Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T30985 | Target Info | |||
| Target Name | Histamine H2 receptor (H2R) | ||||
| Synonyms |
Histamine receptor 2; HH2R; Gastric receptor I
Click to Show/Hide
|
||||
| Target Type | Successful Target | ||||
| Gene Name | HRH2 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 28 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Ergotidine
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Eramin; Ergamine; Histamine; Histaminum; Istamina; Theramine; Free histamine; Histamine Base; Histamine [USAN]; Istamina [Italian]; H7125_SIGMA; [3H]histamine; ALBB-005968; Beta-Aminoethylglyoxaline; Beta-Aminoethylimidazole; Beta-aminothethylglyoxaline; Histamine (DCF); Histamine, Free Base; Histaminum (TN); L-histamine; ZERO/004089; Imidazole-4-ethylamine; Beta-Imidazolyl-4-ethylamine; F411C768-A159-4FC0-A195-291A08BB03AA; 1H-Imidazole-4-ethanamine; 1H-Imidazole-5-ethanamine; 2-(1H-Imidazol-4-yl)ethanamine; 2-(1H-imidazol-4-yl)ethan-1-amine; 2-(1H-imidazol-5-yl)ethanamine; 2-(3H-Imidazol-4-yl)-ethylamine; 2-(4-Imidazolyl)ethylamine; 2-Imidazol-4-ylethylamine; 2-[4-Imidazolyl]ethylamine; 4-(2-Aminoethyl)-1H-imidazole; 4-Imidazoleethylamine; 5-Imidazoleethylamine
Click to Show/Hide
|
||||
| Activity |
Ki = 50118.72 nM
|
[1] | |||
| Compound Name |
A-304121
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
A304121; A 304121
Click to Show/Hide
|
||||
| Activity |
Ki = 70794.58 nM
|
[2] | |||
| Compound Name |
1-{4-[3-((S)-3-Amino-pyrrolidin-1-yl)-propoxy]-phenyl}-ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL319231; BDBM50119696; 4'-[3-[(3S)-3beta-Aminopyrrolizino]propoxy]acetophenone
Click to Show/Hide
|
||||
| Activity |
Ki = 50000 nM
|
[3] | |||
| Compound Name |
Tert-butyl (2R)-2-[4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazine-1-carbonyl]pyrrolidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64120; BDBM50220451
Click to Show/Hide
|
||||
| Activity |
Ki = 50118.72 nM
|
[2] | |||
| Compound Name |
Cyclopropyl(4-(3-(4-((2r)-2-(isopropylamino)propanoyl)-1-piperazinyl)propoxy)phenyl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL304888; SCHEMBL7245321; BDBM50220460
Click to Show/Hide
|
||||
| Activity |
Ki = 50118.72 nM
|
[2] | |||
| Compound Name |
Cyclopropyl-[4-[3-[4-[(2R)-pyrrolidine-2-carbonyl]piperazin-1-yl]propoxy]phenyl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64461; BDBM50220442
Click to Show/Hide
|
||||
| Activity |
Ki = 53703.18 nM
|
[2] | |||
| Compound Name |
N,N-Dimethyl-4-[1-oxo-2-(2-pyrrolidin-1-ylethyl)-3,4-dihydroisoquinolin-6-yl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2031874; SCHEMBL3808157; BDBM50383153
Click to Show/Hide
|
||||
| Activity |
Ki ~ 55000 nM
|
[4] | |||
| Compound Name |
4-[3-(4-Propionylphenoxy)propyl]-1-piperazinecarboxylic acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL62066; BDBM50220142
Click to Show/Hide
|
||||
| Activity |
Ki = 56234.13 nM
|
[5] | |||
| Compound Name |
4-[3-[4-(4-Pyridinyl)phenoxy]propyl]piperazine-1-carboxylic acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL419912
Click to Show/Hide
|
||||
| Activity |
Ki = 57543.99 nM
|
[6] | |||
| Compound Name |
(2R)-2-Amino-1-[4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]-4,4-dimethylpentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL59931; SCHEMBL7245253; BDBM50220438
Click to Show/Hide
|
||||
| Activity |
Ki = 57543.99 nM
|
[2] | |||
| Compound Name |
