Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T34234 | Target Info | |||
| Target Name | Vitamin D3 receptor (VDR) | ||||
| Synonyms |
Vitamin D(3) receptor; Nuclear vitamin D receptor; Nuclear receptor subfamily 1 group I member 1; NR1I1; 1,25-dihydroxyvitamin D3 receptor
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| Target Type | Successful Target | ||||
| Gene Name | VDR | ||||
| Biochemical Class | Nuclear hormone receptor | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 134 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chenodiol
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Approved | Compound Info | ||
| Synonyms |
474-25-9; Chenix; Chenic acid; Chenodeoxycholate; Gallodesoxycholic acid; Chendol; Chenodesoxycholic acid; Cdca; Chenofalk; Anthropodeoxycholic acid; Anthropodesoxycholic acid; Anthropododesoxycholic acid; Chenodesoxycholsaeure; Xenbilox; Henohol; Chenique Acid; Chenodiol [USAN]; 3alpha,7alpha-Dihydroxy-5beta-cholan-24-oic acid; Sodium chenodeoxycholate; Acido chenodeoxicholico; Chenodesoxycholsaeure [German]; Acide chenodeoxycholique; 7-alpha-Hydroxylithocholic acid; Acidum chenodeoxycholicum
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Ursodeoxycholic acid
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Approved | Compound Info | ||
| Synonyms |
Actigall; Antigall; Arsacol; Delursan; Destolit; Deursil; Litursol; Lyeton; Peptarom; Solutrat; UDCA; UDCS; UrSO; Urosiol; Ursacol; Ursobilin; Ursochol; Ursodamor; Ursodeoxycholate; Ursodiol; Ursofalk; Ursolvan; Ursosan; Acide ursodesoxycholique; Acido ursodeossicolico; Acido ursodeossicolico [Italian]; Acido ursodeoxicolico; Acidum ursodeoxycholicum; Deoxyursocholic Acid; Sodium Ursodeoxycholate; Ursacholic Acid; Urso DS; Urso Forte; Ursodeoxy cholic acid; Ursodesoxycholicacid; Ursodexycholic Acid; Ursodiol [USAN]; IU5; U0030; Urso 250; Acide ursodesoxycholique [INN-French]; Acido ursodeoxicolico [INN-Spanish]; Acidum ursodeoxycholicum [INN-Latin]; Actigall (TN); Cholit-ursan; Deursil (TN); Dom-ursodiol c; ISO-URSODEOXYCHOLIC ACID; PHL-ursodiol c; PMS-ursodiol c; U-9000; Urso (TN); Urso Forte (TN); Ursodiol (USP); Ursosan (TN); Ursodeoxycholic acid (JP15/INN); Ursodeoxycholic acid, UDCA, Ursosan, Ursofalk, Urso Forte, Udiliv, Ursodiol; Cholan-24-oic acid, 3,7-dihydroxy-, (3-alpha,5-beta,7-beta)-(9CI); (3alpha,5beta,7beta)-3,7-dihydroxycholan-24-oic acid; (3alpha,5beta,7beta,8xi)-3,7-dihydroxycholan-24-oic acid; (4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid; 17-beta-(1-Methyl-3-carboxypropyl)etiocholane-3-alpha,7-beta-diol; 3 alpha,7 beta-Dihydroxy-5 beta-cholan-24-oic Acid; 3,7-Dihydroxycholan-24-oic acid; 3-alpha,7-beta-Dihydroxy-5-beta-cholanoic acid; 3-alpha,7-beta-Dihydroxycholanic acid; 3-alpha,7-beta-Dioxycholanic acid; 3alpha,7beta-Dihydroxy-5beta-cholan-24-oic acid; 3alpha,7beta-Dihydroxy-5beta-cholanic acid; 5beta-Cholan-24-oic acid-3alpha,7beta-diol; 5beta-Cholanic Acid-3alpha,7beta-diol; 7-beta-Hydroxylithocholic acid; 7beta-Hydroxylithocholic acid
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Cholic Acid
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Approved | Compound Info | ||
| Synonyms |
cholic acid; 81-25-4; Cholalic acid; cholate; Cholalin; Colalin; Cholsaeure; NSC-6135; Cholic acid, 5beta-; 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanic acid; 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholan-24-oic acid; UNII-G1JO7801AE; HSDB 982; (R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid; Cholic acid [USAN]; 3,7,12-Trihydroxycholanic acid; G1JO7801AE; CHEMBL205596; CHEBI:16359; NSC6135; BHQCQFFYRZLCQQ-OELDTZBJSA-N
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| Activity |
EC50 ~ 150000 nM
|
[1] | |||
| Compound Name |
ATX-101
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Phase 3 | Compound Info | ||
| Synonyms |
ATX-101, APIM Therapeutics; Proliferating cell nuclear antigen (peptide, cancer), APIM
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Bevacizumab + Trastuzumab
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Phase 3 | Compound Info | ||
| Synonyms |
Lithocholic acid; LITHOCHOLIC ACID; 434-13-9; Lithocolic acid; Lithocholate; 3alpha-Hydroxy-5beta-cholanic acid; 3alpha-Hydroxy-5beta-cholan-24-oic acid; 3-Hydroxycholan-24-oic acid; 3alpha-Hydroxycholanic acid; 3-alpha-Hydroxycholanic acid; 5beta-Cholanic acid-3alpha-ol; NCI-C03861; 3alpha-Hydroxy-5beta-cholanoic acid; (3alpha,5beta)-3-hydroxycholan-24-oic acid; 3-alpha-Hydroxy-5-beta-cholanic acid; CCRIS 363; UNII-5QU0I8393U; 3alpha-Hydroxy-5beta-cholanate; 5-beta-Cholanic acid, 3-alpha-hydroxy-; Cholan-24-oic acid, 3-hydroxy-,
