Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T27106 | Target Info | |||
| Target Name | FK506-binding protein (FKBP) | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | NO-GeName | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 69 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Gpi-1046
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|
Terminated | Compound Info | ||
| Synonyms |
186452-09-5; gpi-1046; (S)-3-(Pyridin-3-yl)propyl 1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylate; CHEMBL6367; L-Proline, 1-(3,3-dimethyl-1,2-dioxopentyl)-, 3-(3-pyridinyl)propyl ester; (2S)-[3-PYRIDYL-1-PROPYL]-1-[3,3-DIMETHYL-1,2-DIOXOPENTYL]-2-PYRROLIDINECARBOXYLATE; 3-pyridin-3-ylpropyl (2S)-1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylate; 3-(pyridin-3-yl)propyl (2S)-1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylate; GPI; AC1L9I3R; SCHEMBL4766380; BDBM23334; CTK0I3903; DTXSID00332191
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|
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| Activity | FK506 binding protein 4 |
IC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
cycloheximide
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|
Investigative | Compound Info | ||
| Synonyms |
naramycin A; NSC 185; FT 3422-2; NM-MCD 80
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|
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| Activity | FK506 binding protein 14 |
Ki = 76200 nM
|
[2] | ||
| FK506 binding protein 3 |
Ki = 124000 nM
|
[2] | |||
| Compound Name |
1-N-(2-Ethylphenyl)-2-N-(3-phenylpropyl)pyrrolidine-1,2-dicarboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL34559; BDBM50113132; Pyrrolidine-1,2-dicarboxylic acid 1-[(2-ethyl-phenyl)-amide] 2-[(3-phenyl-propyl)-amide]
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|
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| Activity | FK506-binding protein 1A |
Ki ~ 50000 nM
|
[3] | ||
| Compound Name |
Pyrrolidine-1,2-dicarboxylic acid 2-benzylamide 1-[(2-ethyl-phenyl)-amide]
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL33597; BDBM50113112
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|
||||
| Activity | FK506-binding protein 1A |
Ki ~ 50000 nM
|
[3] | ||
| Compound Name |
(1S,9R)-13-{2-[(1S,2R,5R)-1-Hydroxy-5-(2-methoxy-1-methyl-ethyl)-2-methyl-cyclohexyl]-2-oxo-acetyl}-5-hydroxymethyl-3,7-dioxa-13-aza-bicyclo[7.3.1]tridecane-2,8-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL337958; BDBM50288766
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|
||||
| Activity | FK506-binding protein 1A |
Ki ~ 50000 nM
|
[4] | ||
| Compound Name |
1-N,2-N-Dibenzylpyrrolidine-1,2-dicarboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL32414; BDBM50113097; Pyrrolidine-1,2-dicarboxylic acid bis-benzylamide
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|
||||
| Activity | FK506-binding protein 1A |
Ki ~ 50000 nM
|
[3] | ||
| Compound Name |
Pyrrolidine-1,2-dicarboxylic acid 2-butylamide 1-[(2-ethyl-phenyl)-amide]
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL286167; BDBM50113125
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|
||||
| Activity | FK506-binding protein 1A |
Ki ~ 50000 nM
|
[3] | ||
| Compound Name |
1-(Toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid benzylamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL32121; Oprea1_319793; BDBM50113134; EU-0001735
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|
||||
| Activity | FK506-binding protein 1A |
Ki ~ 50000 nM
|
[3] | ||
| Compound Name |
Pyrrolidine-1,2-dicarboxylic acid 2-benzylamide 1-cyclohexylamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL34060; BDBM50113111
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|
||||
