(2,3-dimethylphenoxy)-3-hydroxypiperidine
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
(1S,2S)-2-Bromo-7-oxa-5-aza-bicyclo[3.2.1]octan-6-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL397972; BDBM50201703
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|
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
Z-FF-Fmk
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2368566; Z-Phe-PheCH2F; Z-Phe-Phe-fluoromethyl ketone; SCHEMBL18328618; EX-A3847; BDBM50491472; MFCD03453604; ZINC25667985; Z-Phe-Phe-fluoromethyl ketone, >=98% (TLC), solid
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-Acetyl-6-chloro-2-(2-chloro-4-methylphenylamino)-8-nitroquinolin-4(1H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL521771; BDBM50250190
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-Acetyl-8-bromo-5-chloro-2-(4-chlorophenylamino)quinolin-4(1H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL513042; KSI-3716; SCHEMBL19821437; BDBM50249606; HY-12703; CS-0012282
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3S,4R)-4-(2,3-Dimethylphenoxy)piperidin-3-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL441907; SCHEMBL3959125; BDBM50201704; (3S,4R)-4-(2,3-Dimethylphenoxy)-3-piperidinol; UNII-LHH887104B component ZHFIAFNZGWCLHU-WCQYABFASA-N
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|
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
3-Acetyl-5,8-dichloro-2-(2,4-dichlorophenylamino)quinolin-4(1H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL471915; SCHEMBL22003072; BDBM50249607
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(1R,2S)-2-Phenoxy-7-oxa-5-aza-bicyclo[3.2.1]octane-6-thione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL390643; BDBM50201702
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|
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
3-Acetyl-2-(4-tert-butylphenylamino)-8-chloro-6-nitroquinolin-4(1H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL521636; BDBM50250153; 3-acetyl-2-(4-tert-butylanilino)-8-chloro-6-nitro-1H-quinolin-4-one
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
CID 9821383
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|
Investigative | Compound Info | ||
| Synonyms |
CA-074; CA 074; CHEMBL490920; MFCD00797531; Cathepsin B Inhibitor III; PrNH-tES-Ile-Pro-OH; epoxysuccinyl derivative CA074; SCHEMBL4323476; BDBM16509; CA074; ZINC3927825; AKOS024458382; CS-7886; HY-103350; (L-3-trans-(Propylcarbamyl)oxirane-2-carbonyl)-L-isoleucyl-L-proline; N-{[(2S,3S)-3-(propylcarbamoyl)oxiran-2-yl]carbonyl}-L-isoleucyl-L-proline
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4228921
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50460493
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|
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| Activity |
Ki = 108000 nM
|
[4] | |||
| Compound Name |
7-(Cyanomethylaminomethyl)-5-nitro-8-quinolinol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312216; MDK7677; 2-{[(8-Hydroxy-5-nitroquinoline-7- yl)methyl]amino}-acetonitrile; BDBM50425030; 2-[[(8-hydroxy-5-nitroquinolin-7-yl)methyl]amino]acetonitrile
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|
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| Activity |
Ki = 129000 nM
|
[7] | |||
| Compound Name |
3-(1-Benzyloxycarbonyl-3-methyl-butylcarbamoyl)-1-(2-tert-butoxycarbonylamino-3-phenyl-propionyl)-aziridine-2-carboxylic acid ethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2371128; CHEMBL347731; BDBM50074050
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|
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| Activity |
Ki = 137000 nM
|
[5] | |||
| Compound Name |
1-(2-Benzyloxycarbonylamino-propionyl)-aziridine-2,3-dicarboxylic acid diethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2371130; CHEMBL152581; BDBM50074052; (2S,3S)-1-[N-(Benzyloxycarbonyl)-L-alanyl]-2,3-aziridinedicarboxylic acid diethyl ester
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| Activity |