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
taurolithocholic acid-3-sulphate
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Investigative | Compound Info | ||
| Synonyms |
taurolithocholic acid (TLCA); taurolithocholate; lithocholic acid taurine conjugate; lithocholyltaurine
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-4-methylsulfonyl-3-nitrobenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348867; BDBM50431590
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| Activity |
IC50 = 50000 nM
|
[2] | |||
| Compound Name |
5-[3-[4-(3,3-Dimethyl-2-oxobutoxy)-3-methylphenyl]pentan-3-yl]-N-(4-ethoxyphenyl)-1-ethylpyrrole-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3746210; BDBM50500301
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| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
5-[3-[4-(3,3-Dimethyl-2-oxobutoxy)-3-methylphenyl]pentan-3-yl]-1-ethyl-N-[3-(trifluoromethyl)phenyl]pyrrole-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3747559; BDBM50500294
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| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Hyodeoxycholic acid
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Investigative | Compound Info | ||
| Synonyms |
Iodeoxycholic acid; 7-Deoxyhyocholic acid; Hyodesoxycholic acid; 3alpha,6alpha-Dihydroxy-5beta-cholan-24-oic acid; UNII-7A33Y6EHYK; Hyodeoxycholic acid (HDCA); NSC 60672; 6alpha-Hydroxylithocholate; HYODEOXYCHOLIC_ACID; Hyodeoxycholic Acid Sodium Salt; 7A33Y6EHYK; 3alpha,6alpha-Dihydroxy-5beta-cholanoic acid; Hyodesoxycholsaeure; MFCD00003681; Cholan-24-oic acid, 3,6-dihydroxy-, (3a,5b,6a)-; alpha-Hyodeoxycholic acid; 3alpha,6alpha-Dihydroxy-5beta-cholanic acid; 3alpha,6alpha-Dihydroxy-5 beta,cholan-24-oic acid; 6-alpha-Hydroxylithocholic acid; EINECS 201-483-2; 3alpha,6alpha-Dihydroxycholanic acid; BRN 3218394; 5-beta-Cholanic acid-3-alpha,6-alpha-diol; .alpha.-Hyodeoxycholic acid; 3alpha,6alpha-Dihydroxy-5beta-cholan-24-saeure; 3-alpha,6-alpha-Dihydroxy-5-beta-cholan-24-oic acid; Cholan-24-oic acid, 3,6-dihydroxy-, (3alpha,5beta,6alpha)-; Hyodesoxycholsaure; 3.alpha.,6.alpha.-Dihydroxycholanic acid; A-Dihydroxy-5; A-cholan-24-oic acid; 3.alpha.,6.alpha.-Dihydroxy-5.beta.-cholanic acid; 3.alpha.,6.alpha.-Dihydroxy-5.beta.-cholanoic acid; 5-beta-Cholan-24-oic acid, 3-alpha,6-alpha-dihydroxy-; 4-10-00-01600 (Beilstein Handbook Reference); Hyodeoxycholic acid, >=98%; SCHEMBL207643; AHRO-001; CHEMBL272621; Cholan-24-oic acid, 3,6-dihydroxy-, (3.alpha.,5.beta.,6.alpha.)-; 6-.alpha.-Hydroxylithocholic acid; DTXSID001018971; HY-N0169; ZINC3918159; BDBM50375596; LMST04010024; s2311; AKOS022168200; CCG-268566; DB11789; 5beta-Cholanic acid-3alpha,6alpha-diol; SMP1_000164; NCGC00386169-01; AS-14254; AB0014249; CS-0007886; C15517; 003H681; 5-.beta.-Cholanic acid-3-.alpha.,6-.alpha.-diol; Q5957042; W-104141; BRD-K44009692-001-02-3; (3alpha,5beta,6alpha)-3,6-Dihydroxycholan-24-oic acid; 5-Methyl-[1,3,4]oxadiazol-2-ylmethylaminehydrochloride; 5beta-Cholan-24-oic acid, 3alpha,6alpha-dihydroxy- (8CI); 3-.alpha.,6-.alpha.-Dihydroxy-5-.beta.-cholan-24-oic acid; 5.beta.-Cholan-24-oic acid, 3.alpha.,6.alpha.-dihydroxy-; 3,6-Dihydroxy-5.beta.-cholan-24-oic acid, (3.alpha.,6.alpha.)-
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Ethyl 2-[[5-[3-[4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl]pentan-3-yl]-1-ethylpyrrole-2-carbonyl]-methylamino]acetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3745867; BDBM50500271
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| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
5-[3-[4-(3,3-Dimethyl-2-oxobutoxy)-3-methylphenyl]pentan-3-yl]-1-ethyl-N-[4-(trifluoromethoxy)phenyl]pyrrole-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3746622; BDBM50500266
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| Activity |
EC50 ~ 50000 nM
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[3] | |||
| Compound Name |
Sulfolithocholic acid
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Investigative | Compound Info | ||
| Synonyms |
lithocholic acid sulfate; lithocholic acid 3-sulfate; UNII-0ENK5NMI1I; 0ENK5NMI1I; 3a-Sulfooxy-5b-cholanic acid; 3alpha-sulfooxy-5beta-cholan-24-oic acid; CHEMBL260315; (3alpha,5beta)-3-(sulfooxy)cholan-24-oic acid; Lithocholic acid 3-alpha-sulfate; Lithocholic acid, 3-sulfate; SCHEMBL232940; CTK4H2814; Cholan-24-oic acid, 3-(sulfooxy)-, (3a-alpha,5-beta)-; BDBM50375583; LMST05020015; ZINC12494532; (3a,5b)-3-(Sulfooxy)cholan-24-oic acid; Cholan-24-oic acid,3-(sulfooxy)-, (3a,5b)-; Q27116471; 3-Hydroxy-cholan-24-oic acid, 3-sulfate (3-.alpha., 5-.beta.)
