Target Poor or Non Binder(s) Information
Target General Information | Top | ||||
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Target ID | T21865 | Target Info | |||
Target Name | P-selectin glycoprotein ligand 1 (SELPLG) | ||||
Synonyms |
Selectin P ligand; SPSGL-1; SELPLG; PSGL-1; P-selectin glycoprotein ligand-1; CD162 antigen
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Target Type | Clinical trial Target | ||||
Gene Name | SELPLG | ||||
UniProt ID |
Poor Binders of This Target (in total, 8 binders) | Download | Top | |||
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Compound Name |
Bimosiamose
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Phase 2a | Compound Info | ||
Synonyms |
TBC 1269; TBC-1269
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Activity |
IC50 = 70000 nM
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[1] | |||
Compound Name |
PSI-697
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Phase 1 | Compound Info | ||
Synonyms |
PSI-697; UNII-LH1XC916ME; 851546-61-7; LH1XC916ME; CHEMBL219046; 2-(4-Chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo(H)quinoline-4-carboxylic acid; 2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h]quinoline-4-carboxylic acid; SCHEMBL43527; DIEPFYNZGUUVHD-UHFFFAOYSA-N; ZINC28603970; BDBM50201984; AKOS032945074; CS-5867; DB12211; HY-15526; LS-193902; 2-(4-chloro-benzyl)-3-hydroxy-7,8,9,10-tetrahydro-benzo[h]-quinoline-4-carboxylic acid; 2-(4-Chloro-benzyl)-3-hydroxy-7,8,9,10-tetrahydro-benzo[h]quinoline-4-carboxylic
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Activity |
IC50 = 150000 nM
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[2] | |||
Compound Name |
8-Sec-butyl-2-(4-chlorophenyl)-3-hydroxyquinoline-4-carboxylicacid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL218727; BDBM50201916
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Activity |
IC50 = 75000 nM
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[1] | |||
Compound Name |
6-Bromo-2-(4-chlorophenyl)-3-hydroxy-8-methylquinoline-4-carboxylic acid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL218051; BDBM50201931
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Activity |
IC50 = 125000 nM
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[1] | |||
Compound Name |
2-(4-Chlorophenyl)-3-hydroxy-8-(thien-3-yl)quinoline-4-carboxylicacid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL219045; BDBM50201947
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Activity |
IC50 = 175000 nM
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[1] | |||
Compound Name |
3-Hydroxy-2-(1-phenylethyl)-7,8,9,10-tetrahydrobenzo[h]quinoline-4-carboxylic acid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1215805; SCHEMBL4435185; BDBM50324665; 3-Hydroxy-2-(1-phenylethyl)-7,8,9,10-tetrahydrobenzo[h]quinoline-4-carboxylic
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Activity |
IC50 = 175000 nM
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[2] | |||
Compound Name |
3-Hydroxy-7,8-dimethyl-2-(3-(trifluoromethoxy)phenyl)quinoline-4-carboxylic acid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL218465; BDBM50201944
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Activity |
IC50 = 200000 nM
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[1] | |||
Compound Name |
2-(4-Chlorophenyl)-3-hydroxy-8-phenylquinoline-4-carboxylic acid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL218583; CTK3F8511; DTXSID30582748; BDBM50201901; 2-(4-chlorophenyl)-3-hydroxy-8-phenylquinoline-4-carboxylicacid; 4-Quinolinecarboxylic acid, 2-(4-chlorophenyl)-3-hydroxy-8-phenyl-
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Activity |
IC50 = 200000 nM
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[1] | |||
Click to Show/Hide the Information of All Poor Binders |
Non Binders of This Target (in total, 38 non binders) | Download | Top | |||
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Compound Name |
3-hydroxy-2-phenylquinoline-4-carboxylic acid
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Investigative | Compound Info | ||
Synonyms |
Oxycinchophen; 485-89-2; Oxinofen; Chinoxone; Fenidrone; 3-hydroxy-2-phenylquinoline-4-carboxylic acid; Hydroxycinchophene; Sintofene; Magnofenyl; Reumartril; Magnophenyl; 3-Hydroxy-2-phenylcinchoninic acid; 3-Hydroxycinchophen; oxicinchophen; Oxicinchophenum; Oxycinchophen [INN:BAN]; Oxicincofeno [INN-Spanish]; UNII-UK6392GD5W; Oxycinchophene [INN-French]; Oxycinchophenum [INN-Latin]; 3-Hydroxy-2-phenyl-4-quinolinecarboxylic acid; 3-Hydroxy-2-phenyl-chinchoninsaeure; EINECS 207-624-4; NSC 41784; BRN 0224526; CHEMBL219376
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Activity |
IC50 = 6000000 nM
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[1] | |||
Compound Name |
2-(4-Chlorophenyl)-3-hydroxy-8-methyl-6-(trifluoromethoxy)-quinoline-4-carboxylic acid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL219697; BDBM50201906
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Activity |
IC50 = 225000 nM
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[1] | |||
Compound Name |
2-(4-Chlorophenyl)-3-hydroxy-8-isopropylquinoline-4-carboxylicacid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL218780; BDBM50201928
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Activity |
IC50 = 225000 nM
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[1] | |||
Compound Name |
3-Hydroxy-7,8-dimethyl-2-(4-(trifluoromethoxy)phenyl) quinoline-4-carboxylic acid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL219175; BDBM50201932
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Activity |
IC50 = 240000 nM
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[1] | |||
Compound Name |
3-Hydroxy-2-(4-isopropylphenyl)-7,8-dimethylquinoline-4-carboxylic acid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL218500; BDBM50201911
