Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T34471 | Target Info | |||
| Target Name | Arginine carboxypeptidase (CPN1) | ||||
| Synonyms |
Serum carboxypeptidase N; SCPN; Plasma carboxypeptidase N; Lysine carboxypeptidase; Kininase-1; Carboxypeptidase N small subunit; Carboxypeptidase N polypeptide 1; Carboxypeptidase N catalytic chain; CPN; Anaphylatoxin inactivator; ACBP
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| Target Type | Literature-reported Target | ||||
| Gene Name | CPN1 | ||||
| UniProt ID | |||||
| Non Binders of This Target (in total, 10 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chembl4127473
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Investigative | Compound Info | ||
| Synonyms |
BDBM50275212
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| Activity |
IC50 > 380000 nM
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[1] | |||
| Compound Name |
(5R)-5-(3-Aminopropyl)-1-cyclohexyl-6,7-dihydro-4H-benzimidazole-5-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3235134; BDBM50008273
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| Activity |
IC50 > 1000000 nM
|
[2] | |||
| Compound Name |
(7R)-7-(3-Aminopropyl)-3-[3-(2,4-dichlorophenyl)phenyl]-6,8-dihydro-5H-imidazo[1,2-a]pyridine-7-carboxylic acid;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3235140; BDBM50008279
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| Activity |
IC50 > 1000000 nM
|
[2] | |||
| Compound Name |
(7R)-7-(3-Aminopropyl)-3-phenyl-6,8-dihydro-5H-imidazo[1,2-a]pyridine-7-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3235139; BDBM50008278
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| Activity |
IC50 > 1000000 nM
|
[2] | |||
| Compound Name |
(5R)-5-(3-Aminopropyl)-1-(3-methylbutyl)-6,7-dihydro-4H-benzimidazole-5-carboxylic acid;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3235133; BDBM50008272
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| Activity |
IC50 > 1000000 nM
|
[2] | |||
| Compound Name |
(5r)-5-(3-Aminopropyl)-1-Propyl-4,5,6,7-Tetrahydro-1h-Benzimidazole-5-Carboxylic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3235132; BDBM50008271; Q27452862; (5R)-1-Propyl-5-(3-aminopropyl)-4,5,6,7-tetrahydro-1H-benzoimidazole-5-carboxylic acid; 2B8
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| Activity |
IC50 > 1000000 nM
|
[2] | |||
| Compound Name |
5-(3-Aminopropyl)-1-[2-(4-cyclohexylcyclohexyl)ethyl]-6,7-dihydro-4H-benzimidazole-5-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3235136; BDBM50008275
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| Activity |
IC50 > 1000000 nM
|
[2] | |||
| Compound Name |
5-(3-Aminopropyl)-1-phenyl-6,7-dihydro-4H-benzimidazole-5-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3235137; BDBM50008276
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|
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| Activity |
IC50 > 1000000 nM
|
[2] | |||
| Compound Name |
(5R)-5-(3-Aminopropyl)-1-[(3-phenylphenyl)methyl]-6,7-dihydro-4H-benzimidazole-5-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3235135; BDBM50008274
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|
||||
| Activity |
IC50 > 1000000 nM
|
[2] | |||
| Compound Name |
7-(3-Aminopropyl)-3-ethyl-6,8-dihydro-5H-imidazo[1,2-a]pyridine-7-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3235138; BDBM50008277
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| Activity |
IC50 > 1000000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural basis for the selective inhibition of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) by a selenium-containing inhibitor with chloro-aminopyridine as a basic group. Bioorg Med Chem Lett. 2018 Jul 15;28(13):2256-2260. | ||||
| REF 2 | Design and synthesis of conformationally restricted inhibitors of active thrombin activatable fibrinolysis inhibitor (TAFIa). Bioorg Med Chem. 2014 Apr 1;22(7):2261-8. | ||||
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