Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T33902 | Target Info | |||
| Target Name | Uracil nucleotide/cysteinyl leukotriene receptor (GPR17) | ||||
| Synonyms |
UDP/CysLT receptor; R12; G-protein coupled receptor 17
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| Target Type | Literature-reported Target | ||||
| Gene Name | GPR17 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 8 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-(2-Carboxyethyl)-4,6-dichloro-5-fluoro-1H-indole-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3132883; SCHEMBL14739207
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| Activity |
EC50 = 52000 nM
|
[1] | |||
| Compound Name |
Chembl4216104
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL14739118; BDBM50458847; 3-(2-carboxyethyl)-6,7-dichloro-1H-indole-2-carboxylic acid
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4211988
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Investigative | Compound Info | ||
| Synonyms |
BDBM50458845
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-Carboxy-4,6-dimethoxy-1H-indole-3-propionic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL50976; SCHEMBL9186020; 3-(2-carboxyethyl)-4,6-dimethoxy-1H-indole-2-carboxylic acid
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4210182
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL14739513; BDBM50458877; 3-(2-carboxyethyl)-7-fluoro-6-thiophen-2-yl-1H-indole-2-carboxylic acid
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-Carboxy-6-methoxy-1H-indole-3-propionic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL298929; SCHEMBL9186531; BDBM50458846; 3-(2-carboxyethyl)-6-methoxy-1H-indole-2-carboxylic acid
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4213645
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL14738959; BDBM50458868; 3-(2-carboxyethyl)-7-fluoro-6-(4-fluorophenyl)-1H-indole-2-carboxylic acid
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4209250
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Investigative | Compound Info | ||
| Synonyms |
BDBM50458852
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Improved synthesis of 4-/6-substituted 2-carboxy-1H-indole-3-propionic acid derivatives and structure-activity relationships as GPR17 agonists. Medchemcomm. 2014;5:86-92. | ||||
| REF 2 | 3-(2-Carboxyethyl)indole-2-carboxylic Acid Derivatives: Structural Requirements and Properties of Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17. J Med Chem. 2018 Sep 27;61(18):8136-8154. | ||||
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