Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T28484 | Target Info | |||
| Target Name | Kinesin-like protein KIF11 (KIF11) | ||||
| Synonyms |
Thyroid receptor interacting protein 5; TRIP5; Kinesin-related motor protein Eg5; Kinesin-like spindle protein HKSP; Kinesin-like protein 1; KIF11; Eg5
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| Target Type | Clinical trial Target | ||||
| Gene Name | KIF11 | ||||
| Biochemical Class | Kinesin-like protein family | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 51 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Carbocisteine
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Approved | Compound Info | ||
| Synonyms |
Carbocysteine; Siroxyl; Carbocisteine, Sopar
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| Activity |
IC50 ~ 63000 nM
|
[1] | |||
| Compound Name |
L-cysteine
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Clinical trial | Compound Info | ||
| Synonyms |
52-90-4; Cystein; Half-cystine; (R)-Cysteine; Thioserine; (R)-2-Amino-3-mercaptopropanoic acid; L-(+)-Cysteine; L-Cystein; (2R)-2-amino-3-sulfanylpropanoic acid; beta-Mercaptoalanine; Half cystine; FREE CYSTEINE; Cysteine, L-; L-Cys; L-Alanine, 3-mercapto-; L-Zystein; H-Cys-OH; Cisteinum [Latin]; L-2-Amino-3-mercaptopropionic acid; Cisteina [Spanish]; cisteina; Polycysteine; Cysteinum; Cisteinum; (R)-2-Amino-3-mercaptopropionic acid; L Cysteine; alpha-Amino-beta-thiolpropionic acid; L-2-Amino-3-mercaptopropanoic a
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| Activity |
IC50 ~ 63000 nM
|
[1] | |||
| Compound Name |
Benzylcysteine
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Investigative | Compound Info | ||
| Synonyms |
S-Benzyl-L-cysteine; 3054/1/1; H-Cys(Bzl)-OH; Poly-S-benzylcysteine; (R)-S-Benzylcysteine; (R)-2-amino-3-(benzylthio)propanoic acid; (S)-Benzyl-L-Cys; cysteine, s-(phenylmethyl)-; CHEMBL63130; UNII-9VRE13M548; GHBAYRBVXCRIHT-VIFPVBQESA-N; 9VRE13M548; MFCD00002613; NSC 523123; 25988-62-9; (2R)-2-amino-3-benzylsulfanyl-propanoic acid; B-1025; J-300089; D-S-butylcysteine; BCS; (2R)-2-amino-3-(phenylmethylthio)propanoic acid
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| Activity |
IC50 ~ 63000 nM
|
[1] | |||
| Compound Name |
NSC-125034
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Investigative | Compound Info | ||
| Synonyms |
NSC125034; NSC-125034; CHEMBL239439; 8-Quinolinol, 2,2'-dithiobis-; AC1L5KEF; NCIStruc1_001467; NCIStruc2_001671; SCHEMBL2534563; CTK8A0185; 2,2'-disulfanediyldiquinolin-8-ol; NCI125034; BDBM50198307; ZINC37868596; NCGC00014270; CCG-37229; NCGC00097379-01; NCGC00014270-02; NCI60_000583; 2-(8-hydroxyquinolin-2-yl)disulfanylquinolin-8-ol; 2-[(8-hydroxy-2-quinolyl)disulfanyl]quinolin-8-ol; 2-[(8-hydroxyquinolin-2-yl)disulfanyl]quinolin-8-ol
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| Activity |
IC50 = 145000 nM
|
[2] | |||
| Compound Name |
3-[5-(2-Chloro-phenyl)-2-methyl-3,4-dihydro-2H-pyrazol-3-yl]-phenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL365107; BDBM50164858
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
1-Acetyl-3-(2-methoxyphenyl)-5-phenyl-2-pyrazoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL382712; BDBM50164859; AKOS033609937; MCULE-4192198413; Z1834079468; 1-[3-(2-Methoxy-phenyl)-5-phenyl-4,5-dihydro-pyrazol-1-yl]-ethanone; 1-[3-(2-methoxyphenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-one
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-(2-Morpholinoethylamino)-1-(2-(trifluoromethyl)benzyl)-1H-benzo[d]imidazole-5-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL549873; BDBM50293776
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
2-(2-Aminoethylsulfanyl)-1,2,2-triphenylethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2043395; BDBM50386212
