Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T29130 | Target Info | |||
| Target Name | Signal transducer and activator of transcription 3 (STAT3) | ||||
| Synonyms |
Acute-phase response factor; APRF
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|
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| Target Type | Successful Target | ||||
| Gene Name | STAT3 | ||||
| Biochemical Class | Transcription factor | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 96 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
OLEANOLIC_ACID
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|
Investigative | Compound Info | ||
| Synonyms |
OLEANOLIC ACID; Oleanic acid; 508-02-1; Caryophyllin; Astrantiagenin C; Giganteumgenin C; Virgaureagenin B; 3beta-Hydroxyolean-12-en-28-oic acid; UNII-6SMK8R7TGJ; CCRIS 6493; (3-beta)-3-Hydroxyolean-12-en-28-oic acid; EINECS 208-081-6; NSC114945; 6SMK8R7TGJ; NSC-114945; 3-beta-Hydroxyolean-12-en-28-oic acid; CHEBI:37659; Olean-12-en-28-oic acid, 3-hydroxy-, (3beta)-; oleonolic acid; MFCD00064914
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
4-[(4-Cyclohexylphenyl)methyl-[2-[(4-methylphenyl)sulfonyl-prop-2-enylamino]acetyl]amino]-2-hydroxybenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431987; SCHEMBL10243402; BDBM50440962
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
6-Methyl-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1417722; MLS000083003; HMS2291O08; ZINC4038513; BDBM50189944; STL580382; AKOS032392945; MCULE-5790325702; SMR000046666
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Tetrahydrocurcumin
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|
Investigative | Compound Info | ||
| Synonyms |
1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione; Sabiwhite; Tetrahydrodiferuloylmethane; 1,7-Bis(4-hydroxy-3-methoxyphenyl)-3,5-heptanedione; 3,5-Heptanedione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-; UNII-00U0645U03; CHEMBL318743; MFCD04152347; NSC687845; 00U0645U03; NSC 687845; Tetrahydrocucumin; 3,5-Heptamedopme. 1,7-bis(hydroxy-3methoxyphenyl)heptane; EC 609-201-3; THC (Tetra Hydro Curcumin); SCHEMBL284877; KS-00000IDE; DTXSID30865801; BCP18621; HY-N0893; ZINC4649679; BDBM50059985; s3917; Tetrahydrocurcumin, >=96% (HPLC); AKOS015999950; Tetrahydrocurcumin, analytical standard; CCG-268326; CS-3739; NSC-687845; VN10058; AC-24240; AK-47436; AS-13957; SY047647; AB0024474; FT-0674986; W5754; 062T041; J-504043; Q27135730; 1,7-bis(4-hydroxy-3-methoxy-phenyl)heptane-3,5-dione; 1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-heptane-3,5-dione
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
2-Epi-Sarcophine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3931428; BDBM50197960
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
7-(2-Methoxyethyl)-6-(4-methoxyphenyl)-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3827269; BDBM50190105
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
4-[(4-Cyclohexylphenyl)methyl-[2-[(4-methylphenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431984; BDBM50440963
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
4-[(4-Cyclohexylphenyl)methyl-[2-[(4-methylphenyl)methyl-(4-methylphenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431992; SCHEMBL10243206; BDBM50440960
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
3-(1,4,5,6-Tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3828447; BDBM50189935
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
[(1S,3R,5S,8E,12S,13R)-5,9,13-Trimethyl-1-propan-2-yl-4,16-dioxatricyclo[11.2.1.03,5]hexadec-8-en-12-yl] acetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3975348; BDBM50197969
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
(1S,3R,5S,8E,12S,13R)-5,9,13-Trimethyl-1-propan-2-yl-4,16-dioxatricyclo[11.2.1.03,5]hexadec-8-en-12-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3904515; BDBM50197968
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
6-Pyridin-4-yl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3828577; BDBM50189931
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
6-(5-Chlorothiophen-2-yl)-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3828691; BDBM50189934
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
4-[(4-Cyclohexylphenyl)methyl-[2-[(4-methylphenyl)sulfonyl-(pyridin-3-ylmethyl)amino]acetyl]amino]-2-hydroxybenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431976; SCHEMBL10243330; BDBM50440959
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Serratol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3943485; (-)-serratol; SCHEMBL8626655; BDBM50197959; S(-)-cembra-3E,7E,11E-triene-1-ol; (1S,3E,7E,11E)-4,8,12-trimethyl-1-(propan-2-yl)cyclotetradeca-3,7,11-trien-1-ol; (1S,3E,7E,11E)-4,8,12-trimethyl-1-propan-2-ylcyclotetradeca-3,7,11-trien-1-ol