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Activity |
IC50 = 250000 nM
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[1] | |||
Compound Name |
3-Hydroxy-2-(1-phenylcyclopropyl)-7,8,9,10-tetrahydrobenzo[h]quinoline-4-carboxylic acid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1215806; SCHEMBL4447495; BDBM50324664; 3-Hydroxy-2-(1-phenylcyclopropyl)-7,8,9,10-tetrahydrobenzo-[h]quinoline-4-carboxylic Acid
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Activity |
IC50 = 250000 nM
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[2] | |||
Compound Name |
2-(4-(Diethylamino)phenyl)-3-hydroxy-7,8-dimethylquinoline-4-carboxylic acid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL219176; BDBM50201942
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Activity |
IC50 = 250000 nM
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[1] | |||
Compound Name |
2-(4-Chlorophenyl)-3-hydroxy-8-trifluoromethylquinoline-4-carboxylic acid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL219364; BDBM50201938
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Activity |
IC50 = 250000 nM
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[1] | |||
Compound Name |
2-(4-Chlorophenyl)-8-(dimethylaminophenyl)-3-hydroxyquinoline-4-carboxylic acid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL218669; BDBM50201910
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Activity |
IC50 = 300000 nM
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[1] | |||
Compound Name |
3-Hydroxy-7,8-dimethyl-2-(4-(trifluoromethyl)phenyl)quinoline-4-carboxylic acid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL219174; BDBM50201897
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Activity |
IC50 = 300000 nM
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[1] | |||
Compound Name |
2-(4-Chlorophenyl)-3-hydroxy-6-phenylquinoline-4-carboxylic acid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL384983; BDBM50201922
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Activity |
IC50 = 375000 nM
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[1] | |||
Compound Name |
2-(3-Chlorophenyl)-3-hydroxy-7,8-dimethylquinoline-4-carboxylicacid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL219759; BDBM50201917
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Activity |
IC50 = 400000 nM
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[1] | |||
Compound Name |
2-(4-Bromophenyl)-3-hydroxy-7,8-dimethylquinoline-4-carboxylicacid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL374432; BDBM50201914
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Activity |
IC50 = 400000 nM
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[1] | |||
Compound Name |
2-Benzyl-3-hydroxy-7,8,9,10-tetrahydrobenzo[h]quinoline-4-carboxylic acid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL384767; SCHEMBL1292134; BDBM50201977
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Activity |
IC50 = 413000 nM
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[2] | |||
Compound Name |
2-(4-Chlorophenyl)-3-hydroxy-7,8-dimethylquinoline-4-carboxylicacid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL267210; BDBM50201902
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Activity |
IC50 = 450000 nM
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[1] | |||
Compound Name |
2-(4-Chlorophenyl)-3-hydroxy-6,8-dimethylquinoline-4-carboxylicacid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL375425; BDBM50201920
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Activity |
IC50 = 500000 nM
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[1] | |||
Compound Name |
2-(4-Chlorophenyl)-8-ethyl-3-hydroxyquinoline-4-carboxylicacid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL373494; BDBM50201899
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Activity |
IC50 = 525000 nM
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[1] | |||
Compound Name |
2-(4-Chlorophenyl)-3-hydroxy-8-(trifluoromethoxy)quinoline-4-carboxylic acid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL218083; BDBM50201933
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Activity |
IC50 = 550000 nM
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[1] | |||
Compound Name |
8-Chloro-2-(4-chlorophenyl)-3-hydroxyquinoline-4-carboxylicacid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL384543; BDBM50201895
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Activity |
IC50 = 600000 nM
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[1] | |||
Compound Name |
2-(4-Chlorophenyl)-3-hydroxy-6-(trifluoromethoxy)quinoline-4-carboxylic acid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL218052; BDBM50201892
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Activity |
IC50 = 625000 nM
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[1] | |||
Compound Name |
8-Bromo-2-(4-chlorophenyl)-3-hydroxyquinoline-4-carboxylicacid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL384039; BDBM50201926
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Activity |
IC50 = 625000 nM
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[1] | |||
Compound Name |
2-(4-Chlorophenyl)-3-hydroxy-8-methylquinoline-4-carboxylicacid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL375815; BDBM50201893
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Activity |
IC50 = 700000 nM
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[1] | |||
Compound Name |
3-Hydroxy-7,8-dimethyl-2-(4-morpholinophenyl)quinoline-4-carboxylic acid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL374669; BDBM50201943
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Activity |
IC50 = 1000000 nM
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[1] | |||