| Activity | FK506-binding protein 1A |
Ki ~ 50000 nM
|
[3] | ||
| Compound Name |
2-[3-[(1R)-1-[(2S)-1-[(2S)-2-Cyclohexyl-2-(3,5-dimethoxyphenyl)acetyl]piperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3623613; BDBM50125332
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|
||||
| Activity | FK506 binding protein 4 |
Ki ~ 50000 nM
|
[5] | ||
| Compound Name |
1-Benzenesulfonyl-pyrrolidine-2-carboxylic acid butylamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL33802; BDBM50113141
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|
||||
| Activity | FK506-binding protein 1A |
Ki ~ 50000 nM
|
[3] | ||
| Compound Name |
Pyrrolidine-1,2-dicarboxylic acid 1-[(2-ethyl-phenyl)-amide] 2-(phenethyl-amide)
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL33553; BDBM50113122
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|
||||
| Activity | FK506-binding protein 1A |
Ki ~ 50000 nM
|
[3] | ||
| Compound Name |
Pyrrolidine-1,2-dicarboxylic acid 1-benzylamide 2-butylamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL32998; BDBM50113106
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|
||||
| Activity | FK506-binding protein 1A |
Ki ~ 50000 nM
|
[3] | ||
| Compound Name |
1-(Octane-1-sulfonyl)-pyrrolidine-2-carboxylic acid phenethyl-amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL33581; BDBM50113110
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|
||||
| Activity | FK506-binding protein 1A |
Ki ~ 50000 nM
|
[3] | ||
| Compound Name |
CID 57522929
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2058795; BDBM50388299
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|
||||
| Activity | FK506-binding protein 1A |
IC50 ~ 50000 nM
|
[6] | ||
| FK506 binding protein 4 |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
1-Phenylmethanesulfonyl-piperidine-2-carboxylic acid butylamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL284114; BDBM50113114
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|
||||
| Activity | FK506-binding protein 1A |
Ki ~ 50000 nM
|
[3] | ||
| Compound Name |
Pyrrolidine-1,2-dicarboxylic acid 2-butylamide 1-cyclohexylamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL33095; MLS000121989; HMS2372E15; BDBM50113119; SMR000119402; SR-01000342290; SR-01000342290-1
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|
||||
| Activity | FK506-binding protein 1A |
Ki ~ 50000 nM
|
[3] | ||
| Compound Name |
CID 57522803
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2058793; SCHEMBL15062392; BDBM50388297
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|
||||
| Activity | FK506-binding protein 1A |
IC50 ~ 50000 nM
|
[6] | ||
| FK506 binding protein 4 |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
Pyrrolidine-1,2-dicarboxylic acid 1-cyclohexylamide 2-(phenethyl-amide)
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL34673; BDBM50113143
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|
||||
| Activity | FK506-binding protein 1A |
Ki ~ 50000 nM
|
[3] | ||
| Compound Name |
1-(Octane-1-sulfonyl)-pyrrolidine-2-carboxylic acid benzylamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL33634; BDBM50113107
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|
||||
| Activity | FK506-binding protein 1A |
Ki ~ 50000 nM
|
[3] | ||
| Compound Name |
1-(Toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid butylamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL34052; BDBM50113140; AKOS008534235
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|
||||
| Activity | FK506-binding protein 1A |
Ki ~ 50000 nM
|
[3] | ||
| Compound Name |
SAFit1
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3623612; SCHEMBL16586338; BDBM50125333; HY-102079; CS-0022958
