Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T30219 | Target Info | |||
| Target Name | C3a anaphylatoxin chemotactic receptor (C3AR1) | ||||
| Synonyms |
HNFAG09; C3a-R; C3R1; C3AR; AZ3B
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| Target Type | Literature-reported Target | ||||
| Gene Name | C3AR1 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 7 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-Cyclohexyl-N-[1-[(E)-3-(5-methylpyridin-3-yl)prop-2-enoyl]piperidin-4-yl]-2-phenylacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL234729; BDBM50423083
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| Activity |
IC50 = 50118.72 nM
|
[1] | |||
| Compound Name |
(2R)-2-[(4-Benzhydrylpiperazine-1-carbonyl)amino]-5-(diaminomethylideneamino)pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL228900; BDBM50422997
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| Activity |
IC50 = 50118.72 nM
|
[2] | |||
| Compound Name |
(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2021602; BDBM50416364
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| Activity |
EC50 = 57000 nM
|
[3] | |||
| Compound Name |
2-Phenyl-N-[1-(3-pyridin-3-ylpropanoyl)piperidin-4-yl]-2-(3,3,5,5-tetramethylcyclohexyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL233029; BDBM50423069
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| Activity |
IC50 = 63095.73 nM
|
[1] | |||
| Compound Name |
N-[1-(3-Pyridin-3-ylpropanoyl)piperidin-4-yl]-9,10-dihydroanthracene-9-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL243048; BDBM50423086
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| Activity |
IC50 = 79432.82 nM
|
[1] | |||
| Compound Name |
(2R)-2-[[4-(3-Chlorophenyl)benzoyl]amino]-5-(diaminomethylideneamino)pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL228846; BDBM50411335
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| Activity |
IC50 = 100000 nM
|
[2] | |||
| Compound Name |
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1170640; BDBM50322656
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| Activity |
EC50 = 101000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of new C3aR ligands. Part 2: amino-piperidine derivatives. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3262-5. | ||||
| REF 2 | Discovery of new C3aR ligands. Part 1: arginine derivatives. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3258-61. | ||||
| REF 3 | Selective hexapeptide agonists and antagonists for human complement C3a receptor. J Med Chem. 2010 Jul 8;53(13):4938-48. | ||||
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