Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T37154 | Target Info | |||
| Target Name | Cathepsin A (CTSA) | ||||
| Synonyms |
Protective protein for betagalactosidase; Protective protein cathepsin A; PPCA; Lysosomal protective protein 20 kDa chain; Lysosomal protective protein; Carboxypeptidase L; Carboxypeptidase C; CTSA
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| Target Type | Clinical trial Target | ||||
| Gene Name | CTSA | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
e-64
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Investigative | Compound Info | ||
| Synonyms |
Proteinase inhibitor E 64; UNII-R76F7856MV; CHEMBL374508; R76F7856MV; Thiol protease inhibitor; E 64 (proteinase inhibitor); BRN 1405664; MFCD00080261; 5-18-07-00006 (Beilstein Handbook Reference); SCHEMBL4740187; CTK8C4337; EX-A2284; ANW-71599; BDBM50157741; ZINC13493525; (L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINE HEMIHYDRATE; AKOS016007415; CCG-207844; CCG-208198; CS-4140; NCGC00163544-01; HY-15282; SC-98492; A13257; C01341; E-0010; Q5321373; trans-epoxysuccinyl-l-leucylamido-(4-guanidino)butane; (L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMA
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| Activity |
IC50 > 300000 nM
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[1] | |||
| Compound Name |
Vaborbactam
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Investigative | Compound Info | ||
| Synonyms |
RPX-7009; RPX7009; UNII-1C75676F8V; CHEMBL3317857; 1C75676F8V; Vaborbactam [INN]; RPX 7009; Vaborbactam. RPX7009; Vaborbactam (USAN/INN); Vaborbactam [USAN:INN]; SCHEMBL620289; GTPL10871; Vabomere (vaborbactam + meropenem); EX-A2589; BDBM50089084; MFCD28502176; AKOS032961376; CS-6445; DB12107; SB17184; compound 9f [PMID: 25782055]; NCGC00510003-01; HY-19930; D10998; Q27252228
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| Activity |
IC50 = 1000000 nM
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[2] | |||
| References | Top | ||||
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| REF 1 | Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and G... Antimicrob Agents Chemother. 2007 Feb;51(2):543-50. | ||||
| REF 2 | Discovery of a Cyclic Boronic Acid -Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases. J Med Chem. 2015 May 14;58(9):3682-92. | ||||
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