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(4-Ethoxy-4-oxobutan-2-yl) 5-[3-[4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl]pentan-3-yl]-1-ethylpyrrole-2-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3746400; BDBM50500300
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| Activity |
EC50 ~ 50000 nM
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[3] | |||
| Compound Name |
Glycolithocholic acid
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Investigative | Compound Info | ||
| Synonyms |
Lithocholylglycine; Glycolithocholate; Lithocholic acid glycine conjugate; UNII-Q53GV75CJG; Q53GV75CJG; N-(3a-hydroxy-5b-cholan-24-oyl)-Glycine; CHEMBL258818; N-((3-alpha,5-beta)-3-Hydroxy-24-oxocholan-24-yl)glycine; Glycine, N-[(3a,5b)-3-hydroxy-24-oxocholan-24-yl]-; lithocholoyglycine; Glykolithocholsaure; Glycolithocholic acid (6CI,7CI); 3a-Hydroxy-5b-cholanic acid glycine ester; Glycine, N-((3alpha,5beta)-3-hydroxy-24-oxocholan-24-yl)-; BIDD:PXR0159; SCHEMBL736797; 3a-Hydroxy-5b-cholanoylglycine; CTK1D6430; DTXSID00963828; Glycine, N-((3-alpha,5-beta)-3-hydroxy-24-oxocholan-24-yl)-; ZINC6036201; N-(3a-Hydroxy-5b-cholanoyl)glycine; BDBM50375588; LMST05030009; PDSP2_001234; Lithocholic acid glycine conjugic acid; AKOS030240641; N-(3,24-Dihydroxycholan-24-ylidene)glycine; C15557; N-(3alpha-hydroxy-5beta-cholan-24-oyl)glycine; N-(3alpha-hydroxy-5beta-cholan-24-oyl)-glycine; 3a-Hydroxy-N-(carboxymethyl)-5b-cholan-24-amide; N-(carboxymethyl)-3a-hydroxy-5b-Cholan-24-amide; 5beta-Cholanic acid-3alpha-ol N-(carboxymethyl)-amide; Q27117337; 3alpha-hydroxy-5beta-cholan-24-oic acid N-(carboxymethyl)amide; Glycine, N-(3-alpha-hydroxy-5-beta-cholan-24-oyl)- (8CI); Lithocholylglycine; Glycholithocholic acid 3 sulfate intermediate
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| Activity |
IC50 ~ 50000 nM
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[1] | |||
| Compound Name |
1-Ethyl-5-[3-[4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl]pentan-3-yl]-N-[4-(trifluoromethoxy)phenyl]pyrrole-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3746263; BDBM50500253
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| Activity |
EC50 ~ 50000 nM
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[3] | |||
| Compound Name |
(4-Ethoxycarbonylphenyl) 1-ethyl-5-[3-[4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl]pentan-3-yl]pyrrole-2-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3747151; BDBM50500296
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| Activity |
EC50 ~ 50000 nM
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[3] | |||
| Compound Name |
Lithocholic acid glucuronide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3763659; Lithocholic acid 3-glucuronide; Lithocholate 3-O-beta-D-glucuronide; LCA-3G; lithocholic acid 3-beta-glucuronide; BDBM50139646; lithocholic acid 3-beta-D-glucuronide; lithocholic acid 3-O-(beta-D-glucuronide); 3alpha-(beta-D-glucopyranuronosyloxy)-5beta-cholan-24-oic acid; 24-hydroxy-24-oxo-5beta-cholan-3alpha-yl beta-D-glucopyranosiduronic acid; 3alpha-hydroxy-5beta-cholan-24-oic acid 3-beta-D-glucopyranuronoside; (3alpha,5beta)-24-hydroxy-24-oxocholan-3-yl beta-D-glucopyranosiduronic acid
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| Activity |
EC50 ~ 50000 nM
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[1] | |||
| Compound Name |
Pyridin-2-ylmethyl 5-[3-[4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl]pentan-3-yl]-1-ethylpyrrole-2-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3746368; BDBM50500277
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| Activity |
EC50 ~ 50000 nM
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[3] | |||
| Compound Name |
Pyridin-2-ylmethyl 1-ethyl-5-[3-[4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl]pentan-3-yl]pyrrole-2-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3745811; BDBM50500299
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| Activity |
EC50 ~ 50000 nM
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[3] | |||
| Compound Name |
1-Ethyl-5-[3-[4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl]pentan-3-yl]-N-[3-(trifluoromethyl)phenyl]pyrrole-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3746693; BDBM50500254
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| Activity |
EC50 ~ 50000 nM
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[3] | |||
| Compound Name |
(4-Fluorophenyl)methyl 1-ethyl-5-[3-[4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl]pentan-3-yl]pyrrole-2-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3747093; BDBM50500257
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| Activity |
EC50 ~ 50000 nM
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[3] | |||
| Compound Name |
(3beta,5beta,9beta)-3-(Acetyloxy)cholan-24-Oic Acid
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Investigative | Compound Info | ||
| Synonyms |
lithocholic acid acetate; CHEMBL272041; Lithocholic acid 3-acetate; ACETYLLITHOCHOLIC ACID; SCHEMBL678540; 3alpha-Acetoxy-5beta-cholanic acid; BDBM50375582; ZINC28536877; 3-(Acetyloxy)cholan-24-oic acid #; 3alpha-acetoxy-5beta-cholan-24-oic acid; Q27462645
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| Activity |
IC50 ~ 50000 nM
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[1] | |||
| Compound Name |
N-[2-[4-(4-Fluorophenyl)piperazin-1-yl]-2-oxoethyl]-4-methylsulfonyl-3-nitrobenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348879; BDBM50431578
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| Activity |
