Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T30823 | Target Info | |||
| Target Name | M-phase inducer phosphatase 1 (MPIP1) | ||||
| Synonyms |
Dual specificity phosphatase Cdc25A; Cdc25A phosphatase
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|
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| Target Type | Literature-reported Target | ||||
| Gene Name | CDC25A | ||||
| Biochemical Class | Phosphoric monoester hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 55 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(Z)-5-[(4R,4As,6aR,7R,9aS,9bS)-4,6a-dimethyl-7-(6-methylheptan-2-yl)-2-oxo-4a,5,6,7,8,9,9a,9b-octahydro-1H-cyclopenta[f]isochromen-4-yl]pent-2-enenitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL143666; BDBM50068033
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(S)-5-Hydroxy-4-{(R)-1-hydroxy-2-[(1S,2S,5S,8aR)-1,2,5,8a-tetramethyl-5-(4-methyl-pent-4-enyl)-1,2,3,5,6,7,8,8a-octahydro-naphthalen-1-yl]-ethyl}-5H-furan-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL87951; BDBM50080993
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-(1-Dodecyl-2-oxoindolin-3-yl)acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL493812; BDBM50261105
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|
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| Activity |
IC50 = 50000 nM
|
[3] | |||
| Compound Name |
(Z)-5-[(4S,4As,6aR,7R,9aS,9bS)-4,6a-dimethyl-7-[(2R)-6-methylheptan-2-yl]-2-oxo-4a,5,6,7,8,9,9a,9b-octahydro-1H-cyclopenta[f]isochromen-4-yl]pent-2-enenitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL171487; BDBM50279774
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(2S,3S)-3-[[1-[[(2R,3R,4S,5S,6S)-6-Methoxy-3,4,5-tris(phenylmethoxy)oxan-2-yl]methyl]triazol-4-yl]methoxy]-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1795949; BDBM50347242
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|
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| Activity |
IC50 = 51600 nM
|
[5] | |||
| Compound Name |
(2S,3S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-[[1-[(2R,3R,4S,5R,6R)-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-2-yl]triazol-4-yl]methoxy]butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1795951; BDBM50347244
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|
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| Activity |
IC50 = 53000 nM
|
[5] | |||
| Compound Name |
1-[(1S,4As,8aS)-2,5,5,8a-tetramethyl-1,4,4a,6,7,8-hexahydronaphthalen-1-yl]pent-4-en-2-yl hydrogen sulfate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64626; BDBM50289898
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|
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| Activity |
IC50 = 60000 nM
|
[6] | |||
| Compound Name |
4-(3-(3,4-Dihydroxyphenyl)-3-oxoprop-1-enyl)-7-hydroxy-2H-chromen-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1258522; BDBM50327450
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|
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| Activity |
IC50 = 62000 nM
|
[7] | |||
| Compound Name |
3-(2-(4-((3-Benzoyl-1-cyanoindolizin-5-yl)methoxy)phenyl)-4-methylpentanamido)-3-phenylpropanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200475; BDBM50175706
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|
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| Activity |
IC50 = 69200 nM
|
[8] | |||
| Compound Name |
7-Methoxy-4-(3-(4-methoxyphenyl)-3-oxoprop-1-enyl)-2H-chromen-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1258413; BDBM50327446
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|
||||
| Activity |
IC50 = 70000 nM
|
[7] | |||
| Compound Name |
3-((S)-2-(3-Benzoyl-1-cyanoindolizin-5-yloxy)-4-methylpentanamido)-3-phenylpropanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL372159; BDBM50175705
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|
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| Activity |
IC50 = 70700 nM
|
[8] | |||
| Compound Name |
2-(4-(7-(4-Methoxybenzoyl)cyclopenta[d][1,2]oxazin-4-yl)phenoxy)acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL201662; BDBM50177317
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|
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| Activity |
IC50 = 73300 nM
|
[9] | |||
| Compound Name |
1-[(1S,4As,8aS)-2,5,5,8a-tetramethyl-1,4,4a,6,7,8-hexahydronaphthalen-1-yl]but-3-yn-2-yl hydrogen sulfate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL61058; BDBM50289890
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|