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|
||||
| Activity | FK506 binding protein 4 |
Ki ~ 50000 nM
|
[5] | ||
| Compound Name |
1-((E)-2-Phenyl-ethenesulfonyl)-pyrrolidine-2-carboxylic acid benzylamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL33555; BDBM50113115
Click to Show/Hide
|
||||
| Activity | FK506-binding protein 1A |
Ki ~ 50000 nM
|
[3] | ||
| Compound Name |
CID 57522802
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2058792; BDBM50388296
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|
||||
| Activity | FK506-binding protein 1A |
IC50 ~ 50000 nM
|
[6] | ||
| FK506 binding protein 4 |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(2S)-N-(1-Carbamoylcyclopropyl)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3792925; SCHEMBL16586049; BDBM50162682
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|
||||
| Activity | FK506-binding protein 1A |
Ki = 50300 nM
|
[7] | ||
| Compound Name |
(2S)-N-[(2S)-1-Amino-1-oxobutan-2-yl]-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3794102; SCHEMBL16585974; BDBM50162657
Click to Show/Hide
|
||||
| Activity | FK506-binding protein 1A |
Ki = 51900 nM
|
[7] | ||
| Compound Name |
CID 57522683
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2058787; SCHEMBL15062535; BDBM50388293
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|
||||
| Activity | FK506 binding protein 4 |
IC50 = 66500 nM
|
[6] | ||
| Compound Name |
Methyl (4aS,8S)-2-benzyl-1-oxo-4,4a,5,6,7,8-hexahydro-3H-pyrido[1,2-c]pyrimidine-8-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL292166; BDBM50408095; (4abeta)-2-Benzyl-1-oxooctahydro-1H-pyrido[1,2-c]pyrimidine-8beta-carboxylic acid methyl ester
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|
||||
| Activity | FK506-binding protein 1A |
Ki = 67000 nM
|
[8] | ||
| Compound Name |
4-{4-[(R)-2-((1S,3S,5S)-3,5-Dimethyl-2-oxo-cyclohexyl)-2-hydroxy-ethyl]-2,6-dioxo-piperidin-1-ylmethyl}-benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL334322; BDBM50080532
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|
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| Activity | FK506-binding protein 1A |
IC50 = 68200 nM
|
[2] | ||
| Compound Name |
CID 57522008
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2058227; SCHEMBL15062631; BDBM50388276
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|
||||
| Activity | FK506 binding protein 4 |
IC50 = 69900 nM
|
[6] | ||
| Compound Name |
(2S)-N-[(2R)-1-Amino-1-oxopropan-2-yl]-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793250; SCHEMBL16586033; BDBM50162656
Click to Show/Hide
|
||||
| Activity | FK506-binding protein 1A |
Ki = 71100 nM
|
[7] | ||
| Compound Name |
Methyl (4aS,8S)-1-oxo-2-propyl-4,4a,5,6,7,8-hexahydro-3H-pyrido[1,2-c]pyrimidine-8-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL299276; BDBM50408108; (4abeta)-2-Propyl-1-oxooctahydro-1H-pyrido[1,2-c]pyrimidine-8beta-carboxylic acid methyl ester
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|
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| Activity | FK506-binding protein 1A |
Ki = 83000 nM
|
[8] | ||
| Compound Name |
CID 57522237
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2058232; SCHEMBL15062413; BDBM50388278
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|
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| Activity | FK506 binding protein 4 |
IC50 = 84500 nM
|
[6] | ||
| Compound Name |
4,4-Dimethyl-6,17-dioxa-1-azabicyclo[17.4.0]tricosane-2,3,7,18-tetrone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL320252; BDBM50283391; 7,7-Dimethyl-tetradecahydro-9,20-dioxa-4a-aza-benzocyclononadecene-5,6,10,21-tetraone
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|
