Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T34287 | Target Info | |||
| Target Name | Candida Mannose-6-phosphate isomerase (Candi PMI1) | ||||
| Synonyms |
Phosphomannose isomerase; Phosphohexomutase; PMI1; PMI
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|
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| Target Type | Successful Target | ||||
| Gene Name | Candi PMI1 | ||||
| Biochemical Class | Intramolecular oxidoreductases | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 4 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-[4-(2,4-Dichloro-phenylamino)-butyrylamino]-indan-2-carboxylic acid amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL306106; BDBM50071527
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
2-[4-(4-Chloro-3-methyl-phenoxy)-butyrylamino]-indan-2-carboxylic acid amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL311282; BDBM50071517
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
2-[4-(2,4-Dichloro-phenoxy)-butyrylamino]-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid amide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL305894; BDBM50071536
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| Activity |
IC50 = 93000 nM
|
[1] | |||
| Compound Name |
4-(2,4-Dichloro-phenoxy)-N-(2-hydroxymethyl-indan-2-yl)-butyramide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL306795; BDBM50071532
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| Activity |
IC50 = 140000 nM
|
[1] | |||
| Non Binders of This Target (in total, 9 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-[4-(2,4-Dichloro-phenoxy)-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid amide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL308117; BDBM50071538
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| Activity |
IC50 > 200000 nM
|
[1] | |||
| Compound Name |
2-[4-(3,4-Dichloro-phenoxy)-butyrylamino]-2,3-dihydro-1H-cyclopenta[b]naphthalene-2-carboxylic acid methyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL72383; BDBM50071524
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| Activity |
IC50 > 200000 nM
|
[1] | |||
| Compound Name |
4-(2,4-Dichloro-phenoxy)-N-indan-2-yl-butyramide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL76058; BDBM50071525
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| Activity |
IC50 > 200000 nM
|
[1] | |||
| Compound Name |
N-(1-Carbamoyl-1-methyl-2-phenyl-ethyl)-4-(2,4-dichloro-phenoxy)-butyramide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77470; BDBM50071537
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| Activity |
IC50 > 200000 nM
|
[1] | |||
| Compound Name |
1-[4-(2,4-Dichloro-phenoxy)-butyrylamino]-cyclopentanecarboxylic acid amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL75415; BDBM50071540
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| Activity |
IC50 > 200000 nM
|
[1] | |||
| Compound Name |
2-[4-(3,4-Dichloro-phenoxy)-butyrylamino]-indan-2,5-dicarboxylic acid dimethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL76042; BDBM50071529
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|
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| Activity |
IC50 > 200000 nM
|
[1] | |||
| Compound Name |
1-[4-(2,4-Dichloro-phenoxy)-butyrylamino]-indan-1-carboxylic acid amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77802; BDBM50071522
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| Activity |
IC50 > 200000 nM
|
[1] | |||
| Compound Name |
2-[4-(3,4-Dichloro-phenoxy)-butyrylamino]-2,3-dihydro-1H-cyclopenta[a]naphthalene-2-carboxylic acid methyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL75028; BDBM50071530
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|
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| Activity |
IC50 > 200000 nM
|
[1] | |||
| Compound Name |
2-[4-(2,4-Dichloro-phenoxy)-butyrylamino]-indan-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL421692; BDBM50071526
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|
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| Activity |
IC50 > 500000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Exploring structure-activity relationships around the phosphomannose isomerase inhibitor AF14049 via combinatorial synthesis. Bioorg Med Chem Lett. 1998 Sep 8;8(17):2303-8. | ||||
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