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
[(1R,2S,5E,9E,12S)-1,5,9-Trimethyl-12-propan-2-yl-15-oxabicyclo[10.2.1]pentadeca-5,9-dien-2-yl] 2-phenylacetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3890789; BDBM50197971
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
6-Methyl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1432718; MLS000083005; HMS2329L20; BDBM50189943; SMR000047092
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
1-[6-(4-Methoxyphenyl)-3-(3-phenyl-1H-pyrazol-5-yl)-6,7-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-5-yl]ethanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3828587; BDBM50189948
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
4-[(E)-2-[3-[(E)-2-[4-Hydroxy-3-methoxy-5-(3-methylbut-2-enyl)phenyl]ethenyl]-1H-pyrazol-5-yl]ethenyl]-2-methoxy-6-(3-methylbut-2-enyl)phenol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3290441; BDBM50020589; 4,4'-[1H-Pyrazole-3,5-diylbis(1,2-ethenediyl)]bis(2-prenyl-6-methoxyphenol)
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
1,7-Bis[4-hydroxy-3-methoxy-5-(3-methylbutyl)phenyl]heptane-3,5-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2392186; BDBM50020526
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(+)-Deoxosarcophine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3894504; BDBM50197962
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
5-(2-(N-Benzyl-4-methylphenylsulfonamido)-N-(4-chlorobenzyl)acetamido)-2-hydroxybenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3133481; SCHEMBL17077025; BDBM50496659
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|
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| Activity |
IC50 = 50000 nM
|
[6] | |||
| Compound Name |
[(1R,2S,5R,7S,10E,13S)-1,5,10-Trimethyl-13-propan-2-yl-6,16-dioxatricyclo[11.2.1.05,7]hexadec-10-en-2-yl] acetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3913521; BDBM50197970
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
[(1R,2S,5E,9E,12S)-1,5,9-Trimethyl-12-propan-2-yl-15-oxabicyclo[10.2.1]pentadeca-5,9-dien-2-yl] benzoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3959869; BDBM50197966
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
4-[(4-Cyclohexylphenyl)methyl-[2-(4-methylphenyl)sulfonyloxyacetyl]amino]-2-hydroxybenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2172013; BDBM50396179
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|
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| Activity |
Ki = 50000 nM
|
[7] | |||
| Compound Name |
3-(3-Phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3827729; BDBM50189936
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(1R,5E,9E,12S)-1,5,9-Trimethyl-12-propan-2-yl-15-oxabicyclo[10.2.1]pentadeca-5,9-dien-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3983336; BDBM50197963
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
5-Epi-Incensole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3922508; BDBM50197964; J3.575.146G
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
[(1R,2S,5E,9E,12S)-1,5,9-Trimethyl-12-propan-2-yl-15-oxabicyclo[10.2.1]pentadeca-5,9-dien-2-yl] (E)-3-phenylprop-2-enoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3948101; BDBM50197967
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
5-[[2-[[4-(4-Chlorophenyl)phenyl]sulfonyl-methylamino]acetyl]-[(4-methoxyphenyl)methyl]amino]-2-hydroxybenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3133466; SCHEMBL17077035; BDBM50496660
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|
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| Activity |
IC50 = 50000 nM
|
[6] | |||
| Compound Name |
4-[[2-[(2-Amino-2-oxoethyl)-(4-methylphenyl)sulfonylamino]acetyl]-[(4-cyclohexylphenyl)methyl]amino]-2-hydroxybenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431988; SCHEMBL10243775; BDBM50440961
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Incensole acetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3979367; HY-N4098; BDBM50197958; s9033; CCG-268019; CS-0032104
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
1,7-Bis[3-methoxy-4-hydroxy-5-(3-methyl-2-butenyl)phenyl]-1,6-heptadiene-3,5-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2392187; Diprenylcurcumin; BDBM50020590
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-(3-Phenyl-1H-pyrazol-5-yl)-6-pyridin-4-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3827646; BDBM50189932
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
6-(4-Methoxyphenyl)-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3828474; BDBM50189947
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