Ki = 160000 nM
|
[5] | |||
| Compound Name |
Click to Show/Hide
|
Compound Info | |||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 7 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1-((S)-2-Tert-Butoxycarbonylamino-3-phenyl-propionyl)-aziridine-2,3-dicarboxylic acid diethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2371121; CHEMBL153484; BDBM50074048; (2S,3S)-1-[N-(tert-Butoxycarbonyl)-L-phenylalanyl]-2,3-aziridinedicarboxylic acid diethyl ester
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|
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| Activity |
Ki = 210000 nM
|
[5] | |||
| Compound Name |
5-Nitro-8-(4-methylpiperidino)quinoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312204; MDK0734; 8-(4-methylpiperidin-1-yl)-5-nitroquinoline; BDBM50425024
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| Activity |
Ki = 221000 nM
|
[7] | |||
| Compound Name |
Pyrrolidine, 1-(4-nitro-1-naphthalenyl)-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL570897; 1-(4-nitronaphthalen-1-yl)pyrrolidine; ACMC-20mc9g; (4-nitronaphthyl)pyrrolidine; Oprea1_221230; SCHEMBL3603749; CTK0D5811; DTXSID10403220; 1-(4-nitro-1-naphthyl)pyrrolidine; ZINC4126409; BDBM50415097; AKOS001483561; MCULE-7970978795; EU-0066932; ST50993708; SR-01000390159; SR-01000390159-1
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|
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| Activity |
Ki = 251000 nM
|
[7] | |||
| Compound Name |
3-((S)-1-Benzyloxycarbonyl-3-methyl-butylcarbamoyl)-aziridine-2-carboxylic acid ethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL152803; BDBM50074049
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| Activity |
Ki = 260000 nM
|
[5] | |||
| Compound Name |
Chembl4228576
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Investigative | Compound Info | ||
| Synonyms |
BDBM50460502
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| Activity |
Ki = 329000 nM
|
[4] | |||
| Compound Name |
2-Bromo-4-nitronaphthalen-1-amine
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Investigative | Compound Info | ||
| Synonyms |
2-Bromo-4-nitro-1-naphthalenamine; 2-Bromo-4-nitro-naphthalen-1-ylamine; 2-Bromo-4-nitro-1-naphthylamine; CHEMBL2312203; MFCD00085870; 2-bromo-4-nitro-1-aminonaphthalene; SCHEMBL3609722; CTK2A9597; DTXSID70629368; 1-Amino-2-Bromo-4-nitronaphthalene; 1606AJ; BDBM50425017; ZINC95595255; 1-Naphthalenamine, 2-bromo-4-nitro-; ACN-047841; SB38041; AS-62816; SY129737; CS-0103519; W-3987
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| Activity |
Ki = 354000 nM
|
[7] | |||
| Compound Name |
Chembl4228126
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50460481
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| Activity |
Ki = 462000 nM
|
[4] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Identification of 3-acetyl-2-aminoquinolin-4-one as a novel, nonpeptidic scaffold for specific calpain inhibitory activity. J Med Chem. 2009 May 14;52(9):3093-7. | ||||
| REF 2 | Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing. J Biol Chem. 2007 Jul 20;282(29):20836-46. | ||||
| REF 3 | Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5392-6. | ||||
| REF 4 | Cathepsin B inhibitors: Further exploration of the nitroxoline core. Bioorg Med Chem Lett. 2018 Apr 15;28(7):1239-1247. | ||||
| REF 5 | New peptidic cysteine protease inhibitors derived from the electrophilic alpha-amino acid aziridine-2,3-dicarboxylic acid. J Med Chem. 1999 Feb 25;42(4):560-72. | ||||
| REF 6 | Bicyclic carbamates as inhibitors of papain-like cathepsin proteases. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1254-9. | ||||
| REF 7 | Development of new cathepsin B inhibitors: combining bioisosteric replacements and structure-based design to explore the structure-activity relationships of nitroxoline derivatives. J Med Chem. 2013 Jan 24;56(2):521-33. | ||||
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