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
1-[5-Phenyl-3-(2-trifluoromethyl-phenyl)-4,5-dihydro-pyrazol-1-yl]-ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL445924; BDBM50164854
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
1H-Pyrazole, 1-acetyl-3-(4-chlorophenyl)-4,5-dihydro-5-phenyl-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL195933; ACMC-20liad; CTK3A0704; DTXSID70563495; BDBM50164870; 1-Acetyl-3-(4-chlorophenyl)-5-phenyl-2-pyrazoline; 1-(3-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethanone; 1-[3-(4-Chloro-phenyl)-5-phenyl-4,5-dihydro-pyrazol-1-yl]-ethanone; 1-[3-(4-Chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-one
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| Activity |
IC50 ~ 50000 nM
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[3] | |||
| Compound Name |
1-(3,5-Diphenyl-4,5-dihydro-1H-pyrazol-1-yl)ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL193585; 1-(3,5-diphenyl-3,4-dihydropyrazol-2-yl)ethanone; 1-acetyl-3,5-diphenyl-2-pyrazoline; 1-(3,5-Diphenyl-4,5-dihydro-pyrazol-1-yl)-ethanone; BRN 0221183; 1-Acetyl-3,5-diphenyl-4,5-dihydropyrazole; 1-Acetyl-4,5-dihydro-3,5-diphenyl-1H-pyrazole; 1H-Pyrazole, 4,5-dihydro-1-acetyl-3,5-diphenyl-; 5-23-09-00010 (Beilstein Handbook Reference); KSC937I1N; MLS001212267; SCHEMBL1658926; BSTJKGVHQLTINE-UHFFFAOYSA-; CTK8D7416; DTXSID20952936; HMS1681E17; HMS2849L05; KS-00000YH3; BDBM50164871; STK050480; AKOS000520661; MCULE-7191680733; NCGC00245163-01; SMR000514781; 4,5-Dihydro-(1H)-pyrazole derivative, 1a; ST50112237; 1-acetyl-3,5-diphenyl-4,5-dihydro-(1h)-pyrazole; 1-(3,5-Diphenyl-4,5-dihydro-1H-pyrazol-1-yl)ethan-1-one
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| Activity |
IC50 ~ 50000 nM
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[3] | |||
| Compound Name |
(2R)-4-(2,5-Difluorophenyl)-N,N-dimethyl-2-phenyl-2,5-dihydropyrrole-1-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL382835
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| Activity |
IC50 = 50000 nM
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[6] | |||
| Compound Name |
3-(2-Chloro-phenyl)-5-(3-hydroxy-phenyl)-4,5-dihydro-pyrazole-1-carboxylic acid methyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL365321; BDBM50164863
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| Activity |
IC50 ~ 50000 nM
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[3] | |||
| Compound Name |
Chembl4243138
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463304
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| Activity |
IC50 = 51000 nM
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[7] | |||
| Compound Name |
Chembl4288725
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Investigative | Compound Info | ||
| Synonyms |
BDBM50468764
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| Activity |
IC50 = 53900 nM
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[8] | |||
| Compound Name |
Fmoc-Cys(Trt)-OH
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Investigative | Compound Info | ||
| Synonyms |
FMOC-S-trityl-L-cysteine; Fmoc-L-Cys(Trt)-OH; N-Fmoc-S-trityl-L-cysteine; Fmoc-Cys(Trt); MFCD00038538; N(alpha)-Fluorenylmethyloxycarbonyl-S-tritylcysteine; CHEMBL396414; N-(9-Fluorenylmethoxycarbonyl)-S-trityl-L-cysteine; (2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-tritylsulfanylpropanoic acid; L-Cysteine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-S-(triphenylmethyl)-; Fmoc-S-trityl-cys; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-S-trityl-L-cysteine; (R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(tritylthio)propanoic acid; Na-Fmoc-Ng-trityl-L-glutamine; L-Cysteine, N-((9H-fluoren-9-ylmethoxy)carbonyl)-S-(triphenylmethyl)-; Fmoc-Cyc(Trt)-OH; PubChem10010; Fmoc-S-Trityl-Cys-OH; FMOC-L-CYS(TRT); FMOC-L-CYS(TRITYL); KSC176O9R; FMOC-CYSTEINE(TRT)-OH; FMOC-L-CYSTEINE (TRT); N-(9-Fluorenyl methoxy carbonyl)-S-trityl-L-cysteine; SCHEMBL1738641; FMOC-L-CYSTEINE(TRITYL); CTK0H6798; DTXSID70145699; KS-00000AD0; STR09764; ZINC4284046; ANW-14816; BBL103590; BDBM50213734; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-(triphenylmethyl)-L-cysteine; STL557400; AKOS015924131; AM81677; CS-W007798; MCULE-1796690263; AC-10507; AC-12310; SC-00132; AB0012529; DB-029846; F0652; M03395; 213F327; N-9-Fluorenylmethyloxycarbonyl-S-trityl-L-cysteine; J-300088; N-(alpha)-fluorenylmethyloxycarbonyl-S-tritylcysteine; N-alpha-(9-Fluorenylmethoxycarbonyl)-S-trityl-L-cysteine; Nalpha-(9-Fluorenylmethoxycarbonyl)-S-trityl-L-cysteine; Fmoc-Cys(Trt)-OH, >=95.0% (sum of enantiomers, HPLC); N-alpha-(9-Fluorenylmethyloxycarbonyl)-S-trityl-L-cysteine; (R)-2-(((9H-fluoren-9-yl)methoxy)carbonyl)-3-(tritylthio)propanoic acid; 2(R)-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-tritylsulfanyl-propionic acid
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| Activity |
IC50 = 55000 nM
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[1] | |||
| Compound Name |
(R)-2-Amino-3-(diphenyl(thiophen-2-yl)methylthio)propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688932; NSC-136870; BDBM50339682; ZINC16953104
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| Activity |
Ki = 58333 nM
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[9] | |||
| Compound Name |
Chembl4293322
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Investigative | Compound Info | ||
| Synonyms |
BDBM50468756
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| Activity |
IC50 = 59900 nM
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[8] | |||
| Compound Name |
Chembl4242214
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463298
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| Activity |
IC50 = 60000 nM
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[7] | |||
| Compound Name |
Chembl4247682
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463301
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| Activity |
IC50 = 62100 nM
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[7] | |||
| Compound Name |
(R)-2-(Tritylamino)-3-(tritylthio)propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL398146; TRTIYL-S-TITYL-L-CYSETEINE; (2R)-2-(tritylamino)-3-tritylsulfanylpropanoic acid; N,S-ditrityl-cysteine; N,S-ditrityl-L-cysteine; N,S-di-trityl-L-cystein; SCHEMBL11598983; BDBM23809; ZINC5081022; MFCD00237296; AKOS027327979; S-Trityl-L-Cysteine (STLC) Analogue, 38; (2R)-2-[(triphenylmethyl)amino]-3-[(triphenylmethyl)sulfanyl]propanoic acid
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| Activity |
IC50 ~ 63000 nM
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[1] | |||
| Compound Name |
(R)-2-Amino-3-(tert-butylthio)propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
L-S-t-Butylcysteine; (S)-tert-Butyl-L-Cys; CHEMBL231992; D-S-t-Butylcysteine; S-tert-Butyl-L-cysteine; S-t-BUTYL-L-CYSTEINE; SCHEMBL616529; CTK7D1097; ZINC402734; BDBM50213725; L-Cysteine,S-(1,1-dimethylethyl)-; AKOS006286695; (2R)-2-azaniumyl-3-tert-butylsulfanylpropanoate; (R)-2-AMINO-3-(S-TERT-BUTYLTHIO)PROPANOIC ACID
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| Activity |
IC50 ~ 63000 nM
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[1] | |||
| Compound Name |
S-Diphenylmethyl-L-cysteine
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Investigative | Compound Info | ||
| Synonyms |
