Target Poor or Non Binder(s) Information

Target General Information

Target ID

T24634

Target Info

Target Name

Bacterial UDP-N-acetylglucosamine carboxyvinyltransferase (Bact murA)

Synonyms

UDP-N-acetylglucosamine enolpyruvyl transferase; UDP-GlcNAcenolpyruvyl transferase; MurA protein; MurA; Enoylpyruvate transferase; EPT

Click to Show/Hide

Target Type

Successful Target

Gene Name

Bact murA

Biochemical Class

Alkyl aryl transferase

UniProt ID

P0A749

Poor Binders of This Target (in total, 9 binders)

Download

Top

Compound Name

4-(2-Benzyloxy-ethyl)-1,2-bis-(4-chloro-phenyl)-4-methyl-pyrazolidine-3,5-dione

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL191952; BDBM50166488

Click to Show/Hide

Activity

IC50 ~ 50000 nM

[1]

Compound Name

1,2-Bis-(4-chloro-phenyl)-4-[2-(2,4-difluoro-phenyl)-2-oxo-ethyl]-4-methyl-pyrazolidine-3,5-dione

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL362995; BDBM50166491

Click to Show/Hide

Activity

IC50 ~ 50000 nM

[1]

Compound Name

Costunolide

Click to Show/Hide

Investigative

Compound Info

Synonyms

(+)-costunolide; Costunlide; Costunolid; Costus lactone; Costundide; CHEMBL86416; (E,E)-6-alpha-Hydroxygermacra-1(10),4,11(13)-trien-12-oic acid gamma-lactone; (10S,1R)-3,7-dimethyl-11-methylene-13-oxabicyclo[8.3.0]trideca-2,6-dien-12-one; (E,E)-germacra-1(10),4,11(13)-trien-12-oic acid, 6-alpha-hydroxy-gamma-lactone; melampolide; NSC106404; Costunolide,(S); PubChem6258; SCHEMBL92714; Costunolide, >=97% (HPLC); HMS3269I17; HMS3413B19; HMS3677B19; HY-N0036; BDBM50411242; MFCD00210262; ZINC30726859; AKOS015840065; AKOS015969714; CS-1487; MCULE-2058016705; NCGC00381718-02; AC-28334; AS-17708; V1471; C09382; 553C219; Q5175227; BRD-K26833429-001-01-0

Click to Show/Hide

Activity

IC50 ~ 50000 nM

[2]

Compound Name

1,2-Bis-(4-chloro-phenyl)-4-methyl-4-(6-phenyl-hexyl)-pyrazolidine-3,5-dione

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL189679; BDBM50166484

Click to Show/Hide

Activity

IC50 ~ 50000 nM

[1]

Compound Name

(3Ar,5aS,9aS,9bR)-5a,9-dimethyl-3-methylidene-4,5,6,7,9a,9b-hexahydro-3aH-benzo[g][1]benzofuran-2-one

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL218788; BDBM50194425

Click to Show/Hide

Activity

IC50 ~ 50000 nM

[2]

Compound Name

Parthenolide

Click to Show/Hide

Investigative

Compound Info

Synonyms

(-)-Parthenolide; LSM-4225; CHEMBL540445; NSC-157035; KS-00000MJV; BDBM50433441; ZINC12362725; LMPR0103090002; AK114992; SW220012-1; Q27165422

Click to Show/Hide

Activity

IC50 ~ 50000 nM

[2]

Compound Name

Alantolactone

Click to Show/Hide

Investigative

Compound Info

Synonyms

helenine; Eupatal; helenin; Alant camphor; Inula camphor; Elecampane camphor; UNII-M7GSN5Q1M6; AI3-31147; NSC93131; M7GSN5Q1M6; CHEMBL136356; NSC 93131; Alantic anhydride; EINECS 208-899-3; NSC 302289; Alantcamphor; Spectrum_000297; Spectrum2_000297; Spectrum3_001358; Spectrum4_001772; Spectrum5_000383; Epitope ID:119691; BSPBio_003175; KBioGR_002284; KBioSS_000777; SPECTRUM310010; SCHEMBL155169; SPBio_000234; KBio2_000777; KBio2_003345; KBio2_005913; KBio3_002395; KS-00000KMX; DTXSID90877864; Alantolactone, >=98% (HPLC); HY-N0038; ZINC3881905; BDBM50096873; CA0121; CCG-39639; NSC-93131; s8318; AKOS015906135; CS-3595; EBD2184835; LMPR0103190013; SDCCGMLS-0066583.P001; NCGC00178225-01; NCGC00178225-02; NCGC00178225-05; AC-31414; BS-17042; NCI60_042073; AB0137323; N2660; C09289; W-2808; Q21099633; 4.alpha.H-Eudesma-5, 8.beta.-hydroxy-, .gamma.-lactone; 4alphaH-Eudesma-5,11(13)-dien-12-oic acid, 8beta-hydroxy-, gamma-lactone (8CI)

Click to Show/Hide

Activity

IC50 ~ 50000 nM

[2]

Compound Name

1,2-Bis-(4-chloro-phenyl)-5-[2-(2,4-difluoro-phenyl)-2-oxo-ethoxy]-4-methyl-pyrazolidin-3-one

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL363203; BDBM50166502

Click to Show/Hide

Activity

IC50 ~ 50000 nM

[1]

Compound Name

Dehydrocostus lactone

Click to Show/Hide

Investigative

Compound Info

Synonyms

dehydrocostuslactone; (-)-dehydrocostus lactone; (-)-dehydrocostuslactone; (3aS,6aR,9aR,9bS)-decahydro-3,6,9-tris(methylene)azuleno[4,5-b]furan-2(3H)-one; (3aS,6aR,9aR,9bS)-3,6,9-trimethylenedecahydroazuleno[4,5-b]furan-2(3H)-one; (3aS,6aR,9aR,9bS)-3,6,9-Trimethylenedecahydroazuleno[4,5-b]furan-2(9bH)-one; Dehydrocostus-Lactone; UNII-71TRF5K040; Epiligulyl oxide; CHEMBL88985; SCHEMBL699070; CTK5D9685; DTXSID80891554; 71TRF5K040; ZINC898477; Dehydro-costus lactone (6CI,7CI); EBD10311; HY-N0591; BDBM50370831; s3615; AKOS015896789; CCG-208469; CS-3636; MCULE-3657815830; Dehydrocostus lactone, >=98% (HPLC); NCGC00385838-01; AK168191; Dehydrocostus lactone, analytical standard; SC-19761; D5366; A14809; C09387; 299D482; Q27105152; (-)-Dehydrocostus lactone; Dehydrocostus lactone; Epiligulyl oxide; Azuleno[4,5-b]furan-2(3H)-one,decahydro-3,6,9-tris(methylene)-; (3aS,6aR,9aR,9bS)-Decahydro-3,6,9-tris(methylene)-azuleno[4,5-b]furan-2(3H)-one; Guaia-4(15),10(14),11(13)-trien-12-oic acid, 6alpha-hydroxy-, gamma-lactone

Click to Show/Hide

Activity

IC50 ~ 50000 nM

[2]

Click to Show/Hide the Information of All Poor Binders

References

Top

REF 1

4-Alkyl and 4,4'-dialkyl 1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione derivatives as new inhibitors of bacterial cell wall biosynthesis. Bioorg Med Chem Lett. 2005 May 16;15(10):2527-31.

REF 2

Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5605-9.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.

Prof. Feng ZHU

Prof. Yuzong CHEN