Target Poor or Non Binder(s) Information
Target General Information | Top | ||||
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Target ID | T25637 | Target Info | |||
Target Name | Lysyl oxidase homolog 2 (LOXL2) | ||||
Synonyms |
Lysyl oxidaserelated protein WS914; Lysyl oxidaserelated protein 2; Lysyl oxidaselike protein 2; LOXL2
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Target Type | Clinical trial Target | ||||
Gene Name | LOXL2 | ||||
UniProt ID |
Poor Binders of This Target (in total, 7 binders) | Download | Top | |||
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Compound Name |
PHENETHYLAMINE
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Investigative | Compound Info | ||
Synonyms |
Phenethylamine; 2-phenylethylamine; 2-Phenylethanamine; 64-04-0; Benzeneethanamine; phenylethylamine; 2-Phenethylamine; beta-phenylethylamine; beta-Phenethylamine; 1-Amino-2-phenylethane; beta-Aminoethylbenzene; (2-Aminoethyl)benzene; 2-Amino-1-phenylethane; 1-Phenyl-2-aminoethane; Ethylamine, 2-phenyl-; Ethanamine, 2-phenyl-; 2-Phenylethan-1-Amine; 1-Phenyl-2-amino-athan; 2-Fenylethylamin; 2-Amino-fenylethan; 2-Fenylethylamin [Czech]; PHENETHYLAMINE, BETA; 2-Amino-fenylethan [Czech]; beta-Phenylaethylamin [German]
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Activity |
IC50 = 60100 nM
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[1] | |||
Compound Name |
Benzylamine
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Investigative | Compound Info | ||
Synonyms |
phenylmethanamine; Benzenemethanamine; Monobenzylamine; alpha-Aminotoluene; 1-phenylmethanamine; (Phenylmethyl)amine; (Aminomethyl)benzene; N-Benzylamine; Moringine; Phenylmethylamine; Sumine 2005; Aminotoluene; benzyl amine; Sumine 2006; omega-Aminotoluene; .omega.-Aminotoluene; benzyl-amine; a-Aminotoluene; NSC 8046; UNII-A1O31ROR09; MFCD00008106; .alpha.-Aminotoluene; TOLUENE,ALPHA-AMINO; CHEMBL522; A1O31ROR09; Benzylamine, 99%, pure; Benzylamine, 99.5+%, AcroSeal(R); HSDB 2795; EINECS 202-854-1; benzylarnine; bezylamine; BRN 0741984; AI3-15299; aminomethylbenzene; N[C]c1ccccc1; N-(phenylmethyl)amine; BnNH2; NH2Bn; QuadraPure(TM) BZA; Bzl-NH2; Benzenemethanamine, 9CI; Aminomethylated polystyrene; Benzylamine, reagent grade; DSSTox_CID_1839; SCHEMBL373; ACMC-20aj53; Epitope ID:141489; EC 202-854-1; QuadraPure(TM) Benzylamine; DSSTox_RID_76359; NCIOpen2_007746; DSSTox_GSID_21839; 4-12-00-02155 (Beilstein Handbook Reference); KSC178S3P; laquo Omegaraquo -aminotoluene; Benzylamine, analytical standard; DTXSID5021839; BDBM10999; CTK0H8937; NSC8046; TETRACYCLOHEXYLORTHOSILICATE; NSC-8046; STR00195; ZINC6096244; Benzylamine, ReagentPlus(R), 99%; Tox21_300933; MFCD00130502; MFCD08561140; SBB040473; STL115534; AKOS000119096; QuadraPure BZA, 400-1100 micron; DB02464; EBD2211112; MCULE-6894874255; KS-000002M7; NCGC00166029-01; NCGC00166029-02; NCGC00254835-01; SC-22771; B0406; FT-0622834; FT-0622836; ST45255426; AZ0001-0093; Benzylamine, for GC derivatization, >=99.0%; C15562; 13743-EP2269992A1; 13743-EP2270010A1; 13743-EP2272517A1; 13743-EP2277848A1; 13743-EP2277881A1; 13743-EP2280001A1; 13743-EP2280008A2; 13743-EP2281563A1; 13743-EP2281818A1; 13743-EP2284171A1; 13743-EP2284172A1; 13743-EP2284174A1; 13743-EP2287141A1; 13743-EP2287163A1; 13743-EP2289891A2; 13743-EP2289892A1; 13743-EP2292593A2; 13743-EP2295406A1; 13743-EP2295414A1; 13743-EP2295420A1; 13743-EP2295429A1; 13743-EP2295432A1; 13743-EP2295437A1; 13743-EP2298729A1; 13743-EP2298775A1; 13743-EP2298779A1; 13743-EP2305250A1; 13743-EP2305651A1; 13743-EP2305654A1; 13743-EP2305666A1; 13743-EP2305678A1; 13743-EP2305687A1; 13743-EP2305695A2; 13743-EP2305696A2; 13743-EP2305697A2; 13743-EP2305698A2; 13743-EP2308510A1; 13743-EP2308562A2; 13743-EP2308812A2; 13743-EP2308838A1; 13743-EP2308841A2; 13743-EP2308851A1; 13743-EP2308854A1; 13743-EP2308867A2; 13743-EP2308870A2; 13743-EP2311804A2; 13743-EP2311815A1; 13743-EP2311837A1; 13743-EP2314593A1; 13743-EP2316836A1; 13743-EP2371810A1; 13743-EP2371811A2; 13743-EP2380871A1; 13925-EP2295437A1; 13925-EP2298775A1; 13925-EP2298776A1; 13925-EP2308833A2; 13925-EP2311837A1; 13925-EP2314586A1; 13925-EP2316836A1; Benzylamine, purified by redistillation, >=99.5%; Q424000; BRD-K76133116-001-01-2; Z54748260; F2190-0388; 3F830B2A-ABAA-4E26-971C-53B1C7485954