1-[4-[3-[4-(Pyridine-3-carbonyl)piperazin-1-yl]propoxy]phenyl]hexan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL418658; BDBM50220406
Click to Show/Hide
|
||||
| Activity |
Ki = 60255.96 nM
|
[5] | |||
| Compound Name |
(2R)-2-Amino-1-[4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]pentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL291821; BDBM50220434
Click to Show/Hide
|
||||
| Activity |
Ki = 60255.96 nM
|
[2] | |||
| Compound Name |
4'-(3-Pyrrolizinopropoxy)biphenyl-4-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL25688
Click to Show/Hide
|
||||
| Activity |
Ki = 67608.3 nM
|
[6] | |||
| Compound Name |
Ethyl 4-[3-[4-(1H-imidazol-5-yl)phenoxy]propyl]piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL104947
Click to Show/Hide
|
||||
| Activity |
Ki = 69183.1 nM
|
[6] | |||
| Compound Name |
Ethyl 4-[3-[4-(3-methylbutanoyl)phenoxy]propyl]piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL61231; BDBM50220107
Click to Show/Hide
|
||||
| Activity |
Ki = 69183.1 nM
|
[5] | |||
| Compound Name |
(3R)-3-Amino-4-[4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]-4-oxobutanenitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64124; BDBM50220454
Click to Show/Hide
|
||||
| Activity |
Ki = 72443.6 nM
|
[2] | |||
| Compound Name |
Ethyl 4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL62948; BDBM50220403
Click to Show/Hide
|
||||
| Activity |
Ki = 79432.82 nM
|
[5] | |||
| Compound Name |
1-[4-[3-[4-(Cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]-2-(methylamino)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL60401; BDBM50220422
Click to Show/Hide
|
||||
| Activity |
Ki = 79432.82 nM
|
[2] | |||
| Compound Name |
1-[4-[3-[4-(Methylsulfonyl)piperazino]propoxy]phenyl]-1-hexanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL431172; BDBM50220103
Click to Show/Hide
|
||||
| Activity |
Ki = 83176.38 nM
|
[5] | |||
| Compound Name |
4-[3-[4-[N-(Tert-Butoxycarbonyl)-D-alanyl]piperazino]propoxy]phenylcyclopropyl ketone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64406; BDBM50220417
Click to Show/Hide
|
||||
| Activity |
Ki = 83176.38 nM
|
[2] | |||
| Compound Name |
1-[4-[3-[4-(Cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]-2-[(2R)-pyrrolidin-2-yl]ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL60435; BDBM50220433
Click to Show/Hide
|
||||
| Activity |
Ki = 89125.09 nM
|
[2] | |||
| Compound Name |
(2R)-2-Amino-1-[4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]-3-(1H-imidazol-5-yl)propan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL61792; BDBM50220437
Click to Show/Hide
|
||||
| Activity |
Ki = 89125.09 nM
|
[2] | |||
| Compound Name |
(2R)-2-Amino-1-[4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]-3-(1,3-thiazol-2-yl)propan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL59733; BDBM50220461
Click to Show/Hide
|
||||
| Activity |
Ki = 97723.72 nM
|
[2] | |||
| Compound Name |
4-[3-[4-(3-Thienyl)phenoxy]propyl]piperazine-1-carboxylic acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL105567
Click to Show/Hide
|
||||
| Activity |
Ki = 97723.72 nM
|
[6] | |||
| Compound Name |
(2R)-2-Amino-1-[4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL302829; SCHEMBL7253301; BDBM50220430
Click to Show/Hide
|
||||
| Activity |
Ki = 100000 nM
|
[2] | |||
| Compound Name |
4-[3-(4'-Methoxy-4-biphenylyloxy)propyl]piperazine-1-carboxylic acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL105483
Click to Show/Hide
|
||||
| Activity |