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| Activity | FK506 binding protein 4 |
Ki = 90000 nM
|
[9] | ||
| Compound Name |
2-[3-[(1R)-1-[(2S)-1-[(2S)-2-Cyclohexyl-2-(3-methoxyphenyl)acetyl]piperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3623614; BDBM50125331
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
Ki ~ 100000 nM
|
[5] | ||
| Compound Name |
2-[3-[(1R)-1-[(2S)-1-(1-Benzothiophen-2-ylsulfonyl)piperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2058226; SCHEMBL15069778; BDBM50388275
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
IC50 ~ 100000 nM
|
[6] | ||
| Compound Name |
2-(3,4-Dimethoxyphenoxy)ethyl (2S)-1-(3,5-dichlorophenyl)sulfonylpiperidine-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2058790; BDBM50388294
Click to Show/Hide
|
||||
| Activity | FK506-binding protein 1A |
IC50 ~ 100000 nM
|
[6] | ||
| FK506 binding protein 4 |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
2-[3-[(1R)-1-[(2S)-1-(3,4-Dichlorophenyl)sulfonylpiperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2058235; BDBM50388281
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
IC50 ~ 100000 nM
|
[6] | ||
| Compound Name |
2-[3-[3-(3,4-Dimethoxyphenyl)-1-[[(2S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carbonyl]amino]propyl]phenoxy]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2058804; BDBM50388306
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|
||||
| Activity | FK506 binding protein 4 |
IC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
2-[3-[(1R)-3-(3,4-Dimethoxyphenyl)-1-[(3R)-4-(3,3-dimethyl-2-oxopentanoyl)thiomorpholine-3-carbonyl]oxypropyl]phenoxy]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2058803; BDBM50388305
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
IC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
CID 57522347
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2058236; SCHEMBL15062624; BDBM50388282
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
IC50 ~ 100000 nM
|
[6] | ||
| Compound Name |
CID 57522570
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2058499; SCHEMBL15062747; BDBM50388292
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
IC50 ~ 100000 nM
|
[6] | ||
| Compound Name |
2-[3-[(1R)-3-(3,4-Dimethoxyphenyl)-1-[(2S)-1-pyrimidin-4-ylsulfonylpiperidine-2-carbonyl]oxypropyl]phenoxy]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2058231; BDBM50388277
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|
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| Activity | FK506 binding protein 4 |
IC50 ~ 100000 nM
|
[6] | ||
| Compound Name |
Timcodar
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|
Investigative | Compound Info | ||
| Synonyms |
vx-853; UNII-U141W322WZ; U141W322WZ; VX853; Timcodar [INN]; VX 853; SCHEMBL3673444; CHEMBL2059028; GTPL10868; BDBM50388313; DB12761; Q27290544
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|
||||
| Activity | FK506-binding protein 1A |
IC50 ~ 100000 nM
|
[1] | ||
| FK506 binding protein 4 |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-(3,4-Dimethoxyphenoxy)ethyl (2S)-1-(1,3-benzothiazol-6-ylsulfonyl)piperidine-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2058791; BDBM50388295
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
IC50 ~ 100000 nM
|
[6] | ||
| Compound Name |
CID 57522685
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2058789; SCHEMBL15062446; BDBM50388264
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
IC50 ~ 100000 nM
|
[6] | ||
| Compound Name |
CID 57521881
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2058222; SCHEMBL15063118; BDBM50388271
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
IC50 ~ 100000 nM
|
[6] | ||
| Compound Name |
CID 57522684