Compound Name |
6-Bromo-2-(4-chlorophenyl)-3-hydroxyquinoline-4-carboxylicacid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL218700; SCHEMBL10583075; BDBM50201900; 6-bromo-2-(4-chlorophenyl)-3-hydroxyquinoline-4-carboxylic acid
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Activity |
IC50 = 1000000 nM
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[1] | |||
Compound Name |
3-Hydroxy-2-(4-methoxyphenyl)-7,8-dimethylquinoline-4-carboxylic acid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL219646; BDBM50201904
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Activity |
IC50 = 1000000 nM
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[1] | |||
Compound Name |
3-Hydroxy-7,8-dimethyl-2-p-tolylquinoline-4-carboxylic acid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL219230; BDBM50201894
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Activity |
IC50 = 1000000 nM
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[1] | |||
Compound Name |
8-(4-Carboxyphenyl)-2-(4-chlorophenyl)-3-hydroxyquinoline-4-carboxylic acid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL427238; BDBM50201950
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Activity |
IC50 = 1500000 nM
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[1] | |||
Compound Name |
3-Hydroxy-7,8-dimethyl-2-phenylquinoline-4-carboxylic acid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL218311; CTK3F8504; DTXSID00582750; BDBM50201924; 4-Quinolinecarboxylic acid, 3-hydroxy-7,8-dimethyl-2-phenyl-
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Activity |
IC50 = 1500000 nM
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[1] | |||
Compound Name |
2-(4-Chlorophenyl)-3-hydroxy-7-isopropylquinoline-4-carboxylicacid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL218309; BDBM50201896
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Activity |
IC50 = 1500000 nM
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[1] | |||
Compound Name |
2-(4-Chlorophenyl)-3,6-dihydroxyquinoline-4-carboxylic acid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL374358; BDBM50201929
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Activity |
IC50 = 1500000 nM
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[1] | |||
Compound Name |
2-(4-Chlorophenyl)-3-hydroxy-6-(trifluoromethyl)quinoline-4-carboxylic acid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL386700; BDBM50201913
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Activity |
IC50 = 1600000 nM
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[1] | |||
Compound Name |
2-(4-Chlorophenyl)-3-hydroxy-8-(4-hydroxymethylphenyl)-quinoline-4-carboxylic acid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL219232; BDBM50201903
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Activity |
IC50 = 2000000 nM
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[1] | |||
Compound Name |
2-(4-Chlorophenyl)-3-hydroxy-7-phenylquinoline-4-carboxylicacid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL218584; BDBM50201908
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Activity |
IC50 = 2000000 nM
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[1] | |||
Compound Name |
2-[2-(3,4,5-Trihydroxy-6-{[2-(1-phenyl-ethylcarbamoyl)-benzoylamino]-methyl}-tetrahydro-pyran-2-yl)-acetylamino]-pentanedioic acid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL288811; BDBM50111451
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Activity |
IC50 = 2500000 nM
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[3] | |||
Compound Name |
6-Amino-2-(4-chlorophenyl)-3-hydroxyquinoline-4-carboxylicacid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL217895; BDBM50201915
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Activity |
IC50 = 3000000 nM
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[1] | |||
Compound Name |
3-Hydroxy-2-(4-hydroxyphenyl)-7,8-dimethylquinoline-4-carboxylicacid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL374961; BDBM50201912
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Activity |
IC50 = 3500000 nM
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[1] | |||
Compound Name |
2-(4-Chlorophenyl)-3-hydroxyquinoline-4-carboxylic acid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL375814; SCHEMBL9501955; BDBM50201937
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Activity |
IC50 = 4000000 nM
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[1] | |||
Compound Name |
Sialyl-Lewis X
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Investigative | Compound Info | ||
Synonyms |
3'-Sialyl-Lewis X; sialyl LewisX; Sialyl lewis-x; Sialyl Lex tri; 3'-Sialyl-Lewis-X tetrasaccharide; Sialyl LeX; 3'-SIALYL LEWIS X; 3'-SLeX; SSEA 1; UNII-0PS35WG8U3; 0PS35WG8U3; a-NeuNAc-(2>3)-b-D-Gal-(1>4)(a-L-Fuc-[1>3])-D-GlcNAc; 3-Sialyl Lewis X; SCHEMBL346849; CHEMBL375586; DTXSID60913167; BDBM50450369; ZINC96129530; HY-W020790; CS-0031944; J3.549.354I; Q3959958; W-204175; alpha-NeuNAc-(2>3)-beta-delta-Gal-(1>4)(a-L-Fuc-[1>3])-delta-GlcNAc
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Activity |
IC50 = 15000000 nM
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[2] | |||
Click to Show/Hide the Information of All Non Binders |
References | Top | ||||
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REF 1 | Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists. J Med Chem. 2007 Jan 11;50(1):21-39. | ||||
REF 2 | Discovery of 2-[1-(4-chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic acid (PSI-421), a P-selectin inhibitor with improved pharmacokinetic properties and oral efficacy in models of vascular injury. J Med Chem. 2010 Aug 26;53(16):6003-17. | ||||
REF 3 | Beta-C-mannosides as selectin inhibitors. J Med Chem. 2002 Apr 11;45(8):1563-6. |
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