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| Activity |
IC50 = 74000 nM
|
[6] | |||
| Compound Name |
4-(3-(3,4-Diethylphenyl)buta-1,3-dienyl)-7-ethyl-2-methylene-1,2-dihydronaphthalene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1258414; BDBM50327447
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|
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| Activity |
IC50 = 78000 nM
|
[7] | |||
| Compound Name |
(E)-2-(1-Octyl-2-oxoindolin-3-ylidene)acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL527034; BDBM50260971
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|
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| Activity |
IC50 = 78000 nM
|
[3] | |||
| Compound Name |
2-Methoxy-5-((4-methyl-2-oxo-1,2-dihydro-quinolin-6-yl)methyl)benzenesulfonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
NSC109483; NSC-109483; CHEMBL507159; NCIStruc1_001390; NCIStruc2_001194; CTK7A7541; ZINC8582190; BDBM50388538; CCG-37455; NCGC00014106; NCI109483; NCGC00014106-02; NCGC00097215-01; NCI60_000228; 5-((2-hydroxy-4-methyl-6-quinolinyl)methyl)-2-methoxybenzenesulfonic acid
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|
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| Activity |
IC50 = 86000 nM
|
[10] | |||
| Compound Name |
4-[(1R)-1beta-[(1R)-1,5-Dimethylhexyl]-7abeta-methylhydrindane-4-ylidene]-2-butenoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL157936; BDBM50087140; (E)-4-[(1R,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-but-2-enoic acid
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|
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| Activity |
IC50 = 94000 nM
|
[11] | |||
| Compound Name |
7-Hydroxy-4-(3-(4-hydroxyphenyl)-3-oxoprop-1-enyl)-2H-chromen-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1258521; BDBM50327449
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|
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| Activity |
IC50 = 96000 nM
|
[7] | |||
| Compound Name |
[1-[(1S,4As,8aS)-2,5,5,8a-tetramethyl-1,4,4a,6,7,8-hexahydronaphthalen-1-yl]-3-methylbutan-2-yl] hydrogen sulfate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL59794; BDBM50289901
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|
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| Activity |
IC50 = 98000 nM
|
[6] | |||
| Compound Name |
N-[3-(2-Phenyl-1,3-thiazol-4-yl)phenyl]-2-furamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3219177; ZINC387105; MCULE-9414355543; AQ-432/42868839; N-[3-(2-Phenylthiazole-4-yl)phenyl]-2-furancarboxamide
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|
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
Sulfuric acid mono-[1-(naphthalen-1-ylmethoxymethyl)-3-phenyl-propyl] ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL294317; BDBM50289893
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|
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
(2S,3S)-2-[[(3S,6S,9S,12S,15S)-3-Benzyl-12-[(2S)-butan-2-yl]-6-(1H-indol-3-ylmethyl)-7-methyl-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazacyclononadec-15-yl]carbamoylamino]-3-methylpentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL409618; BDBM50192335
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|
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| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
[1-(2-Methyl-2,3-dihydrobenzimidazol-1-yl)-4-phenylbutan-2-yl] hydrogen sulfate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64500; BDBM50289896; Sulfuric acid mono-[1-(2-methyl-2,3-dihydro-benzoimidazol-1-ylmethyl)-3-phenyl-propyl] ester
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|
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
6-(1-(2-Carboxy-1-phenylethylamino)-4-methyl-1-oxopentan-2-yl)-1-cyanoindolizine-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL381633; BDBM50175710
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|
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
[17-(1,5-Dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yloxythiocarbonylsulfanyl]-acetic acid ethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL354041; BDBM50097545; [[5alpha-Cholestane-3beta-yloxy(thiocarbonyl)]thio]acetic acid ethyl ester
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|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
4-[N-[(3-Chlorophenyl)methyl]-C-pentadecylcarbonimidoyl]-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2062592; BDBM50388822
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|
