Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T36725 | Target Info | |||
| Target Name | Carboxypeptidase B1 (CPB1) | ||||
| Synonyms |
Pancreas-specific protein; PASP; Carboxypeptidase B; CPB
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| Target Type | Patented-recorded Target | ||||
| Gene Name | CPB1 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 4 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
[5-(2-Fluoro-phenyl)-[1,3,4]oxadiazol-2-ylsulfanyl]-acetic acid benzyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL564664; SMR000003655; MLS000072147; MLS002536121; HMS2474N24; ZINC4215871; BDBM50296433; AKOS000800718; SR-01000326892; SR-01000326892-1; benzyl 2-(5-(2-fluorophenyl)-1,3,4-oxadiazol-2-ylthio)acetate; benzyl 2-{[5-(2-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetate
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| Activity |
Ki = 67200 nM
|
[1] | |||
| Compound Name |
(1S,2R)-Methyl 2-((1S,2R)-2-(benzyloxycarbonylamino)cyclobutanecarboxamido)cyclobutanecarboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL483957; BDBM50279418
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| Activity |
Ki = 70000 nM
|
[2] | |||
| Compound Name |
2-(4-Benzyl-5-(furan-2-yl)-4H-1,2,4-triazol-3-ylthio)-1-(4-fluorophenyl)ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL560073; SMR000064940; MLS000058285; MLS002632884; HMS2467K15; ZINC1364282; BDBM50296436; AKOS000669543; MCULE-9183266720; AB00422668-05; Z14359683
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| Activity |
Ki = 74500 nM
|
[1] | |||
| Compound Name |
2-(4-Benzyl-5-(3-methylphenethyl)-4H-1,2,4-triazol-3-ylthio)acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL550865; BDBM50296435
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| Activity |
Ki = 196000 nM
|
[1] | |||
| Non Binders of This Target (in total, 6 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(1R,2S)-Methyl 2-((1R,2S)-2-(benzyloxycarbonylamino)cyclobutanecarboxamido)cyclobutanecarboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL483958; BDBM50279419
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| Activity |
Ki = 275000 nM
|
[2] | |||
| Compound Name |
N-(2-(2-(2-(4-Methoxyphenyl)-2-oxoethyl)-2H-tetrazol-5-yl)phenyl)cyclopropanecarboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL552272; SMR000004319; Oprea1_245519; Oprea1_372478; MLS000068698; HMS2167B23; HMS3319C13; BDBM50296432
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| Activity |
Ki = 292000 nM
|
[1] | |||
| Compound Name |
2-(Pyridin-4-ylmethylamino)-1-(4-tosylpiperazin-1-yl)ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL550115; BDBM50296425
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| Activity |
Ki = 364000 nM
|
[1] | |||
| Compound Name |
Methyl 3-((1R,2S)-2-(benzyloxycarbonylamino)cyclobutanecarboxamido)propanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL485909; BDBM50279381; 3-[[[2beta-[(Benzyloxycarbonyl)amino]cyclobutane-1beta-yl]carbonyl]amino]propionic acid methyl ester
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| Activity |
Ki = 400000 nM
|
[2] | |||
| Compound Name |
Methyl 5-((1S,2R)-2-(benzyloxycarbonylamino)cyclobutanecarboxamido)pentanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL520985; BDBM50279417
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| Activity |
Ki = 410000 nM
|
[2] | |||
| Compound Name |
Methyl 2-((1R,2S)-2-(benzyloxycarbonylamino)cyclobutanecarboxamido)acetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL453955; BDBM50279380
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| Activity |
Ki = 500000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A new type of five-membered heterocyclic inhibitors of basic metallocarboxypeptidases. Eur J Med Chem. 2009 Aug;44(8):3266-71. | ||||
| REF 2 | Cyclobutane-containing peptides: evaluation as novel metallocarboxypeptidase inhibitors and modelling of their mode of action. Bioorg Med Chem. 2009 Jun 1;17(11):3824-8. | ||||
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