(R)-2-amino-3-(benzhydrylthio)propanoic acid; S-Benzhydryl-L-cysteine; H-Cys(Dpm)-OH; L-3-(Diphenylmethylthio)alanine; CYSTEINE, S-DIPHENYLMETHYL-, L-; Cysteine(dpm)-OH; NSC 86162; CHEMBL433998; (2R)-2-amino-3-benzhydrylsulfanylpropanoic acid; L-Cysteine, S-(diphenylmethyl)-; Alanine, 3-(diphenylmethylthio)-, L-; BRN 2565688; Benzhydrylcysteine #; Alanine, 3-[(diphenylmethyl)thio]-, L-; (R)-S-Diphenylmethylcysteine; SCHEMBL1913648; BDBM23773; CTK8G3076; DTXSID90199876; ZINC4787119; 7087AH; MFCD00065211; AKOS024323381; L-Cysteine, S-(diphenylmethyl)- (9CI); S-Trityl-L-Cysteine (STLC) Analogue, 2; S-0214; Alanine, 3-((diphenylmethyl)thio)-, L- (8CI); (2R)-2-amino-3-[(diphenylmethyl)sulfanyl]propanoic acid
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| Activity |
IC50 ~ 63000 nM
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[1] | |||
| Compound Name |
S-(2-Aminoethyl)-L-cysteine
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Investigative | Compound Info | ||
| Synonyms |
L-Thialysine; Thiosine; gamma-Thialysine; S-2-Aminoethyl cysteine; gamma-Thia-lys; 4-thialysine; Aminoethylcysteine; S-beta-Aminoethyl cysteine; 4-thia-L-lysine; (2R)-2-amino-3-(2-aminoethylsulfanyl)propanoic acid; UNII-OS2H9OH0GT; OS2H9OH0GT; thialysine; CHEMBL397565; (R)-2-amino-3-(2-aminoethylthio)propanoic acid; s-2-aminoethylcysteine; 2-amino-3-(2-aminoethylsulfanyl)propanoic acid; 2-AMINOETHYLCYSTEINE; S-Aminoethyl-L-cysteine; NSC 241277; NSC-186915; NCIStruc1_000667; NCIStruc2_001830; S-(b-aminoethyl)-l-cysteine; SCHEMBL110108; L-Cysteine,S-(2-aminoethyl)-; CTK4G3170; DTXSID40183588; S-2-AMINOETHYL-L-CYSTEINE; ZINC5828978; BDBM50213732; CCG-38064; NCGC00014530; NCI186915; AKOS006238308; NCGC00014530-02; NCGC00097634-01; Q7387052; (2R)-2-amino-3-[(2-aminoethyl)sulfanyl]propanoic acid
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| Activity |
IC50 ~ 63000 nM
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[1] | |||
| Compound Name |
(R)-Methyl 2-acetamido-3-((4-methoxyphenyl)diphenylmethylthio)propanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL233547; BDBM50213731
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| Activity |
IC50 ~ 63000 nM
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[1] | |||
| Compound Name |
H-Cys(pMeOBzl)-OH
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Investigative | Compound Info | ||
| Synonyms |
S-(4-Methoxybenzyl)-L-cysteine; s-(4-methoxybenzyl)cysteine; CHEMBL302212; MFCD00037207; (R)-2-Amino-3-(4-methoxy-benzylsulfanyl)-propionic acid; S-p-Methoxybenzyl-L-cysteine; (R)-2-Amino-3-((4-methoxybenzyl)thio)propanoic acid; H-Cys(MeOBzl)-OH; s-p-methoxybenzylcysteine; H-Cys(4-Mob)-OH; S-4-Methoxybenzyl-L-cysteine; SCHEMBL530442; CTK3J1670; KS-00000J6Z; ZINC2384785; BDBM50213724; AKOS010377512; AM81682; AK-81238; DS-16178; V1213; K-6676; 544C312; (R)-3-(4-methoxybenzylthio)-2-aminopropanoic acid; (R)-2-amino-3-(4-methoxy-benzylsulfanyl)propionic acid; (2R)-2-azaniumyl-3-[(4-methoxyphenyl)methylsulfanyl]propanoate
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| Activity |
IC50 ~ 63000 nM
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[1] | |||
| Compound Name |
Boc-Cys(Trt)-OH
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Investigative | Compound Info | ||
| Synonyms |
N-Boc-S-Trityl-L-cysteine; Boc-S-trityl-L-cysteine; N-(tert-Butoxycarbonyl)-S-trityl-L-cysteine; (R)-2-((tert-Butoxycarbonyl)amino)-3-(tritylthio)propanoic acid; Boc-L-Cys(Trt)-OH; Boc-L-cysteine(trityl); MFCD00038251; CHEMBL232727; L-Cysteine, N-[(1,1-dimethylethoxy)carbonyl]-S-(triphenylmethyl)-; BOC-S-trityl-L-cysteine, 99%; (2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-tritylsulfanylpropanoic acid; N-BOC-S-trityl-cysteine; C27H29NO4S; Boc-Cys (Trt)-OH; Boc-S-Trityl-Cys-OH; PubChem12941; N-Boc-S-trityl cysteine; Boc-(L)-Cys(Trt)-OH; BOC-CYSTEINE(TRT)-OH; KSC201S8J; Boc-Cys(Trt)-OH, 97%; SCHEMBL619354; BDBM23811; CTK1A1984; KS-00000IXP; EBD9028; N-t-butoxycarbonyl-S-tritylcysteine; N-BOC-S-(triphenylmethyl)-cysteine; ANW-24635; ZINC12648675; AKOS015838042; AKOS015895409; AM81667; CS-W008178; N-t-butoxycarbonyl-S-trityl-L-Cysteine; AS-12182; SC-09447; AB0044005; DB-022870; S-Trityl-L-Cysteine (STLC) Analogue, 40; A7747; ST50997539; M-1006; N-alpha-(t-Butoxycarbonyl)-S-trityl-L-cysteine; N-alpha-t-Butyloxycarbonyl-S-trityl-L-cysteine; 947B988; A815773; (R)-2-((Boc)amino)-3-(tritylthio)propanoic acid; J-300086; Q-101676; (r)-2-(tert-butoxycarbonylamino)-3-(tritylthio)propanoic acid; (2R)-2-[(tert-butoxy)carbonylamino]-3-(triphenylmethylthio)propanoic acid