6-Cyclohexyl-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3827868; BDBM50189946
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
5-(N-(4-Bromobenzyl)-4-phenoxybenzamido)-2-hydroxybenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3133457; SCHEMBL15668310; BDBM50496655; 5-[(4-bromophenyl)methyl-(4-phenoxybenzoyl)amino]-2-hydroxybenzoic acid
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| Activity |
IC50 = 52000 nM
|
[6] | |||
| Compound Name |
Chembl4174085
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Investigative | Compound Info | ||
| Synonyms |
BDBM50279549
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| Activity |
IC50 = 52600 nM
|
[8] | |||
| Compound Name |
N-[5-(2-Furyl)-1,3,4-oxadiazol-2-yl]-2-(1-naphthyl)-4-quinolinecarboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1687978; SCHEMBL1895922; BDBM50338992; N-[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]-2-naphthalen-1-ylquinoline-4-carboxamide
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| Activity |
IC50 = 55000 nM
|
[9] | |||
| Compound Name |
5-(N-Benzyl-2-(N-methylbiphenyl-4-ylsulfonamido)acetamido)-2-hydroxybenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3133488; SCHEMBL17076891; BDBM50496649; 5-[benzyl-[2-[methyl-(4-phenylphenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acid
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| Activity |
IC50 = 57000 nM
|
[6] | |||
| Compound Name |
[4-[(2S)-2-Acetamido-3-[[(2S)-1-[4-[2-[[(2S)-5-amino-1-[[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-2-oxoethyl]piperazin-1-yl]-4-methyl-1-oxopentan-2-yl]amino]-3-oxopropyl]phenyl] dihydrogen phosphate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL197719
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|
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| Activity |
IC50 = 57100 nM
|
[10] | |||
| Compound Name |
4-[(2S)-2-[(4-Cyanophenyl)formamido]-2-{[(1S)-1-(cyclohexylcarbamoyl)-3-methylbutyl]carbamoyl}ethyl]phenoxyphosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL393817; ISS836; BDBM20276
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|
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| Activity |
IC50 = 58000 nM
|
[11] | |||
| Compound Name |
4-[(2S)-2-[(4-Cyanophenyl)formamido]-2-{[(1S)-3-methyl-1-[(2-methylpropyl)carbamoyl]butyl]carbamoyl}ethyl]phenoxyphosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL234465; ISS841; BDBM20280
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| Activity |
IC50 = 58000 nM
|
[11] | |||
| Compound Name |
4-(3-((3R,6S,8Ar)-3-((S)-5-amino-1-(benzylamino)-1,5-dioxopentan-2-ylcarbamoyl)-5-oxooctahydroindolizin-6-ylamino)-3-oxoprop-1-enyl)phenyl dihydrogen phosphate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL504218; BDBM50267450
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|
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| Activity |
IC50 = 59800 nM
|
[12] | |||
| Compound Name |
2-[[5-Bromo-2-[(4-chlorophenyl)methoxy]phenyl]methylamino]ethanol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1626156; SCHEMBL5699788; ZINC2862112; BDBM50431842; AKOS002617284; MCULE-9325760402
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| Activity |
IC50 = 59910 nM
|
[13] | |||
| Compound Name |
4-[(2S)-2-{[(1S)-1-{[(1S)-5-Amino-1-{[(1S)-3-carbamoyl-1-{[(1S)-2-carbamoyl-1-{[(1R)-1-carbamoyl-2-sulfanylethyl]carbamoyl}ethyl]carbamoyl}propyl]carbamoyl}pentyl]carbamoyl}-2-phenylethyl]carbamoyl}-2-acetamidoethyl]phenoxyphosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
Y(p)FKQNC; CHEMBL423775; BDBM20250; gp130 (813) derived peptide, 5
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| Activity |
IC50 = 60000 nM
|
[14] | |||
| Compound Name |
4-Chloro-3-[5-[(1,3-diethyl-4,6-dioxo-2-sulfanylidene-1,3-diazinan-5-ylidene)methyl]furan-2-yl]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2172009; AO-081/40671530; SCHEMBL1430422; ZINC4489076; BDBM50396171; AKOS000331046; MCULE-8709686581
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| Activity |
IC50 = 60000 nM
|
[7] | |||
| Compound Name |
5-(N-(4-Chlorobenzyl)-2-(N-methylbiphenyl-4-ylsulfonamido)acetamido)-2-hydroxybenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3133489; SCHEMBL17077017; BDBM50496643
Click to Show/Hide
|
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| Activity |
IC50 = 61000 nM
|
[6] | |||
| Compound Name |
N-[5-(4-Chlorophenyl)-1,3,4-oxadiazol-2-yl]-2-phenylquinoline-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1687967; SCHEMBL1900917; BDBM50338996; MLS-0472572.0001; 2-(4-Chlorophenyl)-N-(5-phenyl-1,3,4-oxadiazol-2-yl)-4-quinolinecarboxamide
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| Activity |
