Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T31479 | Target Info | |||
| Target Name | Phospholipase A2 (PLA2G1B) | ||||
| Synonyms |
Secreted phospholipase A(2); Phosphatidylcholine 2-acylhydrolase 1B; PLA2G1B; Group IB phospholipase A2
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| Target Type | Successful Target | ||||
| Gene Name | PLA2G1B | ||||
| Biochemical Class | Carboxylic ester hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 14 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-Benzyl-8-(methoxycarbonylmethyl-amino)-2-methyl-indolizine-1-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL121668; BDBM50053159
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-[[1-[1,2-Dioxo-2-(dimethylamino)ethyl]-2-ethyl-3-benzylindolizin-8-yl]oxy]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL121818; BDBM50053164; (3-Benzyl-1-dimethylaminooxalyl-2-ethyl-indolizin-8-yloxy)-acetic acid
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-[[1-[1,2-Dioxo-2-(methylamino)ethyl]-2-ethyl-3-benzylindolizin-8-yl]oxy]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL121284; BDBM50053134; (3-Benzyl-2-ethyl-1-methylaminooxalyl-indolizin-8-yloxy)-acetic acid
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-Cyclohexylmethyl-8-(methoxycarbonylmethyl-amino)-2-methyl-indolizine-1-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL120389; BDBM50053168
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-[3-Biphenyl-2-ylmethyl-2-ethyl-8-(quinolin-2-ylmethoxy)-indolizin-1-yl]-2-oxo-acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL331067; BDBM50053121; alpha-Oxo-2-ethyl-3-[(1,1'-biphenyl-2-yl)methyl]-8-[(2-quinolyl)methoxy]indolizine-1-acetamide
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| Activity |
IC50 = 55000 nM
|
[1] | |||
| Compound Name |
2-[[(3Z)-1-(2-Amino-2-oxoethyl)-3-[(2,3-dichlorophenyl)methylidene]-2-ethyl-2H-indolizin-8-yl]oxy]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL121424; BDBM50053148
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| Activity |
IC50 = 67000 nM
|
[1] | |||
| Compound Name |
2-[[(3Z)-1-(2-Amino-2-oxoethyl)-2-ethyl-3-[(2-phenylphenyl)methylidene]-2H-indolizin-8-yl]oxy]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL333881; BDBM50053151
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-(Carbamoylcarbonyl)-1-benzyl-2-methyl-1H-indole-4-propionic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL149779; SCHEMBL8502130; BDBM50055376; 3-(3-Aminooxalyl-1-benzyl-2-methyl-1H-indol-4-yl)-propionic acid
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-[4-(3-Phenylmethoxy-2-tetradecoxypropoxy)phenyl]-4H-1,2,4-oxadiazol-5-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL223233; BDBM50206904; (+/-)-1-O-benzyl-3-O-[4-(4,5-dihydro-5-oxo-1,2,4-4H-oxadiazol-3-yl)phenyl]-2-Otetradecylglycerol
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(E)-3-(3-Aminooxalyl-1-benzyl-2-methyl-1H-indol-4-yl)-acrylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL149271; SCHEMBL13484804; BDBM50055392
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-[[(3Z)-1-(2-Amino-2-oxoethyl)-2-ethyl-3-(naphthalen-1-ylmethylidene)-2H-indolizin-8-yl]oxy]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL420896; BDBM50053111
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| Activity |
IC50 = 130000 nM
|
[1] | |||
| Compound Name |
2-[[(3Z)-1-(2-Amino-2-oxoethyl)-3-benzylidene-2-ethyl-2H-indolizin-8-yl]oxy]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL333301; BDBM50053117; {1-Carbamoylmethyl-2-ethyl-3-[1-phenyl-meth-(Z)-ylidene]-2,3-dihydro-indolizin-8-yloxy}-acetic acid
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| Activity |
IC50 = 160000 nM
|
[1] | |||
| Compound Name |