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| Activity |
IC50 ~ 63000 nM
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[1] | |||
| Compound Name |
S-Methyl-L-cysteine
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Investigative | Compound Info | ||
| Synonyms |
S-Methylcysteine; H-Cys(Me)-OH; S-methyl-cysteine; Cysteine, S-methyl-; L-Cysteine, S-methyl-; (R)-2-amino-3-(methylthio)propanoic acid; L-Methylcysteine; UNII-A34I1H07YM; Methylcysteine; 3-(methylthio)-L-alanine; S-Methyl-DL-cysteine; A34I1H07YM; CHEMBL394875; (2R)-2-amino-3-(methylsulfanyl)propanoic acid; MFCD00002612; (2R)-2-amino-3-methylthiopropanoic acid; CCRIS 1972; EINECS 214-701-6; NSC 15387; Acm-thiopropionate; S-methyl-l-cys; D-S-methyl-cysteine; L-S-Methyl-cysteine; (R)-2-Amino-3-(methylmercapto)propionic acid; (-)-S-Methyl-L-cysteine; KSC175I3T; S-methyl-(9CI)-L-cysteine; SCHEMBL110458; L-CH3SCH2CH(NH2)COOH; CTK0H5439; L-Cysteine, S-methyl- (9CI); 3-(methylthio)-L-(8CI)alanine; DTXSID50862579; S-Acetamidomethyl-deamino-cysteine; HY-B2188; ZINC3861771; EINECS 243-203-1; 2067AC; ANW-17233; BDBM50213729; s4786; SBB066379; AKOS000275785; AM82581; CCG-266126; CS-7653; DB02216; GS-3468; Alanine, 3-(methylthio)-, L- (8CI); M0233; ST50307176; V1222; C22040; (R)-2-AMMONIO-3-(METHYLTHIO)PROPANOATE; J-300343; Q27093260; 0DDF4489-1BF1-4858-9127-80A71A348EC8; S-Methyl-L-cysteine, substrate for methionine sulfoxide reductase A
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| Activity |
IC50 ~ 63000 nM
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[1] | |||
| Compound Name |
(R)-3-(((9H-Fluoren-9-yl)methyl)thio)-2-aminopropanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL392255; H-Cys(Fm)-OH; S-(9-Fluolenylmethyl)-L-cysteine; S-9-fluorenylmethyl-l-cysteine; (2R)-2-amino-3-(9H-fluoren-9-ylmethylsulfanyl)propanoic acid; SCHEMBL14537461; CTK3C9722; DTXSID40427156; ZINC2560707; BDBM50213726; L-Cysteine, S-(9H-fluoren-9-ylmethyl)-; (2R)-2-azaniumyl-3-(9H-fluoren-9-ylmethylsulfanyl)propanoate
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| Activity |
IC50 ~ 63000 nM
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[1] | |||
| Compound Name |
Ac-Cys(Trt)-OH
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Investigative | Compound Info | ||
| Synonyms |
N-acetyl-S-trityl-L-cysteine; (2R)-2-acetamido-3-tritylsulfanylpropanoic acid; CHEMBL415259; MFCD00236747; Acetyl-S-trityl-L-cysteine; (R)-N-Acetyl-S-tritylcysteine; Ac-Cys(Trt)-OH;; L-Cysteine, N-acetyl-S-(triphenylmethyl)-; N-acetyl-S-trityl-L-cysteine;; SCHEMBL5967574; BDBM23808; KS-00000SYX; N-alpha-Acetyl-S-trityl-L-cysteine; ZINC4899634; EBD278919; AKOS025289472; DS-7557; S-Trityl-L-Cysteine (STLC) Analogue, 37; K-6980; (2R)-2-acetamido-3-[(triphenylmethyl)sulfanyl]propanoic acid
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| Activity |
IC50 ~ 63000 nM
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[1] | |||
| Compound Name |
Chembl4246224
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463310
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| Activity |
IC50 = 63300 nM
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[7] | |||
| Compound Name |
3-N,3-N,6-Triethyl-2-N-(thiophene-2-)-4,5,6,7-tetrahydro-1-benzothiophene-2,3-diamido