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2058788; SCHEMBL15062388; BDBM50388302
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
IC50 ~ 100000 nM
|
[6] | ||
| Compound Name |
2-(3,4-Dimethoxyphenoxy)ethyl (2S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059023; SCHEMBL14920841; BDBM50388308
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
IC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
2-(3,4-Dimethoxyphenoxy)ethyl (2S)-1-[2-[(1S,2R)-2-ethyl-1-hydroxycyclohexyl]-2-oxoacetyl]piperidine-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059032; BDBM50388317
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
IC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
2-[3-[(1R)-1-[(2S)-1-[3,5-Bis(methoxycarbonyl)phenyl]sulfonylpiperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2057219; SCHEMBL15062619; BDBM50388287
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
IC50 ~ 100000 nM
|
[6] | ||
| Compound Name |
CID 57522121
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2058229; SCHEMBL15062497; BDBM50388301
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
IC50 ~ 100000 nM
|
[6] | ||
| Compound Name |
2-[3-[(1R)-3-(3,4-Dimethoxyphenyl)-1-[(2S)-1-(2-methylpyrimidin-4-yl)sulfonylpiperidine-2-carbonyl]oxypropyl]phenoxy]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2058230; BDBM50388263
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
IC50 ~ 100000 nM
|
[6] | ||
| Compound Name |
2-[3-[(1R)-3-(3,4-Dimethoxyphenyl)-1-[(2S)-1-(3-nitrophenyl)sulfonylpiperidine-2-carbonyl]oxypropyl]phenoxy]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2058228; SCHEMBL15069766; BDBM50388265
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
IC50 ~ 100000 nM
|
[6] | ||
| Compound Name |
2-[3-[(1R)-1-[(2S)-1-[3,5-Bis(trifluoromethyl)phenyl]sulfonylpiperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2058239; SCHEMBL15062453; BDBM50388285
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
IC50 ~ 100000 nM
|
[6] | ||
| Compound Name |
2-[3-[(1R)-1-[(2S)-1-[3-Bromo-5-(trifluoromethyl)phenyl]sulfonylpiperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2058240; SCHEMBL15062428; BDBM50388286
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
IC50 ~ 100000 nM
|
[6] | ||
| Compound Name |
2-[3-[(1R)-1-[[(2S)-1-(3,5-Dichloro-4-hydroxyphenyl)sulfonylpiperidine-2-carbonyl]amino]-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2058798; BDBM50388268
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|
||||
| Activity | FK506-binding protein 1A |
IC50 ~ 100000 nM
|
[6] | ||
| FK506 binding protein 4 |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
2-[3-[(1R)-3-(3,4-Dimethoxyphenyl)-1-[[(2S)-1-[(2-oxo-3H-1,3-benzothiazol-6-yl)sulfonyl]piperidine-2-carbonyl]amino]propyl]phenoxy]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2058799; BDBM50388269
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
IC50 ~ 100000 nM
|
[6] | ||
| Compound Name |
(21S)-1Aza-4,4-dimethyl-6,19-dioxa-2,3,7,20-tetraoxobicyclo[19.4.0] pentacosane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1235837; SCHEMBL5966237; BDBM50403328; DB08520; Q27097719; (21S)-4,4-Dimethyl-6,19-dioxa-1-azabicyclo[19.4.0]pentacosane-2,3,7,20-tetraone
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
Ki = 100000 nM
|
[9] | ||
| Compound Name |
CID 57522006
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2058225; SCHEMBL15062495; BDBM50388274
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
IC50 ~ 100000 nM
|
[6] | ||
| Compound Name |
Methyl (2S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2058805; SCHEMBL1776165; BDBM50388307
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
IC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