IC50 = 61000 nM
|
[9] | |||
| Compound Name |
N-[5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl]-2-thiophen-2-ylquinoline-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1687976; SCHEMBL1900732; BDBM50338994; N-[5-(2-Furyl)-1,3,4-oxadiazol-2-yl]-2-(2-thienyl)-4-quinolinecarboxamide
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| Activity |
IC50 = 63000 nM
|
[9] | |||
| Compound Name |
Methyl 4-({[3-(2-methoxy-2-oxoethyl)-4,8-dimethyl-2-oxo-2H-chromen-7-yl]oxy}methyl)benzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2171900; SCHEMBL19250305; ZINC1129340; BDBM50396173; EiM07-16582; STL460383; AKOS016360386; MCULE-1353186613
Click to Show/Hide
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||||
| Activity |
IC50 = 63000 nM
|
[7] | |||
| Compound Name |
2-(2-Furyl)-N-[5-(2-furyl)-1,3,4-oxadiazol-2-yl]-4-quinolinecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1687977; SCHEMBL1899815; BDBM50338993; 2-(furan-2-yl)-N-[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]quinoline-4-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 66000 nM
|
[9] | |||
| Compound Name |
2-Phenyl-N-(5-phenyl-1,3,4-oxadiazol-2-yl)quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1687969; SCHEMBL1898948; BDBM50338995; 2-Phenyl-N-(5-phenyl-1,3,4-oxadiazol-2-yl)-4-quinolinecarboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 66000 nM
|
[9] | |||
| Compound Name |
7-O-Ethylmorroniside
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4167273; HY-N2608; BDBM50279556; AKOS030573660; ZINC149090119; CS-0023011
Click to Show/Hide
|
||||
| Activity |
IC50 = 67000 nM
|
[8] | |||
| Compound Name |
4-(3-((S)-4-Methyl-1-oxo-1-((S)-2-(3-sulfamoylpropylcarbamoyl)pyrrolidin-1-yl)pentan-2-ylamino)-3-oxoprop-1-enyl)phenyl dihydrogen phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL576736; BDBM50300624
Click to Show/Hide
|
||||
| Activity |
IC50 = 68200 nM
|
[15] | |||
| Compound Name |
Chembl4166828
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50279548
Click to Show/Hide
|
||||
| Activity |
IC50 = 71900 nM
|
[8] | |||
| Compound Name |
N-[5-(3-Furyl)-1,3,4-oxadiazol-2-yl)-2-phenyl-4-quinolinecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1687965; SCHEMBL1899362; BDBM50338998; N-[5-(furan-3-yl)-1,3,4-oxadiazol-2-yl]-2-phenylquinoline-4-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 72000 nM
|
[9] | |||
| Compound Name |
4-[[3-(Carboxymethylsulfanyl)-4-hydroxynaphthalen-1-yl]sulfamoyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2031566; 4-(3-Carboxymethylsulfanyl-4-hydroxy-naphthalen-1-ylsulfamoyl)-benzoic acid; SCHEMBL1428457; ZINC1926256; BDBM50396170; AKOS001680277; MCULE-8865661339; SR-01000285893; SR-01000285893-1; 4-((3-(carboxymethylsulfanyl)-4-hydroxy-1-naphthyl)sulfamoyl)benzoic acid; 4-(N-(3-((Carboxymethyl)thio)-4-hydroxynaphthalen-1-yl)sulfamoyl)benzoic acid; 4-[({3-[(carboxymethyl)thio]-4-hydroxy-1-naphthyl}amino)sulfonyl]benzoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 73000 nM
|
[7] | |||
| Compound Name |
Levomenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(-)-alpha-Bisabolol; alpha-Bisabolol; Bisabolol; Kamillosan; UNII-24WE03BX2T; alpha-(-)-Bisabolol; 24WE03BX2T; (2S)-6-methyl-2-[(1S)-4-methylcyclohex-3-en-1-yl]hept-5-en-2-ol; Levomenolum; Kamilosan; 1-alpha-Bisabolol; Levomenol [INN]; alpha-Bisabolol, L-; alpha-Bisabolol (-)-form; Levomenolum [INN-Latin]; Bisbalol; CCRIS 9081; EINECS 245-423-3; l-.alpha.-Bisabolol; .alpha.-Bisabolol, L-; .alpha.-(-)-Bisabolol; (-)--BISABOLOL; ALPHA-(-)BISABOLOL; DSSTox_CID_22094; DSSTox_RID_79924; DSSTox_GSID_42094; SCHEMBL24989; .alpha.-Bisabolol (-)-form; ((-))-6-Methyl-2-(4-methyl-3-cyclohexen-1-yl)-5-hepten-2-ol; CHEMBL1096927; DTXSID4042094; (-)-6-Methyl-2-(4-methyl-3-cyclohexen-1-yl)-5-hepten-2-ol; HY-N6967; ZINC1849759; [S-(R*,R*)]-.alpha.-Bisabolol; Tox21_301375; 5-Hepten-2-ol, 6-methyl-2-(4-methyl-3-cyclohexen-1-yl)-, (-)-; BDBM50382730; MFCD03412455; DB13153; LMPR0103060001; (-)-alpha-Bisabolol, >=93% (GC); (-)-Alpha-bisabolol(-)-alpha-bisabolol; NCGC00255987-01; (-)-alpha-Bisabolol, analytical standard; CS-0028206; Alpha-Bisabolol 1000 microg/mL in Isopropanol; C09621; Q179896; J-014978; UNII-36HQN158VC component RGZSQWQPBWRIAQ-CABCVRRESA-N; (-)-alpha-Bisabolol, primary pharmaceutical reference standard; Levomenol, United States Pharmacopeia (USP) Reference Standard; (S)-6-Methyl-2-((S)-4-methylcyclohex-3-en-1-yl)hept-5-en-2-ol; 6-Methyl-2-(4-methyl-3-cyclohexen-1-yl)-5-hepten-2-ol, (-)-; 3-Cyclohexene-1-methanol, a,4-dimethyl-a-(4-methyl-3-pentenyl)-,(aS,1S)-
Click to Show/Hide
|
||||
| Activity |
IC50 = 73000 nM
|
[16] | |||
| Compound Name |