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| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
(Z)-2-(1-Hexyl-2-oxoindolin-3-ylidene)acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL447811; BDBM50261055
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
7-(((S)-1-(2-Carboxy-1-phenylethylamino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-1-cyanoindolizine-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL371922; BDBM50175708
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|
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
5-((S)-1-(2-Carboxy-1-phenylethylamino)-4-methyl-1-oxopentan-2-yloxy)-1-cyanoindolizine-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200386; BDBM50175711
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|
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(N-Methylpiperidino)ethanol 2-(hexadecyloxy)ethyl phosphonate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89013; BDBM50051810
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|
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| Activity |
IC50 = 100000 nM
|
[15] | |||
| Compound Name |
3-Hydroxy-2-(hydroxymethyl)-4-[N-[(3-methylphenyl)methyl]-C-pentadecylcarbonimidoyl]-2H-furan-5-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2062591; CHEMBL3260030; RE-12; BDBM50012280; BDBM50388821
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|
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| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
(E)-2-(1-(2-(2-(2-Ethoxyethoxy)ethoxy)ethyl)-2-oxoindolin-3-ylidene)acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL494620; BDBM50261054
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-(4-Nonyl-2,5-dioxo-2,5-dihydrofuran-3-yl)propanoicacid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL375036; BDBM50197857
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|
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| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
N-{3-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]phenyl}cyclopropanecarboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3219176; ZINC8042062; AKOS033148284; MCULE-3175900996; AB00762115-01; Z118604202; N-[3-[4-(p-Anisyl)thiazole-2-yl]phenyl]cyclopropanecarboxamide
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
Dithiocarbonic acid S-phenacyl O-(5alpha-cholestane-3beta-yl) ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL433913; BDBM50097541
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|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Sulfuric acid mono-(1-naphthalen-1-ylmethyl-3-phenyl-propyl) ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL59678; BDBM50289905
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|
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
6-(((S)-1-(2-Carboxy-1-phenylethylamino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-1-cyanoindolizine-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL427374; BDBM50175709
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|
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(E)-2-(1-Hexyl-2-oxoindolin-3-ylidene)acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL498569; SCHEMBL13011230; BDBM50260970
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(2S,3S)-2-[[(3S,6R,9S,12S,15S)-3-Benzyl-6-[2-[2-(carbamoylamino)phenyl]-2-oxoethyl]-7-methyl-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-12-propan-2-yl-1,4,7,10,13-pentazacyclononadec-15-yl]carbamoylamino]-3-methylpentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL439324; BDBM50192337
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|
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| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
(2S,3S)-2-[[(3S,6S,9S,12S,15S)-3-Benzyl-6-(1H-indol-3-ylmethyl)-7-methyl-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-12-propan-2-yl-1,4,7,10,13-pentazacyclononadec-15-yl]carbamoylamino]-3-methylpentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL377360; Brunsvicamide A; BDBM50192336
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| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
3-((S)-2-(1-Cyano-3-(ethoxycarbonyl)indolizin-5-yloxy)-4-methylpentanamido)-3-phenylpropanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200830; BDBM50175707
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|
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
