Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T22839 | Target Info | |||
| Target Name | Pancreatic elastase 1 (CELA1) | ||||
| Synonyms |
Elastase; CELA1
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| Target Type | Successful Target | ||||
| Gene Name | CELA1 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Non Binders of This Target (in total, 3 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-[(1-{2-[2-(3-Methoxycarbonyl-propionylamino)-propionylamino]-propionyl}-pyrrolidine-2-carbonyl)-amino]-2-oxo-4-phenyl-butyric acid methyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL130006; BDBM50014731
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| Activity |
Ki > 1000000 nM
|
[1] | |||
| Compound Name |
(S)-1-(((5-(Dimethylamino)naphthalen-1-yl)sulfonyl)-L-alanyl-L-alanyl)-N-((S)-1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl)pyrrolidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL339870; Mdl 27324; BDBM50014732; Dns-L-Ala-L-Ala-L-Pro-L-Val-Trifluoromethane
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| Activity |
Ki = 1000000 nM
|
[1] | |||
| Compound Name |
N-(3-Methoxycarbonylpropanoyl)-L-Ala-L-Ala-L-Pro-L-Phe-trifluoromethane
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL132171; BDBM50014743
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| Activity |
Ki > 1500000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis of peptidyl fluoromethyl ketones and peptidyl alpha-keto esters as inhibitors of porcine pancreatic elastase, human neutrophil elastase, ... J Med Chem. 1990 Jan;33(1):394-407. | ||||
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