Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T36581 | Target Info | |||
| Target Name | MAPK-activated protein kinase 3 (MAPKAPK3) | ||||
| Synonyms |
MAPKAPK3
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| Target Type | Literature-reported Target | ||||
| Gene Name | MAPKAPK3 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
PHA-767491
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Investigative | Compound Info | ||
| Synonyms |
PHA-767491; 845714-00-3; PHA 767491; CAY10572(PHA-767491); PHA-767491 (CAY10572); 2-Pyridin-4-yl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one; 1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one; Pyrrolopyridinone, 1; Cdc7/Cdk9 Inhibitor; Kinome_2973; JMC502647 Compound 8; MLS006011036; SCHEMBL4767679; GTPL8763; CHEMBL225519; CTK8F8505; CHEBI:95058; BDBM27344; DTXSID50471069; MolPort-009-019-436; HMS3656P19; HMS3229B21; BCP02855; PHA-767491A; PHA767491; ZINC16052718; s2742; 2651AH; AKOS026674124; SB19465; CS-1208
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| Activity |
IC50 = 57700 nM
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[1] | |||
| Compound Name |
7-Methoxy-3,4,5,10-tetrahydro-1H-2,5-methanoazepino[3,4-b]indole-1-carboxylic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL392876; SCHEMBL1655459; BDBM50215481
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| Activity |
IC50 = 90000 nM
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[2] | |||
| Compound Name |
5-Methoxy-9,12-diazatetracyclo[10.3.1.0^{2,10}.0^{3,8}]hexadeca-2(10),3,5,7-tetraene-11-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL394124; SCHEMBL6236960; BDBM50215497
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| Activity |
IC50 = 160000 nM
|
[2] | |||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
6-Methoxy-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-1-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL395157; 6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid; 6-METHOXY-1H,2H,3H,4H,9H-PYRIDO[3,4-B]INDOLE-1-CARBOXYLIC ACID; SCHEMBL608164; SCHEMBL12660570; CTK0H2172; DTXSID00397280; BDBM50215483; MFCD00010826; STL525685; AKOS015894383; MCULE-5714246217; ST065834; 952M635; J-011460; Z2216905627; 6-methoxy-1,2,3,4-tetrahydrobeta-carbolinecarboxylic acid; 6-Methoxy-1,2,3,4-tetrahydro-beta-carboline-1-carboxylic acid; 6-methoxy-2,3,4,9-tetrahydro-1h-beta-carboline-1-carboxylic acid; 1H-Pyrido[3,4-b]indole-1-carboxylic acid, 2,3,4,9-tetrahydro-6-methoxy-; 1H-Pyrido[3,4-b]indole-1-carboxylicacid, 2,3,4,9-tetrahydro-6-methoxy-; 6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-2-ium-1-carboxylate; 6-Methoxy-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-1-carboxylic acid, 97%
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| Activity |
IC50 > 200000 nM
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[2] | |||
| References | Top | ||||
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| REF 1 | Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). J Med Chem. 2007 May 31;50(11):2647-54. | ||||
| REF 2 | Novel tetrahydro-beta-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Bioorg Med Chem Lett. 2007 Aug 15;17(16):4657-63. | ||||
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