2-(3,4-Dimethoxyphenyl)ethyl (2S)-1-[2-[(1S,2R)-1-hydroxy-2-methylcyclohexyl]-2-oxoacetyl]piperidine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059030; BDBM50388315
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
IC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
(2S)-N-[(2S)-1-Amino-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3794214; SCHEMBL16586078; BDBM50162680
Click to Show/Hide
|
||||
| Activity | FK506-binding protein 1A |
Ki = 101000 nM
|
[7] | ||
| Compound Name |
1-Benzyl-4-[(R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxo-cyclohexyl)-2-hydroxy-ethyl]-piperidine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL120492; BDBM50080535; 1-Benzyl-4-[(R)-2-hydroxy-2-[(1S)-2-oxo-3beta,5alpha-dimethylcyclohexyl]ethyl]piperidine-2,6-dione
Click to Show/Hide
|
||||
| Activity | FK506-binding protein 1A |
IC50 = 116700 nM
|
[2] | ||
| Compound Name |
(2R)-2-[[(2S)-1-[(2S)-2-Cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carbonyl]amino]pentanediamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3794273; SCHEMBL16585949; BDBM50162679
Click to Show/Hide
|
||||
| Activity | FK506-binding protein 1A |
Ki = 120000 nM
|
[7] | ||
| Compound Name |
4-[(R)-2-((1S,3S,5S)-3,5-Dimethyl-2-oxo-cyclohexyl)-2-hydroxy-ethyl]-1-methyl-piperidine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL120385; BDBM50080527; 1-Methyl-4-[(R)-2-hydroxy-2-[(1S)-2-oxo-3beta,5alpha-dimethylcyclohexyl]ethyl]piperidine-2,6-dione
Click to Show/Hide
|
||||
| Activity | FK506-binding protein 1A |
IC50 = 124100 nM
|
[2] | ||
| Compound Name |
Pipecolate deriv., 12b
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL565481; BDBM34005
Click to Show/Hide
|
||||
| Activity | FK506-binding protein 1A |
Ki = 137000 nM
|
[10] | ||
| Compound Name |
(S)-1-(3,3-Dimethyl-2-oxo-pentanoyl)-piperidine-2-carboxylic acid 3-pyridin-3-yl-propyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL129537; BDBM50067003; (2S)-1-(1,2-Dioxo-3,3-dimethylpentyl)piperidine-2alpha-carboxylic acid 3-(3-pyridinyl)propyl ester
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
IC50 ~ 150000 nM
|
[1] | ||
| Compound Name |
18-(2-Cyclohexylethyl)-4,4-dimethyl-6,19-dioxa-1-azabicyclo[19.4.0]pentacosane-2,3,7,20-tetrone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL109676; BDBM50283390
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
Ki = 190000 nM
|
[9] | ||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 21 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Cycloheximide acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
UNII-V186SR50A8; CHEMBL120252; V186SR50A8; BDBM50080529; ZINC13557415; 2,6-Piperidinedione, 4-(2-(acetyloxy)-2-(3,5-dimethyl-2-oxocyclohexyl)ethyl)-; Q27291403
Click to Show/Hide
|
||||
| Activity | FK506-binding protein 1A |
IC50 > 200000 nM
|
[2] | ||
| Compound Name |
{4-[(R)-2-(Adamantan-1-ylcarbamoyloxy)-2-((1S,3S,5S)-3,5-dimethyl-2-oxo-cyclohexyl)-ethyl]-2,6-dioxo-piperidin-1-yl}-acetic acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL331865; BDBM50080533
Click to Show/Hide
|
||||
| Activity | FK506-binding protein 1A |
IC50 > 200000 nM
|
[2] | ||
| Compound Name |
(S)-1-[2-((1S,2R,5R)-1-Hydroxy-5-isopropyl-2-methyl-cyclohexyl)-2-oxo-acetyl]-piperidine-2-carboxylic acid benzyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL316255; BDBM50288769
Click to Show/Hide
|
||||
| Activity | FK506-binding protein 1A |
Ki = 210000 nM
|
[4] | ||
| Compound Name |
1-[3-[[(2S)-2-Acetamidopropanoyl]amino]-2-oxopropanoyl]-N-[(2S)-1-(4-nitroanilino)-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL126349; BDBM50118069
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
IC50 = 215000 nM
|
[11] | ||
| Compound Name |