IC50 = 51000 nM
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[2] | |||
| Compound Name |
4-Chloro-N-[(2-methyl-1H-indol-3-yl)(pyridin-4-yl)methyl]aniline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109610; BDBM50446360; STL486627; AKOS000806110; AKOS016089079; MCULE-6718717925
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| Activity |
IC50 = 51500 nM
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[4] | |||
| Compound Name |
4-Chloro-N-[(2-chlorophenyl)-(2-methyl-1H-indol-3-yl)methyl]aniline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2070870; SCHEMBL14742761; BDBM50389856
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| Activity |
IC50 = 54500 nM
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[5] | |||
| Compound Name |
N-[3-(2-Methyl-2,3-dihydroindol-1-yl)-3-oxopropyl]-4-methylsulfonyl-3-nitrobenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348903; BDBM50431554
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| Activity |
IC50 = 55000 nM
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[2] | |||
| Compound Name |
3-[4-[Anilino-(2-methyl-1H-indol-3-yl)methyl]phenyl]propan-1-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2070868; BDBM50389858
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| Activity |
IC50 = 58600 nM
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[5] | |||
| Compound Name |
N-Benzyl-1-(2-chlorophenyl)-1-(2,6-dimethyl-1H-indol-3-yl)methanamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109606; BDBM50446364
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| Activity |
IC50 = 59900 nM
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[4] | |||
| Compound Name |
4-Methylsulfonyl-3-nitro-N-[3-oxo-3-(4-phenylpiperazin-1-yl)propyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348894; BDBM50431563
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| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[2-[(3-Fluorophenyl)methyl-methylamino]-2-oxoethyl]-N-methyl-4-methylsulfonyl-3-nitrobenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349028; BDBM50431528
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| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[4-(4-Methylpiperidin-1-yl)-4-oxobutyl]-4-methylsulfonyl-3-nitrobenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348920; BDBM50431537
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| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[4-[(3-Fluorophenyl)methyl-methylamino]-4-oxobutyl]-4-methylsulfonyl-3-nitrobenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348911; BDBM50431546
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| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[4-(Dibenzylamino)-4-oxobutyl]-4-methylsulfonyl-3-nitrobenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348912; BDBM50431545
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| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-Methyl-N-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]-4-methylsulfonyl-3-nitrobenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349037; BDBM50431614
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| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
[4-(4-Fluorophenyl)piperazin-1-yl]-[1-(4-methylsulfonyl-3-nitrobenzoyl)piperidin-4-yl]methanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349053; BDBM50431598
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| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[2-(4-Methylpiperazin-1-yl)-2-oxoethyl]-4-methylsulfonyl-3-nitrobenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348883; BDBM50431574
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| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
[1-(4-Methylsulfonyl-3-nitrobenzoyl)piperidin-4-yl]-piperidin-1-ylmethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349054; BDBM50431597
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| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[3-(1,3-Dihydroisoindol-2-yl)-3-oxopropyl]-4-methylsulfonyl-3-nitrobenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348902; BDBM50431555
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[2-[Benzyl(methyl)amino]-2-oxoethyl]-N-methyl-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348927; BDBM50431530
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[2-[4-(2-Fluorophenyl)piperazin-1-yl]-2-oxoethyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348878; BDBM50431579
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[2-(Dibenzylamino)-2-oxoethyl]-N-methyl-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349029; BDBM50431527
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-Methyl-4-methylsulfonyl-3-nitro-N-[2-oxo-2-(N-propylanilino)ethyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348926; BDBM50431531
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
4-Methylsulfonyl-3-nitro-N-[4-oxo-4-(4-phenylpiperazin-1-yl)butyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348914; BDBM50431543
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[(3-Fluorophenyl)methyl]-N-methyl-1-(4-methylsulfonyl-3-nitrobenzoyl)piperidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349046; BDBM50431605
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[2-[Di(propan-2-yl)amino]-2-oxoethyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348876; BDBM50431581
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
4-Methylsulfonyl-3-nitro-N-(2-oxo-2-piperidin-1-ylethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348881; BDBM50431576