N-(5-Benzyl-1,3,4-oxadiazol-2-yl)-2-phenyl-4-quinolinecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1687966; SCHEMBL1901388; BDBM50338997; N-(5-benzyl-1,3,4-oxadiazol-2-yl)-2-phenylquinoline-4-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 75000 nM
|
[9] | |||
| Compound Name |
2-Phenyl-N-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1562195; MLS000724695; SCHEMBL1900368; cid_2104460; BDBM50338999; SMR000237566; MLS-0234877.0001; AB00571659-02; 2-Phenyl-N-[5-(2-thienyl)-1,3,4-oxadiazol-2-yl)-4-quinolinecarboxamide
Click to Show/Hide
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||||
| Activity |
IC50 = 75000 nM
|
[9] | |||
| Compound Name |
Chembl4164056
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50279566
Click to Show/Hide
|
||||
| Activity |
IC50 = 79100 nM
|
[8] | |||
| Compound Name |
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-(4-phosphonooxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-[[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]amino]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL348612
Click to Show/Hide
|
||||
| Activity |
IC50 = 80000 nM
|
[14] | |||
| Compound Name |
[4-[(2S)-2-Acetamido-3-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]amino]-5-(dimethylamino)-1,5-dioxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]amino]-3-oxopropyl]phenyl] dihydrogen phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL194453
Click to Show/Hide
|
||||
| Activity |
IC50 = 80000 nM
|
[10] | |||
| Compound Name |
4-(2-(Tosyloxy)acetamido)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4168681; SCHEMBL1999371; BDBM50450181; 4-[[2-(4-methylphenyl)sulfonyloxyacetyl]amino]benzoic acid
Click to Show/Hide
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||||
| Activity |
IC50 = 86000 nM
|
[17] | |||
| Compound Name |
Sweroside
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
UNII-I3YG76417O; I3YG76417O; MFCD09954487; (-)-Sweroside; SCHEMBL307117; CHEMBL456137; MEGxp0_000813; ACon0_001457; ACon1_000233; DTXSID70161955; EBD7300; HY-N0806; ZINC5157983; BDBM50279544; s9072; AKOS015960475; Sweroside, >=95% (LC/MS-ELSD); CCG-268134; MCULE-3649481594; NCGC00180755-01; NCGC00180755-03; AC-11215; AS-56077; CS-0009811; N1314; W1780; C17071; 142S862; Q-100156; BRD-K31299876-001-01-5; Q27151406
Click to Show/Hide
|
||||
| Activity |
IC50 = 89500 nM
|
[8] | |||
| Compound Name |
[4-[[4-[(4-Methoxyphenyl)carbamoyl]-2-phenyl-1,3-oxazol-5-yl]methyl]phenyl] dihydrogen phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3696065; BDBM144580; US8969578, 13
Click to Show/Hide
|
||||
| Activity |
IC50 = 90000 nM
|
[18] | |||
| Compound Name |
4-[3-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-3-oxo-propenyl]-benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2171898; ZINC4030996; BDBM50396175; CCG-10846; 4-[(E)-3-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-oxoprop-1-enyl]benzoic acid; AKOS000616969; BIM-0023790.P001; ST50232503; 4-((1E)-3-(2H,3H-benzo[3,4-e]1,4-dioxan-6-yl)-3-oxoprop-1-enyl)benzoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 91000 nM
|
[7] | |||
| Compound Name |
5-(2-(N-Benzylbiphenyl-4-ylsulfonamido)-N-(4-morpholinobenzyl)acetamido)-2-hydroxybenzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3133470; SCHEMBL17076967; BDBM50496642
Click to Show/Hide
|
||||
| Activity |
IC50 = 94700 nM
|
[6] | |||
| Compound Name |
2-Phosphoryloxy-7-carbonyl-naphthyl-Leu-Pro-Gln-Thr-NH2
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL443407; BDBM50293275
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
[4-[(2S)-2-Acetamido-3-[[(2S)-1-[(2S)-2-[[(2S)-5-amino-1-[[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]-methylamino]-3-oxopropyl]phenyl] dihydrogen phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL194427
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
[4-[(2S)-2-Acetamido-3-[[(2S)-1-[(2S)-2-[[(2S)-5-amino-1-[[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3,3-diphenylpropan-2-yl]amino]-3-oxopropyl]phenyl] dihydrogen phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL197658
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
Chembl4169822
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50279565
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
Chembl4168853
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50279555
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
[(3S)-2-Acetyl-3-[[(2S)-1-[(2S)-2-[[(2S)-5-amino-1-[[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]carbamoyl]-3,4-dihydro-1H-isoquinolin-6-yl] dihydrogen phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2372260
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
6-Phosphoryloxyindole-3-acetic-Leu-Pro-Gln-Thr-NH2
