Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T35809 | Target Info | |||
| Target Name | Bromodomain-containing protein 1 (BRD1) | ||||
| Synonyms |
Bromodomain and PHD finger-containing protein 2; BRPF2; BRL; BR140-like protein
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| Target Type | Literature-reported Target | ||||
| Gene Name | BRD1 | ||||
| Biochemical Class | Bromodomain | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 2 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-[1,3-Dimethyl-6-[(2r)-2-Methylpiperazin-1-Yl]-2-Oxidanylidene-Benzimidazol-5-Yl]-N-Ethyl-2-Methoxy-Benzamide
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Investigative | Compound Info | ||
| Synonyms |
GSK9311; CHEMBL3827932; BCP24866; EX-A1172; BDBM50189407; AKOS032960381; CS-6907; GSK9311, >=98% (HPLC); HY-100729; Q27456914
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| Activity |
IC50 = 50118.72 nM
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[1] | |||
| Compound Name |
4-Cyano-N-(1,3-diethyl-2-oxoquinolin-6-yl)benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4059509; BDBM50249797
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain. ACS Med Chem Lett. 2016 May 9;7(6):552-7. | ||||
| REF 2 | Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins. J Med Chem. 2017 Aug 24;60(16):6998-7011. | ||||
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