2-[[(3Z)-1-(2-Amino-2-oxoethyl)-2-ethyl-3-(naphthalen-2-ylmethylidene)-2H-indolizin-8-yl]oxy]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL121899; BDBM50053099
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|
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| Activity |
IC50 = 170000 nM
|
[1] | |||
| Compound Name |
2-[[(3Z)-1-(2-Amino-2-oxoethyl)-3-[(3-chlorophenyl)methylidene]-2-ethyl-2H-indolizin-8-yl]oxy]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL434216; BDBM50053162
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|
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| Activity |
IC50 = 200000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 28 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-[[(3Z)-1-(2-Amino-2-oxoethyl)-2-ethyl-3-[[3-(trifluoromethyl)phenyl]methylidene]-2H-indolizin-8-yl]oxy]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL119718; BDBM50053167
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|
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| Activity |
IC50 = 240000 nM
|
[1] | |||
| Compound Name |
2-[[(3Z)-3-[(2-Benzylphenyl)methylidene]-1-carbamoyl-2-ethyl-2H-indolizin-8-yl]oxy]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL120733; BDBM50053150
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|
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| Activity |
IC50 = 400000 nM
|
[1] | |||
| Compound Name |
2-[[(3Z)-3-Benzylidene-1-carbamoyl-2-methyl-2H-indolizin-8-yl]oxy]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL331296; BDBM50053107; {1-Carbamoyl-2-methyl-3-[1-phenyl-meth-(Z)-ylidene]-2,3-dihydro-indolizin-8-yloxy}-acetic acid
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| Activity |
IC50 = 420000 nM
|
[1] | |||
| Compound Name |
4-[[(3Z)-1-(2-Amino-2-oxoethyl)-3-benzylidene-2-methyl-2H-indolizin-8-yl]oxy]butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL120879; BDBM50053129
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|
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| Activity |
IC50 = 910000 nM
|
[1] | |||
| Compound Name |
Bis[3-[[4-[(4-carboxy-3-methoxy-2,5,6-trimethylphenoxy)carbonyl]-3-methoxy-2,5,6-trimethylphenoxy]carbonyl]-4-methoxyphenyl] ether
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL409657; BDBM50055431
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|
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| Activity |
IC50 = 6500000 nM
|
[4] | |||
| Compound Name |
4-[4-[5-[3-[4-(4-Carboxy-3-methoxy-2,5,6-trimethylphenoxy)carbonyl-3-methoxy-2,5,6-trimethylphenoxy]carbonyl-4-methoxy-5-methylphenoxy]-2,4-dimethoxybenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL384003; BDBM50055422
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|
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| Activity |
IC50 = 6600000 nM
|
[4] | |||
| Compound Name |
Bis[3-[[4-[(4-carboxy-3-methoxy-2,5,6-trimethylphenoxy)carbonyl]-3-methoxy-2,5,6-trimethylphenoxy]carbonyl]-4-methoxyphenyl] sulfone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL406814; SCHEMBL8855718; BDBM50055420
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|
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| Activity |
IC50 = 9000000 nM
|
[4] | |||
| Compound Name |
4-[4-[2,4-Dihydroxy-3,6-dimethyl-5-[[(2-oxo-2-phenylmethoxyethyl)amino]methyl]benzoyl]oxy-2-hydroxy-3,5,6-trimethylbenzoyl]oxy-2-hydroxy-3,5,6-trimethylbenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3706743
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|
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| Activity |
IC50 = 10000000 nM
|
[4] | |||
| Compound Name |
Bis[3-[[4-[(4-carboxy-3-methoxy-2,5,6-trimethylphenoxy)carbonyl]-3-methoxy-2,5,6-trimethylphenoxy]carbonyl]-4-methoxyphenyl] sulfoxide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL428448; SCHEMBL8855600; BDBM50055426
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|