2,5-Dioxo-4-octylfuran-3-propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL228357; BDBM50197850; 3-(4-octyl-2,5-dioxo-2,5-dihydrofuran-3-yl)propanoicacid
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| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
2,5-Dioxo-4-hexylfuran-3-propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL228356; BDBM50197853; 3-(4-hexyl-2,5-dioxo-2,5-dihydrofuran-3-yl)propanoicacid
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| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
2-[17-(1,5-Dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yloxythiocarbonylsulfanyl]-propionic acid ethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL168935; BDBM50097533; 2-[[5alpha-Cholestane-3beta-yloxy(thiocarbonyl)]thio]propionic acid ethyl ester
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
4-[17-(1,5-Dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yloxythiocarbonylsulfanyl]-3-oxo-butyric acid ethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL168934; BDBM50097536; 4-[[5alpha-Cholestane-3beta-yloxy(thiocarbonyl)]thio]-3-oxobutyric acid ethyl ester
Click to Show/Hide
|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(E)-2-(2-Oxo-1-(3-phenylpropyl)indolin-3-ylidene)acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL444927; BDBM50261014
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Sulfuric acid mono-[2-(benzothiazol-2-yloxy)-1-benzyl-ethyl] ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL59929; BDBM50289907
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|
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
5-[3-Pyridin-2-yl-6-(5-sulfofuran-2-yl)-1,2,4-triazin-5-yl]furan-2-sulfonic acid
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Investigative | Compound Info | ||
| Synonyms |
Ferene; CHEMBL1270061; 3-(2-PYRIDYL)-5,6-bis-[2-(5-FURYL-SULFONIC ACID)]-1,2,4-TRIAZINE; 2-Furansulfonic acid, 5,5'-[3-(2-pyridinyl)-1,2,4-triazine-5,6-diyl]bis-; NSC-601364; NSC601364; ACMC-20ltah; NCIStruc1_001777; NCIStruc2_001716; SCHEMBL2946864; CTK3G6293; ZINC1607791; BDBM50328823; NCGC00182101-01; NCGC00182101-02; NCI60_004528; 551P147; 5,5'-(3-(pyridin-2-yl)-1,2,4-triazine-5,6-diyl)difuran-2-sulfonic acid; 5,5'-[3-(2-Pyridyl)-1,2,4-triazine-5,6-diyl]bis(2-furansulfonic acid); 5,5''-(3-(pyridin-2-yl)-1,2,4-triazine-5,6-diyl)difuran-2-sulfonic acid; 5-[3-(2-pyridyl)-6-(5-sulfo-2-furyl)-1,2,4-triazin-5-yl]furan-2-sulfonic acid
Click to Show/Hide
|
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| Activity |
IC50 = 110000 nM
|
[10] | |||
| Compound Name |
(2S,3S)-3-[[1-[[(2R,3R,4S,5R,6S)-6-Methoxy-3,4,5-tris(phenylmethoxy)oxan-2-yl]methyl]triazol-4-yl]methoxy]-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1795945; BDBM50347240
Click to Show/Hide
|
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| Activity |
IC50 = 118700 nM
|
[5] | |||
| Compound Name |
(2S)-3-[[1-[[(2R,3S,4S,5R,6S)-6-Methoxy-3,4,5-tris(phenylmethoxy)oxan-2-yl]methyl]triazol-4-yl]methoxy]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1795946; BDBM50347241
Click to Show/Hide
|
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| Activity |
IC50 ~ 120000 nM
|
[5] | |||
| Compound Name |
(2S)-3-[[1-[[(2R,3R,4S,5R,6S)-6-Methoxy-3,4,5-tris(phenylmethoxy)oxan-2-yl]methyl]triazol-4-yl]methoxy]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1795944; BDBM50347239
Click to Show/Hide
|
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| Activity |
IC50 ~ 120000 nM
|
[5] | |||
| Compound Name |
(2S,3S)-3-[[1-[[(2R,3S,4S,5R,6S)-6-Methoxy-3,4,5-tris(phenylmethoxy)oxan-2-yl]methyl]triazol-4-yl]methoxy]-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1795947; BDBM50347246
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| Activity |
IC50 ~ 120000 nM
|
[5] | |||
| Compound Name |
[(4-{3-[4-(Difluoro-phosphono-methyl)-benzyloxy]-phenoxymethyl}-phenyl)-difluoro-methyl]-phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL140524; SCHEMBL13727362; BDBM50107740; [m-Phenylenebis[(oxymethylene-p-phenylene)(difluoromethylene)]]bis(phosphonic acid)
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| Activity |
IC50 = 163000 nM
|
[17] | |||
| Compound Name |
[(4-{2-[4-(Difluoro-phosphono-methyl)-benzyloxy]-phenoxymethyl}-phenyl)-difluoro-methyl]-phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL337604; BDBM50107744; [o-Phenylenebis[(oxymethylene-p-phenylene)(difluoromethylene)]]bis(phosphonic acid)
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| Activity |
IC50 = 163000 nM
|
[17] | |||
| Compound Name |