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL228328; BDBM24177; thiophene containing compound, 40
Click to Show/Hide
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||||
| Activity |
IC50 = 69000 nM
|
[10] | |||
| Compound Name |
Chembl4247167
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463305
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||||
| Activity |
IC50 = 70000 nM
|
[7] | |||
| Compound Name |
Chembl4249742
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463312
Click to Show/Hide
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||||
| Activity |
IC50 = 71900 nM
|
[7] | |||
| Compound Name |
Chembl4243604
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463299
Click to Show/Hide
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||||
| Activity |
IC50 = 75000 nM
|
[7] | |||
| Compound Name |
N-[3-(Diethylcarbamoyl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3-thiazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL388098; BDBM24155; thiazole containing compound, 18
Click to Show/Hide
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||||
| Activity |
IC50 = 76000 nM
|
[10] | |||
| Compound Name |
4-({[3-(Methoxycarbonyl)-2-methylnaphtho[1,2-b]furan-5-yl]amino}sulfonyl)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1551717; MLS000948132; HMS2251H11; ZINC8439331; BDBM50383083; MCULE-1246062208; SMR000620453; SR-01000087982; SR-01000087982-1
Click to Show/Hide
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||||
| Activity |
IC50 = 79100 nM
|
[11] | |||
| Compound Name |
Chembl4246993
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463318
Click to Show/Hide
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||||
| Activity |
IC50 = 90000 nM
|
[7] | |||
| Compound Name |
Chembl4239372
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50463303
Click to Show/Hide
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||||
| Activity |
IC50 = 90000 nM
|
[7] | |||
| Compound Name |
3-N,3-N-Diethyl-2-N-(thiophene-2-)thiophene-2,3-diamido
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL228688; BDBM24149; thiophene containing compound, 12
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
3-N,3-N-Diethyl-2-N-(thiophene-2-)-1-benzothiophene-2,3-diamido
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL376365; BDBM24181; thiophene containing compound, 44
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
2-(Thiophene-2-carbonylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-(thiophene-2-amido)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid; Oprea1_521823; MLS000111877; CHEMBL229012; cid_703864; SCHEMBL3918724; BDBM24161; ZINC87317; thiophene containing compound, 24; HMS1729D11; HMS2420E24; STK965631; AKOS000539827; CCG-285487; MCULE-6359068818; NCGC00077597-02; SMR000107796; ST50050547; MLS-0035921.0001; AB00292564-05; AB00292564-12; Z55175721; F0825-0155; 2-(Thiophene-2-carboxamido)-4,5,6,7-tetrahydrobenzothiophene-3-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
3-N,3-N-Diethyl-2-N-(thiophene-2-)-4H,5H,6H,7H-thieno[2,3-c]pyridine-2,3-diamido
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL228384; BDBM24180; thiophene containing compound, 43
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
Ethyl 2-[(2-thienylcarbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC690134; ethyl 2-(thiophene-2-amido)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate; Oprea1_576654; Oprea1_773956; MLS000104933; CHEMBL375015; BDBM24160; CTK8C9345; ZINC64400; thiophene containing compound, 23; HMS2326H18; STK413001; AKOS000541335; CCG-104013; MCULE-1974382252; NSC-690134; NCI60_032400; SMR000054863; ST015457; AG-690/33894016; SR-01000410164; SR-01000410164-1; Z27680777
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
