Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T29741 | Target Info | |||
| Target Name | NADPH oxidase 4 (NOX4) | ||||
| Synonyms |
Renal NAD(P)Hoxidase; Renal NAD(P)H-oxidase; RENOX; Kidney superoxideproducing NADPH oxidase; Kidney superoxide-producing NADPH oxidase; Kidney oxidase1; Kidney oxidase-1; KOX1; KOX-1
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| Target Type | Clinical trial Target | ||||
| Gene Name | NOX4 | ||||
| Biochemical Class | NADH/NADPH oxidoreductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 10 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(1R,8S,10S)-9-(1,3-Benzodioxol-5-ylmethyl)-3-bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3347542; SCHEMBL17600685; BDBM50497259
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(1R,8S,10S)-3-Bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3347491; SCHEMBL17600687; BDBM50497268; ZINC19691570
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(1R,8S,10S)-3-Bromo-9-[(3-fluorophenyl)methyl]-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3347549; SCHEMBL17600675; BDBM50497261
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-[[(1R,8S,10S)-3-Bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-trien-9-yl]methyl]-5-methyl-1,2-oxazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3347543; BDBM50497272
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(1R,8S,10S)-3-Bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-pentyl-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3347550; BDBM50497271
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(1R,8S,10S)-3-(3,4-Dichlorophenyl)-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2,4,6-triene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3347554; SCHEMBL17600682; BDBM50497263
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(1R,8S,10S)-9-[(3-Fluorophenyl)methyl]-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2,4,6-triene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3347503; SCHEMBL17600673; BDBM50497265
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(1R,8S,10S)-3-Bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-methylsulfonyl-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3347583; SCHEMBL17600677; BDBM50497273
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(1R,8S,10S)-3-Bromo-11,11-dimethyl-10-(2-methylpropyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3347502; BDBM50497257
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(1R,8S,10S)-3-(3,4-Dichlorophenyl)-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-pentyl-9-azatricyclo[6.2.2.02,7]dodeca-2,4,6-triene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3347567; SCHEMBL17600680; BDBM50497260
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | WO patent application no. 2014179592A1, TETRAHYDROISOQUINOLINES AS SELECTIVE NADPH OXIDASE 2 INHIBITORS | ||||
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