Target Poor or Non Binder(s) Information
Target General Information | Top | ||||
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Target ID | T25317 | Target Info | |||
Target Name | Cholestenol delta-isomerase (EBP) | ||||
Synonyms |
Emopamilbinding protein; EBP; Delta(8)Delta(7) sterol isomerase; D8D7 sterol isomerase; 3betahydroxysteroidDelta(8),Delta(7)isomerase
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Target Type | Clinical trial Target | ||||
Gene Name | EBP | ||||
Biochemical Class | Intramolecular oxidoreductases | ||||
UniProt ID |
Poor Binders of This Target (in total, 6 binders) | Download | Top | |||
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Compound Name |
Terbinafine
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Approved | Compound Info | ||
Synonyms |
Bramazil; Lamasil; TerbiFoam; Terbina; Lamisil AT; Lamisil Tablet; Ternbinafine HCl; Lamasil (TN); Lamisil (TN); SF 86-327; Terbisil (TN); Zabel (TN); SF-86-327; Terbinafine (USAN/INN); Terbinafine [USAN:BAN:INN]; Lamisil, Terbinex, Corbinal, Zabel, Terbinafine; Terbinafine, SF-86-327, Lamisil, TBNF; (2E)-N,6,6-trimethyl-N-(1-naphthylmethyl)-2-hepten-4-yn-1-amine; (2E)-N,6,6-trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine; (E)-N,6,6-trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine; (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalene methanamine; (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethylamine; (E)-N-(6,6-dimethyl-2-heptenynyl)-N-methyl-1-naphthalenementhamin hydrochloride
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Activity |
Ki ~ 50000 nM
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[1] | |||
Compound Name |
Testosterone
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Approved | Compound Info | ||
Synonyms |
AndroGel; Androderm; Androlin; Andronaq; Andropatch; Androsorb; Andrusol; Depotest; Halotensin; Homosteron; Homosterone; Intrinsa; LibiGel; Malerone; Mertestate; Neotestis; Oreton; Orquisteron; Perandren; Primotest; Primoteston; Relibra; Striant; Sustanon; Sustanone; Teslen; Testandrone; Testaqua; Testiculosterone; Testim; Testobase; Testoderm; Testogel; Testolin; Testopropon; Testosteroid; Testosteron; Testosterona; Testosteronum; Testostosterone; Testoviron; Testrone; Testryl; Virormone; Virosterone; Beta testosterone; Cristerona T; Cristerone T; Malogen in Oil; Oreton F; Percutacrine androgenique; Synandrol F; Testoderm Tts; Testopel Pellets; Testosterone and its esters; Testosterone hydrate; Testosterone solution; Testoviron Schering; Testoviron T; Testro AQ; Virilon IM; AA 2500; Andro 100; Andronate 100; Andronate 200; Andropository 200; Andryl 200; CDB 111C; CMC_13449; COL 1621; CP 601B; Everone 200; Sustason 250; Testamone 100; Testred Cypionate 200; Androderm (TN); Androgel (TN); Geno-cristaux gremy; Malestrone (amps); Malogen, aquaspension injection; Neo-Hombreol F; Neo-testis; Oreton-F; Scheinpharm Testone-Cyp; Striant (TN); T-Cypionate; Testim (TN); Testoject-50; Testosterona [INN-Spanish]; Testosterone [Androgenic steroids, anabolic]; Testosterone [INN:BAN]; Testosteronum [INN-Latin]; Trans-Testosterone; Testosterone (JAN/USP); Testrin-P.A; Delta4-Androsten-17beta-ol-3-one; Delta4-androsten-17b-ol-3-one; Androst-4-en-17beta-ol-3-one; Delta(sup 4)-Androsten-17(beta)-ol-3-one; (17beta)-17-Hydroxyandrost-4-en-3-one; (8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one; 17-Hydroxy-(17-beta)-androst-4-en-3-one; 17-Hydroxy-(17beta)-androst-4-en-3-one; 17-Hydroxy-4-androsten-3-one; 17-beta-Hydroxy-delta(sup 4)-androsten-3-one; 17-beta-Hydroxyandrost-4-en-3-one; 17b-hydroxy-4-androsten-3-one; 17beta-Hydroxy-3-oxo-4-androstene; 17beta-Hydroxy-4-androsten-3-one; 17beta-Hydroxy-delta(sup4)-androsten-3-one; 17beta-Hydroxyandrost-4-en-3-one; 17beta-Hydroxyandrost-4-ene-3-one; 4-Androsten-17-ol-3-one; 4-Androsten-17beta-ol-3-one; 4-androstene-17beta-ol-3-one; 7-beta-Hydroxyandrost-4-en-3-one
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Activity |