2-(Thiophene-2-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-[(2-thienylcarbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide; CBMicro_024249; Cambridge id 5546389; MixCom6_001273; Oprea1_447465; ARONIS020616; CHEMBL229013; SCHEMBL3914843; BDBM24162; KS-00004CAN; ZINC38784; thiophene containing compound, 25; CCG-10934; STK015621; AKOS000487396; MCULE-2989063127; 2-(thiophene-2-carbonylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide; ST055055; BIM-0023999.P001; SR-01000525011; SR-01000525011-1; Z27358574; F0016-0644; 2-(thiophene-2-amido)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide; 2-N-(thiophene-2-)-4,5,6,7-tetrahydro-1-benzothiophene-2,3-diamido; 2-(2-thienylcarbonylamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide; 2-[(2-Thienyl)carbonylamino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
Chembl4241249
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463313
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||||
| Activity |
IC50 = 106200 nM
|
[7] | |||
| Compound Name |
Chembl4239414
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463306
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||||
| Activity |
IC50 = 120000 nM
|
[7] | |||
| Compound Name |
Chembl4251217
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463300
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||||
| Activity |
IC50 = 120000 nM
|
[7] | |||
| Compound Name |
Chembl4244405
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463307
Click to Show/Hide
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||||
| Activity |
IC50 = 128700 nM
|
[7] | |||
| Compound Name |
Chembl4246927
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463317
Click to Show/Hide
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||||
| Activity |
IC50 = 133500 nM
|
[7] | |||
| Compound Name |
(2R)-2-Amino-3-(2-oxo-1,1,2-triphenylethyl)sulfanylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2043390; BDBM50386217
Click to Show/Hide
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||||
| Activity |
IC50 ~ 150000 nM
|
[5] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and biological evaluation of L-cysteine derivatives as mitotic kinesin Eg5 inhibitors. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3921-4. | ||||
| REF 2 | Pharmacophore identification of KSP inhibitors. Bioorg Med Chem Lett. 2007 Feb 1;17(3):722-6. | ||||
| REF 3 | Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP. Bioorg Med Chem Lett. 2005 Apr 15;15(8):2041-5. | ||||
| REF 4 | Substituted benzimidazoles: A novel chemotype for small molecule hKSP inhibitors. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3405-9. | ||||
| REF 5 | Doing the methylene shuffle--further insights into the inhibition of mitotic kinesin Eg5 with S-trityl L-cysteine. Eur J Med Chem. 2012 Aug;54:483-98. | ||||
| REF 6 | Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1775-9. | ||||
| REF 7 | Design and synthesis of novel thiadiazole-thiazolone hybrids as potential inhibitors of the human mitotic kinesin Eg5. Bioorg Med Chem Lett. 2018 Sep 15;28(17):2930-2938. | ||||
| REF 8 | Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors. Eur J Med Chem. 2018 Aug 5;156:641-651. | ||||
| REF 9 | Structure-activity relationship and multidrug resistance study of new S-trityl-L-cysteine derivatives as inhibitors of Eg5. J Med Chem. 2011 Mar 24;54(6):1576-86. | ||||
| REF 10 | Synthesis and SAR of thiophene containing kinesin spindle protein (KSP) inhibitors. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3562-9. | ||||
| REF 11 | Receptor-ligand interaction-based virtual screening for novel Eg5/kinesin spindle protein inhibitors. J Med Chem. 2012 Mar 22;55(6):2561-73. | ||||
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