Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T21507 | Target Info | |||
| Target Name | Fatty acid-binding protein 5 (FABP5) | ||||
| Synonyms |
Psoriasis-associated fatty acid-binding protein homolog; PA-FABP; Fatty acid-binding protein, epidermal; Fatty Acid BindingProtein mal1; Epidermal-type fatty acid-binding protein; E-FABP
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| Target Type | Patented-recorded Target | ||||
| Gene Name | FABP5 | ||||
| Biochemical Class | Fatty acid binding protein | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 10 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1-[(5-Chloro-2-phenylphenyl)carbamoylamino]cyclopropane-1-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3967738; SCHEMBL16097403; BDBM212448; US9278918, 34
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-[[4-Chloro-2-(4-fluorophenyl)phenyl]carbamoylamino]cyclopentane-1-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3938704; SCHEMBL16104993; BDBM212459; US9278918, 49
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-[(4-Chloro-2-phenylphenyl)carbamoylamino]cyclopropane-1-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3943391; SCHEMBL16099476; BDBM212453; US9278918, 43
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-[[4-Chloro-2-(4-fluorophenyl)phenyl]carbamoylamino]cyclopropane-1-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3980900; SCHEMBL16099855; BDBM212460; US9278918, 50
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-[(5-Chloro-4-fluoro-2-phenylphenyl)carbamoylamino]cyclopropane-1-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3969505; SCHEMBL16098785; BDBM212452; US9278918, 42
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-[Methyl-[(2-phenylphenyl)carbamoyl]amino]cyclopropane-1-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3931426; SCHEMBL16097813; BDBM212446; US9278918, 32
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2,4,6-Triisopropylbenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
2,4,6-tri(propan-2-yl)benzoic acid; 2,4,6-Triisopropyl benzoic acid; 2,4,6-Tris(1-methylethyl)benzoic acid; MFCD00015031; CHEMBL3400905; Benzoic acid,2,4,6-tris(1-methylethyl)-; Benzoic acid, 2,4,6-tris(1-methylethyl)-; 2,4,6-tris(methylethyl)benzoic acid; NSC60075; EINECS 256-400-2; ACMC-20aoew; PubChem7877; SCHEMBL810177; CTK4J1468; DTXSID50197939; ZINC156213; (2,4,6-triisopropyl)benzoic acid; STR04838; BDBM50063855; NSC-60075; SBB057885; AKOS015911526; 2,4,6-tris(propan-2-yl)benzoic acid; MCULE-7566273823; 2,4,6-Triisopropylphenylcarboxylic acid; AK135720; SY271357; DB-019836; FT-0609885; ST50406976; Q27456668
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
1-[[2-Phenyl-5-(trifluoromethyl)phenyl]carbamoylamino]cyclopropane-1-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3968270; SCHEMBL16098532; BDBM212458; US9278918, 48
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-[[5-Chloro-2-(4-fluorophenyl)phenyl]carbamoylamino]cyclopropane-1-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3958454; SCHEMBL16099622; BDBM212450; US9278918, 40
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-[(5-Chloro-2-phenylphenyl)carbamoylamino]cyclobutane-1-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3893057; SCHEMBL16099625; BDBM212449; US9278918, 35
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | US patent application no. 9278918B2, Urea derivatives and their use as fatty-acid binding protein (FABP) inhibitors | ||||
| REF 2 | Novel fatty acid binding protein 4 (FABP4) inhibitors: virtual screening, synthesis and crystal structure determination. Eur J Med Chem. 2015 Jan 27;90:241-50. | ||||
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