Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T39677 | Target Info | |||
| Target Name | Bile-salt-activated lipase (CEL) | ||||
| Synonyms |
Pancreatic lysophospholipase; Pancreatic cholesterol esterase; Cholesterol esterase; Carboxyl ester lipase; CEL; Bile-salt-stimulated lipase; BSSL; BAL
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| Target Type | Clinical trial Target | ||||
| Gene Name | CEL | ||||
| Biochemical Class | Carboxylic ester hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 8 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-(2,3,4,5,6-Pentafluorophenyl)-4,5,6,7-tetrahydro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL503392; BDBM50244754
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-(6-Bromopyridin-2-yl)-4,5,6,7-tetrahydro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL459683; BDBM50244704
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4,5-Dimethyl-2-(2,3,5,6-tetrafluoropyridin-4-yl)-isothiazol-3(2H)-one 1,1-dioxide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL512758; BDBM50244752
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-(2,3,5,6-Tetrafluoropyridin-4-yl)-4,5,6,7-tetrahydro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL461945; BDBM50244751; 2-(2,3,5,6-Tetrafluoro-4-pyridyl)-4,5,6,7-tetrahydro-1,2-benzoisothiazole-3(2H)-one 1,1-dioxide
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-(6-Chloropyridin-2-yl)-4,5,6,7-tetrahydro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL513281; BDBM50244703; 2-(6-Chloro-2-pyridyl)-4,5,6,7-tetrahydro-1,2-benzoisothiazole-3(2H)-one 1,1-dioxide
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1,1-Dioxo-2-pyridin-4-yl-4,5,6,7-tetrahydro-1,2-benzothiazol-3-one;perchloric acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL512569
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
5-Methyl-4-phenyl-2-(2,3,5,6-tetrafluoropyridin-4-yl)-isothiazol-3(2H)-one 1,1-dioxide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL461946; BDBM50244753
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-(3,5-Difluoropyridin-2-yl)-4,5,6,7-tetrahydro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL459684; BDBM50244705
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and elastase-inhibiting activity of 2-pyridinyl-isothiazol-3(2H)-one 1,1-dioxides. Bioorg Med Chem. 2008 Sep 1;16(17):8127-35. | ||||
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