Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T34562 | Target Info | |||
| Target Name | Serum paraoxonase/arylesterase 1 (PON1) | ||||
| Synonyms |
Serum paraoxonase; Serum aryldialkylphosphatase 1; Serum aryldiakylphosphatase 1; PON 1; PON; K-45; Aromatic esterase 1; A-esterase 1
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| Target Type | Literature-reported Target | ||||
| Gene Name | PON1 | ||||
| Biochemical Class | Carboxylic ester hydrolase | ||||
| UniProt ID | |||||
| Non Binders of This Target (in total, 11 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Phenylphosphate
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Investigative | Compound Info | ||
| Synonyms |
Phenylphosphoric acid; Phenylphosphate; Phenyl dihydrogen phosphate; 701-64-4; Phosphoric acid, monophenyl ester; Phenyl phosphate; phenol phosphate; MONOPHENYL PHOSPHATE; monophenylphosphate; Phenolic phosphate; UNII-75M88J863E; EINECS 211-857-7; CHEMBL26128; CHEBI:37548; CMPQUABWPXYYSH-UHFFFAOYSA-N; 75M88J863E; HPS; phenoxyphosphonic acid; Phosphoric acid phenyl; 1o4o; ACMC-1BB8F; Dihydrogen Phenyl Phosphate; AC1L20DG; DSSTox_RID_80630; DSSTox_CID_24981; SCHEMBL20263; DSSTox_GSID_44981; Phosphoric Acid Phenyl Ester; Phenyl dihydroge
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| Activity |
IC50 = 3250000 nM
|
[1] | |||
| Compound Name |
4-nitrophenyl phosphate
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Investigative | Compound Info | ||
| Synonyms |
4-nitrophenyl phosphate; 4-Nitrophenyl dihydrogen phosphate; 330-13-2; Nitrophenylphosphate; Phosphoric acid, mono(4-nitrophenyl) ester; p-nitrophenyl phosphate; p-Nitrophenyl dihydrogen phosphate; p-Nitrophenol phosphate; p-Nitrophenylphosphate; (4-nitrophenyl) dihydrogen phosphate; PNPP; NSC 404086; Phenol, p-nitro-, dihydrogen phosphate; CHEMBL24231; (4-nitrophenoxy)phosphonic acid; CHEBI:17440; XZKIHKMTEMTJQX-UHFFFAOYSA-N; pNPP Alkaline Phosphatase Substrate; Phosphoric acid, mono(p-nitrophenyl) ester (8CI); Phosphoric ac
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| Activity |
IC50 = 18500000 nM
|
[1] | |||
| Compound Name |
4-[[3-(Benzotriazol-1-ylmethyl)benzimidazol-3-ium-1-yl]methyl]-7,8-dimethylchromen-2-one;chloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3759001; BDBM50144690
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| Activity |
IC50 = 237500 nM
|
[2] | |||
| Compound Name |
4-[(2,3-Dimethylimidazol-3-ium-1-yl)methyl]-5,7-dimethylchromen-2-one;chloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3759337; BDBM50139136
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| Activity |
IC50 = 317310 nM
|
[2] | |||
| Compound Name |
1-(1H-Benzimidazol-1-ylmethyl)-1H-1,2,3-benzotriazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3758357; 1-(1H-1,3-Benzodiazol-1-ylmethyl)-1H-1,2,3-benzotriazole; SCHEMBL14805493; BDBM50144740; 1-(1h-benzimidazol-1-ylmethyl)-1h-benzotriazole; 1H-1,2,3-benzotriazole, 1-(1H-benzimidazol-1-ylmethyl)-
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| Activity |
IC50 = 564130 nM
|
[2] | |||
| Compound Name |
2-[(2,3-Dimethylimidazol-3-ium-1-yl)methyl]-1H-benzimidazole;chloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3758838; BDBM50144738
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| Activity |
IC50 = 625710 nM
|
[2] | |||
| Compound Name |
4-[[3-(Benzotriazol-1-ylmethyl)benzimidazol-3-ium-1-yl]methyl]-6-tert-butylchromen-2-one;chloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3759697; BDBM50144691
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| Activity |
IC50 = 627000 nM
|
[2] | |||
| Compound Name |
Phosphoric acid, p-aminophenyl diethyl ester
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Investigative | Compound Info | ||
| Synonyms |
Aminoparaoxon; p-Aminophenyl diethyl phosphate; CHEMBL42577; Phosphoric acid 4-amino-phenyl ester diethyl ester; (4-aminophenyl) diethyl phosphate; BRN 3056897; DTXSID20164411; 4-Aminophenyl diethyl phosphate #; O-(p-aminophenyl) diethyl phosphate; BDBM50127646; Phosphoric acid (4-aminophenyl)diethyl ester; Phosphoric acid, (4-aminophenyl) diethyl ester; Phosphoric acid, 4-aminophenyl diethyl ester (9CI)
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| Activity |
IC50 = 1280000 nM
|
[1] | |||
| Compound Name |
1-[(3-Benzylbenzimidazol-1-ium-1-yl)methyl]benzotriazole;chloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3758332; BDBM50144742
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| Activity |
IC50 = 2064200 nM
|
[2] | |||
| Compound Name |
Diethyl phenyl phosphate
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Investigative | Compound Info | ||
| Synonyms |
Phosphoric acid, diethyl phenyl ester; CHEMBL296745; Phosphoric acid, diethyl phenyl ester (8CI)(9CI); Phosphoric acid diethyl ester phenyl ester; AC1L29OT; NSC 171165; AI3-19536; Diethyl phenyl phosphate #; SureCN133234; SCHEMBL133234; DTXSID60179786; ZINC1532338; Phosphoric acid diethyl phenyl ester; BDBM50127647; NSC171165; NSC-171165; DB-129768; C11732; Q27106406
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| Activity |
IC50 = 3270000 nM
|
[1] | |||
| Compound Name |
1-[(3-Butylbenzimidazol-1-ium-1-yl)methyl]benzotriazole;chloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3760112; BDBM50144741
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| Activity |
IC50 = 3333300 nM
|
[2] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure-activity relationship on human serum paraoxonase (PON1) using substrate analogues and inhibitors. Bioorg Med Chem Lett. 2003 May 19;13(10):1623-6. | ||||
| REF 2 | Functionalized imidazolium and benzimidazolium salts as paraoxonase 1 inhibitors: Synthesis, characterization and molecular docking studies. Bioorg Med Chem. 2016 Mar 15;24(6):1392-401. | ||||
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