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL471109; BDBM50293276
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
Chembl4177450
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50279532
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
[4-[(2S)-2-Acetamido-3-[[(2S)-1-[(2R)-2-[[(2S)-5-amino-1-[[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]amino]-3-oxopropyl]phenyl] dihydrogen phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL370649
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
Chembl4176712
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50279543
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
3-Phosphoryloxycinn-Leu-Pro-Gln-Thr-NH2
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL500738; BDBM50293278
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
Chembl4160015
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50279568
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
4-[(4-Cyclohexylphenyl)methyl-[2-[methyl-(1-methylimidazol-4-yl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1829865; SCHEMBL10243505; BDBM50353438
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[19] | |||
| Compound Name |
6-(3,4-Dihydroxyphenyl)-8-hydroxy-1,3-dimethyl-4H-cyclohepta[c]furan-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL524275; BAS 00888278; Oprea1_168192; Oprea1_852496; ZINC277993; BDBM50265058; AKOS000562727; SR-01000318981; SR-01000318981-1
Click to Show/Hide
|
||||
| Activity |
IC50 = 106000 nM
|
[20] | |||
| Compound Name |
[(2R,3S,4S,5R,6S)-3,5-Dihydroxy-2-methyl-6-[(2S)-6-methyl-2-[(1S)-4-methylcyclohex-3-en-1-yl]hept-5-en-2-yl]oxyoxan-4-yl] 3-methylbut-2-enoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2023565; BDBM50382732
Click to Show/Hide
|
||||
| Activity |
IC50 = 110000 nM
|
[16] | |||
| Compound Name |
4-[(4-Cyclohexylphenyl)methyl-[2-[(4-methylphenyl)sulfonyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]acetyl]amino]-2-hydroxybenzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2023989; SCHEMBL10243757; BDBM50382463
Click to Show/Hide
|
||||
| Activity |
IC50 = 115000 nM
|
[2] | |||
| Compound Name |
2-Hydroxy-5-(N-(4-methoxybenzyl)-4-phenoxybenzamido)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3133454; SCHEMBL17076997; BDBM50496656; 2-hydroxy-5-[(4-methoxyphenyl)methyl-(4-phenoxybenzoyl)amino]benzoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 118100 nM
|
[6] | |||
| Compound Name |
4-[(2S)-2-[(4-Cyanophenyl)formamido]-2-{[(1S)-3-methyl-1-[(pyridin-4-ylmethyl)carbamoyl]butyl]carbamoyl}ethyl]phenoxyphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL234817; ISS843; BDBM20281
Click to Show/Hide
|
||||
| Activity |
IC50 = 123000 nM
|
[11] | |||
| Compound Name |
[4-[[4-[(4-Methoxyphenyl)carbamoyl]-2-naphthalen-1-yl-1,3-thiazol-5-yl]methyl]phenyl] dihydrogen phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3696069; BDBM144584; US8969578, 19
Click to Show/Hide
|
||||
| Activity |
IC50 = 125000 nM
|
[18] | |||
| Compound Name |
(S)-2-((2S,3R)-2-((S)-2-((S)-1-((S)-2-((S)-2-Acetamido-3-(4-(phosphonomethyl)phenyl)propanamido)-4-methylpentanoyl)pyrrolidine-2-carboxamido)-5-amino-5-oxopentanamido)-3-hydroxybutanamido)-3-methylbutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL396939; BDBM50213223
Click to Show/Hide
|
||||
| Activity |
IC50 = 138000 nM
|
[21] | |||
| Compound Name |
4-[[2-[(4-Chlorophenyl)methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]-[(3,5-ditert-butylphenyl)methyl]amino]-2-hydroxybenzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358611; SCHEMBL17308728; BDBM50033887
Click to Show/Hide
|
||||
| Activity |
Ki = 143800 nM
|
[22] | |||
| Compound Name |
3-[[2-Chloro-4-[(1,3-dioxoinden-2-ylidene)methyl]-6-ethoxyphenoxy]methyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2171899; SCHEMBL1430629; ZINC9322196; BDBM50396174; STK160362; AKOS000329628; MCULE-8512891890
Click to Show/Hide
|
||||
| Activity |
IC50 = 144000 nM
|
[7] | |||
| Compound Name |
(3S)-3-[({[(1S)-2-Carbamoyl-1-{[(1S)-1-carbamoyl-2-phenylethyl]carbamoyl}ethyl]carbamoyl}methyl)carbamoyl]-3-[(2S)-2-[(2S)-2-acetamido-3-[4-(phosphonooxy)phenyl]propanamido]-3-hydroxypropanamido]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Y(p)SDGNF; CHEMBL346706; BDBM20247; gp130 (673) derived peptide, 2
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[14] | |||
| Compound Name |
[4-[(2S)-2-Acetamido-3-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-5-amino-1-[(2R)-2-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1,5-dioxopentan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-oxopropyl]phenyl] dihydrogen phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL348182
Click to Show/Hide
|
||||
| Activity |
