Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T27861 | Target Info | |||
| Target Name | Protein cereblon (CRBN) | ||||
| Synonyms |
Protein cereblon
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| Target Type | Clinical trial Target | ||||
| Gene Name | CRBN | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 1 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Glutarimide
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Investigative | Compound Info | ||
| Synonyms |
Piperidine-2,6-dione; 2,6-Piperidinedione; 2,6-Diketopiperidine; NSC 58190; Acetylglycinamide Impurity B; 2,6-dioxopiperidine; UNII-MV728O9612; MFCD00006670; NSC 168666; CHEMBL3763941; NSC58190; MV728O9612; EINECS 214-340-4; BRN 0110052; Glutarimide, 98%; piperidin-2,6-dione; ACMC-2099da; SCHEMBL26618; 5-21-09-00557 (Beilstein Handbook Reference); 2,6-Piperidinedione (9CI); DTXSID7074452; CTK0H6864; ZINC1530742; ANW-16412; BDBM50146597; NSC-58190; AKOS009159209; CS-W023103; MCULE-7505150579; NE40071; AK-80203; DS-15888; SC-65454; SY049583; DB-093528; FT-0626735; G0269; C07275; 53116-EP2292593A2; 53116-EP2305651A1; 53116-EP2308842A1; 53116-EP2308854A1; 121G897; A802510; J-002721; Q3109315; Z1696871313
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| Activity |
Ki = 103100 nM
|
[1] | |||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Dimethyl sulfone
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Investigative | Compound Info | ||
| Synonyms |
Methyl sulfone; Methylsulfonylmethane; DIMETHYLSULFONE; Dimethyl sulphone; Sulfonylbismethane; Methane, sulfonylbis-; sulfonyldimethane; Sulphonylbismethane; methylsulfone; Methylsulfonyl methane; METHANESULFONYLMETHANE; (methylsulfonyl)methane; DMSO2; METHYL SULFONYL METHANE; UNII-9H4PO4Z4FT; NSC 63345; Methane, 1,1'-sulfonylbis-; MFCD00007566; 9H4PO4Z4FT; CHEMBL25028; CCRIS 2938; EINECS 200-665-9; dimethylsulfon; dimethylsulphone; methy sulfone; AI3-25306; Lignisul MSM; Sulfonylbis-methane; Opti MSM; Sulfone, dimethyl-; (methylsulphonyl)methane; Dimethyl sulfone solution; Dimethyl sulfone, 98%; 2-Thiapropane2,2-dioxide; ACMC-209o0h; MolMap_000019; DSSTox_CID_23937; DSSTox_GSID_43937; KSC352Q8H; SPECTRUM1505358; DTXSID4043937; CTK2F2883; HY-Y1314; KS-00000V5O; NSC63345; ZINC4658606; Tox21_303712; ANW-35391; BDBM50026473; NSC-63345; AKOS015897615; CCG-214558; DB14090; MCULE-3320409932; NE10495; NCGC00095990-01; NCGC00357027-01; DB-050533; CS-0017786; FT-0625160; M0509; M1239; EN300-79559; C11142; 74380-EP2269993A1; 74380-EP2270002A1; 74380-EP2308857A1; 74380-EP2371797A1; 74380-EP2371798A1; 74380-EP2371800A1; 74380-EP2371804A1; 90984-EP2280012A2; 90984-EP2305248A1; 162163-EP2281815A1; A835859; Q423842; F0001-1776; Z417007936; Dimethyl sulfone, Standard for quantitative NMR, TraceCERT(R); Methylsulfonylmethane, United States Pharmacopeia (USP) Reference Standard
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| Activity |
Ki = 137490000 nM
|
[1] | |||
| References | Top | ||||
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| REF 1 | A FRET-Based Assay for the Identification and Characterization of Cereblon Ligands. J Med Chem. 2016 Jan 28;59(2):770-4. | ||||
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