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
2,3-Dihydroindol-1-yl-[1-(4-methylsulfonyl-3-nitrobenzoyl)piperidin-4-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349056; BDBM50431594
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
1,3-Dihydroisoindol-2-yl-[1-(4-methylsulfonyl-3-nitrobenzoyl)piperidin-4-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349057; BDBM50431593
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
4-Methylsulfonyl-3-nitro-N-[3-oxo-3-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]propyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348898; BDBM50431559
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[3-[4-(4-Methylphenyl)piperazin-1-yl]-3-oxopropyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348895; BDBM50431562
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-Methyl-4-methylsulfonyl-3-nitro-N-(2-oxo-2-piperidin-1-ylethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349036; BDBM50431615
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[4-(1,3-Dihydroisoindol-2-yl)-4-oxobutyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348922; BDBM50431535
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[4-(3,4-Dihydro-1H-isoquinolin-2-yl)-4-oxobutyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348906; BDBM50431551
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[4-[Benzyl(methyl)amino]-4-oxobutyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348909; BDBM50431548
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[3-(2,3-Dihydroindol-1-yl)-3-oxopropyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348901; BDBM50431556
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[2-[Benzyl(methyl)amino]-2-oxoethyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348871; BDBM50431586
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-Benzyl-N-methyl-1-(4-methylsulfonyl-3-nitrobenzoyl)piperidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349044; BDBM50431607
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[2-(Dibenzylamino)-2-oxoethyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348874; BDBM50431583
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[3-[4-(4-Fluorophenyl)piperazin-1-yl]-3-oxopropyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348897; BDBM50431560
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[2-(N-Methylanilino)-2-oxoethyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348868; BDBM50431589
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
4-Methylsulfonyl-3-nitro-N-[2-oxo-2-(N-propylanilino)ethyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348869; BDBM50431588
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
1-(4-Methylsulfonyl-3-nitrobenzoyl)-N,N-di(propan-2-yl)piperidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349049; BDBM50431602
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-Methyl-4-methylsulfonyl-3-nitro-N-[2-oxo-2-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349035; BDBM50431616
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[3-[Di(propan-2-yl)amino]-3-oxopropyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348893; BDBM50431564
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[3-[Benzyl(methyl)amino]-3-oxopropyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348888; BDBM50431569
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N,N-Dibenzyl-1-(4-methylsulfonyl-3-nitrobenzoyl)piperidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349047; BDBM50431604
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[3-(3,4-Dihydro-2H-quinolin-1-yl)-3-oxopropyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348904; BDBM50431553
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[4-(1-Adamantylamino)-4-oxobutyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348905; BDBM50431552
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
4-Methylsulfonyl-3-nitro-N-[2-oxo-2-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348880; BDBM50431577
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[4-[(2-Fluorophenyl)methyl-methylamino]-4-oxobutyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348910; BDBM50431547
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[2-(2,3-Dihydroindol-1-yl)-2-oxoethyl]-N-methyl-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349038; BDBM50431613
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-Methyl-4-methylsulfonyl-3-nitro-N-[2-oxo-2-(4-phenylpiperidin-1-yl)ethyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349030; BDBM50431526
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[2-(1-Adamantylamino)-2-oxoethyl]-N-methyl-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348924; BDBM50431533
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[2-[(2-Fluorophenyl)methyl-methylamino]-2-oxoethyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348872; BDBM50431585
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-Benzyl-1-(4-methylsulfonyl-3-nitrobenzoyl)-N-phenylpiperidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349043; BDBM50431608
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-Methyl-N-[2-(2-methyl-2,3-dihydroindol-1-yl)-2-oxoethyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349040; BDBM50431611
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
[1-(4-Methylsulfonyl-3-nitrobenzoyl)piperidin-4-yl]-(4-phenylpiperazin-1-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349050; BDBM50431601
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