Ki ~ 100000 nM
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[1] | |||
Compound Name |
Progesterone
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Approved | Compound Info | ||
Synonyms |
progesterone; 57-83-0; Agolutin; Pregn-4-ene-3,20-dione; Luteohormone; Crinone; 4-Pregnene-3,20-dione; Utrogestan; Syngesterone; Progestin; Luteol; Corpus luteum hormone; Progesterol; Progesteronum; Pregnenedione; Glanducorpin; Prometrium; Corlutin; Cyclogest; Progestron; Gestormone; Progestone; Gestone; Progestasert; Progestronol; Methylpregnone; Hormoflaveine; Syngestrets; Proluton; Progekan; Nalutron; Lutoform; Gynlutin; Gesterol; Fologenon; Corporin; Corlutina; Syntolutan; Prolidon; Membrettes; Lutocyclin; Luteodyn; Lucorteum; Corluvite; LPCN-1107; Progesterone (oral, preterm labor); Progesterone (oral, preterm labor), Lipocine
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Activity |
Ki ~ 100000 nM
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[1] | |||
Compound Name |
(11-BETA)-11,21-DIHYDROXY-PREGN-4-ENE-3,20-DIONE
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Investigative | Compound Info | ||
Synonyms |
Corticosterone; CORTICOSTERONE; 50-22-6; 17-Deoxycortisol; Reichstein's substance H; Kendall's compound B; Corticosteron; 11beta,21-Dihydroxyprogesterone; Compound B; Reichstein's B; 11-Hydroxycorticoaldosterone; (11beta)-11,21-Dihydroxypregn-4-ene-3,20-dione; 11beta,21-Dihydroxy-4-pregnene-3,20-dione; 4-Pregnene-11beta,21-diol-3,20-dione; 11,21-Dihydroxyprogesterone; 11Beta,21-dihydroxypregn-4-ene-3,20-dione; 11,12-Dihydroxyprogesterone; UNII-W980KJ009P; CCRIS 6753; 11-beta,21-Dihydroxypregn-3,20-dione; CHEBI:16827; NSC9705; corticosterone
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Activity |
Ki ~ 100000 nM
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[1] | |||
Compound Name |
Jervine
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Investigative | Compound Info | ||
Synonyms |
Iervin; 11-Ketocyclopamine; UNII-19V3ECX465; C27H39NO3; Jerwiny [Polish]; CHEMBL186779; 19V3ECX465; NSC23898; MFCD01684066; HSDB 3502; Jerwiny; NSC7520; NSC 7520; EINECS 207-417-9; BRN 0059109; NSC-7520; Veratraman-11-one,23-epoxy-3-hydroxy-, (3.beta.,23.beta.)-; WLN: L D6 B566 CV FX DU LUTJ A1 E1 OQ F-& CT56 BOX FMTJ D1 H1; Jervin-11-one; Veratraman-11-one, 17,23-epoxy-3-hydroxy-, (3beta,23beta)-; (3beta, 23beta)-17,23-Epoxy-3-hydroxyveratraman-11-one; 17,23beta-Epoxy-3beta-hydroxyveratraman-11-one; SCHEMBL61568; 4-27-00-03590 (Beilstein Handbook Reference); DTXSID70895026; HY-N0836; ZINC4098876; BDBM50170645; Jervine, >=98% (HPLC), powder; NSC-23898; s4747; Veratraman-11-one, 17,23-epoxy-3-hydroxy-, (3-beta,23-beta)-; AKOS025405251; CCG-208226; BS-17082; 17,23-Epoxy-3-hydroxyveratraman-11-one; J0009; X0086; C10811; Q3278036; (3beta,23beta)-17,23-Epoxy-3-hydroxyveratraman-11-one; UNII-4I27BB349X component CLEXYFLHGFJONT-DNMILWOZSA-N; UNII-QVO4N8484O component CLEXYFLHGFJONT-DNMILWOZSA-N; Veratraman-11-one, 17,23-epoxy-3-hydroxy-, (3-beta,23-beta)- (9CI); Veratraman-11-one, 17,23-epoxy-3-hydroxy-, (3beta,23beta)- (9CI)
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Activity |
Ki ~ 100000 nM
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[1] | |||
Compound Name |
(22R,25R)-Spirosol-5-en-3beta-ol
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Investigative | Compound Info | ||
Synonyms |
solasodine; CHEMBL372484; SCHEMBL456187; BDBM50170662; LMST01150004; AKOS024278702; ST023803
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Activity |
Ki ~ 100000 nM
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[1] | |||
Click to Show/Hide the Information of All Poor Binders |
References | Top | ||||
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REF 1 | Discovery of high-affinity ligands of sigma1 receptor, ERG2, and emopamil binding protein by pharmacophore modeling and virtual screening. J Med Chem. 2005 Jul 28;48(15):4754-64. |
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