Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T32780 | Target Info | |||
| Target Name | Asialoglycoprotein receptor 1 (ASGR1) | ||||
| Synonyms |
Hepatic lectin H1; HL-1; C-type lectin domain family 4 member H1
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| Target Type | Clinical trial Target | ||||
| Gene Name | ASGR1 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 1 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
D-Galactosamine pentaacetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL610736; D-Galactopyranose, 2-(acetylamino)-2-deoxy-, 1,3,4,6-tetraacetate; 2-Acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-D-galactopyranose; [(2R,3R,4R,5R)-5-acetamido-3,4,6-triacetyloxyoxan-2-yl]methyl acetate; SCHEMBL11223742; 2-Acetamido-2-deoxy-D-galactopyranose-1,3,4,6-tetra-O-acetate; KS-00000G0I; BDBM50304486; CA0197; KM1760; MFCD00050926; AKOS016010524; AS-11050; AB0008617; 375G605; W-203745; 2-Acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy- D-galactopyranose; 2-Acetylamino-1,3,4,6-tetra-O-acetyl-2-deoxy-D-galactopyranose
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| Activity |
IC50 = 113000 nM
|
[1] | |||
| Non Binders of This Target (in total, 4 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Beta-D-Glucose
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Investigative | Compound Info | ||
| Synonyms |
beta-D-glucose; beta-D-glucopyranose; 492-61-5; glucoside; b-D-Glucopyranose; beta-glucose; beta-Dextrose; b-Glucose; b-d-glucose; UNII-J4R00M814D; 28905-12-6; .beta.-D-Glucopyranose; 9001-37-0; (2R,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol; CHEMBL1614854; CHEBI:15903; WQZGKKKJIJFFOK-VFUOTHLCSA-N; J4R00M814D; Curdlan; (2R,3R,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol; .beta.-D-Glucose; BGC; ZYMOSAN; Glucose, (beta-D)-Isomer; Callose; b-Dextrose; beta-D-Glucopyranose, anhydrous
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| Activity |
IC50 > 30000000 nM
|
[1] | |||
| Compound Name |
beta-D-Galactose
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Investigative | Compound Info | ||
| Synonyms |
beta-D-galactopyranose; beta-Galactose; beta-D-Gal; Gal-beta; UNII-RQ6K52J67A; beta-D-Galactoside; CHEMBL300520; RQ6K52J67A; (2R,3R,4S,5R,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol; Galactopyranose, beta-D-; betaGal; delta-Galactose; b-Galactose; beta-Gal; Galactitol,1,5-anhydro-1-C-phenyl-; b-D-Galactose; Beta D-Galactose; beta-D-galactosides; beta-delta-galactoside; I(2)-D-Galactose; beta-delta-galactosides; beta-aD-aGalactopyranose; 6-(hydroxymethyl)tetrahydropyran-2,3,4,5-tetraol; Epitope ID:136044; SCHEMBL42465; (2R,3R,4S,5R,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol; CTK5D7169; DTXSID001015884; ZINC2597049; BDBM50077229; AKOS030242895; C00962; Q27103248; (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)oxane-2,3,4,5-tetraol; (2R,3R,4S,5R,6R)-6-(hydroxymethyl)tetrahydropyran-2,3,4,5-tetrol
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| Activity |
IC50 = 1049000 nM
|
[1] | |||
| Compound Name |
(2R,3R,4S,5S,6R)-2,3,4,5-Tetramethoxy-6-(methoxymethyl)tetrahydro-2H-pyran
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL595499; SCHEMBL15281431; BDBM50304487; .beta.-D-Galactopyranoside, permethylated; 1-O,2-O,3-O,4-O,6-O-Pentamethyl-beta-D-galactopyranose
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| Activity |
IC50 = 1828000 nM
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[1] | |||
| Compound Name |
alpha-D-Galactopyranoside, methyl 2,3,4,6-tetra-O-methyl-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL594347; Methyl 2,3,4,6-tetra-O-methylhexopyranoside #; SCHEMBL7151360; .alpha.-D-Galactopyranoside, methyl 2,3,4,6-tetra-O-methyl-; Galactopyranoside, methyl 2,3,4,6-tetra-O-methyl-, .alpha.-D-; BDBM50304488; methyl 2,3,4,6-tetra-O-methyl-alpha-d-galactopyranoside; 1-O,2-O,3-O,4-O,6-O-Pentamethyl-alpha-D-galactopyranose; Methyl D-galactoside, 2,3,4,6-tetra-O-methyl (pyranoside); (2S,3R,4S,5S,6R)-2,3,4,5-tetramethoxy-6-(methoxymethyl)tetrahydro-2H-pyran
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| Activity |
IC50 = 2831000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design, synthesis and evaluation of monovalent ligands for the asialoglycoprotein receptor (ASGP-R). Bioorg Med Chem. 2009 Oct 15;17(20):7254-64. | ||||
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