4-Methylsulfonyl-3-nitro-N-(3-oxo-3-piperidin-1-ylpropyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348899; BDBM50431558
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[3-(N-Methylanilino)-3-oxopropyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348886; BDBM50431571
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-Methyl-4-methylsulfonyl-3-nitro-N-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349031; BDBM50431525
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
(4-Methylpiperazin-1-yl)-[1-(4-methylsulfonyl-3-nitrobenzoyl)piperidin-4-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2346688; BDBM50431595
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
4-Methylsulfonyl-3-nitro-N-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348877; BDBM50431580
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[2-[(2-Fluorophenyl)methyl-methylamino]-2-oxoethyl]-N-methyl-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349027; BDBM50431529
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
4-Methylsulfonyl-3-nitro-N-(4-oxo-4-piperidin-1-ylbutyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348919; BDBM50431538
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[(2-Fluorophenyl)methyl]-N-methyl-1-(4-methylsulfonyl-3-nitrobenzoyl)piperidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349045; BDBM50431606
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
[1-(4-Methylsulfonyl-3-nitrobenzoyl)piperidin-4-yl]-(4-phenylpiperidin-1-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349048; BDBM50431603
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[2-[4-(4-Fluorophenyl)piperazin-1-yl]-2-oxoethyl]-N-methyl-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349034; BDBM50431617
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-(1-Adamantyl)-1-(4-methylsulfonyl-3-nitrobenzoyl)piperidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349041; BDBM50431610
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[4-[4-(4-Methylphenyl)piperazin-1-yl]-4-oxobutyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348915; BDBM50431542
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[2-[4-(2-Fluorophenyl)piperazin-1-yl]-2-oxoethyl]-N-methyl-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349033; BDBM50431523
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
4-Methylsulfonyl-3-nitro-N-[4-oxo-4-(N-propylanilino)butyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348908; BDBM50431549
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[2-(N-Benzylanilino)-2-oxoethyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348870; BDBM50431587
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
3,4-Dihydro-1H-isoquinolin-2-yl-[1-(4-methylsulfonyl-3-nitrobenzoyl)piperidin-4-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349042; BDBM50431609
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[3-[(3-Fluorophenyl)methyl-methylamino]-3-oxopropyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348890; BDBM50431567
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[4-(2,3-Dihydroindol-1-yl)-4-oxobutyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348921; BDBM50431536
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-Methyl-N-[2-[4-(4-methylphenyl)piperazin-1-yl]-2-oxoethyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349032; BDBM50431524
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[4-(2-Methyl-2,3-dihydroindol-1-yl)-4-oxobutyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348923; BDBM50431534
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[2-(1-Adamantylamino)-2-oxoethyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348866; BDBM50431591
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[3-[(2-Fluorophenyl)methyl-methylamino]-3-oxopropyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348889; BDBM50431568
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-N-methyl-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348925; BDBM50431532
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[3-(4-Methylpiperidin-1-yl)-3-oxopropyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348900; BDBM50431557
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[2-(4-Methylpiperidin-1-yl)-2-oxoethyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348882; BDBM50431575
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
(2-Methyl-2,3-dihydroindol-1-yl)-[1-(4-methylsulfonyl-3-nitrobenzoyl)piperidin-4-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349058; BDBM50431592
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
4-Methylsulfonyl-3-nitro-N-[4-oxo-4-(4-phenylpiperidin-1-yl)butyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348913; BDBM50431544
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[3-(3,4-Dihydro-1H-isoquinolin-2-yl)-3-oxopropyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348885; BDBM50431572
Click to Show/Hide
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| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl]-N-methyl-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349039; BDBM50431612
Click to Show/Hide
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||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[2-[(3-Fluorophenyl)methyl-methylamino]-2-oxoethyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348873; BDBM50431584
Click to Show/Hide
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||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[4-(N-Methylanilino)-4-oxobutyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348907; BDBM50431550
Click to Show/Hide