4,4-Dimethyl-6,19-dioxa-1-azabicyclo[19.4.0]pentacosane-2,3,7,20-tetrone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL109750; SCHEMBL5158007; BDBM50283388; 1,19-(1,2-Piperidinediyl)-3,3-dimethyl-5,18-dioxanonadecane-1,2,6,19-tetraone; 7,7-Dimethyl-hexadecahydro-9,22-dioxa-4a-aza-benzocyclohenicosene-5,6,10,23-tetraone
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
Ki = 290000 nM
|
[9] | ||
| Compound Name |
(2S)-N-(2-Amino-2-oxoethyl)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793184; SCHEMBL16586248; BDBM50162502
Click to Show/Hide
|
||||
| Activity | FK506-binding protein 1A |
Ki > 300000 nM
|
[7] | ||
| Compound Name |
(2S)-N-[(2S)-1-Amino-4-hydroxy-1-oxobutan-2-yl]-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3794045; SCHEMBL16586133; BDBM50162676
Click to Show/Hide
|
||||
| Activity | FK506-binding protein 1A |
Ki = 317000 nM
|
[7] | ||
| Compound Name |
(2S)-1-[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]propanoyl]amino]acetyl]-N-[(2S,3S)-3-methyl-1-oxo-1-(2-phenylethylamino)pentan-2-yl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1790321; BDBM50369809
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
IC50 = 325000 nM
|
[12] | ||
| Compound Name |
(8E,10Z)-4,4-Dimethyl-6,19-dioxa-1-azabicyclo[19.4.0]pentacosa-8,10-diene-2,3,7,20-tetrone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL111188; BDBM50283387
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
Ki = 340000 nM
|
[9] | ||
| Compound Name |
(2S)-1-[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]propanoyl]amino]acetyl]-N-[(2S,3S)-1-(2,2-diphenylethylamino)-3-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1790320; BDBM50369810
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
IC50 = 365000 nM
|
[12] | ||
| Compound Name |
2-[3-[(1R)-1-[(2S)-1-[(2S)-2-Cyclohexyl-2-phenylacetyl]piperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3623615; BDBM50125329
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
Ki > 500000 nM
|
[5] | ||
| Compound Name |
2-[3-[(1R)-1-[(2S)-1-[(2R)-2-Cyclohexylpent-4-enoyl]piperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3623616; SCHEMBL16585966; BDBM50125328
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
Ki > 500000 nM
|
[5] | ||
| Compound Name |
N-Succinyl-ala-ala-pro-phe-p-nitroanilide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Suc-aapf-pna; N-Succinyl-Ala-Ala-Pro-Phe-pNA; N-Succinyl-Ala-Ala-Pro-Phe p-nitroanilide; CHEMBL298712; Cathepsin g substrate I,colorimetric; Suc-Ala-Ala-Pro-Phe-p-nitroanilide; Succinyl-Ala-Ala-Pro-Phe-p-nitroanilide; N-Suc-Ala-Ala-Pro-Phe-pNA; succinyl-Ala-Ala-Pro-Phe p-nitroanilide; N-Succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine p-nitroanilide; succinyl-L-Ala-L-Ala-L-Pro-L-Phe-p-nitroanilide; N-succinyl-L-Ala-L-Ala-L-Pro-L-Phe-p-nitroanilide; N-Succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide; Suc-Ala-Ala-Pro-Phe-p-NA; succinyl-Ala-Ala-Pro-Phe-pNA; C30H36N6O9; 1004AC; BDBM50087877; MFCD00077161; ZINC29464478; N-Suc-Ala-Ala-Pro-Phe-p-nitroanilide; Succinyl-Ala-Ala-Pro-Phe-4-nitroanilide; N-succinyl-l-Ala-Ala-Pro-Phe-p-nitroanilide; succinyl-L-Ala-L-Ala-L-Pro-L-Phe p-nitroanilide; Succinyl-Ala-Ala-Pro-Phe-p-nitroanilide - CAS 70967-97-4
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
IC50 = 540000 nM
|
[11] | ||
| Compound Name |
(2S)-1-[(2R)-2-[[(2S)-2-Acetamidopropanoyl]amino]propanoyl]-N-[(2S)-1-(4-nitroanilino)-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2370636
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
IC50 = 640000 nM
|
[11] | ||
| Compound Name |
(8E,10E)-4,4-Dimethyl-6,19-dioxa-1-azabicyclo[19.4.0]pentacosa-8,10-diene-2,3,7,20-tetrone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL111691; BDBM50283389