2-[(1S,4As,8aS)-2,5,5,8a-tetramethyl-1,4,4a,6,7,8-hexahydronaphthalen-1-yl]ethyl hydrogen sulfate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL61864; BDBM50289895
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||||
| Activity |
IC50 = 170000 nM
|
[6] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 19 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-Phenyl-1-((1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl)-butan-2-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64045; BDBM50289892
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| Activity |
IC50 > 290000 nM
|
[6] | |||
| Compound Name |
2-(4-Methylmorpholin-4-ium-4-yl)ethyl tetradecyl phosphate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89141; BDBM50051808
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| Activity |
IC50 = 290000 nM
|
[15] | |||
| Compound Name |
(N-Methylpiperidino)ethanol 2-(tetradecyloxy)ethyl phosphonate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL86560; BDBM50051815
Click to Show/Hide
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||||
| Activity |
IC50 = 300000 nM
|
[15] | |||
| Compound Name |
4-[1-Hydroxy-2-(1-methylcyclohexyl)ethyl]-5-hydroxy-2,5-dihydrofuran-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL86451; BDBM50093973; 5-Hydroxy-4-[1-hydroxy-2-(1-methyl-cyclohexyl)-ethyl]-5H-furan-2-one
Click to Show/Hide
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||||
| Activity |
IC50 > 300000 nM
|
[18] | |||
| Compound Name |
[(1R,7Ar)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-octahydro-inden-4-yl]-acetic acid methyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL345921; BDBM50087139; [(1R)-1beta-[(1R)-1,5-Dimethylhexyl]-7abeta-methylhydrindane-4-yl]acetic acid methyl ester
Click to Show/Hide
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| Activity |
IC50 > 300000 nM
|
[11] | |||
| Compound Name |
[(1R)-1beta-[(1R)-1,5-Dimethylhexyl]-7abeta-methylhydrindan-4-ylidene]acetic acid methyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL155993; BDBM50087144
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| Activity |
IC50 > 300000 nM
|
[11] | |||
| Compound Name |
1-Phenyl-3-((1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl)-propan-2-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL294581; BDBM50289891
Click to Show/Hide
|
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| Activity |
IC50 > 310000 nM
|
[6] | |||
| Compound Name |
1-((1S,4As,8aS)-2,5,5,8a-Tetramethyl-1,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl)-pent-4-en-2-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL60311; BDBM50289908
Click to Show/Hide
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| Activity |
IC50 > 360000 nM
|
[6] | |||
| Compound Name |
(N-Methylmorpholino)ethanol 2-(tetradecycloxy)ethyl phosphonate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89650; BDBM50051811
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|
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| Activity |
IC50 = 380000 nM
|
[15] | |||
| Compound Name |
Hexadecyl 2-(1-methylpiperidinium-1-yl)ethyl phosphate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89618; BDBM50051816; (N-methylpiperidino)ethanol hexadecyl phosphonate; Hexadecyl[2-(N-Methylpiperidinio)ethyl]phosphate; D-20317
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| Activity |
IC50 = 460000 nM
|
[15] | |||
| Compound Name |
(N-Methylpiperidino)ethanol tetradecyl phosphonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL314931; BDBM50051813
Click to Show/Hide
|
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| Activity |
IC50 = 490000 nM
|
[15] | |||
| Compound Name |
Dodecyl 2-(4-methylmorpholin-4-ium-4-yl)ethyl phosphate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL418940; BDBM50051806
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| Activity |
IC50 = 500000 nM
|
[15] | |||
| Compound Name |
(N-Methylmorpholino)ethanol 2-(dodecyloxy)ethyl phosphonate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL86791; BDBM50051814
Click to Show/Hide
|
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| Activity |
IC50 = 610000 nM
|
[15] | |||
| Compound Name |
4-[(3E,6E)-4,7-Dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-3,6-dienyl]-5-hydroxy-5H-furan-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL314657; BDBM50080996
Click to Show/Hide
|
||||
| Activity |
IC50 = 990000 nM
|
[2] | |||
| Compound Name |