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||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
[4-(4-Methylphenyl)piperazin-1-yl]-[1-(4-methylsulfonyl-3-nitrobenzoyl)piperidin-4-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349051; BDBM50431600
Click to Show/Hide
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||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
[4-(2-Fluorophenyl)piperazin-1-yl]-[1-(4-methylsulfonyl-3-nitrobenzoyl)piperidin-4-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349052; BDBM50431599
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
4-Methylsulfonyl-3-nitro-N-[3-oxo-3-(4-phenylpiperidin-1-yl)propyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348892; BDBM50431565
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
(4-Methylpiperidin-1-yl)-[1-(4-methylsulfonyl-3-nitrobenzoyl)piperidin-4-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349055; BDBM50431596
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[4-[4-(2-Fluorophenyl)piperazin-1-yl]-4-oxobutyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348916; BDBM50431541
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
4-Chloro-N-[(2-chlorophenyl)-(6-methoxy-2-methyl-1H-indol-3-yl)methyl]aniline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109602; BDBM50446367
Click to Show/Hide
|
||||
| Activity |
IC50 = 63100 nM
|
[4] | |||
| Compound Name |
N-[4-[4-(4-Fluorophenyl)piperazin-1-yl]-4-oxobutyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348917; BDBM50431540
Click to Show/Hide
|
||||
| Activity |
IC50 = 65000 nM
|
[2] | |||
| Compound Name |
N-[3-[4-(2-Fluorophenyl)piperazin-1-yl]-3-oxopropyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348896; BDBM50431561
Click to Show/Hide
|
||||
| Activity |
IC50 = 66000 nM
|
[2] | |||
| Compound Name |
4-Chloro-N-[(1-methylimidazol-2-yl)-(2-methyl-1H-indol-3-yl)methyl]aniline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109612; BDBM50446375
Click to Show/Hide
|
||||
| Activity |
IC50 = 66800 nM
|
[4] | |||
| Compound Name |
(4S,7S,10S,16S)-16-[[(2S)-2-[[(2S)-2-Acetamido-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-21,22-dihydroxy-13,13-dimethyl-7,10-bis(2-methylpropyl)-6,9,12,15-tetraoxo-1,19-dioxa-5,8,11,14-tetrazacyclotricosane-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3397913; DPI-02; BDBM50062944; J3.509.362A
Click to Show/Hide
|
||||
| Activity |
IC50 = 67000 nM
|
[6] | |||
| Compound Name |
3-[(2-Chlorophenyl)-phenylsulfanylmethyl]-2-methyl-1H-indole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2070879; SCHEMBL14746042; BDBM50389847
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 70000 nM
|
[5] | |||
| Compound Name |
N-[(2-Chlorophenyl)-(1-methylindol-3-yl)methyl]aniline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2070877; SCHEMBL15862002; BDBM50389849
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 70000 nM
|
[5] | |||
| Compound Name |
3,3'-[(2-Chlorophenyl)methanediyl]bis(2-methyl-1H-indole)
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109616; ZINC6588712; BDBM50446374; STL487609; AKOS000809100; MCULE-6549580954
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 75000 nM
|
[4] | |||
| Compound Name |
4-Chloro-N-[(2-methyl-1H-indol-3-yl)(pyridin-3-yl)methyl]aniline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109609; BDBM50446361; STK966524; AKOS000808987; AKOS016074419; MCULE-3315582045; ST45177243; (4-chlorophenyl)[(2-methylindol-3-yl)-3-pyridylmethyl]amine
Click to Show/Hide
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||||
| Activity |
IC50 ~ 75000 nM
|
[4] | |||
| Compound Name |
Chembl4210149
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
BDBM50453451
Click to Show/Hide
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||||
| Activity |
IC50 ~ 80000 nM
|
[7] | |||
| Compound Name |
Chembl4205749
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
BDBM50453453
Click to Show/Hide
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||||
| Activity |
IC50 ~ 80000 nM
|
[7] | |||
| Compound Name |
Chembl4209627
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50453460
Click to Show/Hide
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||||
| Activity |
IC50 ~ 80000 nM
|
[7] | |||
| Compound Name |
Chembl4205247
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50453440
Click to Show/Hide
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||||
| Activity |
IC50 ~ 80000 nM
|
[7] | |||
| Compound Name |
Chembl4203307
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
BDBM50453448
Click to Show/Hide
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||||
| Activity |
IC50 ~ 80000 nM
|
[7] | |||
| Compound Name |
Calcitroic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
UNII-F7KIE52YT0; F7KIE52YT0; 1alpha-Hydroxy-23-carboxytetranorvitamin D; CHEMBL3544529; SCHEMBL1249405; DTXSID60904030; BDBM50139645; LMST03020013; ZINC38791535; C18230; 1alpha-hydroxy-24,25,26,27-tetranorvitamin D3 23-carboxylic acid; (1S,3R,5Z,7E)-1,3-dihydroxy-24-nor-9,10-secochola-5,7,10(19)-trien-23-oic acid; 1alpha,3beta-dihydroxy-9,10-seco-24-nor-5,7,10(19)-cholatrien-23-oic acid
Click to Show/Hide
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||||
| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4214540
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50453452
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-[(2-Chlorophenyl)-(2,6-dimethyl-1H-indol-3-yl)methyl]-2-methoxypyridin-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109619; BDBM50446354
Click to Show/Hide
|
||||
| Activity |