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| Activity |
IC50 = 11000000 nM
|
[4] | |||
| Compound Name |
(3-Benzyl-1-carbamoylmethyl-2-methyl-2,3-dihydro-indolizin-8-yloxy)-acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL332761; BDBM50053100
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|
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| Activity |
IC50 = 12000000 nM
|
[1] | |||
| Compound Name |
4-(3-Benzyl-1-carbamoylmethyl-2-methyl-2,3-dihydro-indolizin-8-yloxy)-butyric acid methyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL121383; BDBM50053169
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|
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| Activity |
IC50 = 15000000 nM
|
[1] | |||
| Compound Name |
4-[4-[3-[[5-[4-(4-Carboxy-3-methoxy-2,5,6-trimethylphenoxy)carbonyl-3-methoxy-2,5,6-trimethylphenoxy]carbonyl-2,4-dihydroxy-3,6-dimethylphenyl]methyl]-2,4-dihydroxy-6-methylbenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL384002; BDBM50055413
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|
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| Activity |
IC50 = 18000000 nM
|
[4] | |||
| Compound Name |
Bis[3-[[4-[(4-carboxy-3-methoxy-2,5,6-trimethylphenoxy)carbonyl]-3-methoxy-2,5,6-trimethylphenoxy]carbonyl]-4-methoxyphenyl] sulfide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL264973; SCHEMBL9057347; BDBM50055433
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|
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| Activity |
IC50 = 55000000 nM
|
[4] | |||
| Compound Name |
4-[4-[2,4-Dihydroxy-3,6-dimethyl-5-[[[(1S)-1-phenylethyl]amino]methyl]benzoyl]oxy-2-hydroxy-3,5,6-trimethylbenzoyl]oxy-2-hydroxy-3,5,6-trimethylbenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3706745
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| Activity |
IC50 = 60000000 nM
|
[4] | |||
| Compound Name |
Succinic acid bis[4-[(4-carboxy-3-methoxy-2,5,6-trimethylphenoxy)carbonyl]-3-methoxy-2,5,6-trimethylphenyl] ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL146849; SCHEMBL8855515; BDBM50055424
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| Activity |
IC50 = 60000000 nM
|
[4] | |||
| Compound Name |
4-[5-[[5-(4-Carboxy-3-methoxy-2,5,6-trimethylphenoxy)carbonyl-2,4-dimethoxy-3,6-dimethylphenyl]methyl]-2,4-dimethoxy-3,6-dimethylbenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL341607; BDBM50055415; Bis[5-[(4-carboxy-3-methoxy-2,5,6-trimethylphenoxy)carbonyl]2,4-dimethoxy-36-dimethylphenyl]methane
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| Activity |
IC50 = 90000000 nM
|
[4] | |||
| Compound Name |
4-[4-[2,4-Dihydroxy-3,6-dimethyl-5-[(1-phenylethylamino)methyl]benzoyl]oxy-2-hydroxy-3,5,6-trimethylbenzoyl]oxy-2-hydroxy-3,5,6-trimethylbenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3085276; BDBM50055412
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|
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| Activity |
IC50 = 98000000 nM
|
[4] | |||
| Compound Name |
4-[4-[5-[[5-[4-(4-Carboxy-3-hydroxy-2,5,6-trimethylphenoxy)carbonyl-3-hydroxy-2,5,6-trimethylphenoxy]carbonyl-2,4-dihydroxy-3,6-dimethylphenyl]methyl]-2,4-dihydroxy-3,6-dimethylbenzoyl]oxy-2-hydroxy-3,5,6-trimethylbenzoyl]oxy-2-hydroxy-3,5,6-trimethylbenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL9043305; CHEMBL3706744
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| Activity |
IC50 > 100000000 nM
|
[4] | |||
| Compound Name |
4-[4-[5-[[5-[4-(4-Carboxy-3-methoxy-2,5,6-trimethylphenoxy)carbonyl-3-methoxy-2,5,6-trimethylphenoxy]carbonyl-2,4-dimethoxy-3,6-dimethylphenyl]methyl]-2,4-dimethoxy-3,6-dimethylbenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL8855442; CHEMBL3706742
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| Activity |