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
Ki = 840000 nM
|
[9] | ||
| Compound Name |
2-[3-[(1R)-1-[(2S)-1-[(2R)-2-Cyclohexylpropanoyl]piperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3623617; SCHEMBL16586196; BDBM50125327
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
Ki > 1000000 nM
|
[5] | ||
| Compound Name |
Suc-Ala-Gly-Pro-Phe-pNA
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL125967; BDBM50118071; MFCD00238369; ZINC27307277
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
IC50 = 1450000 nM
|
[11] | ||
| Compound Name |
4,4-Dimethyl-6,11-dioxa-1-azabicyclo[11.4.0]heptadecane-2,3,7,12-tetrone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL419746; BDBM50283392; 7,7-Dimethyl-octahydro-9,14-dioxa-4a-aza-benzocyclotridecene-5,6,10,15-tetraone
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
Ki = 2900000 nM
|
[9] | ||
| Compound Name |
N-{1-[(Ethoxy-{2-[1-(4-nitro-phenylcarbamoyl)-2-phenyl-ethylcarbamoyl]-pyrrolidin-1-yl}-phosphinoylmethyl)-carbamoyl]-ethyl}-succinamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL126888; BDBM50118067
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
IC50 = 5400000 nM
|
[11] | ||
| Compound Name |
(2S)-1-[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-5-aminopentanoyl]amino]propanoyl]amino]acetyl]-N-[(2R,3R)-1-[[(2R)-1-amino-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL295941; BDBM50087861
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
IC50 > 10000000 nM
|
[12] | ||
| Compound Name |
4,4-Dimethyl-6,23-dioxa-1-azabicyclo[23.4.0]nonacosane-2,3,7,24-tetrone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL324019; BDBM50283386; 7,7-Dimethyl-icosahydro-9,26-dioxa-4a-aza-benzocyclopentacosene-5,6,10,27-tetraone
Click to Show/Hide
|
||||
| Activity | FK506 binding protein 4 |
Ki = 11000000 nM
|
[9] | ||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Evaluation of synthetic FK506 analogues as ligands for the FK506-binding proteins 51 and 52. J Med Chem. 2012 May 10;55(9):4114-22. | ||||
| REF 2 | Synthesis and cytotoxic evaluation of cycloheximide derivatives as potential inhibitors of FKBP12 with neuroregenerative properties. J Med Chem. 1999 Sep 9;42(18):3615-22. | ||||
| REF 3 | Solid-phase synthesis of FKBP12 inhibitors: N-sulfonyl and N-carbamoylprolyl/pipecolyl amides. Bioorg Med Chem Lett. 2002 May 20;12(10):1429-33. | ||||
| REF 4 | Design, synthesis and X-ray crystallographic studies of [7.3.1] and [8.3.1] macrocyclic FKBP-12 ligands. Bioorg Med Chem Lett. 1996 Feb 20;6(4):385-90. | ||||
| REF 5 | Structure-Affinity Relationship Analysis of Selective FKBP51 Ligands. J Med Chem. 2015 Oct 8;58(19):7796-806. | ||||
| REF 6 | Exploration of pipecolate sulfonamides as binders of the FK506-binding proteins 51 and 52. J Med Chem. 2012 May 10;55(9):4123-31. | ||||
| REF 7 | Rapid, Structure-Based Exploration of Pipecolic Acid Amides as Novel Selective Antagonists of the FK506-Binding Protein 51. J Med Chem. 2016 Mar 24;59(6):2410-22. | ||||
| REF 8 | Structure-based design of novel, urea-containing FKBP12 inhibitors. J Med Chem. 1996 Apr 26;39(9):1872-84. | ||||
| REF 9 | Synthesis and structure-activity relationships of macrocyclic FKBP ligands. Bioorg Med Chem Lett. 1994 Jan 20;4(2):321-4. | ||||
| REF 10 | Structure-based design of novel human Pin1 inhibitors (I). Bioorg Med Chem Lett. 2009 Oct 1;19(19):5613-6. | ||||
| REF 11 | Synthesis and evaluation of Glypsi(PO(2)R-N)Pro-containing pseudopeptides as novel inhibitors of the human cyclophilin hCyp-18. J Med Chem. 2002 Aug 29;45(18):3928-33. | ||||
| REF 12 | Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs. J Med Chem. 2000 May 4;43(9):1770-9. | ||||
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