6-(2-Hydroxy-5-oxo-2,5-dihydro-furan-3-yl)-3-[(E)-4-methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hex-3-enyl]-5,6-dihydro-pyran-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL85451; BDBM50080998
Click to Show/Hide
|
||||
| Activity |
IC50 = 1000000 nM
|
[2] | |||
| Compound Name |
(N-Methylmorpholino)ethanol 2-(hexadecyloxy)ethyl phosphonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89292; BDBM50051807
Click to Show/Hide
|
||||
| Activity |
IC50 = 1000000 nM
|
[15] | |||
| Compound Name |
(N-Methylpiperidino)ethanol dodecyl phosphonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89135; BDBM50051812
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[15] | |||
| Compound Name |
2(5H)-Furanone, 5-hydroxy-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
5-Hydroxyfuran-2(5H)-one; 5-Hydroxy-2(5H)-furanone; 5-hydroxy-2,5-dihydrofuran-2-one; 2-hydroxy-2H-furan-5-one; CHEMBL310010; beta-Formylacrylic acid lactol; 5-hydroxy-5H-furan-2-one; SCHEMBL120200; 5-Hydroxy-2(5H)-furanone #; CTK8G9194; DTXSID10930763; 2(5H)?-?Furanone, 5-?hydroxy-; BDBM50080999; MFCD00015554; AKOS006283554; CM11011; Q18349236
Click to Show/Hide
|
||||
| Activity |
IC50 = 12000000 nM
|
[2] | |||
| Compound Name |
N-(2-Methoxy-5-oxo-2,5-dihydro-furan-2-ylmethyl)-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL315006; BDBM50080997; N-(2-Methoxy-5-oxo-2,5-dihydrofuran-2-ylmethyl)benzamide
Click to Show/Hide
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| Activity |
IC50 = 21000000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Novel CDC25A phosphatase inhibitors from pyrolysis of 3-alpha-azido-B-homo-6-oxa-4-cholesten-7-one on silica gel. J Med Chem. 1998 Nov 19;41(24):4677-80. | ||||
| REF 2 | Dysidiolide and related gamma-hydroxy butenolide compounds as inhibitors of the protein tyrosine phosphatase, CDC25. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2537-8. | ||||
| REF 3 | Design and synthesis of N-alkyl oxindolylidene acetic acids as a new class of potent Cdc25A inhibitors. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3350-3. | ||||
| REF 4 | Syntheses and biological activities of a novel group of steroidal derived inhibitors for human Cdc25A protein phosphatase. J Med Chem. 2001 Mar 1;44(5):834-48. | ||||
| REF 5 | Facile fabrication of promising protein tyrosine phosphatase (PTP) inhibitor entities based on 'clicked' serine/threonine-monosaccharide hybrids. Bioorg Med Chem. 2011 Jul 1;19(13):3892-900. | ||||
| REF 6 | Synthesis and phosphatase inhibitory activity of analogs of sulfircin. Bioorg Med Chem Lett. 1997 Aug 5;7(15):2015-20. | ||||
| REF 7 | Synthesis and biological evaluation of novel coumarin-based inhibitors of Cdc25 phosphatases. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5827-30. | ||||
| REF 8 | 3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors. Bioorg Med Chem Lett. 2006 Jan 1;16(1):59-63. | ||||
| REF 9 | PTP-1B inhibitors: cyclopenta[d][1,2]-oxazine derivatives. Bioorg Med Chem Lett. 2006 Feb;16(3):499-502. | ||||
| REF 10 | Discovery of new inhibitors of Cdc25B dual specificity phosphatases by structure-based virtual screening. J Med Chem. 2012 May 10;55(9):4142-58. | ||||
| REF 11 | Synthesis of a novel class of cdc25A inhibitors from vitamin D3. Bioorg Med Chem Lett. 2000 Apr 3;10(7):615-7. | ||||
| REF 12 | Prospective use of molecular field points in ligand-based virtual screening: efficient identification of new reversible Cdc25 inhibitors. Medchemcomm. 2013;4:1148-55. | ||||
| REF 13 | Brunsvicamides A-C: sponge-related cyanobacterial peptides with Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory activity. J Med Chem. 2006 Aug 10;49(16):4871-8. | ||||
| REF 14 | Dual-Specificity Phosphatase CDC25A/B Inhibitor Identified from a Focused Library with Nonelectrophilic Core Structure. ACS Med Chem Lett. 2012 Apr 12;3(4):294-298. | ||||
| REF 15 | Alkyl and alkoxyethyl antineoplastic phospholipids. J Med Chem. 1996 Jun 21;39(13):2609-14. | ||||
| REF 16 | Synthesis and biological evaluation of dialkylsubstituted maleic anhydrides as novel inhibitors of Cdc25 dual specificity phosphatases. Eur J Med Chem. 2007 Feb;42(2):243-7. | ||||
| REF 17 | Structure of protein tyrosine phosphatase 1B in complex with inhibitors bearing two phosphotyrosine mimetics. J Med Chem. 2001 Dec 20;44(26):4584-94. | ||||
| REF 18 | Synthesis of the novel analogues of dysidiolide and their structure-activity relationship. Bioorg Med Chem Lett. 2000 Nov 20;10(22):2571-4. | ||||
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