Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
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| Target ID | T35173 | Target Info | |||
| Target Name | Cellular inhibitor of apoptosis 2 (BIRC3) | ||||
| Synonyms |
hIAP1; hIAP-1; TNFR2TRAFsignaling complex protein 1; TNFR2-TRAF-signaling complex protein 1; RNF49; RING-type E3 ubiquitin transferase BIRC3; RING finger protein 49; MIHC; Inhibitor of apoptosis protein 1; IAP1; IAP homolog C; CIAP2; C-IAP2; Baculoviral IAP repeatcontaining protein3; Baculoviral IAP repeat-containing protein 3; Apoptosis inhibitor 2; API2
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| Target Type | Clinical trial Target | ||||
| Gene Name | BIRC3 | ||||
| Biochemical Class | Acyltransferase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 2 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(3S,6S,10As)-N-[(S)-[1-[4-[4-[4-[4-[(S)-[[(3S,6S,10aS)-6-[[(2S)-2-acetamido-3-(1H-indol-3-yl)propanoyl]amino]-5-oxo-2,3,6,7,8,9,10,10a-octahydro-1H-pyrrolo[1,2-a]azocine-3-carbonyl]amino]-phenylmethyl]triazol-1-yl]butyl]phenyl]butyl]triazol-4-yl]-phenylmethyl]-6-[[(2S)-2-acetamido-3-(1H-indol-3-yl)propanoyl]amino]-5-oxo-2,3,6,7,8,9,10,10a-octahydro-1H-pyrrolo[1,2-a]azocine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1774155; BDBM50343514
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| Activity |
IC50 ~ 50000 nM
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[1] | |||
| Compound Name |
(5S,8S,10Ar)-N-benzhydryl-5-[[(2S)-3-(1H-indol-3-yl)-2-(methylamino)propanoyl]amino]-3-(3-methylbutanoyl)-6-oxo-1,2,4,5,8,9,10,10a-octahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2158052; SCHEMBL12851758; BDBM50393506
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| Activity |
IC50 = 75000 nM
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[2] | |||
| References | Top | ||||
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| REF 1 | Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity. J Med Chem. 2011 May 12;54(9):3306-18. | ||||
| REF 2 | A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment. J Med Chem. 2011 Apr 28;54(8):2714-26. | ||||
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