IC50 = 150000 nM
|
[14] | |||
| Compound Name |
[4-[(2S)-2-Acetamido-3-[[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-oxopropyl]phenyl] dihydrogen phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2371210
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[14] | |||
| Compound Name |
[4-[[4-(Hexylcarbamoyl)-2-phenyl-1,3-thiazol-5-yl]methyl]phenyl] dihydrogen phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2228791; CHEMBL3696062; BDBM144577; US8969578, 9
Click to Show/Hide
|
||||
| Activity |
IC50 = 150000 nM
|
[18] | |||
| Compound Name |
STAT5 Inhibitor
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
STAT5-IN-1; STAT5; N'-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide; N'-[(4-oxo-4H-chromen-3-yl)methylene]nicotinohydrazide; N-[(E)-(4-oxochromen-3-yl)methylideneamino]pyridine-3-carboxamide; SCHEMBL2563928; CHEMBL1241908; CCG-1475; EX-A2552; MFCD00124694; CS-6859; BS-16416; HY-101853; S6784; STAT5 Inhibitor 1 [285986-31-4]; EC-000.2533; J-017149; SR-01000638229-1; (E)-N'-((4-oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
Click to Show/Hide
|
||||
| Activity |
IC50 = 180000 nM
|
[23] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 17 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-Hydroxy-5-[N-benzyl-N-(benzyl p-toluenesulfonylamino)acetylamino]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3133495; SCHEMBL15705785; BDBM50496636; 5-(N-Benzyl-2-(N-benzyl-4-methylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid; 5-[benzyl-[2-[benzyl-(4-methylphenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 201300 nM
|
[6] | |||
| Compound Name |
[4-[[4-[(4-Cyclohexylphenyl)carbamoyl]-2-naphthalen-1-yl-1,3-oxazol-5-yl]methyl]phenyl] dihydrogen phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2228317; CHEMBL3696067; BDBM144582; US8969578, 17
Click to Show/Hide
|
||||
| Activity |
IC50 = 255000 nM
|
[18] | |||
| Compound Name |
2-Hydroxy-4-[[2-[methyl-(4-methylphenyl)sulfonylamino]acetyl]amino]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431982; BDBM50440965
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[2] | |||
| Compound Name |
5-[[2-[Benzyl-(4-phenylphenyl)sulfonylamino]acetyl]-[(4-piperidin-4-ylphenyl)methyl]amino]-2-hydroxybenzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3133468; BDBM50496658
Click to Show/Hide
|
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| Activity |
IC50 > 300000 nM
|
[6] | |||
| Compound Name |
2-Hydroxy-4-[[2-[(4-methylphenyl)sulfonylamino]acetyl]amino]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431981; SCHEMBL12359540; BDBM50440966
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[2] | |||
| Compound Name |
2-Hydroxy-4-[[2-[(4-methylphenyl)sulfonyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]acetyl]amino]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431983; SCHEMBL10243365; BDBM50440964
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[2] | |||
| Compound Name |
4-[(2S)-2-[(4-Cyanophenyl)formamido]-2-{[(1S)-3-methyl-1-(phenylcarbamoyl)butyl]carbamoyl}ethyl]phenoxyphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL438852; ISS838; BDBM20277
Click to Show/Hide
|
||||
| Activity |
IC50 = 310000 nM
|
[11] | |||
| Compound Name |
[4-[[4-[(4-Cyclohexylphenyl)carbamoyl]-2-naphthalen-1-yl-1,3-thiazol-5-yl]methyl]phenyl] dihydrogen phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2229716; CHEMBL3696068; BDBM144583; US8969578, 18
Click to Show/Hide
|
||||
| Activity |
IC50 = 350000 nM
|
[18] | |||
| Compound Name |
2-(Benzo[d][1,3]dioxol-5-yl)-N-(3,4-dihydroxyphenethyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL508923; BDBM50265057
Click to Show/Hide
|
||||
| Activity |
IC50 = 357000 nM
|
[20] | |||
| Compound Name |
Phaeosphaeride A
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3632630; BDBM50133594
Click to Show/Hide
|
||||
| Activity |
IC50 = 610000 nM
|
[24] | |||
| Compound Name |
4-[(2S)-2-[(4-Cyanophenyl)formamido]-2-{[(1S)-1-[(3-hydroxypropyl)carbamoyl]-3-methylbutyl]carbamoyl}ethyl]phenoxyphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL234466; ISS835; BDBM20275
Click to Show/Hide
|
||||
| Activity |
IC50 = 620000 nM
|
[11] | |||
| Compound Name |
[4-[[4-[(4-Cyclohexylphenyl)carbamoyl]-2-phenyl-1,3-thiazol-5-yl]methyl]phenyl] dihydrogen phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2229334; CHEMBL3696063; BDBM144578; US8969578, 11
Click to Show/Hide
|
||||
| Activity |
IC50 = 775000 nM
|
[18] | |||
| Compound Name |
4-[(2S)-2-{[(1S)-1-(Benzylcarbamoyl)-3-methylbutyl]carbamoyl}-2-[(4-cyanophenyl)formamido]ethyl]phenoxyphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL398067; ISS839; BDBM20278
Click to Show/Hide
|
||||
| Activity |
