Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T36806 | Target Info | |||
| Target Name | Kidney-type arginase (ARG2) | ||||
| Synonyms |
Non-hepatic arginase; Human penile arginase; Arginase II; ARG2
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| Target Type | Clinical trial Target | ||||
| Gene Name | ARG2 | ||||
| Biochemical Class | Carbon-nitrogen hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 1 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-Amino-6-borono-2-(2-hydroxyethyl)hexanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348494; BDBM50431957
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| Activity |
IC50 = 57000 nM
|
[1] | |||
| Non Binders of This Target (in total, 3 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(2S)-2-Amino-6-borono-2-(2-piperidin-1-ylethyl)hexanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2326091; SCHEMBL10207709; BDBM50427902; ZINC170183245
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| Activity |
IC50 > 300000 nM
|
[2] | |||
| Compound Name |
Chembl4250607
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Investigative | Compound Info | ||
| Synonyms |
BDBM50462601
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| Activity |
Ki = 322000 nM
|
[3] | |||
| Compound Name |
Chembl4238387
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Investigative | Compound Info | ||
| Synonyms |
BDBM50462600
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| Activity |
Ki = 437000 nM
|
[3] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | 2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors. Bioorg Med Chem Lett. 2013 Apr 1;23(7):2027-30. | ||||
| REF 2 | Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potent inhibitors of human arginases I and II for treatment of myocardial reperfusion injury. J Med Chem. 2013 Mar 28;56(6):2568-80. | ||||
| REF 3 | Rational design of novel irreversible inhibitors for human arginase. Bioorg Med Chem. 2018 Aug 7;26(14):3939-3946. | ||||
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