Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T25315 | Target Info | |||
| Target Name | C-X-C chemokine receptor type 3 (CXCR3) | ||||
| Synonyms |
Interferon-inducible protein 10 receptor; IP-10 receptor; GPR9; G protein-coupled receptor 9; Chemokine receptor CXCR3/interferon-inducible protein-10; Chemokine receptor CXCR3; CXCR3/IP-10; CXCR-3; CXC-R3; CKR-L2; CD183 antigen; CD183
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| Target Type | Preclinical Target | ||||
| Gene Name | CXCR3 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 15 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-(2-Acetyl-6-phenylbenzimidazol-1-yl)-1-(4-bromophenyl)ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL409900; BDBM50371850
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| Activity |
IC50 ~ 50000 nM
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[1] | |||
| Compound Name |
4-(3-Chloro-5-(methylcarbamoyl)pyridin-2-yl)-1-(1-(4-chlorobenzyl)piperidin-4-yl)piperazine-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1681880; BDBM50337248
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-(2-Acetyl-5-phenylbenzimidazol-1-yl)-1-(4-bromophenyl)ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL269810; BDBM50371851
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-[1-Methyl-3-[2-(4-nitrophenyl)-2-oxoethyl]benzimidazol-2-ylidene]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL428959; SCHEMBL14373659; BDBM50371848
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
1-(5-Chloro-6-(4-(1-(4-chlorobenzyl)piperidin-4-yl)piperazin-1-yl)pyridin-3-yl)-3-(3,4-dichlorophenyl)urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL568684; BDBM50301353
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
2-(2-Acetyl-5-methoxybenzimidazol-1-yl)-1-(4-bromophenyl)ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL269811; BDBM50371864
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-(2-Acetyl-6-methoxybenzimidazol-1-yl)-1-(4-bromophenyl)ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL269812; BDBM50371852
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N,4-Dimethyl-N-(2-(thiophene-3-carbonyl)phenyl)benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL604583; BDBM50305731
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| Activity |
IC50 ~ 60000 nM
|
[4] | |||
| Compound Name |
[(4-Methylphenyl)sulfonyl](2-{[(4-methylphenyl)sulfonyl]prop-2-enylamino}pheny l)prop-2-enylamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL604277; ZINC2573080; BDBM50305737; SBB057090; AKOS024364667; MCULE-3639320640; ST50997002; N,N'-Diallyl-N,N'-ditosyl-1,2-benzenediamine; N,N''-(1,2-phenylene)bis(N-allyl-4-methylbenzenesulfonamide)
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| Activity |
IC50 ~ 60000 nM
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[4] | |||
| Compound Name |
n,n'-1,2-Phenylenebis(n,4-dimethylbenzenesulfonamide)
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL595990; NSC101062; Oprea1_370376; CBDivE_001423; DTXSID20295299; ZINC636919; BDBM50305735; AKOS002161609; MCULE-1311888097; NSC-101062; N,N-o-phenylene-bis(p-toluenesulfonamide); ST50036099; p-Toluenesulfonamide,N'-o-phenylenebis[N-methyl-; N,N'-Ditosyl-N,N'-dimethyl-1,2-phenylenediamine; N,N''-(1,2-phenylene)bis(N-methyl-1-phenylmethanesulfonamide)
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| Activity |
IC50 ~ 60000 nM
|
[4] | |||
| Compound Name |
N-[2-(Dimethylamino)ethyl]-N-[1-[3-(4-hydroxyphenyl)-4-oxoquinazolin-2-yl]ethyl]decanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL371154; BDBM50167786
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| Activity |
IC50 ~ 100000 nM
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[5] | |||
| Compound Name |
1-[(4-Chloro-2-fluorophenyl)methyl]-N-(3,3-diphenylpropyl)piperidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL472494; BDBM50413600
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| Activity |
Ki ~ 100000 nM
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[6] | |||
| Compound Name |
N-[2-(Dimethylamino)ethyl]-N-[1-[4-oxo-3-[4-(trifluoromethyl)phenyl]quinazolin-2-yl]ethyl]decanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL371577; BDBM50167779
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-(2-Acetyl-1H-benzimidazol-1-yl)-1-phenylethanone
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Investigative | Compound Info | ||
| Synonyms |
NSC674256; CHEMBL270144; CTK8D1410; BDBM50371854; STL257911; ZINC13214615; AKOS022097893; MCULE-9146834889; NSC-674256; NCI60_026322; 2-(2-acetylbenzimidazol-1-yl)-1-phenyl-ethanone; Ethanone, 2-(2-acetyl-1H-benzimidazol-1-yl)-1-phenyl-
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[2-(2-Acetylbenzimidazol-1-yl)acetyl]benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL403059; BDBM50371856
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of small molecule benzimidazole antagonists of the chemokine receptor CXCR3. Bioorg Med Chem Lett. 2008 Mar 1;18(5):1573-6. | ||||
| REF 2 | II. SAR studies of pyridyl-piperazinyl-piperidine derivatives as CXCR3 chemokine antagonists. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1527-31. | ||||
| REF 3 | Novel CXCR3 antagonists with a piperazinyl-piperidine core. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5205-8. | ||||
| REF 4 | Identification of a new class of small molecule C5a receptor antagonists. Bioorg Med Chem Lett. 2010 Jan 15;20(2):662-4. | ||||
| REF 5 | Synthesis and structure-activity relationship of 3-phenyl-3H-quinazolin-4-one derivatives as CXCR3 chemokine receptor antagonists. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2910-3. | ||||
| REF 6 | Exploring a pocket for polycycloaliphatic groups in the CXCR3 receptor with the aid of a modular synthetic strategy. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2252-7. | ||||
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