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Activity |
IC50 = 64700 nM
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[1] | |||
Compound Name |
2-Mercapto-3-phenylpyrido[2,3-d]pyrimidin-4(3H)-one
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1927732; 3-phenyl-2-sulfanyl-3H,4H-pyrido[2,3-d]pyrimidin-4-one; Pyrido[2,3-d]pyrimidin-4(1H)-one,2,3-dihydro-3-phenyl-2-thioxo-; 3-phenyl-2-thioxo-1H-pyrido[3,2-e]pyrimidin-4-one; SCHEMBL9385552; CTK4C2581; DTXSID30526263; BDBM50463613; ZINC12505242; AKOS001354687; AKOS016874068; MCULE-4066581615; NE57339; Propyl (3,4-dichlorophenyl)carbamodithioate; EN300-26511; Z55664353; 3-PHENYL-2-SULFANYLIDENE-1H-PYRIDO[2,3-D]PYRIMIDIN-4-ONE; 3-phenyl-2-thioxo-2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-one; 3-Phenyl-2-sulfanylidene-2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-one; 3-phenyl-2-sulfanylidene-2H,3H,4H,8H-pyrido[2,3-d]pyrimidin-4-one
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Activity |
IC50 = 75000 nM
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[2] | |||
Compound Name |
3-Tert-Butyl-1-phenyl-2-pyrazolin-5-one
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Investigative | Compound Info | ||
Synonyms |
5-tert-butyl-2-phenyl-4H-pyrazol-3-one; CHEMBL4241417; 3-tert-Butyl-1-phenyl-1H-pyrazol-5(4H)-one; MFCD00051762; 3H-Pyrazol-3-one, 5-(1,1-dimethylethyl)-2,4-dihydro-2-phenyl-; 3-(tert-butyl)-1-phenyl-2-pyrazolin-5-one; NSC57945; Maybridge1_001591; SCHEMBL7528553; CTK5C4203; HMS546A07; DTXSID30288874; BDBM50463616; BTB 07042; CCG-54368; NSC-57945; SBB039881; AKOS000271442; ZINC100023293; MCULE-9741439096; PS-11150; ST097005; BB 0219324; FT-0616391; 2-Pyrazolin-5-one, 3-tert-butyl-1-phenyl-; J3.613.734G; 1-Phenyl-3-tert-butyl-1H-pyrazole-5(4H)-one; 3-(tert-Butyl)-1-phenyl-1H-pyrazol-5(4H)-one; SR-01000596944; SR-01000596944-1; SR-01000596944-2; 5-(tert-butyl)-2-phenyl-2,4-dihydro-3H-pyrazol-3-one; 5-tert-Butyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one #; 3H-Pyrazol-3-one,5-(1,1-dimethylethyl)-2,4-dihydro-2-phenyl-
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Activity |
IC50 ~ 100000 nM
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[2] | |||
Compound Name |
(1S,2R)-2-Phenylcyclopropan-1-amine;(1R,2S)-2-phenylcyclopropan-1-amine
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3989843
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Activity |
IC50 ~ 100000 nM
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[1] | |||
Compound Name |
(E)-Diethyl 5-(2-(3-amino-5-oxo-1-phenyl-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-3-methylthiophene-2,4-dicarboxylate
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Investigative | Compound Info | ||
Synonyms |
CHEMBL4251179; CBDivE_006951; ZINC2680202; BDBM50463615; STK370664; AKOS001028606; AKOS002712097; AKOS030694792; ZINC100295864; MCULE-6547837707; ST50865272; F0239-0600
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Activity |
IC50 ~ 100000 nM
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[2] | |||
Compound Name |
4-Methylaminobenzylamine
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Investigative | Compound Info | ||
Synonyms |
4-(aminomethyl)-N-methylaniline; CHEMBL4084448; MFCD03410998; SCHEMBL2290799; CTK4F4281; DTXSID60629216; ACN-S003701; ZINC2524626; BDBM50232696; Benzenemethanamine, 4-(methylamino)-; AKOS011384428; MCULE-7793480817; NE23704; AS-44227
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Activity |
IC50 ~ 100000 nM
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[1] | |||
Click to Show/Hide the Information of All Poor Binders |
References | Top | ||||
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REF 1 | Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX. ACS Med Chem Lett. 2017 Mar 1;8(4):423-427. | ||||
REF 2 | Inhibition of the LOX enzyme family members with old and new ligands. Selectivity analysis revisited. Bioorg Med Chem Lett. 2018 Oct 1;28(18):3113-3118. |
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