Ki = 100000 nM
|
[6] | |||
| Compound Name |
(1-{(S)-1-[3-(4-Acetyl-phenoxy)-propyl]-pyrrolidin-3-ylcarbamoyl}-2-hydroxy-ethyl)-carbamic acid tert-butyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL102390; BDBM50119700
Click to Show/Hide
|
||||
| Activity |
Ki = 100000 nM
|
[3] | |||
| Compound Name |
4-[3-(4-beta-Alanylpiperazino)propoxy]phenylcyclopropyl ketone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL61120; BDBM50220468; L021800
Click to Show/Hide
|
||||
| Activity |
Ki = 100000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 6 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
imbutamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Imbutamine; 4-(1H-imidazol-5-yl)butan-1-amine; 40546-47-2; 1H-Imidazole-4-butanamine; imidazole-4-butanamine; 4-(4-aminobutyl)imidazole; CHEMBL90019; GTPL1249; SCHEMBL3885328; CTK8I6140; BDBM22907; DTXSID90542303; 4-(1H-imidazol-4-yl)butanamine; VJSUMPPMFYQOMP-UHFFFAOYSA-N; VUF-4701; 4-(1H-Imidazol-4-yl)-butylamine; BDBM50170164; AKOS032954093; AKOS006310860
Click to Show/Hide
|
||||
| Activity |
Ki = 794328.23 nM
|
[7] | |||
| Compound Name |
AF353
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
AF-353; AF 353
Click to Show/Hide
|
||||
| Activity |
Ki = 100000000 nM
|
[8] | |||
| Compound Name |
impentamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
PDSP1_000940; PDSP2_000926
Click to Show/Hide
|
||||
| Activity |
Ki = 3.98E+12 nM
|
[7] | |||
| Compound Name |
6-(1H-Imidazol-5-yl)hexan-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL554031; SCHEMBL9220957; VUF-4732; BDBM50407522
Click to Show/Hide
|
||||
| Activity |
Ki = 5.01E+12 nM
|
[7] | |||
| Compound Name |
8-(1H-Imidazol-5-yl)octan-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL90063; VUF-4733; BDBM50407520
Click to Show/Hide
|
||||
| Activity |
Ki = 3.16E+13 nM
|
[7] | |||
| Compound Name |
1H-Imidazole-5-decanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL94249; BDBM50407521; 10-(1H-imidazol-5-yl)decan-1-amine
Click to Show/Hide
|
||||
| Activity |
Ki = 5.01E+13 nM
|
[7] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Histamine H4 receptor agonists. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7191-9. | ||||
| REF 2 | Structure-activity relationships of non-imidazole H(3) receptor ligands. Part 2: binding preference for D-amino acids motifs. Bioorg Med Chem Lett. 2002 Aug 5;12(15):2035-7. | ||||
| REF 3 | Synthesis and evaluation of potent pyrrolidine H(3) antagonists. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3055-8. | ||||
| REF 4 | 2-(Pyrrolidin-1-yl)ethyl-3,4-dihydroisoquinolin-1(2H)-one derivatives as potent and selective histamine-3 receptor antagonists. J Med Chem. 2012 Mar 8;55(5):2452-68. | ||||
| REF 5 | Structure-activity relationships of non-imidazole H(3) receptor ligands. Part 1. Bioorg Med Chem Lett. 2002 Aug 5;12(15):2031-4. | ||||
| REF 6 | Aminoalkoxybiphenylnitriles as histamine-3 receptor ligands. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3077-9. | ||||
| REF 7 | Homologs of histamine as histamine H3 receptor antagonists: a new potent and selective H3 antagonist, 4(5)-(5-aminopentyl)-1H-imidazole. J Med Chem. 1995 Jan 20;38(2):266-71. | ||||
| REF 8 | Identification and SAR of novel diaminopyrimidines. Part 1: The discovery of RO-4, a dual P2X(3)/P2X(2/3) antagonist for the treatment of pain. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1628-31. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.