IC50 = 101400 nM
|
[4] | |||
| Compound Name |
N-[1-(2-Methyl-1H-indol-3-yl)ethyl]aniline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2070866; SCHEMBL14746047; BDBM50389861
Click to Show/Hide
|
||||
| Activity |
IC50 = 104800 nM
|
[5] | |||
| Compound Name |
Methyl lithocholate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL260735; NSC63558; 3alpha-Hydroxy-5beta-cholan-24-oic acid Methyl ester; Q63396421; Methyl 3.alpha.-hydroxy-5.beta.-cholanoate; Methyl 3.alpha.-hydroxy-5.beta.-cholan-24-oate; Cholan-24-oic acid, methyl ester, (3.alpha.,5.beta.)-; NSC-63558; NSC 8116; EINECS 215-002-9; NSC 63558; Methyl isolithocholate; Lithocholic acid methyl; SCHEMBL337581; NSC8116; Methyl 3-hydroxycholan-24-oate #; NSC-8116; ZINC4411327; BDBM50375564; NCI60_011892; 5beta-Cholanic acid-3alpha-ol methyl ester; 5beta-Cholan-24-oic acid, 3alpha-hydroxy-, methyl ester (8CI); Cholan-24-oic acid, 3-hydroxy-, methyl ester, (3alpha,5beta)- (9CI)
Click to Show/Hide
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||||
| Activity |
EC50 ~ 150000 nM
|
[1] | |||
| Compound Name |
Lithocholic acid 24-glucuronide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764957; LCA-24G; lithocholic acid 24-glucuronic acid; BDBM50139647; lithocholic acid 24-beta-glucuronide; lithocholic acid 24-beta-D-glucuronide; lithocholic acid 24-O-(beta-D-glucuronide); 1-O-(3alpha-hydroxy-24-oxo-5beta-cholan-24-yl)-beta-D-glucopyranuronic acid; 1-O-[(3alpha,5beta)-3-hydroxy-24-oxocholan-24-yl]-beta-D-glucopyranuronic acid
Click to Show/Hide
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||||
| Activity |
EC50 ~ 150000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 7 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(4S,7S,10S,16S)-16-[[(2S)-2-[[(2S)-2-Amino-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-13,13-dimethyl-7,10-bis(2-methylpropyl)-6,9,12,15-tetraoxo-1,19-dioxa-5,8,11,14-tetrazacyclotricosane-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2409530; BDBM50437736
Click to Show/Hide
|
||||
| Activity |
IC50 = 220000 nM
|
[8] | |||
| Compound Name |
(3R,6S,9S,15S)-15-[[(2S)-2-[[(2S)-2-Amino-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-12,12-dimethyl-6,9-bis(2-methylpropyl)-5,8,11,14-tetraoxo-1,17-dioxa-4,7,10,13-tetrazacyclohenicosane-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2409532; BDBM50437740
Click to Show/Hide
|
||||
| Activity |
IC50 = 430000 nM
|
[8] | |||
| Compound Name |
(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-prop-2-enoxybutanoyl]amino]-2-methylpropanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-prop-2-enoxybutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3397912; BDBM50062945
Click to Show/Hide
|
||||
| Activity |
IC50 = 500000 nM
|
[6] | |||
| Compound Name |
(3S,6S,9S,15S)-15-[[(2S)-2-[[(2S)-2-Amino-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-12,12-dimethyl-6,9-bis(2-methylpropyl)-5,8,11,14-tetraoxo-1,18-dioxa-4,7,10,13-tetrazacyclodocosane-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2409529; BDBM50437737
Click to Show/Hide
|
||||
| Activity |
IC50 = 520000 nM
|
[8] | |||
| Compound Name |
(3R,6S,9S,15R)-15-[[(2S)-2-[[(2S)-2-Amino-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-12,12-dimethyl-6,9-bis(2-methylpropyl)-5,8,11,14-tetraoxo-1,17-dioxa-4,7,10,13-tetrazacyclohenicosane-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2409528; BDBM50437738
Click to Show/Hide
|
||||
| Activity |
IC50 = 600000 nM
|
[8] | |||
| Compound Name |
(3S,6S,9S,15R)-15-[[(2S)-2-[[(2S)-2-Amino-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-12,12-dimethyl-6,9-bis(2-methylpropyl)-5,8,11,14-tetraoxo-1,17-dioxa-4,7,10,13-tetrazacyclohenicosane-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2409527; BDBM50437739
Click to Show/Hide
|
||||
| Activity |
IC50 = 610000 nM
|
[8] | |||
| Compound Name |
(3S,6S,9S,15S)-15-[[(2S)-2-[[(2S)-2-Amino-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-12,12-dimethyl-6,9-bis(2-methylpropyl)-5,8,11,14-tetraoxo-1,17-dioxa-4,7,10,13-tetrazacyclohenicosane-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2409533; BDBM50437741
Click to Show/Hide
|
||||
| Activity |
IC50 = 610000 nM
|
[8] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and evaluation of vitamin D receptor-mediated activities of cholesterol and vitamin D metabolites. Eur J Med Chem. 2016 Feb 15;109:238-46. | ||||
| REF 2 | Synthesis and evaluation of methylsulfonylnitrobenzamides (MSNBAs) as inhibitors of the thyroid hormone receptor-coactivator interaction. Bioorg Med Chem Lett. 2013 Mar 15;23(6):1891-5. | ||||
| REF 3 | Novel nonsecosteroidal VDR ligands with phenyl-pyrrolyl pentane skeleton for cancer therapy. Eur J Med Chem. 2016 Jan 1;107:48-62. | ||||
| REF 4 | Development of novel Vitamin D Receptor-Coactivator Inhibitors. ACS Med Chem Lett. 2014 Feb 13;5(2):199-204. | ||||
| REF 5 | Discovery of the first irreversible small molecule inhibitors of the interaction between the vitamin D receptor and coactivators. J Med Chem. 2012 May 24;55(10):4640-51. | ||||
| REF 6 | Structural development of stapled short helical peptides as vitamin D receptor (VDR)-coactivator interaction inhibitors. Bioorg Med Chem. 2015 Mar 1;23(5):1055-61. | ||||
| REF 7 | Novel VDR antagonists based on the GW0742 scaffold. Bioorg Med Chem Lett. 2018 Feb 1;28(3):351-354. | ||||
| REF 8 | Development of stapled short helical peptides capable of inhibiting vitamin D receptor (VDR)-coactivator interactions. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4292-6. | ||||
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