IC50 > 100000000 nM
|
[4] | |||
| Compound Name |
Bis[3-[(4-carboxy-3-methoxy-2,5,6-trimethylphenoxy)-carbonyl]-4-methoxyphenyl]ether
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL436619; SCHEMBL8855399; BDBM50055416
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| Activity |
IC50 > 100000000 nM
|
[4] | |||
| Compound Name |
Bis[3-[[4-[(4-carboxy-3-methoxy-2,5,6-trimethylphenoxy)-carbonyl]-4-methoxyphenyl]sulfide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL433939; SCHEMBL8855388; BDBM50055425
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| Activity |
IC50 > 100000000 nM
|
[4] | |||
| Compound Name |
2-Methoxy-4-[2-methoxy-4-[2-methoxy-5-(4-methoxyphenyl)sulfanylbenzoyl]oxy-3,5,6-trimethylbenzoyl]oxy-3,5,6-trimethylbenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL345972; BDBM50055428
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|
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| Activity |
IC50 = 100000000 nM
|
[4] | |||
| Compound Name |
Isophthalic acid bis[4-[(4-carboxy-3-methoxy-2,5,6-trimethylphenoxy)carbonyl]-3-methoxy-2,5,6-trimethylphenyl] ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL358582; BDBM50055419
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|
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| Activity |
IC50 > 100000000 nM
|
[4] | |||
| Compound Name |
4-[4-[6-[4-(4-Carboxy-3-methoxy-2,5,6-trimethylphenoxy)carbonyl-3-methoxy-2,5,6-trimethylphenoxy]carbonyl-4-oxopyran-2-carbonyl]oxy-2-methoxy-3,5,6-trimethylbenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL348303; BDBM50055418
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| Activity |
IC50 = 100000000 nM
|
[4] | |||
| Compound Name |
4-[4-[5-[3-[4-[4-(2,2-Dimethylpropanoyloxymethoxycarbonyl)-3-methoxy-2,5,6-trimethylphenoxy]carbonyl-3-methoxy-2,5,6-trimethylphenoxy]carbonyl-4-methoxyphenyl]sulfanyl-2-methoxybenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL406947; BDBM50055421
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|
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| Activity |
IC50 > 100000000 nM
|
[4] | |||
| Compound Name |
4-[4-[5-[(2,4-Dimethoxy-3,6-dimethylphenyl)methyl]-2,4-dimethoxy-3,6-dimethylbenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3706746
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|
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| Activity |
IC50 > 100000000 nM
|
[4] | |||
| Compound Name |
Fumaric acid bis[4-[(4-carboxy-3-methoxy-2,5,6-trimethylphenoxy)carbonyl]-3-methoxy-2,5,6-trimethylphenyl] ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL357772; SCHEMBL8855414; BDBM50055414
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|
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| Activity |
IC50 > 100000000 nM
|
[4] | |||
| Compound Name |
Thielocin A1
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL407586; BDBM50055417
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|
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| Activity |
IC50 = 135000000 nM
|
[4] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Potent inhibitors of secretory phospholipase A2: synthesis and inhibitory activities of indolizine and indene derivatives. J Med Chem. 1996 Sep 13;39(19):3636-58. | ||||
| REF 2 | Indole inhibitors of human nonpancreatic secretory phospholipase A2. 3. Indole-3-glyoxamides. J Med Chem. 1996 Dec 20;39(26):5159-75. | ||||
| REF 3 | Inhibition of secreted phospholipase A2. 4-glycerol derivatives of 4,5-dihydro-3-(4-tetradecyloxybenzyl)-1,2,4-4H-oxadiazol-5-one with broad activities. J Med Chem. 2007 Apr 5;50(7):1618-26. | ||||
| REF 4 | Synthesis and phospholipase A2 inhibitory activity of thielocin B3 derivatives. J Med Chem. 1996 Dec 20;39(26):5183-91. | ||||
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