Target Poor or Non Binder(s) Information
Target General Information | Top | ||||
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Target ID | T25200 | Target Info | |||
Target Name | Ribonuclease L (RNASEL) | ||||
Synonyms |
Ribonuclease 4; RNase L; RNS4; 25Adependent ribonuclease; 25Adependent RNase; 2-5A-dependent ribonuclease; 2-5A-dependent RNase
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Target Type | Literature-reported Target | ||||
Gene Name | RNASEL | ||||
Biochemical Class | Endoribonucleases | ||||
UniProt ID |
Poor Binders of This Target (in total, 6 binders) | Download | Top | |||
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Compound Name |
[(2R,3S,4R,5S)-5-(6-Aminopurin-9-yl)-3-[[(2R,3S,4R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-4-hydroxyoxolan-2-yl]methyl [(2R,3S,4R,5S)-5-(6-aminopurin-9-yl)-4-hydroxy-2-phosphonooxyoxolan-3-yl] hydrogen phosphate
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Investigative | Compound Info | ||
Synonyms |
CHEMBL605454; BDBM50366436
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Activity |
IC50 ~ 50000 nM
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[1] | |||
Compound Name |
2-[(3-Chloro-2-methylphenyl)imino]-5-(4-nitrobenzylidene)-1,3-thiazolidin-4-one
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Investigative | Compound Info | ||
Synonyms |
CHEMBL260229; BDBM50373171; ZINC15016524; AKOS000358390; C-5973265
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Activity |
EC50 = 50000 nM
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[2] | |||
Compound Name |
[(2R,3R,4R,5S)-5-(6-Aminopurin-9-yl)-4-[[(2R,3S,4R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-3-hydroxyoxolan-2-yl]methyl [(2S,3R,4S,5R)-2-(6-aminopurin-9-yl)-4-hydroxy-5-phosphonooxyoxolan-3-yl] hydrogen phosphate
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Investigative | Compound Info | ||
Synonyms |
CHEMBL608875; 2'-5' Linked-Oligoriboadenylate; BDBM50366438
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Activity |
IC50 ~ 50000 nM
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[1] | |||
Compound Name |
N-[1-[(4-Acetylphenyl)carbamothioylamino]-2,2,2-trichloroethyl]-2-phenylacetamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL265469; C-6131864; CBMicro_046590; BDBM50373174; AKOS002686673; MCULE-9136191148; BIM-0046683.P001; N-(1-(((4-ACETYLANILINO)CARBOTHIOYL)AMINO)-2,2,2-TRI-CL-ETHYL)-2-PHENYLACETAMIDE
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Activity |
EC50 = 79000 nM
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[2] | |||
Compound Name |
Butyl 4-[[2,2,2-trichloro-1-(propanoylamino)ethyl]carbamothioylamino]benzoate
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Investigative | Compound Info | ||
Synonyms |
CHEMBL408340; SCHEMBL14385199; BDBM50373170; C-6131645
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Activity |
EC50 = 90000 nM
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[2] | |||
Compound Name |
4-(3-(1-Acetylamino-2,2,2-trichloro-ethyl)-thioureido)-benzoic acid butyl ester
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Investigative | Compound Info | ||
Synonyms |
CHEMBL406556; CBMicro_046591; SCHEMBL14385200; BDBM50373167; AKOS002686911; MCULE-2859388001; BIM-0046611.P001; C-6131416
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Activity |
EC50 = 99000 nM
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[2] | |||
Click to Show/Hide the Information of All Poor Binders |
References | Top | ||||
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REF 1 | Synthesis and properties of 2'-5' and 3'-5' linked alpha-oligoriboadenylates. Bioorg Med Chem Lett. 1996 Aug 6;6(15):1785-90. | ||||
REF 2 | Small-molecule activators of RNase L with broad-spectrum antiviral activity. Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9585-90. |
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