Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T35194 | Target Info | |||
| Target Name | Dual specificity protein phosphatase 1 (DUSP1) | ||||
| Synonyms |
VH1; Protein-tyrosine phosphatase CL100; PTPN10; Mitogen-activated protein kinase phosphatase 1; MKP1; MKP-1; MAP kinase phosphatase-1; MAP kinase phosphatase 1; Dual specificity protein phosphatase hVH1; CL100
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| Target Type | Clinical trial Target | ||||
| Gene Name | DUSP1 | ||||
| Biochemical Class | Phosphoric monoester hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 19 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-Hydroxy-2-(hydroxymethyl)-4-[N-[(2-hydroxyphenyl)methyl]-C-pentadecylcarbonimidoyl]-2H-furan-5-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2062712; RE-44; BDBM50388818
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-(N-Benzyl-C-pentadecylcarbonimidoyl)-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one
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|
Investigative | Compound Info | ||
| Synonyms |
RE-1; CHEMBL2062590; BDBM50388807
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[N-[(3-Chlorophenyl)methyl]-C-pentadecylcarbonimidoyl]-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2062592; BDBM50388822
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[N-[[2-(Dimethylamino)phenyl]methyl]-C-pentadecylcarbonimidoyl]-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2062714; BDBM50388820
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-Hydroxy-2-(hydroxymethyl)-4-[N-[(3-methylphenyl)methyl]-C-pentadecylcarbonimidoyl]-2H-furan-5-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2062591; CHEMBL3260030; RE-12; BDBM50012280; BDBM50388821
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-Hydroxy-2-(hydroxymethyl)-4-[N-[(4-methoxyphenyl)methyl]-C-pentadecylcarbonimidoyl]-2H-furan-5-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2062708; BDBM50388813
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-[1-(2-Methylbenzylamino)hexadecane-1-ylidene]-5-(hydroxymethyl)tetrahydrofuran-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2062528; BDBM50388815
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[N-[(2-Chlorophenyl)methyl]-C-pentadecylcarbonimidoyl]-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2062710; BDBM50388816
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[N-[(4-Chlorophenyl)methyl]-C-pentadecylcarbonimidoyl]-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2062598; BDBM50388810
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[N-[(3-Fluorophenyl)methyl]-C-pentadecylcarbonimidoyl]-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2062593; BDBM50388823
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-Hydroxy-2-(hydroxymethyl)-4-[N-[(4-hydroxyphenyl)methyl]-C-pentadecylcarbonimidoyl]-2H-furan-5-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2062707; BDBM50388812
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-Hydroxy-2-(hydroxymethyl)-4-[N-[(3-methoxyphenyl)methyl]-C-pentadecylcarbonimidoyl]-2H-furan-5-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2062595; BDBM50388825
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[N-[[4-(Dimethylamino)phenyl]methyl]-C-pentadecylcarbonimidoyl]-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2062709; BDBM50388814
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[N-[(2-Fluorophenyl)methyl]-C-pentadecylcarbonimidoyl]-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2062711; BDBM50388817
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-Hydroxy-2-(hydroxymethyl)-4-[N-[(4-methylphenyl)methyl]-C-pentadecylcarbonimidoyl]-2H-furan-5-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2062597; BDBM50388809
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[N-[(4-Fluorophenyl)methyl]-C-pentadecylcarbonimidoyl]-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2062599; BDBM50388811
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-Hydroxy-2-(hydroxymethyl)-4-[N-[(2-methoxyphenyl)methyl]-C-pentadecylcarbonimidoyl]-2H-furan-5-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2062713; BDBM50388819
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-Hydroxy-2-(hydroxymethyl)-4-[N-[(3-hydroxyphenyl)methyl]-C-pentadecylcarbonimidoyl]-2H-furan-5-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2062594; BDBM50388824
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[N-[[3-(Dimethylamino)phenyl]methyl]-C-pentadecylcarbonimidoyl]-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2062596; BDBM50388808
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Dual-Specificity Phosphatase CDC25A/B Inhibitor Identified from a Focused Library with Nonelectrophilic Core Structure. ACS Med Chem Lett. 2012 Apr 12;3(4):294-298. | ||||
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