IC50 = 800000 nM
|
[11] | |||
| Compound Name |
5-(N-Benzyl-2-(N,4-dimethylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3133487; SCHEMBL17076974; BDBM50496640; 5-[benzyl-[2-[methyl-(4-methylphenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[6] | |||
| Compound Name |
2-Phenyl-5-[(4-phosphonooxyphenyl)methyl]-1,3-oxazole-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3696060; BDBM144575; US8969578, 7
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[18] | |||
| Compound Name |
N-(4-Cyclohexylphenyl)-5-[(4-hydroxyphenyl)methyl]-2-phenyl-1,3-oxazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3696064; BDBM144579; US8969578, 12
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[18] | |||
| Compound Name |
[4-[[4-(Hexylcarbamoyl)-2-phenyl-1,3-oxazol-5-yl]methyl]phenyl] dihydrogen phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2382102; CHEMBL3696061; BDBM144576; US8969578, 8
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[18] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Electrophilic Triterpenoid Enones: A Comparative Thiol-Trapping and Bioactivity Study. J Nat Prod. 2017 Aug 25;80(8):2276-2283. | ||||
| REF 2 | Inhibiting aberrant signal transducer and activator of transcription protein activation with tetrapodal, small molecule Src homology 2 domain binders: promising agents against multiple myeloma. J Med Chem. 2013 Sep 26;56(18):7190-200. | ||||
| REF 3 | Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3581-5. | ||||
| REF 4 | SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase. J Med Chem. 2014 Jul 10;57(13):5638-48. | ||||
| REF 5 | Neuroactive and Anti-inflammatory Frankincense Cembranes: A Structure-Activity Study. J Nat Prod. 2016 Jul 22;79(7):1762-8. | ||||
| REF 6 | Development of new N-Arylbenzamides as STAT3 Dimerization Inhibitors. Medchemcomm. 2013 Jun;4(6):932-941. | ||||
| REF 7 | Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein. J Med Chem. 2012 Aug 9;55(15):6645-68. | ||||
| REF 8 | Cornusides A-O, Bioactive Iridoid Glucoside Dimers from the Fruit of Cornus officinalis. J Nat Prod. 2017 Dec 22;80(12):3103-3111. | ||||
| REF 9 | Identification of a New Series of STAT3 Inhibitors by Virtual Screening. ACS Med Chem Lett. 2010 Jul 13;1(8):371-5. | ||||
| REF 10 | Investigation of the binding determinants of phosphopeptides targeted to the SRC homology 2 domain of the signal transducer and activator of transcription 3. Development of a high-affinity peptide inhibitor. J Med Chem. 2005 Oct 20;48(21):6661-70. | ||||
| REF 11 | Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: structural recognition of STAT SH2 domains. Bioorg Med Chem Lett. 2007 Apr 1;17(7):1875-8. | ||||
| REF 12 | Conformationally constrained peptidomimetic inhibitors of signal transducer and activator of transcription. 3: Evaluation and molecular modeling. J Med Chem. 2009 Apr 23;52(8):2429-42. | ||||
| REF 13 | Identification and characterization of small molecule inhibitors of signal transducer and activator of transcription 3 (STAT3) signaling pathway by virtual screening. Bioorg Med Chem Lett. 2013 Apr 1;23(7):2225-9. | ||||
| REF 14 | Identification of a high-affinity phosphopeptide inhibitor of Stat3. Bioorg Med Chem Lett. 2003 Feb 24;13(4):633-6. | ||||
| REF 15 | Structure-affinity relationships of glutamine mimics incorporated into phosphopeptides targeted to the SH2 domain of signal transducer and activator of transcription 3. J Med Chem. 2009 Oct 8;52(19):6126-41. | ||||
| REF 16 | STAT-3 inhibitory bisabolanes from Carthamus glaucus. J Nat Prod. 2012 Mar 23;75(3):453-8. | ||||
| REF 17 | Andrographolide derivative as STAT3 inhibitor that protects acute liver damage in mice. Bioorg Med Chem. 2018 Oct 1;26(18):5053-61. | ||||
| REF 18 | US patent application no. 8969578B2, Inhibitors of STAT3 | ||||
| REF 19 | Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5605-9. | ||||
| REF 20 | Discovery of the catechol structural moiety as a Stat3 SH2 domain inhibitor by virtual screening. Bioorg Med Chem Lett. 2008 Sep 15;18(18):4988-92 | ||||
| REF 21 | New syntheses of tetrazolylmethylphenylalanine and O-malonyltyrosine as pTyr mimetics for the design of STAT3 dimerization inhibitors. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3943-6. | ||||
| REF 22 | Nanomolar-Potency Small Molecule Inhibitor of STAT5 Protein. ACS Med Chem Lett. 2014 Sep 19;5(11):1202-1206. | ||||
| REF 23 | Inhibitors of Stat5 protein signalling. Medchemcomm. 2012;3:22-7. | ||||
| REF 24 | Synthesis of natural phaeosphaeride A derivatives and an in vitro evaluation of their anti-cancer potential. Bioorg Med Chem Lett. 2015 Dec 1;25(23):5566-9. | ||||
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